Chapter 32 : Population Genetics

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The first part of this chapter contains a general introduction to bacterial population genetics, and the second part reviews the available data on the genetic diversity within and the mechanisms that have generated this diversity. Three types of population structures includes clonal, panmictic, and epidemic. Genetic diversity arises by intragenomic genetic events including point mutations, deletions, insertions, and rearrangements. As early as 1986, it was recognized that exhibits an unusual degree of genetic heterogeneity. Compatibility matrices yielded results that were consistent with frequent recombination in . The frequency of both recombination and purification remains to be quantitated. Biogeographical diversity of three virulence-associated genes such as , , and could arise by various mechanisms, ranging from founder effects associated with vertical transmission to selection for antigenic or functional variants with differential fitness for certain host populations. Subsequent analyses of the same housekeeping genes from additional isolates from Indonesia and South Africa have confirmed the original conclusions, but further analyses are needed to test whether virulence genes such as also fall into three populations. An initial study failed to detect genomic changes in paired isolates obtained 2 years apart from 20 patients, but two subsequent studies have shown that strains can indeed change during chronic colonization.

Citation: Suerbaum S, Achtman M. 2001. Population Genetics, p 355-361. In Mobley H, Mendz G, Hazell S (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555818005.ch32

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Restriction Fragment Length Polymorphism
Random Amplified Polymorphic DNA
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Figure 1

Comparison of the mean homoplasy ratio (H) and mean genetic distance at synonymous sites (D) among different bacterial species. The sources of the data for these analyses are given in reference 1. Modified from reference with permission.

Citation: Suerbaum S, Achtman M. 2001. Population Genetics, p 355-361. In Mobley H, Mendz G, Hazell S (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555818005.ch32
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