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Chapter 12 : Zoonotic Agents in Swine-to-Human Xenotransplants

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Abstract:

This chapter talks about infectious agents that have the potential to be transmitted via swine xenografts. These infectious agents fall into three categories: traditional zoonotic organisms, swine-specific organisms and undiscovered swine-specific organisms. Risk of disease transmission via xenografts and the public health aspects of porcine xenotransplantation are discussed. The chapter addresses the history, occurrence, etiology, epidemiology, mode of transmission, animal infection, diagnosis, prevention and control, human infection, and public health aspects of each specific disease. The intention is to narrow the scope of the review to describe the occurrence, the epidemiology, and the clinical signs of the traditional zoonotic diseases in the pig. The knowledge of the epidemiology, especially mode of transmission, in the pig itself is essential for the design of facilities and the establishment of biosafety and disease control programs that can minimize the risk of transmitting infectious disease agents via swine xenografts. The majority of affected herds may have no recognizable signs. is now recognized as the most common swine-maintained serovar. Carrier pigs are probably the most common route of introduction, with infected replacement gilts or boars being one of the most important means of introducing infection. For those swine-specific organisms that are sequestered in tissues such as gastrointestinal tract, tonsil, and upper respiratory tract of clinically healthy donors, the risk of being transmitted via xenografts is probably minimal.

Citation: Matthews P. 2001. Zoonotic Agents in Swine-to-Human Xenotransplants, p 217-238. In Platt J (ed), Xenotransplantation. ASM Press, Washington, DC. doi: 10.1128/9781555818043.ch12

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Porcine reproductive and respiratory syndrome virus
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References

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Tables

Generic image for table
Table 1

Swine-specific organisms

Citation: Matthews P. 2001. Zoonotic Agents in Swine-to-Human Xenotransplants, p 217-238. In Platt J (ed), Xenotransplantation. ASM Press, Washington, DC. doi: 10.1128/9781555818043.ch12

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