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Chapter 1 : Overview

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Overview, Page 1 of 2

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Abstract:

has been the subject of intense investigation since its culture from a gastric biopsy in 1982. The bacteriology of the microaerophilic spiral-shaped bacterium is fascinating. is a member of a rapidly growing genus. New species are being isolated at a fast rate from many vertebrate hosts. Cogent explanations of the adaptation of to the gastric environment and the regulation of its physiology by environmental factors are given for a substantial body of experimental knowledge by placing it in the framework of the genome of the organism. Survival and proliferation depend intrinsically on the flux of nutrients. The diversity of is made clear in the discussion of pathways related to cell structure and function, which relates its unique murein with the ability of the bacterium to colonize its niche. Mutagenesis is straightforward, and it is relatively easy to construct a double-crossover allelic exchange mutant. can colonize its human host for life. It is therefore well adapted for life in the stomach. In summary, the authors are approaching 20 years of research on a bacterium proven to be the cause of gastritis and indisputably correlated with the development of peptic ulcers and the progression to cancer.

Citation: Mobley H, Mendz G, Hazell S. 2001. Overview, p 3-5. In Mobley H, Mendz G, Hazell S (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555818005.ch1

Key Concept Ranking

Bacterial Proteins
0.47256342
Agricultural Microbiology
0.4190284
Microbial Ecology
0.4190284
Type III Secretion System
0.4147098
0.47256342
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Figure 1

Helicobacter-related articles cited in Medline since the culture of H. pylori. The Medline database was searched by year for “Helicobacter” or “Campylobacter pylori” or “Campylobacter pyloridis.” The total number of cited articles for all three categories is shown by year. In 1999, the last year for which a complete database exists, 2,091 articles appeared on these topics.

Citation: Mobley H, Mendz G, Hazell S. 2001. Overview, p 3-5. In Mobley H, Mendz G, Hazell S (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555818005.ch1
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