Chapter 14 : Potential Medical Impact of Endogenous Retroviruses

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Potential Medical Impact of Endogenous Retroviruses, Page 1 of 2

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The recent in vitro observation that porcine endogenous retroviruses (PERV) can infect human cells has ignited tremendous fear among investigators in the xenotransplantation field and health officials. This chapter reviews the available experience with other endogenous retroviruses in different animal situations, with the aim of better understanding the potential impact of such organisms in the field of xenotransplantation. All mammals that have been examined so far, including pigs and baboons, have endogenous retrovirus DNA sequences integrated in their genomes. Although transmitted in the germ line, they exhibit a very significant sequence homology to exogenous retroviruses. The true source of endogenous retroviruses remains to be elucidated. One hypothesis is that they are viral remnants of remote infections with exogenous forms of the virus. Alternative explanations include that retroviruses may be derived from retrotransposons or that endogenous retroviruses are the precursors of exogenous retroviral agents. The majority of endogenous retroviruses act as colonizers in the germ line of the host and are noninfectious. The exact functions of the remaining "competent" or partially defective endogenous retroviruses remain enigmatic. It is speculated that, among a number of possible functions, they may enhance the pathogenicity of exogenous retroviruses by the recombination and production of a hybrid virus with altered receptor specificity and species tropism, now capable of infecting a new range of hosts. New animal viruses are being discovered on a regular basis, as detection methods are becoming more sophisticated. Similarly, many more animal endogenous retroviruses are yet to be discovered and fully characterized.

Citation: Abu-Nader R, Paya C. 2001. Potential Medical Impact of Endogenous Retroviruses, p 251-259. In Platt J (ed), Xenotransplantation. ASM Press, Washington, DC. doi: 10.1128/9781555818043.ch14

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Mouse mammary tumor virus
Simian foamy virus
Feline leukemia virus
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1. Akiyoshi, D. E.,, M. Denaro,, H. Zhu,, J. L. Greenstein,, P. Banerjee,, and J. Fishman. 1998. Identification of a full-length cDNA for an endogenous retrovirus of miniature swine. J. Virol. 72:45034507.
2. Akiyoshi, D. E.,, I. Suzuka,, N. Shimizu,, K. Sekiguchi,, H. Hoshino,, M. Kodama,, and K. Shimotohno. 1986. Molecular cloning of unintegrated closed circular DNA of porcine retrovirus. FEBS Lett. 198:339343.
3. Allan, J. S.,, S. R. Broussard,, M. G. Michaels,, T. E. Starzl,, K. L. Leighton,, E. M. Whitehead,, A. G. Comuzzie,, R. E. Lanford,, M. M. Leland,, W. M. Switzer,, and W. Heneine. 1998. Amplification of simian retroviral sequences from human recipients of baboon liver transplants. AIDS Res. Hum. Retrov. 14:8211182114.
4. Bailey, L. L.,, S. L. Nehlsen-Cannarella,, W. Concepcion,, and W. B. Jolley. 1985. Baboon-to-human cardiac xenotransplantation in a neonate. JAMA 254:33213329.
5. Barnard, C. N.,, A. Wolpowitz,, and J. G. Losman. 1977. Heterotopic cardiac transplantation with a xenograft for assistance of the left heart in cardiogenic shock after cardiopulmonary bypass. S. Afr. Med. J. 52:10351039.
6. Boeke, J. D.,, and J. P. Stoye,. 1997. Retrotransposons, endogenous retroviruses, and the evolution of retroele-ments, p. 343435. In J. M. Coffin,, S. H. Hughes,, and H. E. Varmus (ed.), Retroviruses. Cold Spring Harbor Press, Cold Spring Harbor, N.Y.
7. Brown, J.,, A. L. Matthews,, P. A. Sandstrom,, and L. E. Chapman. 1998. Xenotransplantation and the risk of retroviral zoonosis. Trends Microbiol. 6:411415.
8. Chari, R. S.,, B. H. Collins,, J. C. Magee,, M. DiMaio,, A. D. Kirk,, R. C. Harland,, R. L. McCann,, J. L. Piatt,, and W. C. Meyers. 1994. Brief report: treatment of hepatic failure with ex-vivo pig-liver perfusion followed by liver transplantation. N. Engl. J. Med. 331:234237.
9. Coffin, J. M., 1992. Structure and classification of retroviruses, p. 1949. In J. A. Levy (ed.), The Retroviridae, vol. 1. Plenum Press, New York, N.Y.
10. Ehlers, B.,, S. TJlrich,, and M. Goltz. 1999. Detection of two novel porcine herpesviruses with high similarity to gammaherpesviruses. J. Gen. Virol. 80(PT4):971978.
11. Friedlander, A.,, and R. Patarca. 1999. Endogenous proviruses. Crit. Rev. Oncol. 10:129159.
12. Gao, F.,, E. Bailes,, D. L. Robertson,, Y. Chen,, C. M. Rodenburg,, S. F. Michael,, L. B. Cummins,, L. O. Arthur,, M. Peeters,, G. M. Shaw,, P. M. Sharp,, and B. H. Hahn. 1999. Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. Nature 397:436441.
13. Groth, C. G.,, O. Korsgren,, A. Tibell,, J. Tollemar,, E. Moller,, J. Bolinder,, J. Ostman,, F. P. Reinholt,, C. Hellerstrom,, and A. Andersson. 1994. Transplantation of porcine fetal pancreas to diabetic patients. Lancet 344:14021404.
14. Hardy, W. D., 1993. Feline oncoretroviruses, p. 109180. In J. A. Levy (ed.), The Retroviridae, vol. 2. Plenum Press, New York, N.Y.
15. Heneine, W.,, W. M. Switzer,, P. Sandstrom,, J. Brown,, S. Vedapuri,, C. A. Schable,, A. S. Khan,, N. W. Lerche,, M. Schweizer,, D. Neumann-Haefelin,, L. E. Chapman,, and T. M. Folks. 1998. Identification of a human population infected with simian foamy viruses. Nature Med. 4:403407.
16. Heneine, W.,, A. Tibell,, W. M. Switzer,, P. Sandstrom,, G. V. Rosales,, A. Mathews,, O. Korsgren,, L. E. Chapman,, T. M. Folks,, and C. G. Groth. 1998. No evidence of infection with porcine endogenous retrovirus in recipients of porcine islet-cell xenografts. Lancet 352:695699.
17. Hitchcock, C. R.,, J. C. Kiser,, R. L. Telander,, and E. L. Seljeskog. 1964. Baboon renal grafts. JAMA 189:158161.
18. Isacson, O.,, and X. O. Breakefleld. 1997. Benefits and risks of hosting animal cells in the human brain. Nature Med. 3:964969.
19. Khabbaz, R. F.,, W. Heneine,, J. R. George,, B. Parekh,, T. Woods,, W. M. Switzer,, H. M. McClure,, M. Murphey-Corb,, and T. M. Folks. 1994. Brief report: infection of a laboratory worker with simian immunodeficieny virus. N. Engl. J. Med. 330:172177.
20. Kozak, C. A.,, and S. Ruscetti,. 1992. Retroviruses in rodents, p. 405481.In J.A. Levy (ed.), The Retroviridae, vol. 1. Plenum Press, New York, N.Y.
21. Kroneman, A.,, L. A. H. M. Cornelissen,, M. C. Horzinek,, R. J. de Groot,, and H. F. Egberink. 1998. Identification and characterization of a porcine torovirus. J. Virol. 72:35073511.
22. Le Ussier, P.,, J. P. Stoye,, Y. Takeuchi,, C. Patience,, and R. A. Weiss. 1997. Two sets of human-tropic pig retrovirus. Nature 389:681682.
23. Lieber, M. M.,, C. J. Sherr,, G. J. Torado,, R. E. Benveniste,, R. Callahan,, and H. G. Coon. 1975. Isolation from the Asian mouse Mus caroli of an endogenous type C virus related to infectious primate type C viruses. Proc. Natl. Acad. Sci. USA 72:23152319.
24. Martin, J.,, E. Herniou,, J. Cook,, R. W. O'Neill,, and M. Tristem. 1999. Interclass transmission and phyletic host tracking in murine leukemia virus-related retroviruses. J. Virol. 73:24422449.
25. McAllister, R. M.,, M. Nicolson,, M. B. Gardner,, R. W. Rongey,, S. Rasheed,, P. S. Sarma,, R. J. Huebner,, M. Hatanaka,, S. Oroszlan,, R. V. Gilden,, A. Kabigting,, and L. Vernon. 1972. C-type virus released from cultured human rhabdomyosarcoma cells. Nature New Biol. 235:36.
26. Meng, X.-J.,, R. H. Purcell,, P. G. Halbur,, J. R. Lehman,, D. M. Webb,, T. S. Tsareva,, J. S. Haynes,, B.J. Tbacker,, and S. U. Emerson. 1997. A novel virus in swine is closely related to the human hepatitis E virus. Proc. Natl. Acad. Sci. USA 94:98609865.
27. Michaels, M. G. 1997. Infectious concerns of cross-species transplantation: xenozoonoses. World J. Surg. 21:968974.
28. Onions, D.,, D. Hart,, C. Mahoney,, D. Galbraith,, and K. Smith. 1998. Endogenous retroviruses and the safety of porcine xenotransplantation. Trends Microbiol. 6:430431.
29. Paradis, K.,, G. Langford,, Z. Long,, W. Heneine,, P. Sandstrom,, W. M. Switzer,, L. E. Chapman,, C. Lockey,, D. Onions, the XEN 111 Study Group, and E. Otto. 1999. Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue. Science 285:12361241.
30. Patience, C.,, G. S. Patton,, Y. Takeuchi,, R. A. Weiss,, M. O. McClure,, L. Rydberg,, and M. E. Breimer. 1998. No evidence of pig DNA or retroviral infection in patients with short-term extracorporeal connection to pig kidneys. Lancer 352:699701.
31. Patience, C.,, Y. Takeuchi,, and R. A. Weiss. 1997. Infection of human cells by an endogenous retrovirus of pigs. Nature Med. 3:282286.
32. Patience, C.,, Y. Takeuchi,, and R. A. Weiss. 1998. Zoonosis in xenotransplantation. Curr. Opin. Immunol. 10:539542.
33. Piatt, J. L. 1994. A perspective on xenograft rejection and accomodation. Immunol. Rev. 141:127149.
34. Piatt, J. L. 1998. New directions for organ transplantation. Nature 392:1117.
35. Reemtsma, K.,, B. H. McCracken,, J. U. Schlegel,, M. A. Pearl,, C. W. Pearce,, C. W. DeWitt,, P. E. Smith,, R. L. Hewitt,, R. L. Flinner,, and O. Creech, Jr. 1964. Renal heterotransplantation in man. Ann. Surg. 160:384410.
36. Rosenberg, N.,, and P. Jolicoeur,. 1997. Retroviral pathogenesis, p. 475585. In J. M. Coffin,, S. H. Hughes,, and H. E. Varmus (ed.), Retroviruses. Cold Spring Harbor Press, Cold Spring Harbor, N.Y.
37. Schweizer, M.,, V. Falcone,, J. Gange,, R. Turek,, and D. Neumann-Haefelin. 1997. Simian foamy virus isolated from an accidentally infected human individual. J. Virol. 71:48214824.
38. Starzl, T. E.,, J. Fung,, A. Tzakis,, S. Todo,, A. J. Demetris,, I. R. Marino,, H. Doyle,, A. Zeevi,, V. Warty,, M. Michaels,, S. Kusne,, W. A. Rudert,, and M. Trucco. 1993. Baboon-to-human liver transplantation. Lancet 341:6571.
39. Starzl, T. E.,, T. L. Marchioro,, G. N. Peters,, C. H. Kirkpatrick,, W. E. C. Wilson,, K. A. Porter,, D. Rifkind,, D. A. Ogden,, C. R. Hitchcock,, and W. R. Waddell. 1964. Renal heterotransplantation from baboon to man: experience with 6 cases. Transplantation 2:752776.
40. Starzl, T. E.,, A. Tzakis,, J. J. Fung,, S. Todo,, A. J. Demetris,, R. Manez,, I. R. Marino,, L. Valdivia,, and N. Murase. 1994. Prospects of clinical xenotransplantation. Transplant. Proc. 26:1082.
41. Stoye, J. P.,, C. Moroni,, and J. M. Coffin. 1991. Virological events leading to spontaneous AKR thymomas. J. Virol. 65:12731285.
42. Takeuchi, Y.,, C. Patience,, S. Magre,, R. A. Weiss,, P. T. Banerjee,, P. Le Tissier,, and J. P. Stoye. 1998. Host range and interference studies of three classes of pig endogenous retrovirus. J. Virol. 72:99869991.
43. Temin, H. M. 1980. Origin of retroviruses from cellular moveable genetic elements. Cell 21:599600.
44. Temin, H. M., 1992. Origin and general nature of retroviruses, p. 118. In J. A. Levy (ed.), The Retroviridae, vol. 1. Plenum Press, New York, N.Y.
45. Tralka, T. S.,, C. L. Yee,, A. B. Rabson,, N. A. Wivel,, K. J. Stromberg,, A. S. Rabson,, and J. C. Costa. 1983. Murine type C retroviruses and intracisternal A-particles in human tumors serially passaged in nude mice. J. Natl. Cancer Inst. 71:591596.
46. van der Kuyl, A. C.,, J. T. Dekker,, and J. Goudsmit. 1996. Baboon endogenous virus evolution and ecology. Trends Microbiol. 4:5559.
47. van der Kuyl, A. C.,, J. T. Dekker,, and J. Goudsmit. 1995. Full-length proviruses of baboon endogenous virus (BaEV) and dispersed reverse transcriptase retroelements in the genome of baboon species. J. Virol. 69:59175924.
48. Weiss, R. A. 1978. Why cell biologists should be aware of genetically transmitted viruses. Natl. Cancer Inst. Monogr. 48:183189.
49. Weiss, R. A. 1999. Xenografts and retroviruses. Science 285:12211222.
50. Wilkinson, D. A.,, D. L. Mager,, and J. A. C. Leong,. 1994. Endogenous human retroviruses, p. 465535. In J. A. Levy (ed.), The Retroviridae, vol. 3. Plenum Press, New York, N.Y.
51. Wilson, C. A.,, S. Wong,, J. Muller,, C. E. Davidson,, T. M. Rose, and R Burd. 1998. Type C retrovirus released from porcine primary peripheral blood mononuclear cells infects human cells. J. Virol. 72:30823087.
52. Zhu, T.,, B. T. Korber,, A. J. Nahmias,, E. Hooper,, P. M. Sharp,, and D. D. Ho. 1998. An African HIV-1 sequence from 1959 and implications for the origin of the epidemic. Nature 391:594597.


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Table 1

Summary of characteristics of different types of endogenous retroviruses

Citation: Abu-Nader R, Paya C. 2001. Potential Medical Impact of Endogenous Retroviruses, p 251-259. In Platt J (ed), Xenotransplantation. ASM Press, Washington, DC. doi: 10.1128/9781555818043.ch14

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