Chapter 17 : Species

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Species, Page 1 of 2

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This chapter provides an introduction to the rapidly expanding but still very limited knowledge about the interactions of these species and their reservoirs and vectors and the adaptations these bacteria have developed to maintain persistent infection in the host mammalian species. There are now at least 13 named species and probably an equal number of unnamed species. Of these, only four have been definitively associated with human disease: , , , and . infection may be asymptomatic or may be characterized by high fever, severe shin pain, and relapsing symptoms over weeks to months. The species most commonly associated with endocarditis in humans is , and most patients with require replacement of the infected cardiac valve. Granulomatous inflammatory disease (CSD), most commonly of the lymph nodes, occurs in immunocompetent humans infected with . In humans and cats, and bacteremia, respectively, persist despite the development of a humoral antibody response. The study of pathogenesis is still in its infancy, and although there is a tractable system for genetic manipulation (via conjugation), it will be essential to identify and characterize virulence factors. The availability of the genome sequence in the near future will greatly enhance these studies, and the next phase of comparative genomics and microarrays will provide further insight into the mechanisms of pathogenesis and persistence of .

Citation: Koehler J. 2000. Species, p 339-353. In Nataro J, Blaser M, Cunningham-Rundles S (ed), Persistent Bacterial Infections. ASM Press, Washington, DC. doi: 10.1128/9781555818104.ch17
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Pattern of fever in a volunteer (vol. 2) experimentally infected with blood from vol. 1, a patient infected with . Prolonged bacteremia is present, diagnosed by positive xenodiagnosis and isolation of from the patient's blood. BAP, blood agar plates; S. C, subcutaneous; +, present; -, absent. (Reprinted from reference with permission of the publisher.)

Citation: Koehler J. 2000. Species, p 339-353. In Nataro J, Blaser M, Cunningham-Rundles S (ed), Persistent Bacterial Infections. ASM Press, Washington, DC. doi: 10.1128/9781555818104.ch17
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Image of FIGURE 2

Reservoirs, vectors, and mammalian infections associated with species. The species are shown in boxes, with the respective mammalian reservoir just below each box. The mode of transmission (arthropod vector or cat scratch) is shown next to each arrow, and the resultant mammalian infection is shown at the end of each arrow. (Reprinted from reference with permission of the publisher.)

Citation: Koehler J. 2000. Species, p 339-353. In Nataro J, Blaser M, Cunningham-Rundles S (ed), Persistent Bacterial Infections. ASM Press, Washington, DC. doi: 10.1128/9781555818104.ch17
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1. Abbott, R. C.,, B. B. Chomel,, R. W. Kasten,, K. A. Floyd-Hawkins,, Y. Kikuchi,, J. E. Koehler,, and N. C. Pedersen. 1997. Experimental and natural infection of cats with Bartonella henselae. Comp. Immunol. Microbiol. Infect. Dis. 20:4151.
2. Barbour, A. G. 1993. Linear DNA of Borrelia species and antigenic variation. Trends Microbiol. 1:236239.
3. Batterman, H. J.,, J. A. Peek,, J. S. Loutit,, S. Falkow,, and L. S. Tompkins. 1995. Bartonella henselae and Bartonella quintana adherence to and entry into cultured human epithelial cells. Infect. Immun. 63:45534556.
4. Benson, L. A.,, S. Kar,, G. McLaughlin,, and G. M. Ihler. 1986. Entry of Bartonella bacilliformis into erythrocytes. Infect. Immun. 54:347353.
5. Bergmans, A. M.,, J. W. Groothedde,, J. F. Schellekens,, J. D. van Embden,, J. M. Ossewaarde,, and L. M. Schouls. 1995. Etiology of cat scratch disease: comparison of polymerase chain reaction detection of Bartonella (formerly Rochalimaea) and Afipia felis DNA with serology and skin tests. J. Infect. Dis. 171:916923.
6. Bergmans, A. M. C.,, C. M. A. de Jong,, G. van Amerongen,, C. S. Schot,, and L. M. Schouls. 1997. Prevalence of Bartonella species in domestic cats in the Netherlands. J Clin. Microbiol. 35:22562261.
7. Birtles, R. J.,, T. G. Harrison,, and D. H. Molyneux. 1994. Grahamella in small woodland mammals in the U.K.: isolation, prevalence and host specificity. Ann. Trop. Med. Parasitol. 88:317327.
8. Brenner, D. J.,, S. P. O’Connor,, H. H. Winkler,, and A. G. Steigerwalt. 1993. Proposals to unify the genera Bartonella and Rochalimaea, with descriptions of Bartonella quintana comb, nov., Bartonella vinsonii comb, nov., Bartonella henselae comb, nov., and Bartonella elizabethae comb, nov., and to remove the family Bartonellaceae from the order Rickettsiales. Int. J. Syst. Bacteriol. 43:777786.
9. Broqui, P.,, and D. Raoult. 1996. Bartonella quintana invades and multiplies within endothelial cells in vitro and in vivo and forms intracellular blebs. Res. Microbiol 147:719731.
10. Brouqui, P.,, B. Lascola,, V. Roux,, and D . Raoult. 1999. Chronic Bartonella quintana bacteremia in homeless patients. N. Engl J. Med. 340: 184189.
11. Caceres-Rios, H.,, J. Rodriguez-Tafur,, F. Bravo-Puccio,, C. Maguina-Vargas,, C. S. Diaz,, D. C. Ramos,, and R. Patarca. 1995. Verruga peruana: an infectious endemic angiomatosis. Crit. Rev. Oncog. 6:4756.
12. Chomel, B. B. 1996. Cat-scratch disease and bacillary angiomatosis. Rev. Sci. Tech. 15: 10611073.
13. Chomel, B. B.,, R. C. Abbott,, R. W. Kasten,, K. A. Floyd-Hawkins,, P. H. Kass,, C. A. Glaser,, N. C. Pedersen,, and J. E. Koehler. 1995. Bartonella henselae prevalence in domestic cats in California: risk factors and association between bacteremia and antibody titers. J. Clin. Microbiol. 33:24452450.
14. Chomel, B. B.,, E. T. Carlos,, R. W. Kasten,, K. Yamamoto,, C .-C. Chang,, R. S. Carlos,, M. V. Abenes,, and C. M. Pajares. 1999. Bartonella henselae and Bartonella clarridgeiae infection in domestic cats from the PhiHppines. Am. J. Trop. Med. Hyg. 60:593597.
15. Chomel, B. B.,, R. W. Kasten,, K. Floyd- Hawkins,, B. Chi,, K. Yamamoto,, J. Roberts-Wilson,, A. N. Gurfield,, R. C. Abbott,, N. C. Pedersen,, and J. E. Koehler. 1996. Experimental transmission o f Bartonella henselae by the cat flea. J. Clin. Microbiol 34:19521956.
16. Dalton, M. J.,, L. E. Robinson,, J. Cooper,, R. L. Regnery,, J. G. Olson,, and J. E. Childs. 1995. Use of Bartonella antigens for serologic diagnosis of cat-scratch disease at a national referral center. Arch. Intern. Med. 155:16701676.
17. Dehio, C.,, and M. Meyer. 1997. Maintenance of broad-host-range incompatibility group P and group Q plasmids and transposition of Tn5 in Bartonella henselae following conjugal plasmid transfer from Escherichia coli.]. Bacteriol. 179:538540.
18. Dehio, C.,, M. Meyer,, J. Berger,, H. Schwarz,, and C. Lanz. 1997. Interaction of Bartonella henselae with endothelial cells results in bacterial aggregation on the cell surface and the subsequent engulfment and internalisation of the bacterial aggregate by a unique structure, the invasome. J. Cell Sci. 110:21412154.
19. Domingue, G. J., Sr.,, and H. B. Woody. 1997. Bacterial persistence and expression of disease. Clin. Microbiol. Rev. 10:320344.
20. Drancourt, M.,, J. L. Mainardi,, P. Brouqui,, F. Vandenesch,, A. Carta,, F. Lehnert,, J. Etienne,, F. Goldstein,, J. Acar,, and D. Raoult. 1995. Bartonella (Rochalimaea) quintana endocarditis in three homeless men. N. Engl. J. Med. 332:419423.
21. Finlay, B. B.,, and S. Falkow. 1997. Common themes in microbial pathogenicity revisited. Microb. Mol. Biol. Rev. 61:136169.
22. Foil, L.,, E. Andress,, R. L. Freeland,, A. F. Roy,, R. Rutledge,, P. C. Triche,, and K. L. O'Reilly. 1998. Experimental infection of domestic cats with Bartonella henselae by inoculation of Ctenocephalides felis (Siphonaptera: Pulicidae) feces. J. Med. Entomol. 35:625628.
23. Golenbock, D. T.,, R. Y. Hampton,, N. Qureshi,, K. Takayama,, and C. R. H. Raetz. 1991. Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes. J. Biol. Chem. 226:1949019498.
24. Guptill, L.,, L. Slater,, C.-C. Wu,, T.-L. Lin,, L. T. Glickman,, D. F. Welch,, and H. Hogen-Esch. 1997. Experimental infection of young specific pathogen-free cats with Bartonella henselae. J. Infect. Dis. 176:206216.
25. Heller, R.,, M. Artois,, V. Xemar,, D. De Briel,, H. Gehin,, B. Jaulhac,, H. Monteil,, and Y. Piemont. 1997. Prevalence of Bartonella henselae and Bartonella clarridgeiae in stray cats.J. Clin. Microbiol. 35:13271331.
26. Heller, R.,, M. Kubina,, P. Mariet,, P. Riegel,, G. Delacour,, C. Dehio,, F. Lamarque,, R. Kasten,, H.-J. Bouloui s,, H. Monteil,, B. Chomel,, and Y. Piemont. 1999. Bartonella alsatica sp. nov., a n ew Bartonella species isolated from the blood of wild rabbits. Int. J. Syst. Bacteriol. 49:283288.
27. Heller, R.,, P. Riegel,, Y. Hansmann,, G. Delacour,, D. Bermond,, C. Dehio,, F. Lamarque,, H. Monteil,, B. Chomel,, and Y. Piemont. 1998. Bartonella tribocorum sp. nov., a new Bartonella species isolated from the blood of wild rats. Int. J. Syst. Bacteriol 48:13331339.
28. Higgins, J. A.,, S. Radulovic,, D. C. Jaworski,, and A. F. Azad. 1996. Acquisition of the cat scratch disease agent Bartonella henselae by cat fleas (Siphonaptera: Pulicidae). J. Med. Entomol 33:490495.
29. Ito, S.,, and J. W. Vinson. 1965. Fine structure of Rickettsia quintana cultivated in vitro and in the louse. J. Bacteriol. 89:481495.
30. Jameson, P.,, C. Greene,, R. Regnery,, M. Dryden,, A. Marks,, J. Brown,, J. Cooper,, B. Glaus,, and R. Greene. 1995. Prevalence of Bartonella henselae antibodies in pet cats throughout regions of North America. J. Infect. Dis. 172: 11451149.
31. Koehler, J. E., 1998. Bartonella: an emerging human pathogen, p. 147163. In W. M. Scheld,, D. Armstrong,, and J. M. Hughes (ed.), Emerging Infections I. ASM Press, Washington, D.C.
32. Koehler, J. E.,, C. A. Glaser,, and J. W. Tappero. 1994. Rochalimaea henselae infection. A new zoonosis with the domestic cat as reservoir. JAMA 271:531535.
33. Koehler, J. E.,, P. E. LeBoit,, B. M. Egbert,, and T. G. Berger. 1988. Cutaneous vascular lesions and disseminated cat-scratch disease in patients with the acquired immunodeficiency syndrome (AIDS)-related complex. Ann. Intern. Med. 109:449455.
34. Koehler, J. E.,, F. D. Quinn,, T. G. Berger,, P. E. LeBoit,, and J. W. Tappero. 1992. Isolation of Rochalimaea species from cutaneous and osseous lesions of bacillary angiomatosis. N. Engl. J. Med. 327:16251631.
35. Koehler, J. E.,, and D. A. Relman,. 1999. Bartonella species, p. 578583. In V. L. Yu,, T. C. Merigan, Jr.,, and S. L. Barriere (ed.), Antimicrobial Therapy and Vaccines. Williams and Wilkins, Baltimore, Md.
36. Koehler, J. E.,, M. A. Sanchez,, C. S. Garrido,, M. J. Whitfeld,, F. M. Chen,, T. G. Berger,, M. C. Rodriguez-Barradas,, P. E. Le Boit,, and J. W. Tappero. 1997. Molecular epidemiology of Bartonella infections in patients with bacillary angiomatosis-peliosis. N. Engl J. Med. 337:18761883.
37. Koehler, J. E.,, and J. W. Tappero. 1993. Bacillary angiomatosis and bacillary peliosis in patients infected with human immunodeficiency virus. Clin. Inject. Dis. 17:612624.
38. Kordick, D. L.,, and E. B. Breitschwerdt. 1995. Intraerythrocytic presence of Bartonella henselae. J. Clin. Microbiol. 33:16551656.
39. Kordick, D. L.,, and E. B. Breitschwerdt. 1998. Persistent infection of pets with three Bartonella species. Emerg. Inject. Dis. 4:325328.
40. Kordick, D. L.,, T. T. Brown,, K. Shin,, and E. B. Breitschwerdt. 1999. Clinical and pathologic evaluation of chronic Bartonella henselae or Bartonella clarridgeiae infection in cats. J. Clin. Microbiol. 37:15361547.
41. Kordick, D. L.,, M. G. Papich,, and E. B. Breitschwerdt. 1997. Efficacy of enrofloxacin or doxycycline for treatment of Bartonella henselae or Bartonella clarridgeiae infection in cats. Antimicrob. Agents Chemother. 41:24482455.
42. Kordick, D. L.,, B. Swaminathan,, C. E. Greene,, K. H. Wilson,, A. M. Whitney,, S. O’Connor,, D. G. Hollis,, G. M. Matar,, A. G. Steigerwalt,, G. B. Malcolm,, P. S. Hayes,, T. L. Hadfield,, E. B. Breitschwerdt,, and D. J. Brenner. 1996. Bartonella vinsonii subsp. berkhoffii subsp. nov., isolated from dogs; Bartonella vinsonii subsp. vinsonii; and emended description of Bartonella vinsonii. Int. J. Syst. Bacteriol. 46:704709.
43. Kosoy, M. Y.,, R. L. Regnery,, O. I. Kosaya,, D. C. Jones,, E. L. Marston,, and J. E. Childs. 1998. Isolation of Bartonella spp. from embryos and neonates of naturally infected rodents. J. Wildl Dis. 34:305309.
44. Kosoy, M. Y.,, R. L. Regnery,, T. Tzianabos,, E. L. Marston,, D. C. Jones,, D. Green,, G. O. Maupin,, J. G. Olson,, and J. E. Childs. 1997. Distribution, diversity, and host specificity of Bartonella in rodents from the southeastern United States. Am.]. Trop. Med. Hyg. 57:578588.
45. LeBoit, P. E., 1997. Bacillary angiomatosis, p. 407415. In D. H. Connor,, F. W. Chandler,, H. J. Manz,, D. A. Schwartz,, and E. E. Lack (ed.), Pathology of Infectious Diseases, vol. 1. Appleton and Lange, Stamford, Conn.
46. LeBoit, P. E.,, T. G. Berger,, B. M. Egbert,, J. H. Beckstead,, T. S. B. Yen,, and M. H. Stoler. 1989. Bacillary angiomatosis: the histopathology and differential diagnosis of a pseudoneoplastic infection in patients with human immunodeficiency virus disease. Am. J. Surg. Pathol. 13:909920.
47. Lee, A. K.,, and S. Falkow. 1998. Constitutive and inducible green fluorescent protein expression in Bartonella henselae. Infect. Immun. 66: 39643967.
48. Lucey, D.,, M. J. Dolan,, C. W. Moss,, M. Garcia,, D. G. Hollis,, S. Wegner,, G. Morgan,, R. Almeida,, D. Leong,, K. S. Greisen, et al. 1992. Relapsing illness due to Rochalimaea henselae in immunocompetent hosts: implication for therapy and n ew epidemiological associations. Clin. Infect. Dis. 14:683688.
49. Margileth, A. M. 1993. Cat scratch disease. Adv. Pediatr. Infect. Dis. 8:121.
50. Montgomery, E. A.,, and F. U. Garcia,. 1997. Bartonellosis–infection by Bartonella bacilliformis, p. 431439. In D. H. Connor,, F. W. Chandler,, H. J. Manz,, D. A. Schwartz,, and E. E. Lack (ed.), Pathology of Infectious Diseases, vol. 1. Appleton and Lange, Stamford, Conn.
51. Osborne, B. M.,, J. J. Butler,, and B. Mackay. 1987. Ultrastructural observations in cat scratch disease. Am. J. Clin. Pathol. 87:739744.
52. Raoult, D.,, P. E. Fournier,, M. Drancourt,, T. J. Marrie,, J. Etienne,, J. Cosserat,, P. Cacoub,, Y. Poinsignon,, P. Leclercq,, and A. M. Sefton. 1996. Diagnosis of 22 new cases o f Bartonella endocarditis. Ann. Intern. Med. 125:646652.
53. Regnery, R. L.,, J. A. Rooney,, A. M. Johnson,, S. L. Nesby,, P. Manzewitsch,, K. Beaver,, and J. G. Olson. 1996. Experimentally induced Bartonella henselae infections followed by challenge exposure and antimicrobial therapy in cats. Am. J. Vet. Res. 57:17141719.
54. Relman, D. A.,, J. S. Loutit,, T. M. Schmidt,, S. Falkow,, and L. S. Tompkins. 1990. The agent o f bacillary angiomatosis: an approach to the identification of uncultured pathogens. N. Engl. J. Med. 323:15731580.
55. Robertson, B. D.,, and T. F. Meyer. 1992. Genetic variation in pathogenic bacteria. Trends Genet. 8:422428.
56. Rodriguez-Barradas, M. C.,, J. C. Bandres,, R. J. Hamill,, J. Trial,, J. E. R. Clarridge,, R. E. Baughn,, and R. D. Rossen. 1995. In vitro evaluation of the role of humoral immunity against Bartonella henselae. Infect. Immun. 63: 23672370.
57. Rodriguez-Barradas, M. C.,, R. J. Hamill,, E. D. Houston,, P. R. Georghiou,, J. E. Clarridge,, R. L. Regnery,, and J. E. Koehler. 1995. Genomic fingerprinting of Bartonella species by repetitive element PCR for distinguishing species and isolates. / Clin. Microbiol. 33:10891093.
58. Roux, V.,, and D. Raoult. 1995. Inter-and in-traspecies identification of Bartonella (Rochalimaea) species. J. Clin. Microbiol 33:15731579.
59. Rydkina, E. B.,, V. Roux,, E. M. Gagua,, A. B. Predtechenski,, I. V. Tarasevich,, and D. Raoult. 1999. Bartonella quintana in body lice collected from homeless persons in Russia. Emerg. Infect. Dis. 5:176178.
60. Salyers, A. A.,, and D. D. Whitt. 1994. Bacterial Pathogenesis: a Molecular Approach, p. 290300. American Society for Microbiology, Washington, D.C.
61. Sander, A.,, C. Buhler,, K. Pelz,, E. von Cramm,, and W. Bredt. 1997. Detection and identification of two Bartonella henselae variants in domestic cats in Germany. J. Clin. Microbiol 35: 584587.
62. Schouls, L. M.,, I. Van De Pol,, S. G. T. Rijpkema,, and C. S. Schot. 1999. Detection and identification of Ehrlichia, Borrelia burgdorferi sensu lato, and Bartonella species in Dutch Ixodes ricinus ticks. J. Clin. Microbiol 37:22152222.
63. Spach, D. H.,, A. S. Kanter,, N. A. Daniels,, D. J. Nowowiejski,, A. M. Larson,, R. A. Schmidt,, B. Swaminathan,, and D. J. Brenner. 1995. Bartonella (Rochalimaea) species as a cause o f apparent "culture-negative" endocarditis. Clin. Infect. Dis. 20:10441047.
64. Stoler, M. H.,, T. A. Bonfiglio,, R. T. Steigbigel,, and M. Pereira. 1983. An atypical subcutaneous infection associated with acquired immune deficiency syndrome. Am. J. Clin. Pathol. 80:714718.
65. Strong, R. P. 1918. Trench Fever: Report of Commission, Medical Research Committee, American Red Cross. Oxford University Press, Oxford, England.
66. Swift, H. F. 1920. Trench fever. Arch. Intern. Med. 26:7698.
67. Varela, G.,, J. W. Vinson,, and C. Molina-Pasquel. 1969. Trench fever. II. Propagation of Rickettsia quintana on cell-free medium from the blood of two patients. Am. J. Trop. Med. Hyg. 18:708712.
68. von Krampitz, H. E. 1962. Weitere Untersuchungen an Grahamella Brumpt 1911. Z. Tropenmed. Parasitol. 13:3453.
69. Weinman, D., 1968. Bartonellosis, p. 324. In D. Weinman, and M. Ristoc (ed.), Infectious Blood Diseases of Man and Animals. Academic Press, Inc., New York, N.Y.
70. Weinman, D.,, and J. P. Kreier,. 1977. Bartonella and Grahamella, p. 197233. In J. P. Kreier (ed.), Parasitic Protozoa, vol. 4. Academic Press, Inc., New York, N.Y.
71. Weinman, D.,, and H. Pinkerton. 1937. Carrion's disease. IV. Natural sources of bartonella in the endemic zone. Proc. Soc. Exp. Biol. Med. 37: 596598.
72. Wong, M. T.,, M. J. Dolan,, C. P. Lattuada, Jr.,, R. L. Regnery,, M. L. Garcia,, E. C. Mokulis,, R. A. LaBarre,, D. P. Ascher,, J. A. Delmar,, J. W. Kelly, et al. 1995. Neuroretinitis, aseptic meningitis, and lymphadenitis associated with Bartonella (Rochalimaea) henselae infection in immunocompetent patients and patients infected with human immunodeficiency virus type 1. Clin. Infect. Dis. 21:352360.
73. X u, Y. H.,, Z. Y. Lu,, and G. M. Ihler. 1995. Purification of deformin, an extracellular protein synthesized by Bartonella bacilliformis which causes deformation of erythrocyte membranes. Biochim. Biophys. Acta 1234:173183.
74. Yamamoto, K.,, B. B. Chomel,, R. W. Kasten,, C. C. Chang,, T. Tseggai,, P. R. Decker,, M. Mackowiak,, K. A. Floyd-Hawkins,, and N. C. Pedersen. 1998. Homologous protection but lack of heterologous protection by various species and types o f Bartonella in specific pathogenfree cats. Vet. Immunol. Immunopathol. 65: 191204.
75. Yamamoto, K.,, B. B. Chomel,, L.J. Lowenstin e,, Y. Kikuchi,, L. G. Phillips,, B. C. Barr,, P. K. Swift,, K. R. Jones,, S. P. D. Riley,, R. W. Kasten,, J. E. Foley,, and N. C. Pedersen. 1998. Bartonella henselae antibody prevalence in free-ranging and captive wild felids from California. J. Wildl. Dis. 34:5663.


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species and human infection

Citation: Koehler J. 2000. Species, p 339-353. In Nataro J, Blaser M, Cunningham-Rundles S (ed), Persistent Bacterial Infections. ASM Press, Washington, DC. doi: 10.1128/9781555818104.ch17

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