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Chapter 41 : Markers of Infection

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Abstract:

Markers for the presence of a infection consist of features or events that suggest that the infection is, or has been, present and include alterations in gastroduodenal structure and function, as well as tests to detect the bacterium itself or the presence of bacterial enzymes. It is now recognized that primary mucosa-associated gastric lymphoma (MALT lymphoma) and approximately 10% of cases of nonulcer dyspepsia are also directly related to infection. There are a number of biochemical markers suggestive of the presence of an active or past infection. A group of expert pathologists recommended that for diagnosis of infection and characterization of the pattern of gastritis, two biopsies should routinely be taken from the antrum and two from the body of the stomach for histological evaluation. The accuracy of rapid urease testing is high, such that a correlation between histology and rapid urease testing provides a simple measure to gauge the accuracy of the pathology department. Detection of anti- antibody is the easiest noninvasive approach to test for the presence of an infection. With some tests only a few drops of fingerstick blood are required and the results are available in less than 5 min.

Citation: Graham D, Qureshi W. 2001. Markers of Infection, p 499-510. In Mobley H, Mendz G, Hazell S (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555818005.ch41

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Figures

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Figure 1

Example of the El-Zimaity dual stain of gastric mucosa ( ). The stain combines periodic acid-Schiff and a silver stain and is the preferred stain when the density of is very low or when searching for in the duodenum.

Citation: Graham D, Qureshi W. 2001. Markers of Infection, p 499-510. In Mobley H, Mendz G, Hazell S (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555818005.ch41
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Image of Figure 2
Figure 2

Examples of three commercial rapid urease tests including the original CLO test and two second-generation tests. One of each pair is the control, the other is after the color change.

Citation: Graham D, Qureshi W. 2001. Markers of Infection, p 499-510. In Mobley H, Mendz G, Hazell S (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555818005.ch41
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References

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1. Agha-Amiri, K.,, D. Mainz,, U. Peitz,, S. Kahl,, A. Leodolter,, and P. Malfertheiner. 1999. Evaluation of an enzyme immunoassay for detecting Helicobacter pylori antigens in human stool samples. Z. Gastroenterol. 37: 1145 1149.
2. Al-Assi, M. T.,, K. Miki,, J. H. Walsh,, D. P. Graham,, M. Asaka,, and D. Y. Graham. 1999. Noninvasive evaluation of Helicobacter pylori therapy: role of fasting on postprandial gastrin, pepsinogen I, pepsinogen II, or serum IgG antibodies. Am. J. Gastroenterol. 94: 2367 2372.
3. Alemohammad, M. M.,, T. J. Foley,, and H. Cohen. 1993. Detection of immunoglobulin G antibodies to Helicobacter pylori in urine by an enzyme immunoassay method. J. Clin. Microbiol. 31: 2174 2177.
4. Asaka, M.,, T. Kimura,, M. Kudo,, H. Takeda,, S. Mitani,, T. Miyazaki,, K. Miki,, and D. Y. Graham. 1992. Relationship of Helicobacter pylori to serum pepsinogens in an asymptomatic Japanese population. Gastroenterology 102: 760 766.
5. Aucher, P.,, M. L. Petit,, P. R. Mannant,, L. Pezennec,, P. Babin,, and J. L. Fauchere. 1998. Use of immunoblot assay to define serum antibody patterns associated with Helicobacter pylori infection and with H. pylori-related ulcers. J. Clin. Microbiol. 36: 931 936.
6. Bielanski, W.,, and S. J. Konturek. 1996. New approach to 13C-urea breath test: capsule-based modification with low-dose of 13C-urea in the diagnosis of Helicobacter pylori infection. J. Physiol. Pharmacol. 47: 545 553.
7. Braden, B.,, L. P. Duan,, W. F. Caspary,, and B. Lembcke. 1994. More convenient 13C-urea breath test modifications still meet the criteria for valid diagnosis of Helicobacter pylori infection. Z. Gastroenterol. 32: 198 202.
8. Braden, B.,, H. G. Posselt,, P. Ahrens,, R. Kitz,, C. F. Dietrich,, and W. F. Caspary. 2000. New immunoassay in stool provides an accurate noninvasive diagnostic method for Helicobacter pylori screening in children. Pediatrics 106: 115 117.
9. Braden, B.,, F. Schafer,, W. F. Caspary,, and B. Lembcke. 1996. Nondispersive isotope-selective infrared spectroscopy: a new analytical method for 13C-urea breath tests. Scand. J. Gastroenterol. 31: 442 445.
10. Bravo, L. E.,, J. L. Realpe,, C. Campo,, R. Mera,, and P. Correa. 1999. Effects of acid suppression and bismuth medications on the performance of diagnostic tests for Helicobacter pylori infection. Am. J. Gastroenterol. 94: 2380 2383.
11. Burnie, J. P.,, W. Lee,, J. C. Dent,, and C. A. McNulty. 1988. Immunoblot fingerprinting of Campylobacter pylori. J. Med. Microbiol. 27: 153 159.
12. Calam, J. 1997. Helicobacter pylori and hormones. Yale J. Biol. Med. 69: 39 49.
13. Caselli, M.,, N. Figura,, L. Trevisani,, P. Pazzi,, P. Guglielmetti,, M. R. Bovolenta,, and G. Stabellini. 1989. Patterns of physical modes of contact between Campylobacter pylori and gastric epithelium: implications about the bacterial pathogenicity. Am.J. Gastroenterol. 84: 511 513.
14. Chang, M. C.,, M. S. Wu,, H. H. Wang,, H. P. Wang,, and J. T. Lin. 1999. Helicobacter pylori stool antigen (HpSA) test—a simple, accurate and non-invasive test for detection of Helicobacter pylori infection. Hepatogastroenterology 46: 299 302.
15. Chen, T. S.,, S. H. Tsay,, F. Y. Chang,, and S. D. Lee. 1994. Effect of eradication of Helicobacter pylori on serum pepsinogen I, gastrin, and insulin in duodenal ulcer patients: a 12-month follow-up study. Am. J. Gastroenterol. 89: 1511 1514.
16. Chittajallu, R. S.,, C. A. Dorrian,, J. E. Ardill,, and K. E. McColl. 1992. Effect of Helicobacter pylori on serum pepsinogen I and plasma gastrin in duodenal ulcer patients. Scand. J. Gastroenterol. 27: 20 24.
17. Cohen, H.,, S. Rose,, D. N. Lewin,, B. Retama,, W. Naritoku,, C. Johnson,, L. Bautista,, H. Crowe,, and A. Pronovost. 1999. Accuracy of four commercially available serologic tests, including two office-based tests and a commercially available 13C urea breath test, for diagnosis of Helicobacter pylori. Helicobacter 4: 49 53.
18. Dixon, M. F.,, R. M. Genta,, J. H. Yardley,, and P. Correa. 1996. Classification and grading of gastritis. The updated Sydney system. International Workshop on the Histopathology of Gastritis, Houston, 1994. Am. J. Surg. Pathol. 20: 1161 1181.
19. Dore, M. P.,, and D. Y. Graham. 2000. Pathogenesis of duodenal ulcer disease: the rest of the story. Baillieres Best Pract. Res. Clin. Gastroenterol. 14: 97 107.
20. El-Zaatari, F. A.,, A. M. Nguyen,, R. M. Genta,, P. D. Klein,, and D. Y. Graham. 1995. Determination of Helicobacter pylori status by reverse transcription-polymerase chain reaction. Comparison with urea breath test. Dig. Dis. Sci. 40: 109 113.
21. El-Zaatari, F. A.,, S. M. Oweis,, and D. Y. Graham. 1997. Uses and cautions for use of polymerase chain reaction for detection of Helicobacter pylori. Dig. Dis. Sci. 42: 2116 2119.
22. El-Zimaity, H. M.,, M. T. Al-Assi,, R. M. Genta,, and D. Y. Graham. 1995. Confirmation of successful therapy of Helicobacter pylori infection: number and site of biopsies or a rapid urease test. Am. J. Gastroenterol. 90: 1962 1964.
23. El-Zimaity, H. M.,, and D. Y. Graham. 1999. Evaluation of gastric mucosal biopsy site and number for identification of Helicobacter pylori or intestinal metaplasia: role of the Sydney system. Hum. Pathol. 30: 72 77.
24. El-Zimaity, H. M.,, H. Ota,, S. Scott,, D. E. Killen,, and D. Y. Graham. 1998. A new triple stain for Helicobacter pylori suitable for the autostainer: carbol fuchsin/Alcian blue/hematoxylin-eosin. Arch. Pathol. Lab. Med. 122: 732 736.
25. El-Zimaity, H. M.,, A. M. Segura,, R. M. Genta,, and D. Y. Graham. 1998. Histologic assessment of Helicobacter pylori status after therapy: comparison of Giemsa, Diff-Quik, and Genta stains. Mod. Pathol. 11: 288 291.
26. El Zimaity, H. M.,, J. Wu,, T. Akamatsu,, and D. Y. Graham. 1999. A reliable method for the simultaneous identification of H. pylori and gastric metaplasia in the duodenum. J. Clin. Pathol. 52: 914 916.
27. El Zimaity, H. M.,, J. Wu,, and D. Y. Graham. 1999. Modified Genta triple stain for identifying Helicobacter pylori. J. Clin. Pathol. 52: 693 694.
28. Evans, D. J., Jr.,, D. G. Evans,, D. Y. Graham,, and P. D. Klein. 1989. A sensitive and specific serologic test for detection of Campylobacter pylori infection. Gastroenterology 96: 1004 1008.
29. Evans, D. J., Jr.,, D. G. Evans,, S. S. Kirkpatrick,, and D. Y. Graham. 1991. Characterization of the Helicobacter pylori urease and purification of its subunits. Microb. Pathog. 10: 15 26.
30. Faigel, D. O.,, N. Magaret,, C. Corless,, D. A. Lieberman,, and M. B. Fennerty. 2000. Evaluation of rapid antibody tests for the diagnosis of Helicobacter pylori infection. Am. J. Gastroenterol. 95: 72 77.
31. Fanti, L.,, G. Mezzi,, A. Cavallero,, G. Gesu,, C. Bonato,, and E. Masci. 1999. A new simple immunoassay for detecting Helicobacter pylori infection: antigen in stool specimens. Digestion 60: 456 460.
32. Faulde, M.,, J. P. Schroder,, and D. Sobe. 1992. Serodiagnosis of Helicobacter pylori infections by detection of immunoglobulin G antibodies using an immunoblot technique and enzyme immunoassay. Eur. J. Clin. Microbiol. Infect. Dis. 11: 589 594.
33. Feldman, R. A.,, and S.J. Evans. 1995. Accuracy of diagnostic methods used for epidemiological studies of Helicobacter pylori. Aliment. Pharmacol. Ther. 9(Suppl. 2): 21 31.
34. Forne, M.,, J. Dominguez,, F. Fernandez-Banares,, J. Lite,, M. Esteve,, N. Gali,, J. C. Espinos,, S. Quintana,, and J. M. Viver. 2000. Accuracy of an enzyme immunoassay for the detection of Helicobacter pylori in stool specimens in the diagnosis of infection and posttreatment check-up. Am. J. Gastroenterol. 95: 2200 2205.
35. Furuta, T.,, E. Kaneko,, S. Baba,, H. Arai,, and H. Futami. 1997. Percentage changes in serum pepsinogens are useful as indices of eradication of Helicobacter pylori. Am. J. Gastroenterol. 92: 84 88.
36. Genta, R. M.,, and D. Y. Graham. 1994. Comparison of biopsy sites for the histopathologic diagnosis of Helicobacter pylori: a topographic study of H. pylori density and distribution. Gastrointest. Endosc. 40: 342 345.
37. Genta, R. M.,, G. O. Robason,, and D. Y. Graham. 1994. Simultaneous visualization of Helicobacter pylori and gastric morphology: a new stain. Hum. Pathol. 25: 221 226.
38. Gisbert, J. P.,, D. Boixeda,, T. Vila,, L. de Rafael,, C. Redondo,, and C. M. de Argila. 1996. Basal and stimulated gastrin levels and gastric acid output five months after therapy for Helicobacter pylori eradication in duodenal ulcer patients. J. Clin. Gastroenterol. 22: 90 95.
39. Graham, D. Y. 2000. Therapy of Helicobacter pylori: current status and issues. Gastroenterology 118: S2 S8.
40. Graham, D. Y.,, A. Opekun,, G. M. Lew,, D. J. Evans, Jr.,, P. D. Klein,, and D. G. Evans. 1990. Ablation of exaggerated meal-stimulated gastrin release in duodenal ulcer patients after clearance of Helicobacter (Campylobacter) pylori infection. Am.J. Gastroenterol. 85: 394 398.
41. Graham, D. Y.,, A. Opekun,, G. M. Lew,, P. D. Klein,, and J. H. Walsh. 1991. Helicobacter pylori-associated exaggerated gastrin release in duodenal ulcer patients. The effect of bombesin infusion and urea ingestion. Gastroenterology 100: 1571 1575.
42. Graham, D. Y.,, M. S. Osato,, C. A. Olson,, J. Zhang,, and N. Figura. 1998. Effect of H. pylori infection and CagA status on leukocyte counts and liver function tests: extra-gastric manifestations of H. pylori infection. Helicobacter 3: 174 178.
43. Graham, D. Y.,, J. L. Smith,, and A. A. Bouvet. 1990. What happens to tablets and capsules in the stomach: endoscopic comparison of disintegration and dispersion characteristics of two microencapsulated potassium formulations. J. Pharm. Sci. 79: 420 424.
44. Gutierrez, O.,, M. Melo,, A. M. Segura,, A. Angel,, R. M. Genta,, and D. Y. Graham. 1997. Cure of Helicobacter pylori infection improves gastric acid secretion in patients with corpus gastritis. Scand. J. Gastroenterol. 32: 664 668.
45. Hamlet, A.,, L. Stage,, H. Lonroth,, C. Cahlin,, C. Nystrom,, and A. Petterson. 1999. A novel tablet-based 13C urea breath test for Helicobacter pylori with enhanced performance during acid suppression therapy. Scand. J. Gastroenterol. 34: 367 374.
46. Han, S. W.,, R. Flamm,, C. Y. Hachem,, H. Y. Kim,, J. E. Clarridge,, D. G. Evans,, J. Beyer,, J. Drnec,, and D. Y. Graham. 1995. Transport and storage of Helicobacter pylori from gastric mucosal biopsies and clinical isolates. Eur. J. Clin. Microbiol. Infect. Dis. 14: 349 352.
47. Harris, R. A.,, D. K. Owens,, H. Witherell,, and J. Parsonnet. 1999. Helicobacter pylori and gastric cancer: what are the benefits of screening only for the CagA phenotype of H. pylori? Helicobacter 4: 69 76.
48. Haycock, G. B.,, G. J. Schwartz,, and D. H. Wisotsky. 1978. Geometric method for measuring body surface area: a height-weight formula validated in infants, children, and adults. J. Pediatr. 93: 62 66.
49. Hildebrand, P.,, and C. Beglinger. 1997. Nondispersive infrared spectrometry: a new method for the detection of Helicobacter pylori infection with the 13C-urea breath test. Clin. Infect. Dis. 25: 1003 1005.
50. Ishihara, S.,, T. Kaji,, A. Kawamura,, M. A. Rumi,, H. Sato,, T. Okuyama,, K. Adachi,, R. Fukuda,, M. Watanabe,, T. Hashimoto,, K. Hirakawa,, Y. Matsushima,, T. Chiba,, and Y. Kinoshita. 2000. Diagnostic accuracy of a new non-invasive enzyme immunoassay for detecting Helicobacter pylori in stools after eradication therapy. Aliment. Pharmacol. Ther. 14: 611 614.
51. Karttunen, T. J.,, S. Niemela,, and T. Kerola. 1996. Blood leukocyte differential in Helicobacter pylori infection. Dig. Dis. Sci. 41: 1332 1336.
52. Karvar, S.,, H. Karch,, M. Frosch,, W. Burghardt,, and U. Gross. 1997. Use of serum-specific immunoglobulins A and G for detection of Helicobacter pylori infection in patients with chronic gastritis by immunoblot analysis. J. Clin. Microbiol. 35: 3058 3061.
53. Katsuragi, K.,, A. Noda,, T. Tachikawa,, A. Azuma,, F. Mukai,, K. Murakami,, T. Fujioka,, M. Kato,, and M. Asaka. 1998. Highly sensitive urine-based enzyme-linked immunosorbent assay for detection of antibody to Helicobacter pylori. Helicobacter 3: 289 295.
54. Kist, M.,, S. Strobel,, T. Kirchner,, and H. G. Dammann. 1999. Impact of ELISA and immunoblot as diagnostic tools one year after eradication of Helicobacter pylori in a multicentre treatment study. FEMS Immunol. Med. Microbiol. 24: 239 242.
55. Klein, P. D.,, and D. Y. Graham,. 1989. Campylobacter pylori detection by the 13C-urea breath test, p. 94 106. In B. Rathbone, and V. Healtley (ed.), Campylobacter pylori and Gastroduodenal Disease. Blackwell Scientific Publications, Oxford, United Kingdom.
56. Klein, P. D.,, and D. Y. Graham. 1993. Minimum analysis requirements for the detection of Helicobacter pylori infection by the 13C-urea breath test. Am. J. Gastroenterol. 88: 1865 1869.
57. Klein, P. D.,, H. M. Malaty,, S. J. Czinn,, S. C. Emmons,, R. F. Martin,, and D. Y. Graham. 1999. Normalizing results of 13C-urea breath testing for CO2 production rates in children. J. Pediatr. Gastroenterol. Nutr. 29: 297 301.
58. Klein, P. D.,, H. M. Malaty,, R. F. Martin,, K. S. Graham,, R. M. Genta,, and D. Y. Graham. 1996. Noninvasive detection of Helicobacter pylori infection in clinical practice: the 13C urea breath test. Am. J. Gastroenterol. 91: 690 694.
59. Kosunen, T. U.,, K. Seppala,, S. Sarna,, and P. Sipponen. 1992. Diagnostic value of decreasing IgG, IgA, and IgM antibody titres after eradication of Helicobacter pylori. Lancet 339: 893 895.
60. Kumagai, T.,, H. M. Malaty,, D. Y. Graham,, S. Hosogaya,, K. Misawa,, K. Furihata,, H. Ota,, C. Sei,, E. Tanaka,, T. Akamatsu,, T. Shimizu,, K. Kiyosawa,, and T. Katsuyama. 1998. Acquisition versus loss of Helicobacter pylori infection in Japan: results from an 8-year birth cohort study. J. Infect. Dis. 178: 717 721.
61. Laine, L.,, D. Chun,, C. Stein,, I. El-Beblawi,, V. Sharma,, and P. Chandrasoma. 1996. The influence of size or number of biopsies on rapid urease test results: a prospective evaluation. Gastrointest. Endosc. 43: 49 53.
62. Laine, L.,, R. Estrada,, D. N. Lewin,, and H. Cohen. 1996. The influence of warming on rapid urease test results: a prospective evaluation. Gastrointest. Endosc. 44: 429 432.
63. Levi, S.,, K. Beardshall,, I. Swift,, W. Foulkes,, R. Playford,, P. Ghosh,, and J. Calam. 1989. Antral Helicobacter pylori, hypergastrinaemia, and duodenal ulcers: effect of eradicating the organism. Br. Med. J. 299: 1504 1505.
64. Levi, S.,, C. T. Dollery,, S. R. Bloom,, J. Calam,, T. M. Cox,, H. J. Hodgson,, M. S. Losowsky,, M. B. Pepys,, N. A. Wright,, and O. M. Wrong. 1989. Campylobacter pylori, duodenal ulcer disease, and gastrin. Br. Med. J. 299: 1093 1094.
65. Loy, C. T.,, L. M. Irwig,, P. H. Katelaris,, and N. J. Talley. 1996. Do commercial serological kits for Helicobacter pylori infection differ in accuracy? A meta-analysis. Am. J. Gastroenterol. 91: 1138 1144.
66. Maconi, G.,, M. Lazzaroni,, O. Sangaletti,, S. Bargiggia,, L. Vagu,, and G. Bianchi Porro. 1997. Effect of Helicobacter pylori eradication on gastric histology, serum gastrin and pepsinogen I levels, and gastric emptying in patients with gastric ulcer. Am. J. Gastroenterol. 92: 1844 1848.
67. Maeda, S.,, H. Yoshida,, H. Matsunaga,, K. Ogura,, O. Kawamata,, Y. Shiratori,, and M. Omata. 2000. Detection of clarithromycin-resistant Helicobacter pylori strains by a preferential homoduplex formation assay. J. Clin. Microbiol. 38: 210 214.
68. Makristathis, A.,, E. Pasching,, K. Schutze,, M. Wimmer,, M. L. Rotter,, and A. M. Hirschl. 1998. Detection of Helicobacter pylori in stool specimens by PCR and antigen enzyme immunoassay. J. Clin. Microbiol. 36: 2772 2774.
69. Malaty, H. M.,, H. M. El-Zimaity,, R. M. Genta,, P. D. Klein,, and D. Y. Graham. 1996. Twenty-minute fasting version of the US 13C-urea breath test for the diagnosis of H. pylori infection. Helicobacter 1: 165 167.
70. Malaty, H. M.,, and D. Y. Graham. 1999. Epidemiology of Helicobacter pylori infection: disease management implications for peptic ulcer disease. Dis. Manage. Health Outcomes 6: 9 18.
71. Malaty, H. M.,, D. Y. Graham,, W. A. Wattigney,, S. R. Srinivasan,, M. Osato,, and G. S. Berenson. 1999. Natural history of Helicobacter pylori infection in childhood: 12-year follow-up cohort study in a biracial community. Clin. Infect. Dis. 28: 279 282.
72. Malaty, H. M.,, T. Kumagai,, E. Tanaka,, H. Ota,, K. Kiyosawa,, D. Y. Graham,, and T. Katsuyama. 2000. Evidence from a nine-year birth cohort study in Japan of transmission pathways of Helicobacter pylori infection. J. Clin. Microbiol. 38: 1971 1973.
73. McNamara, D.,, H. Whelan,, H. Hamilton,, S. Beattie,, and C. O'Morain. 1999. HpSA: assessment of a new non-invasive diagnostic assay for Helicobacter pylori infection in an Irish population. Ir. J. Med. Sci. 168: 111 113.
74. Meijer, B. C.,, J. C. Thijs,, J. H. Kleibeuker,, A. A. van Zwet,, and R. J. Berrelkamp. 1997. Evaluation of eight enzyme immunoassays for detection of immunoglobulin G against Helicobacter pylori. J. Clin. Microbiol. 35: 292 294.
75. Misawa, K.,, T. Kumagai,, T. Shimizu,, K. Furihata,, H. Ota,, T. Akamatsu,, and T. Katsuyama. 1998. A new histological procedure for re-evaluation of the serological test for Helicobacter pylori. Eur. J. Clin. Microbiol. Infect. Dis. 17: 14 19.
76. Miwa, H.,, M. Hirose,, S. Kikuchi,, T. Terai,, R. Iwazaki,, O. Kobayashi,, Y. Takei,, T. Ogihara,, and N. Sato. 1999. How useful is the detection kit for antibody to Helicobacter pylori in urine (URINELISA) in clinical practice? Am. J. Gastroenterol. 94: 3460 3463.
77. Miwa, H.,, T. Murai,, R. Ohkura,, A. Nagahara,, H. Watanabe,, T. Terai,, S. Watanabe,, and N. Sato. 1998. Usefulness of the [ 13C]-urea breath test for detection of Helicobacter pylori infection in fasting patients. J. Gastroenterol. Hepatol. 13: 1039 1043.
78. Mobley, H. L.,, and R. P. Hausinger. 1989. Microbial ureases: significance, regulation, and molecular characterization. Microbiol. Rev. 53: 85 108.
79. Mulholland, G.,, J. E. Ardill,, D. Fillmore,, R. S. Chittajallu,, G. M. Fullarton,, and K. E. McColl. 1993. Helicobacter pylori related hypergastrinaemia is the result of a selective increase in gastrin 17. Gut 34: 757 761.
80. Newell, D. G.,, P. R. Hawtin,, A. R. Stacey,, M. H. MacDougall,, and A. C. Ruddle. 1991. Estimation of prevalence of Helicobacter pylori infection in an asymptomatic elderly population comparing 14C]urea breath test and serology. J. Clin. Pathol. 44: 385 387.
81. Ni, Y. H.,, J. T. Lin,, S. F. Huang,, J. C. Yang,, and M. H. Chang. 2000. Accurate diagnosis of Helicobacter pylori infection by stool antigen test and 6 other currently available tests in children. J. Pediatr. 136: 823 827.
82. Nilsson, I.,, A. Ljungh,, P. Aleljung,, and T. Wadstrom. 1997. Immunoblot assay for serodiagnosis of Helicobacter pylori infections. J. Clin. Microbiol. 35: 427 432.
83. Oderda, G.,, A. Rapa,, B. Ronchi,, P. Lerro,, M. Pastore,, A. Staiano,, G. L. de'Angelis,, and P. Strisciuglio. 2000. Detection of Helicobacter pylori in stool specimens by non-invasive antigen enzyme immunoassay in children: multicentre Italian study. Br. Med. J. 320: 347 348.
84. Ohara, H.,, T. Suzuki,, T. Nakagawa,, M. Yoneshima,, M. Yamamoto,, D. Tsujino,, S. Murai,, N. Saito,, N. Kokubun,, and M. Kajiwara. 1995. 13C-UBT using an infrared spectrometer for detection of Helicobacter pylori and for monitoring the effects of lansoprazole. J. Clin. Gastroenterol. 20( Suppl. 2): S115 S117.
85. Ohara, S.,, M. Kato,, M. Asaka,, and T. Toyota. 1998. Studies of 13C-urea breath test for diagnosis of Helicobacter pylori infection in Japan. J. Gastroenterol. 33: 6 13.
86. Ohara, S.,, M. Kato,, M. Asaka,, and T. Toyota. 1998. The UBiT-100 13C02 infrared analyzer: comparison between infrared spectrometric analysis and mass spectrometric analysis. Helicobacter 3: 49 53.
87. Ohkura, R.,, H. Miwa,, T. Murai,, A. Nagahara,, K. Ohta,, K. Sato,, T. Yamada,, and N. Sato. 2000. Usefulness of a novel enzyme immunoassay for the detection of Helicobacter pylori in feces. Scand. J. Gastroenterol. 35: 49 53.
88. Ota, H.,, and R. M. Genta,. 1997. Morphological characterization of the gastric mucosa during infection with H. pylori, p. 15 28. In P. Ernst,, P. Michetti,, and P. D. Smith (ed.), The Immunobiology of H. pylori: from Pathogenesis to Prevention. Lippincott-Raven, Philadelphia, Pa..
89. Parsonnet, J.,, H. Shmuely,, and T. Haggerty. 1999. Fecal and oral shedding of Helicobacter pylori from healthy infected adults. JAMA 282: 2240 2245.
90. Prewett, E. J.,, J. T. Smith,, C. U. Nwokolo,, M. Hudson,, A. M. Sawyerr,, and R. E. Pounder. 1991. Eradication of Helicobacter pylori abolishes 24-hour hypergastrinaemia: a prospective study in healthy subjects. Aliment. Pharmacol. Ther. 5: 283 290.
91. Puspok, A.,, S. Bakos,, and G. Oberhuber. 1999. A new, noninvasive method for detection of Helicobacter pylori: validity in the routine clinical setting. Eur.J. Gastroenterol. Hepatol. 11: 1139 1142.
92. Raymond, J.,, C. Sauvestre,, N. Kalach,, M. Bergeret,, and C. Dupont. 2000. Immunoblotting and serology for diagnosis of Helicobacter pylori infection in children. Pediatr. Infect. Dis. J. 19: 118 121.
93. Romero, G. M.,, J. Vargas,, L. Grande,, M. A. Otero,, S. Bernal,, and F. M. Castro. 2000. Usefulness of Helicobacter pylori antigen detection in stools in the diagnosis of infection and confirming eradication after treatment. Med. Clin. (Barcelona) 114: 571 573.
94. Rotter, J. L.,, G. Petersen,, I. M. Samloff,, R. B. McConnell,, A. Ellis,, M. A. Spence,, and D. L. Rimoin. 1979. Genetic heterogeneity of hyperpepsinogenemic I and normopepsinogenemic I duodenal ulcer disease. Ann. Intern. Med. 91: 372 377.
95. Schofield, W. N. 1985. Predicting basal metabolic rate, new standards and review of previous work. Hum. Nutr. Clin. Nutr. 39(Suppl. 1): 5 41.
96. Scott, D. R.,, E. A. Marcus,, D. L. Weeks,, A. Lee,, K. Melchers,, and G. Sachs. 2000. Expression of the Helicobacter pylori urel gene is required for acidic pH activation of cytoplasmic urease. Infect. Immun. 68: 470 477.
97. Sevin, E.,, D. Lamarque,, J. C. Delchier,, C. J. Soussy,, and J. Tankovic. 1998. Codetection of Helicobacter pylori and of its resistance to clarithromycin by PCR. PEMS Microbiol. Lett. 165: 369 372. ( Erratum, 173:275, 1999.).
98. Simor, A. E.,, E. Lin,, F. Saibil,, L. Cohen,, M. Louie,, S. Pearen,, and H. A. Donhoffer. 1996. Evaluation of enzyme immunoassay for detection of salivary antibody to Helicobacter pylori. J. Clin. Microbiol. 34: 550 553.
99. Sipponen, P.,, J. Valle,, K. Varis,, M. Kekki,, T. Ihamaki,, and M. Siurala. 1990. Fasting levels of serum gastrin in different functional and morphologic states of the antrofundal mucosa. An analysis of 860 subjects. Scand. J. Gastroenterol. 25: 513 519.
100. Smith, J. T.,, R. E. Pounder,, C. U. Nwokolo,, S. Lanzon Miller,, D. G. Evans,, D. Y. Graham,, and D. J. Evans, Jr. 1990. Inappropriate hypergastrinaemia in asymptomatic healthy subjects infected with Helicobacter pylori. Gut 31: 522 525.
101. Sorberg, M.,, L. Engstrand,, M. Strom,, K. A. Jonsson,, H. Jorbeck,, and M. Granstrom. 1997. The diagnostic value of enzyme immunoassay and immunoblot in monitoring eradication of Helicobacter pylori. Scand. J. Infect. Dis. 29: 147 151.
102. Sunnerstam, B.,, T. Kjerstadius,, L. Jansson,, J. Giesecke,, M. Bergstrom,, and J. Ejderhamn. 1999. Detection of Helicobacter pylori antibodies in a pediatric population: comparison of three commercially available serological tests and one in-house enzyme immunoassay. J. Clin. Microbiol. 37: 3328 3331.
103. Vaira, D.,, P. Malfertheiner,, F. Megraud,, A. T. Axon,, M. Deltenre,, G. Gasbarrini,, C. O'Morain,, J. M. Pajares Garcia,, M. Quina,, and G. N. Tytgat. 2000. Noninvasive antigen-based assay for assessing Helicobacter pylori eradication: a European multicenter study. The European Helicobacter pylori HpSA Study Group. Am. J. Gastroenterol. 95: 925 929.
104. Vaira, D.,, P. Malfertheiner,, F. Megraud,, A. T. Axon,, M. Deltenre,, A. M. Hirschl,, G. Gasbarrini,, C. O'Morain,, J. M. Garcia,, M. Quina,, and G. N. Tytgat. 1999. Diagnosis of Helicobacter pylori infection with a new non-invasive antigen-based assay. HpSA European Study Group. Lancet 354: 30 33.
105. Vakil, N.,, A. Affi,, J. Robinson,, M. Sundaram,, and S. Phadnis. 2000. Prospective blinded trial of a fecal antigen test for the detection of Helicobacter pylori infection. Am. J. Gastroenterol. 95: 1699 1701.
106. van Der, E. A.,, R. W. Der Hulst,, P. Roorda,, G. N. Tytgat,, and J. Dankert. 1999. Evaluation of three commercial serological tests with different methodologies to assess Helicobacter pylori infection. J. Clin. Microbiol. 37: 4150 4152.
107. Westblom, T. U.,, and B. D. Bhatt. 1999. Diagnosis of Helicobacter pylori infection. Curr. Top. Microbiol. Immunol. 241: 215 235.
108. Wilcox, M. H.,, T. H. Dent,, J. O. Hunter,, J. J. Gray,, D. F. Brown,, D. G. Wight,, and E. P. Wraight. 1996. Accuracy of serology for the diagnosis of Helicobacter pylori infection—a comparison of eight kits. J. Clin. Pathol. 49: 373 376.
109. Woo, J. S.,, H. M. El-Zimaity,, R. M. Genta,, M. M. Yousfi,, and D. Y. Graham. 1996. The best gastric site for obtaining a positive rapid urease test. Helicobacter 1: 256 259.
110. Xia, H. X.,, C. T. Keane,, J. Chen,, J. Zhang,, E. J. Walsh,, A. P. Moran,, J. S. Hua,, F. Megraud,, and C. A. O'Morain. 1994. Transportation of Helicobacter pylori cultures by optimal systems. J. Clin. Microbiol. 32: 3075 3077.
111. Yamaoka, Y.,, and D. Y. Graham. 1999. CagA status and gastric cancer: unreliable serological tests produce unreliable data. Gastroenterology 117: 745.
112. Yamaoka, Y.,, T. Kodama,, D. Y. Graham,, and K. Kashima. 1998. Comparison of four serological tests to determine the CagA or VacA status of Helicobacter pylori strains. J. Clin. Microbiol. 36: 3433 3434.
113. Yousfi, M. M.,, H. M. El-Zimaity,, R. A. Cole,, R. M. Genta,, and D. Y. Graham. 1996. Detection of Helicobacter pylori by rapid urease tests: is biopsy size a critical variable? Gastrointest. Endosc. 43: 222 224.
114. Yousfi, M. M.,, H. M. El-Zimaity,, R. A. Cole,, R. M. Genta,, and D. Y. Graham. 1996. Does using a warmer influence the results of rapid urease testing for Helicobacter pylori? Gastrointest. Endosc. 43: 260 261.
115. Yousfi, M. M.,, R. Reddy,, M. S. Osato,, and D. Y. Graham. 1996. Culture of Helicobacter pylori: effect of preimmersion of biopsy forceps in formalin. Helicobacter 1: 62 64.

Tables

Generic image for table
Table 1

Recommendations for collecting gastric mucosal biopsies for detection of

Citation: Graham D, Qureshi W. 2001. Markers of Infection, p 499-510. In Mobley H, Mendz G, Hazell S (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555818005.ch41
Generic image for table
Table 2

Considerations regarding the accuracy of the C-urea breath test

Citation: Graham D, Qureshi W. 2001. Markers of Infection, p 499-510. In Mobley H, Mendz G, Hazell S (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555818005.ch41

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