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Chapter 1 : An Overview: Molecular Mimicry and Disease

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An Overview: Molecular Mimicry and Disease, Page 1 of 2

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Abstract:

This chapter discusses the microbe-host interactions by using several different microbe-host disease states to illustrate the importance and nature of the cross-reactions in the genetically programmed host. The concept of autoimmunity playing a role in this disease was introduced more than 50 years ago by a number of investigators when antibodies to the heart were noted in the sera of patients with acute rheumatic fever (ARF) and/or rheumatic heart disease. Turning to the cellular reactivity in patients with rheumatic fever (RF), lymphocytes from the RF valvular lesions have been an area of active investigation in the laboratory. For example, using a panel of monoclonal antibodies specific for various cell surface markers, researchers demonstrated that the valvular lesions contained equal numbers of macrophages and T cells. Helper T cells predominated in the more active cardiac lesions; the ratio of T helper cells to T suppressor cells in patients with chronic carditis closely resembled that seen in normal peripheral blood. The acute disease is the result of multiplication of the organism in the reticuloendothelial system followed by direct invasion of muscle tissue, the liver, and occasionally the meninges. As noted in a section on cross-reactivity, there appears to be a clear molecular association between structures of the HLA-B27 allele and antigens of . This is a clear case of molecular mimicry between host and microbes, and the sera of AS patients contain antibodies that are cross-reactive with both molecules.

Citation: Visvanathan K, Zabriskie J. 2000. An Overview: Molecular Mimicry and Disease, p 1-16. In Cunningham M, Fujinami R (ed), Molecular Mimicry, Microbes, and Autoimmunity. ASM Press, Washington, DC. doi: 10.1128/9781555818074.ch1

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Figure 1

Schematic representation of the various structures of the group A streptococcus. Note the wide variety of cross-reactions between its antigens and mammalian tissues.

Citation: Visvanathan K, Zabriskie J. 2000. An Overview: Molecular Mimicry and Disease, p 1-16. In Cunningham M, Fujinami R (ed), Molecular Mimicry, Microbes, and Autoimmunity. ASM Press, Washington, DC. doi: 10.1128/9781555818074.ch1
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Image of Figure 2
Figure 2

Schematic drawing of the two-dimensional structure of lipid A of gram-negative organisms and the peptidoglycan structure of gram-positive organisms. While there are obvious differences in their structures, the stenciled areas of each structure are quite similar.

Citation: Visvanathan K, Zabriskie J. 2000. An Overview: Molecular Mimicry and Disease, p 1-16. In Cunningham M, Fujinami R (ed), Molecular Mimicry, Microbes, and Autoimmunity. ASM Press, Washington, DC. doi: 10.1128/9781555818074.ch1
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References

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1. Albani, S.,, and D. A. Carson,. 1997. Etiology and pathogenesis of rheumatoid arthritis, p. 985. In W. J. Koopman (ed.), Arthritis and Allied Conditions, vol. 1 The Williams & Wilkins Co., Baltimore, Md.
2. Anderton, S. M.,, R. van der Zee,, A. Noordzij,, and W. van Eden. 1994. Differential mycobacterial 65-kDa heat shock protein T cell epitope recognition after adjuvant arthritis-inducing or protective immunization protocols. J. Immunol. 152:36563664.
3. Anderton, S. M.,, R. van der Zee,, B. Prakken,, A. Noordzij,, and W. van Eden. 1995. Activation of T cells recognizing self 60-kD heat shock protein can protect against experimental arthritis. J. Exp. Med. 181:943952.
4. Bokisch, V. A.,, D. Bernstein,, and R. M. Krause. 1972. Occurrence of 19S and 7S anti-IgGs during hyper-immunization of rabbits with streptococci. J. Exp. Med. 136:799815.
5. Boog, C. J.,, E. R. de Graeff-Meeder,, M. A. Lucassen,, R. van der Zee,, M. M. Voorhorst-Ogink,, P. J. van Kooten,, H. J. Geuze,, and W. van Eden. 1992. Two monoclonal antibodies generated against human hsp60 show reactivity with synovial membranes of patients with juvenile chronic arthritis. J. Exp. Med. 175:18051810.
6. Bradley, D. S.,, G. H. Nabozny,, S. Cheng,, P. Zhou,, M. M. Griffiths,, H. S. Luthra,, and C. S. David. 1997. HLA-DQB1 polymorphism determines incidence, onset, and severity of collagen-induced arthritis in transgenic mice. Implications in human rheumatoid arthritis. J. Clin. Investig. 100:22272234.
7. Brennan, F. M.,, R. N. Maini,, and M. Feldmann. 1992. TNF alpha—a pivotal role in rheumatoid arthritis? Br. J. Rheumatol. 31:293298.
8. Chang, Y. H.,, C. M. Pearson,, and C. Abe. 1980. Adjuvant polyarthritis IV induction by a synthetic adjuvant: immunological, histopathologic, and other studies. Arthritis Rheum. 23:735741.
9. Cheadle, W. B. 1889. Harvean lectures on the various manifestations of the rheumatic state as exemplified in childhood and early life. Lancet i:821827.
10. Chien, Y. H.,, and M. M. Davis. 1993. How alpha beta T-cell receptors “see” peptide/MHC complexes. Immunol. Today 14:597602.
11. Cossio, P. M.,, R. P. Laguens,, C. Diez,, A. Szarfman,, A. Segal,, and R. M. Arana. 1974. Chagasic cardiopathy. Antibodies reacting with plasma membrane of striated muscle and endothelial cells. Circulation 50:12521259.
12. Cunningham, M. W.,, S. M. Antone,, J. M. Gulizia,, B. M. McManus,, V. A. Fischetti,, and C. J. Gauntt. 1992. Cytotoxic and viral neutralizing antibodies crossreact with streptococcal M protein, enteroviruses, and human cardiac myosin. Proc. Natl. Acad. Sci. USA 89:13201324.
13. Damian, R. T. 1964. Molecular mimicry: antigen sharing by parasite and host and its consequences. Am. Nat. 98:129149.
14. d'Imperio Lima, M. R.,, H. Eisen,, P. Minoprio,, M. Joskowicz,, and A. Coutinho. 1986. Persistence of polyclonal B cell activation with undetectable parasitemia in late stages of experimental Chagas' disease. J. Immunol. 137:353356.
15. Ebringer, A. 1983. The cross-tolerance hypothesis, HLA-B27 and ankylosing spondylitis. Br. J. Rheumatol. 22(4 Suppl. 2):5366.
16. Ebringer, A.,, P. Cowling,, N. Ngwa-Suh,, D. C. O. James,, and R. Ebringer,. 1976. Cross-reactivity between Klebsiella aerogenes species and B27 lymphocyte antigens as an aetiological factor in ankylosing spondylitis, p. 27. In J. Dausset, and A. Svejgaard (ed.), HLA and Disease, vol. 8. Institut National de la Santé et da la Recherch Médicale, Paris, France.
17. Ebringer, R.,, D. Cawdell,, and A. Ebringer. 1979. Klebsiella pneumoniae and acute anterior uveitis in ankylosing spondylitis. Br. Med. J. 1(6160):383.
18. Ebringer, R. W.,, D. R. Cawdell,, P. Cowling,, and A. Ebringer. 1978. Sequential studies in ankylosing spondylitis. Association of Klebsiella pneumoniae with active disease. Ann. Rheum. Dis. 37:146151.
19. Engle, M. A.,, J. C. McCabe,, P. A. Ebert,, and J. Zabriskie. 1974. The postpericardiotomy syndrome and antiheart antibodies. Circulation 49:401406.
20. Ewing, C.,, R. Ebringer,, G. Tribbick,, and H. M. Geysen. 1990. Antibody activity in ankylosing spondylitis sera to two sites on HLA B27.1 at the MHC groove region (within sequence 65-85), and to a Klebsiella pneumoniae nitrogenase reductase peptide (within sequence 181-199). J. Exp. Med. 171:16351647.
21. Finnegan, A.,, B. W. Needleman,, and R. J. Hodes. 1990. Function of autoreactive T cells in immune responses. Immunol. Rev. 116:1531.
22. Fischetti, V. A. 1989. Streptococcal M protein: molecular design and biological behavior. Clin. Microbiol. Rev. 2:285314.
23. Freire-de-Lima, C.,, L. M. Pecanha,, and G. A. Dos Reis. 1996. Chronic experimental Chagas' disease: functional syngeneic T-B-cell cooperation in vitro in the absence of an exogenous stimulus. Infect. Immun. 64:28612866.
24. Gazzinelli, R. T.,, M. J. Morato,, R. M. Nunes,, J. R. Cancado,, Z. Brener,, and G. Gazzinelli. 1988. Idiotype stimulation of T lymphocytes from Trypanosoma cruzi-infected patients. J. Immunol. 140:31673172.
25. Guilherme, L.,, E. Cunha-Neto,, V. Coelho,, R. Snitcowsky,, P. M. Pomerantzeff,, R. V. Assis,, F. Pedra,, J. Neumann,, A. Goldberg,, M. E. Patarroyo, et al. 1995. Human heart-infiltrating T-cell clones from rheumatic heart disease patients recognize both streptococcal and cardiac proteins. Circulation 92:415420.
26. Hochberg, M. C., 1984. Epidemiology, p. 142. In A. Calvin (ed.), Spondyloarthropathies. Grune and Stratton, New York, N.Y.
27. Husby, G.,, I. van de Ryn,, J. B. Zabriskie,, Z. H. Abdin,, and R. C. WilliamsJr.. 1976. Antibodies reacting with cytoplasm of subthalamic and caudate nuclei neurons in chorea and acute rheumatic fever. J. Exp. Med. 144:10941110.
28. Jindal, S.,, A. K. Dudani,, B. Singh,, C. B. Harley,, and R. S. Gupta. 1989. Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen. Mol. Cell. Biol. 9:22792283.
29. Jones, E. M.,, D. G. Colley,, S. Tostes,, E. R. Lopes,, C. L. Vnencak-Jones,, and T. L. McCurley. 1992. A Trypanosoma cruzi DNA sequence amplified from inflammatory lesions in human chagasic cardiomyopathy. Trans. Assoc. Am. Physicians 105:182189.
30. Kaplan, M. H.,, and J. D. Frengley. 1969. Autoimmunity to the heart in cardiac disease. Current concepts of the relation of autoimmunity to rheumatic fever, postcardiotomy and postinfarction syndromes and cardiomyopathies. Am. J. Cardiol. 24:459473.
31. Karlsson-Parra, A.,, K. Soderstrom,, M. Ferm,, J. Ivanyi,, R. Kiessling,, and L. Klareskog. 1990. Presence of human 65 kD heat shock protein (hsp) in inflamed joints and subcutaneous nodules of RA patients. Scand. J. Immunol. 31:283288.
32. Kemeny, E.,, G. Husby,, R. C. WilliamsJr.,, and J. B. Zabriskie. 1994. Tissue distribution of antigen(s) defined by monoclonal antibody D8/17 reacting with B lymphocytes of patients with rheumatic heart disease. Clin. Immunol. Immunopathol. 72:3543.
33. Khanna, A. K.,, D. R. Buskirk,, R. C. WilliamsJr.,, A. Gibofsky,, M. K. Crow,, A. Menon,, M. Fotino,, H. M. Reid,, T. Poon-King,, P. Rubinstein, et al. 1989. Presence of a non-HLA B cell antigen in rheumatic fever patients and their families as defined by a monoclonal antibody. J. Clin. Investig. 83:17101716.
34. Klasen, I. S.,, M. J. Melief,, A. G. van Halteren,, W. R. Schouten,, M. van Blankenstein,, G. Hoke,, H. de Visser,, H. Hooijkaas,, and M. P. Hazenberg. 1994. The presence of peptidoglycan-polysaccharide complexes in the bowel wall and the cellular responses to these complexes in Crohn's disease. Clin. Immunol. Immunopathol. 71:303308.
35. Kuhn, R.,, J. Lohler,, D. Rennick,, K. Rajewsky,, and W. Muller. 1993. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75:263274.
36. Kulkarni, A. B.,, C. G. Huh,, D. Becker,, A. Geiser,, M. Lyght,, K. C. Flanders,, A. B. Roberts,, M. B. Sporn,, J. M. Ward,, and S. Karlsson. 1993. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc. Natl. Acad. Sci. USA 90:770774.
37. Lagercrantz, R.,, S. Hammarstrom,, P. Perlmann,, and B. E. Gustafsson. 1968. Immunological studies in ulcerative colitis. IV. Origin of autoantibodies. J. Exp. Med. 128:13391352.
38. Minoprio, P.,, S. Itohara,, C. Heusser,, S. Tonegawa,, and A. Coutinho. 1989. Immunobiology of murine T. cruzi infection: the predominance of parasite-nonspecific responses and the activation of TCRI T cells. Immunol. Rev. 112:183207.
39. Mombaerts, P.,, E. Mizoguchi,, M. J. Grusby,, L. H. Glimcher,, A. K. Bhan,, and S. Tonegawa. 1993. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell 75:274282.
40. Moreland, L. W.,, S. W. Baumgartner,, M. H. Schiff,, E. A. Tindall,, R. M. Fleischmann,, A. L. Weaver,, R. E. Ettlinger,, S. Cohen,, W. J. Koopman,, K. Mohler,, M. B. Widmer,, and C. M. Blosch. 1997. Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein. N. Engl. J. Med. 337:141147.
41. Noer, H. R. 1966. An “experimental” epidemic of Reiter's syndrome. JAMA 198:693698.
42. Ogawasara, M.,, D. H. Kono,, and D. T. Y. Yu. 1986. Mimicry of human histocompatibility HLA-B27 antigens by Klebsiella pneumoniae. Infect. Immun. 51:901908.
43. Patarroyo, M. E.,, R. J. Winchester,, A. Vejerano,, A. Gibofsky,, F. Chalem,, J. B. Zabriskie,, and H. G. Kunkel. 1979. Association of a B-cell alloantigen with susceptibility to rheumatic fever. Nature 278:173174.
44. Pearson, C. M. 1956. Development of arthritis, periarthritis and periostitis in rats given adjuvant. Proc. Soc. Exp. Biol. Med. 91:95101.
45. Perlmann, P.,, S. Hammarstrom,, R. Lagercrantz,, and B. E. Gustafsson. 1965. Antigen from colon of germfree rats and antibodies in human ulcerative colitis. Ann. N. Y. Acad. Sci. 124:377394.
46. Rabin, R. L.,, M. M. Bieber,, and N. N. Teng. 1993. Lipopolysaccharide and peptidoglycan share binding sites on human peripheral blood monocytes. J. Infect. Dis. 168:135142.
47. Read, S. E.,, V. A. Fischetti,, V. Utermohlen,, R. E. Falk,, and J. B. Zabriskie. 1974. Cellular reactivity studies to streptococcal antigens. Migration inhibition studies in patients with streptococcal infections and rheumatic fever. J. Clin. Investig. 54:439450.
48. Rose, N. R.,, K. W. Beisel,, A. Herskowitz,, M. Neu,, L. J. Wolfgram,, F. Alvarez,, M. D. Traystman,, and S. W. Craig. 1987. Cardiac myosin and autoimmune myocarditis. CIBA Found. Symp. 29:324.
49. Sadlack, B.,, H. Merz,, H. Schorle,, A. Schimpl,, A. C. Feller,, and I. Horak. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75:253261.
49a. Saegusa, J.,, B. S. Prabhakar,, K. Essani,, P. R. McClintock,, Y. Fukuda,, V. J. Ferrans,, and A. L. Notkins. 1986. Monoclonal antibody to coxsackievirus B4 reacts with myocardium. J. Infect. Dis. 153: 372373. (Letter.)
50. Sargent, S. J.,, E. H. Beachey,, C. E. Corbett,, and J. B. Dale. 1987. Sequence of protective epitopes of streptococcal M proteins shared with cardiac sarcolemmal membranes. J Immunol. 139:12851290.
51. Sartor, R. B. 1995. Current concepts of the etiology and pathogenesis of ulcerative colitis and Crohn's disease. Gastroenterol. Clin. N. Am. 24(3):475507.
52. Sartor, R. B. 1994. Cytokines in intestinal inflammation: pathophysiological and clinical considerations. Gastroenterology 106:533539.
53. Schwimmbeck, P. L.,, D. T. Yu,, and M. B. Oldstone. 1987. Autoantibodies to HLA B27 in the sera of HLA B27 patients with ankylosing spondylitis and Reiter's syndrome. Molecular mimicry with Klebsiella pneumoniae as potential mechanism of autoimmune disease. J. Exp. Med. 166:173181.
54. Taurog, J. D.,, and R. E. Hammer. 1996. Experimental spondyloarthropathy in HLA-B27 transgenic rats. Clin. Rheumatol. 15(SuppI. l):2227.
55. Taurog, J. D.,, S. D. Maika,, W. A. Simmons,, M. Breban,, and R. E. Hammer. 1993. Susceptibility to inflammatory disease in HLA-B27 transgenic rat lines correlates with the level of B27 expression. J. Immunol. 150:41684178.
56. Taurog, J. D.,, J. A. Richardson,, J. T. Croft,, W. A. Simmons,, M. Zhou,, J. L. Fernandez-Sueiro,, E. Balish,, and R. E. Hammer. 1994. The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J. Exp. Med. 180:23592364.
57. Toyoda, H.,, S. J. Wang,, H. Y. Yang,, A. Redford,, D. Magalong,, D. Tyan,, C. K. McElree,, S. R. Pressman,, F. Shanahan,, S. R. Targan, et al. 1993. Distinct associations of HLA class II genes with inflammatory bowel disease. Gastroenterology 104:741748.
58. Trentham, D. E.,, A. S. Townes,, and A. H. Kang. 1977. Autoimmunity to type II collagen an experimental model of arthritis. J. Exp. Med. 146:857868.
59. van den Broek, M. F.,, E. J. Hogervorst,, M. C. Van Bruggen,, W. Van Eden,, R. van der Zee,, and W. B. van den Berg. 1989 . Protection against streptococcal cell wall-induced arthritis by pretreatment with the 65-kD mycobacterial heat shock protein. J. Exp. Med. 170:449466.
60. van de Ryn, I.,, J. B. Zabriskie,, and M. McCarty. 1977. Group A streptococcal antigens cross-reactive with myocardium. Purification of heart-reactive antibody and isolation and characterization of the streptococcal antigen. J. Exp. Med. 146:579599.
61. van Eden, W.,, J. E. Thole,, R. van der Zee,, A. Noordzij,, J. D. van Embden,, E. J. Hensen,, and I. R. Cohen. 1988. Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis. Nature 331:171173.
62. Van Voorhis, W. C.,, and H. Eisen. 1989. Fl-160. A surface antigen of Trypanosoma cruzi that mimics mammalian nervous tissue. J. Exp. Med. 169:641652.
63. von Kreuter, B. F.,, and C. A. Santos-Buch. 1986. Pathoimmune polymyositis induced in C3H/HeJ mice by Trypanosoma cruzi infection. Clin. Exp. Rheumatol. 4:8389.
64. Yang, H.,, J. I. Rotter,, H. Toyoda,, C. Landers,, D. Tyran,, C. K. McElree,, and S. R. Targan. 1993. Ulcerative colitis: a genetically heterogeneous disorder defined by genetic (HLA class II) and subclinical (antineu-trophil cytoplasmic antibodies) markers. J. Clin. Investig. 92:10801084.
65. Yang, L. C.,, P. R. Soprey,, M. K. Wittner,, and E. N. Fox. 1977. Streptococcal-induced cell-mediated-immune destruction of cardiac myofibers in vitro. J. Exp. Med. 146:344360.
66. Yoshinaga, M.,, F. Figueroa,, M. R. Wahid,, R. H. Marcus,, E. Suh,, and J. B. Zabriskie. 1995. Antigenic specificity of lymphocytes isolated from valvular specimens of rheumatic fever patients. J. Autoimmun. 8:601613.

Tables

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Table 1

A selection of cross-reactions between microbes and mammalian tissues

Citation: Visvanathan K, Zabriskie J. 2000. An Overview: Molecular Mimicry and Disease, p 1-16. In Cunningham M, Fujinami R (ed), Molecular Mimicry, Microbes, and Autoimmunity. ASM Press, Washington, DC. doi: 10.1128/9781555818074.ch1

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