Chapter 18 : Persistence of Infective Endocarditis

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Infective endocarditis describes a family of persistent microbial infections of the heart valves. This chapter explores their ability to behave as endogenous pathogens and is instructive as we try to understand persistence of the larger constellation of endocarditis-associated pathogens. Infective endocarditis generally occurs in individuals with previously diseased or damaged heart valves, most frequently after bacteremia containing viridans streptococci or . Many of the most common microorganisms associated with infective endocarditis are considered to be of low virulence, often causing no known disease in their native niches. Patients with infective endocarditis show elevated anti-phospholipid antibodies associated with endothelial-cell activation, thrombin generation, and impairment of fibrinolysis. Adhesion to platelets and preformed platelet-fibrin clots would appear intuitively to be associated with the ability of microbes to infect platelet vegetations and cause infective endocarditis. Dextran synthesis by viridans streptococci has been suggested to be a virulence factor in infective endocarditis, promoting adhesion and persistence. The ability of microbes to induce platelet aggregation in vitro may be associated with the pathogenicity of those strains in infective endocarditis. The host distinguishes the commensals from exogenous pathogens. When commensals breach the mucosa and infect the heart valves in infective endocarditis, the host immune repertoire against these endogenous pathogens is programmed for systemic tolerance.

Citation: Herzberg M. 2000. Persistence of Infective Endocarditis, p 357-374. In Nataro J, Blaser M, Cunningham-Rundles S (ed), Persistent Bacterial Infections. ASM Press, Washington, DC. doi: 10.1128/9781555818104.ch18

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Macrophage Inflammatory Protein 1 alpha
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Tripartite model of infective endocarditis. The persistence of endocarditis reflects the balance between the host's ability to repair an injured valve and promote or support a bland nonbacterial thrombotic vegetation and the virulence of the infecting microbe.

Citation: Herzberg M. 2000. Persistence of Infective Endocarditis, p 357-374. In Nataro J, Blaser M, Cunningham-Rundles S (ed), Persistent Bacterial Infections. ASM Press, Washington, DC. doi: 10.1128/9781555818104.ch18
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Image of FIGURE 2

Mechanisms of microbial persistence in infective endocarditis.

Citation: Herzberg M. 2000. Persistence of Infective Endocarditis, p 357-374. In Nataro J, Blaser M, Cunningham-Rundles S (ed), Persistent Bacterial Infections. ASM Press, Washington, DC. doi: 10.1128/9781555818104.ch18
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1. Adderson, E.E.,, A. R. Shikhman,, K. E. Ward,, and M. W. Cunningham. 1998. Molecular analysis ofpolyreactive monoclonal antibodies from rheumatic carditis: humananti-N-acetylglucosamine/anti-myosin antibody V region genes. J. Immunol. 161:20202031.
2. Allison, D. G.,, B. Ruiz,, C. Sanjose,, A. Jaspe,, and P. Gilbert. 1998. Extracellular products as mediators of the formation and detachment of Pseudomonas fluorescens biofilms. FEMS Microbiol. Lett. 167:179184.
3. Arning, M.,, A. Gehrt,, C. Aul,, V. Runde,, U. Hadding,, and W. Schneider. 1990. Septicemia due to Streptococcus mitis in neutropenic patients with acute leukemia. Blut 61:364368.
4. Asada, Y.,, K. Marutsuka,, K. Hatakeyama,, Y. Sato,, S. Hara,, A. Kisanuki,, and S. Sumiyoshi. 1998. The role of tissue factor in the pathogenesis of thrombosis and atherosclerosis. J. Atheroscler. Thromb. 4:135139.
5. Bancsi, M. J.,, J. Thompson,, and R. M. Bertina. 1994. Stimulation of monocyte tissue factor expression in an in vitro model of bacterial endocarditis. Infect. Immun. 62:56695672.
6. Bancsi, M. J.,, M. H. Veltrop,, R. M. Bertina,, and J. Thompson. 1996. Influence of monocytes and antibiotic treatment on tissue factor activity o f endocardial vegetations in rabbits infected with Streptococcus sanguis. Infect. Immun. 64:448451.
7. Bancsi, M. J.,, M. H. Veltrop,, R. M. Bertina,, and J. Thompson. 1996. Role of phagocytosis in activation of the coagulation system in Streptococcus sanguis endocarditis. Infect. Immun. 64:51665170.
8. Bayer, A. S.,, P. M. Sullam,, M. Ramos,, C. Li,, A. L. Cheung,, and M. R. Yeaman. 1995. Staphylococcus aureus induces platelet aggregation via a fibrinogen-dependent mechanism which is independent of principal platelet glycoprotein Ilb/IIIa fibrinogen-binding domains. Infect. Immun. 63:36343641.
9. Bayer, A. S.,, M. D. Ramos,, B. E. Menzies,, M. R. Yeaman,, A. J. Shen,, and A. L. Cheung. 1997. Hyperproduction of alpha-toxin by Staphylococcus aureus results in paradoxically reduced virulence in experimental endocarditis: a host defense role for platelet microbicidal proteins. Infect. Immun. 65:46524660.
10. Bayer, A. S.,, D. Cheng,, M. R. Yeaman,, G. R. Corey,, M. S. McClelland,, L.J. Harrel,, and V. G. Fowler, Jr. 1998. In vitro resistance to thrombin-induced platelet microbicidal protein among clinical bacteremic isolates of Staphylococcus aureus correlates with an endovascular infectious source. Antimicrob. Agents Chemother. 42:31693172.
11. Bayer, A. S.,, A. F. Bolger,, K. A. Taubert,, W. Wilson,, J. Steckelberg,, A. W. Karchmer,, M. Levison,, H. F. Chambers,, A. S. Dajani,, M. H. Gurwitz,, J. W. Newburger, et al. 1998. Diagnosis and management of infective endocarditis. Circulation 98:29362948.
12. Bayer, A. S.,, S. N. Coulter,, C. K. Stover,, and W. R. Schwan. 1999. Impact of the highaffinity proline permease gene (putP) on the virulence of Staphylococcus aureus in experimental endocarditis. Infect. Immun. 67:740744.
13. Bochud, P. Y.,, T. Calandra,, and P. Francioli. 1994. Bacteremia due to viridans streptococci in neutropenic patients: a review. Am. J. Med. 97:256264.
14. Buiting, A. G.,, J. Thompson,, J. J. Emeis,, H. Mattie,, E. J. Brommer,, and R. van Furth. 1987. Effects of tissue-type plasminogen activator on Staphylococcus epidermidis-infected plasma clots as a model of infected endocardial vegetations. J. Antimicrob. Chemother. 19:771780.
15. Burne, R. A.,, Y. Y. Chen,, and J. E. Penders. 1997. Analysis of gene expression in Streptococcus mutans in biofilms in vitro. Adv. Dent. Res. 11:100109.
16. Byers, H. L.,, K. A. Homer,, and D. Beighton. 1996. Utilization of sialic acid by viridans streptococci. J. Dent. Res. 75:15641571.
17. Casadevall, A.,, and L.-A. Pirofski. 1999. Host-pathogen interactions: redefining the basic concepts of virulence and pathogenicity. Infect. Immun. 67:37033713.
18. Cheung, A. L.,, C. C. Nast,, and A. S. Bayer. 1998. Selective activation of sar promoters with the use of green fluorescent protein transcriptional fusions as the detection system in the rabbit endocarditis model. Infect. Immun. 66:59885993.
19. Clawson, C. C.,, J. G. White,, and M. C. Herzberg. 1980. Platelet interaction with bacteria. VI. Contrasting the role of fibrinogen and fibronectin. Am. J. Hematol. 9:4353.
20. Costerton, J. W.,, P. S. Stewart,, and E. P. Greenberg. 1999. Bacterial biofilms: a common cause of persistent infections. Science 284: 13181322.
21. Coulter, S. N.,, W. R. Schwan,, E. Y. Ng,, M. H. Langhorne,, H. D. Ritchie,, S. Westbrock-Wadman,, W. O. Hufhagle,, K. R. Folger,, A. S. Bayer,, and C. K. Stover. 1998. Staphylococcus aureus genetic loci impacting growth and survival in multiple infection environments. Mol. Microbiol. 30:393404.
22. Cowles, J. W.,, S. L. Spitalnik,, and N. Blumberg. 1989. The fine specificity of Lewis blood group antibodies. Evidence for maturation of the immune response. Vox Sang. 56:107111.
23. Crawford, I.,, and C. Russell. 1986. Comparative adhesion of seven species of streptococci isolated from the blood of patients with sub-acute bacterial endocarditis to fibrin-platelet clots in vitro. J. Appl. Bacteriol. 60:127133.
24. Danforth, J. M.,, R. M. Strieter,, S. L. Kunkel,, D. A. Arenberg,, G. M. VanOtteren,, and T. J. Standiford. 1995. Macrophage inflammatory protein-1 alpha expression in vivo and in vitro: the role of lipoteichoic acid. Clin. Immunol. Immunopathol. 74:7783.
25. Davies, D. G.,, M. R. Parsek,, J. P. Pearson,, B. H. Iglewski,, J. W. Costerton,, and E. P. Greenberg. 1998. The involvement of cell-to-cell signals in the development of a bacterial biofilm. Science 280:295298.
26. Demuth, D. R.,, Y. Duan,, W. Brooks,, A. R. Holmes,, R. McNab,, and H. F. Jenkinson. 1996. Tandem genes encode cell-surface polypeptides SspA and SspB which mediate adhesion of the oral bacterium Streptococcus gordonii to human and bacterial receptors. Mol. Microbiol. 20:403413.
27. Derre, I.,, G. Rapoport,, and T. Msadek. 1999. CtsR, a novel regulator of stress and heat shock response, controls clp and molecular chaperone gene expression in gram-positive bacteria. Mol. Microbiol. 31:117131.
28. Dhawan, V. K.,, A. S. Bayer,, and M. R. Yeaman. 1998. In vitro resistance to thrombin-induced platelet microbicidal protein is associated with enhanced progression and hematogenous dissemination in experimental Staphylococcus aureus infective endocarditis. Infect. Immun. 66:34763479.
29. Douglas, C. W.,, P. R. Brown,, and F. E. Preston. 1990. Platelet aggregation by oral streptococci. FEMS Microbiol. Lett. 60:6367.
30. Douglas, C. W.,, J. Heath,, K. K. Hampton,, and F. E. Preston. 1993. Identity of viridans streptococci isolated from cases of infective endocarditis. J. Med. Microbiol. 39:179182.
31. Drake, T. A.,, G. M. Rodgers,, and M. A. Sande. 1984. Tissue factor is a major stimulus for vegetation formation in enterococcal endocarditis in rabbits. J. Clin. Investig. 73:17501753.
32. Drake, T. A.,, and M. Pang. 1988. Staphylococcus aureus induces tissue factor expression in cultured human cardiac valve endothelium. J. Infect. Dis. 157:749756.
33. Drake, T. A.,, and M. Pang. 1989. Effects of interleukin-1, lipopolysaccharide, and streptococci on procoagulant activity of cultured human cardiac valve endothelial and stromal cells. Infect. Immun. 57:507512.
34. Drake, T. A.,, J. H. Morrissey,, and T. S. Edgington. 1989. Selective cellular expression of tissue factor in human tissues. Implications for disorders ofhemostasis and thrombosis. Am. J. Pathol. 134:10871097.
35. Drangsholt, M. T. 1998. A new causal model of dental diseases associated with endocarditis. Ann. Periodontol. 3:184196.
36. Durack, D. T. 1975. Experimental bacterial endocarditis. IV. Structure and evolution of very early lesions. J. Pathol 115:8189.
37. Durack, D. T. 1995. Prevention of infective endocarditis. N. Engl J. Med. 332:3844.
38. Dyson, C.,, R. A. Barnes,, and G. A. Harrison. 1999. Infective endocarditis: an epidemiological review of 128 episodes. J. Infect. 38:8793.
39. Edoute, Y.,, N. Haim,, D. Rinkevich,, B. Brenner,, and S. A. Reisner. 1997. Cardiac valvular vegetations in cancer patients: a prospective echocardiographic study of 200 patients. Am. J. Med. 102:252258.
40. Elting, L. S.,, G. P. Bodey,, and B. H. Keefe. 1992. Septicemia and shock syndrome due to viridans streptococci: a case-control study of predisposing factors. Clin. Inject. Dis. 14:12011207.
41. Erickson, P. R.,, and M. C. Herzberg. 1987. A collagen-like immunodeterminant on the surface of Streptococcus sanguis induces platelet aggregation. J. Immunol 138:33603366.
42. Erickson, P. R.,, and M. C. Herzberg. 1990. Purification and partial characterization of a 65-kDa platelet aggregation-associated protein antigen from the surface o f Streptococcus sanguis. J. Biol Chem. 265:1408014087.
43. Erickson, P. R.,, and M. C. Herzberg. 1993. Evidence for the covalent linkage of carbohydrate polymers to a glycoprotein from Streptococcus sanguis. J. Biol Chem. 268:2378023783.
44. Erickson, P. R.,, and M. C. Herzberg. 1993. The Streptococcus sanguis platelet aggregation-associated protein. Identification and characterization of the minimal platelet-interactive domain. J. Biol Chem. 268:16461649.
45. Erickson, P. R.,, and M. C. Herzberg. 1995. Altered expression of the platelet aggregation-associated protein from Streptococcus sanguis after growth in the presence of collagen. Infect. Immun. 63:10841088.
46. Erickson, P. R.,, and M. C. Herzberg. 1999. Emergence of antibiotic resistant Streptococcus sanguis in dental plaque o f children after frequent antibiotic therapy. Pediatr. Dent. 21:181185.
47. Erickson, P. R.,, M. C. Herzberg,, and G. Tierney. 1992. Cross-reactive immunodeterminants on Streptococcus sanguis and collagen. Predicting a structural motif of platelet-interactive domains. J. Biol Chem. 267:1001810023.
48. Ferguson, D. J.,, A. A. McColm,, D. M. Ryan,, and P. Acred. 1988. A morphological study of the effect of treatment with the antibiotic ceftazidime on experimental staphylococcal endocarditis and aortitis. Br. J. Exp. Pathol 69:551561.
49. Ford, I.,, C. W. Douglas,, F. E. Preson,, A. Lawless,, and K. K. Hampton. 1993. Mechanisms of platelet aggregation by Streptococcus sanguis, a causative organism in infective endocarditis. Br. J. Haematol 84:95100.
50. Ford, I.,, C. W. Douglas,, J. Heath,, C. Rees,, and F. E. Preston. 1996. Evidence for the involvement of complement proteins in platelet aggregation by Streptococcus sanguis NCTC 7863. Br. J. Haematol. 94:729739.
51. Ford, I.,, C. W. Douglas,, D. Cox,, D. G. Rees,, J. Heath,, and F. E. Preston. 1997. The role of immunoglobulin G and fibrinogen in platelet aggregation by Streptococcus sanguis. Br. J. Haematol. 97:737746.
52. Fukuda, Y.,, Y. Kuroiwa,, H. Tabuchi,, T. Ohshige,, J. Sanada,, Y. Minami,, S. Takaoka,, H. Kataoka,, S. Furukawa,, K. Miyahara,, K. Nakamura,, and S. Hashimoto. 1982. A thrombotic tendency in patients with infective endocarditis. Jpn. Circ. J. 46:460467.
53. Gong, K.,, D. Y. Wen,, T. Ouyang,, A. T. Rao,, and M. C. Herzberg. 1995. Platelet receptors for the Streptococcus sanguis adhesin and aggregation-associated antigens are distinguished by antiidiotypical monoclonal antibodies. Infect. Immun. 63:36283633.
54. Gong, K.,, T. Ouyang,, and M. C. Herzberg. 1998. A streptococcal adhesion system for salivary pellicle and platelets. Infect. Immun. 66: 53885392.
55. Gutschik, E.,, S. Moller,, and N. Christensen. 1979. Experimental endocarditis in rabbits. 3. Significance of the proteolytic capacity of the infecting strains of Streptococcus faecalis. Acta Pathol. Microbiol Scand. Sect. B 87:353362.
56. Hausner, M.,, and S. Wuertz. 1999. High rates of conjugation in bacterial biofilms as determined by quantitative in situ analysis. Appl Environ. Microbiol. 65:37103713.
57. Havarstein, L. S.,, P. Gaustad,, I. F. Nes,, and D. A. Morrison. 1996. Identification of the streptococcal competence-pheromone receptor. Mol Microbiol. 21:863869.
58. Havarstein, L. S.,, R. Hakenbeck,, and P. Gaustad. 1997. Natural competence in the genus Streptococcus: evidence that streptococci can change pherotype by interspecies recombinational exchanges. J. Bacteriol 179:65896594.
59. Hazlett, K. R. O.,, J. E. Mazurkiewicz,, and J. A. Banas. 1999. Inactivation of the gbpA gene of Streptococcus mutans alters structural and functional aspects of plaque biofilm which are compensated by recombination of the gtJB and gtJC genes. Infect. Immun. 67:39093914.
60. Herzberg, M. C.,, and K. L. Brintzenhofe. 1983. ADP-like platelet aggregation activity generated by viridans streptococci incubated with exogenous ATP. Infect. Immun. 40:120125.
61. Herzberg, M. C.,, K. L. Brintzenhofe,, and C. C. Clawson. 1983. Aggregation of human platelets and adhesion of Streptococcus sanguis. Infect. Immun. 39:14571469.
62. Herzberg, M. C.,, K. L. Brintzenhofe,, and C. C. Clawson. 1983. Cell-free released components of Streptococcus sanguis inhibit human platelet aggregation. Infect. Immun. 42:394401.
63. Herzberg, M. C.,, K. Gong,, G. D. MacFarlane,, P. R. Erickson,, A. H. Soberay,, P. H. Krebsbach,, G. Manjula,, K. Schilling,, and W. H. Bowen. 1990. Phenotypic characterization of Streptococcus sanguis virulence factors associated with bacterial endocarditis. Infect. Immun. 58: 515522.
64. Herzberg, M. C.,, P. R. Erickson,, P. K. Kane,, D. J. Clawson,, C. C. Clawson,, and F. A. Hoff. 1990. Platelet-interactive products of Streptococcus sanguis protoplasts. Infect. Immun. 58: 41174125.
65. Herzberg, M.C.,, G. D. MacFarlane,, K. Gong,, N. N. Armstrong,, A. R. Witt,, P. R. Erickson,, and M. W. Meyer. 1992. The platelet interactivity phenotype of Streptococcus sanguis influences the course of experimental endocarditis. Infect. Immun. 60:48094818.
66. Herzberg, M. C.,, L. K. Krishnan,, and G. D. MacFarlane. 1993. Involvement of alpha 2-adrenoreceptors and G proteins in the modulation of platelet secretion in response to Streptococcus sanguis. Crit. Rev. Oral Biol. Med. 4:435442.
67. Herzberg, M. C. 1996. Platelet-streptococcal interactions in endocarditis. Crit. Rev. Oral Biol Med. 7:222236.
68. Herzberg, M. C.,, M. W. Meyer,, A. Kilic,, and L. Tao. 1997. Host-pathogen interactions in bacterial endocarditis: streptococcal virulence in the host. Adv. Dent. Res. 11:6974.
69. Hienz, S. A.,, T. Schennings,, A. Heimdahl,, and J. I. Flock. 1996. Collagen binding of Staphylococcus aureus is a virulence factor in experimental endocarditis. J. Inject. Dis. 174:8388.
70. Hirota, K.,, H. Kanitani,, K. Nemoto,, T. Ono,, and Y. Miyake. 1995. Cross-reactivity between human sialyl Lewis(x) oligosaccharide and common causative oral bacteria of infective endocarditis. FEMS Immunol. Med. Microbiol. 12:159164.
71. Homer, K. A.,, S. Kelley,, J. Hawkes,, D. Beighton,, and M. C. Grootveld. 1996. Metabolism of glycoprotein-derived sialic acid and N-acetylglucosamine by Streptococcus oralis. Microbiology 142:12211230.
72. Huebner, J.,, and D. A. Goldmann. 1999. Coagulase-negative staphylococci: role as pathogens. Annu. Rev. Med. 50:223236.
73. Ikeda, K.,, K. Nagasawa,, T. Horiuchi,, T. Tsuru,, H. Nishizaka,, and Y. Niho. 1997. C5a induces tissue factor activity on endothelial cells. Thromb. Haemost. 77:394398.
74. Jenkinson, H. F.,, R. A. Baker,, and G. W. Tannock. 1996. A binding-lipoprotein-dependent oligopeptide transport system in Streptococcus gordonii essential for uptake of hexa-and heptapeptides. J. Bacteriol. 178:6877.
75. Jiang, Y.,, L. Magli,, and M. Russo. 1999. Bacterium-dependent induction of cytokines in mononuclear cells and their pathologic consequences in vivo. Infect. Immun. 67:21252130.
76. Juarez, Z. E.,, and M. W. Stinson. 1999. An extracellular protease of Streptococcus gordonii hydrolyzes type IV collagen and collagen analogues. Infect. Immun. 67:271278.
77. Kessler, C. M.,, E. Nussbaum,, and C. U. Tuazon. 1987. In vitro correlation of platelet aggregation with occurrence of disseminated intravascular coagulation and subacute bacterial endocarditis. J. Lab. Clin. Med. 109:647652.
78. Kilic, A. O.,, M. C. Herzberg,, M. W. Meyer,, X. Zhao,, and L. Tao. 1999. Streptococcal reporter gene-fusion vector for identification of in vivo expressed genes. Plasmid 42:6772.
79. Kleerebezem, M.,, L. E. Quadri,, O. P. Kuipers,, and W. M. de Vos. 1997. Quorum sensing by peptide pheromones and two-component signal-transduction systems in Gram-positive bacteria. Mol. Microbiol. 24:895904.
80. Kupferwasser, I.,, H. Darius,, A. M. Muller,, S. Mohr-Kahaly,, T. Westermeier,, H. Oelert,, R. Erbel,, and J. Meyer. 1998. Clinical and morphological characteristics in Streptococcus bovis endocarditis: a comparison with other causative microorganisms in 177 cases. Heart 80:276280.
81. Kupferwasser, L. I.,, G. Hafher,, S. Mohr-Kahaly,, R. Erbel,, J. Meyer,, and H. Darius. 1999. The presence of infection-related antiphospholipid antibodies in infective endocarditis determines a major risk factor for embolic events. J. Am. Coll. Cardiol. 33:13651371.
82. Kupferwasser, L. I.,, M. R. Yeaman,, S. M. Shapiro,, C. C. Nast,, P. M. Sullam,, S. G. Filler,, and A. S. Bayer. 1999. Acetylsalicylic acid reduces vegetation bacterial density, hematogenous bacterial dissemination, and frequency of embolic events in experimental Staphylococcus aureus endocarditis through antiplatelet and antibacterial effects. Circulation 99:27912797.
83. Kurland, S.,, E. EnghofF,, J. Landelius,, S. O. Nystrom,, A. Hambraeus,, and G. Friman. 1999. A 10-year retrospective study of infective endocarditis at a university hospital with special regard to the timing of surgical evaluation in S. viridans endocarditis. Scand. J. Infect. Dis. 31:8791.
84. Lawson, C. A.,, S. D. Yan,, S. F. Yan,, H. Liao,, Y. S. Zhou,, J. Sobel,, W. Kisiel,, D. M. Stern,, and D. J. Pinsky. 1997. Monocytes and tissue factor promote thrombosis in a murine model of oxygen deprivation. J. Clin. Investig. 99: 17291738.
85. Lee, J. C.,, J. S. Park,, S. E. Shepherd,, V. Carey,, and A. Fattom. 1997. Protective efficacy of antibodies to the Staphylococcus aureus type 5 capsular polysaccharide in a modified model of endocarditis in rats. Infect. Immun. 65:41464151.
86. Levi, M.,, and H. ten Cate. 1999. Disseminated intravascular coagulation. N. Engl. J. Med. 341: 586592.
87. Libman, H.,, and R. D. Arbeit. 1984. Complications associated with Staphylococcus aureus bacteremia. Arch. Intern. Med. 144:541545.
88. Lunsford, R. D.,, and J. London. 1996. Natural genetic transformation in Streptococcus gordonii: comX imparts spontaneous competence on strain wicky. J. Bacteriol. 178:58315835.
89. Lunsford, R. D.,, and A. G. Roble. 1997. comYA, a gene similar to comGA of Bacillus subtilis, is essential for competence factor-dependent DNA transformation in Streptococcus gordonii. J. Bacteriol. 179:31223126.
90. MacFarlane, G. D.,, D. E. Sampson,, D. J. Clawson,, C. C. Clawson,, K. L. Kelly,, and M. C. Herzberg. 1994. Evidence for an ecto-ATPase on the cell wall of Streptococcus sanguis. Oral Microbiol. Immunol. 9:180185.
91. Manganelli, R.,, and I. van de Rijn. 1999. Characterization of emb, a gene encoding the major adhesin of Streptococcus defectivus. Infect. Immun. 67:5056.
92. Manning, J. E.,, E. B. Hume,, N. Hunter,, and K. W. Knox. 1994. An appraisal of the virulence factors associated with streptococcal endocarditis. J. Med. Microbiol. 40:110114.
93. Mayo, J. A.,, H. Zhu,, D. W. Harty,, and K. W. Knox. 1995. Modulation of glycosidase and protease activities by chemostat growth conditions in an endocarditis strain of Streptococcus sanguis. Oral Microbiol. Immunol. 10:342348.
94. McNab, R.,, H. F. Jenkinson,, D. M. Loach,, and G. W. Tannock. 1994. Cell-surface-associated polypeptides CshA and CshB of high molecular mass are colonization determinants in the oral bacterium Streptococcus gordonii. Mol. Microbiol. 14:743754.
95. McNab, R.,, and H. F. Jenkinson. 1998. Altered adherence properties of a Streptococcus gordonii hppA (oligopeptide permease) mutant result from transcriptional effects on cshA adhesin gene expression. Microbiology 144:127136.
96. McNab, R.,, H. Forbes,, P. S. Handley,, D. M. Loach,, G. W. Tannock,, and H. F. Jenkinson . 1999. Cell wall-anchored CshA polypeptide (259 kilodaltons) in Streptococcus gordonii forms surface fibrils that confer hydrophobic and adhesive properties. J. Bacteriol. 181:30873095.
97. Meddens, M. J.,, J. Thompson,, H. Mattie,, and R. van Furth. 1984. Role of granulocytes in the prevention and therapy of experimental Streptococcus sanguis endocarditis in rabbits. Antimicrob. Agents Chemother. 25:263267.
98. Meddens, M. J.,, J. Thompson,, W. C. Bauer,, and R. van Furth. 1984. Role of granulocytes and monocytes in experimental Escherichia coli endocarditis. Infect. Immun. 43:491496.
99. Meddens, M. J.,, J. Thompson,, H. Mattie,, and R. van Furth. 1985. Role of granulocytes and monocytes in the prevention and therapy of experimental Staphylococcus epidermidis endocarditis in rabbits. J. Infect. 11:4150.
100. Mercer, D. K.,, K. P. Scott,, W. A. Bruce-Johnson,, L. A. Glover,, and H. J. Flint. 1999. Fate of free DNA and transformation of the oral bacterium Streptococcus gordonii DL1 by plasmid DNA in human saliva. Appl. Environ. Microbiol. 65:610.
101. Meyer, M. W.,, A. R. Witt,, L. K. Krishnan,, M. Yokota,, M. J. Roszkowski,, J. D. Rudney,, and M. C. Herzberg. 1995. Therapeutic advantage of recombinant human plasminogen activator in endocarditis: evidence from experiments in rabbits. Thromb. Haemost. 73:680682.
102. Michiels, M. J.,, and M. G. Bergeron. 1996. Differential increased survival of staphylococci and limited ultrastructural changes in the core of infected fibrin clots after daptomycin administration. Antimicrob. Agents Chemother. 40:203211.
103. Munro, C. L.,, and F. L. Macrina. 1993. Sucrose-derived exopolysaccharides of Streptococcus mutans V403 contribute to infectivity in endocarditis. Mol. Microbiol. 8:133142.
104. Nakanishi, K.,, F. Tajima,, Y. Nakata,, H. Osada,, K. Ogata,, T. Kawai,, C. Torikata,, T. Suga,, K. Takishima,, T. Aurues,, and T. Ikeda. 1998. Tissue factor is associated with the nonbacterial thrombotic endocarditis induced by a hypobaric hypoxic environment in rats. Virchows Arch. 433:375379.
105. Ni Eidhin, D.,, S. Perkins,, P. Francois,, P. Vaudaux,, M. Hook,, and T. J. Foster. 1998. Clumping factor B (ClfB), a new surface-located fibrinogen-binding adhesin of Staphylococcus aureus. Mol. Microbiol. 30:245257.
106. O'Connor, D. T.,, M. H. Weisman,, and J. Fierer. 1978. Activation of the alternate complement pathway in Staphylococcus aureus infective endocarditis and its relationship to thrombocytopenia, coagulation abnormalities, and acute glomerulonephritis. Clin. Exp. Immunol. 34:179187.
107. Olaison, L.,, H. Hogevik,, and K. Alestig. 1997. Fever, C-reactive protein, and other acute-phase reactants during treatment of infective endocarditis. Arch. Intern. Med. 157:885892.
108. O'Toole, G. A.,, and R. Kolter. 1998. Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development. Mol. Microbiol. 30:295304.
109. Parry, G. C.,, J. H. Erlich,, P. Carmeliet,, T. Luther,, and N. Mackman. 1998. Low levels of tissue factor are compatible with development and hemostasis in mice. J. Clin. Investig. 101: 560569.
110. Pearson, J. P.,, C. Van Delden,, and B. H. Iglewski. 1999. Active efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signals. J. Bacteriol. 181:12031210.
111. Rohmann, S.,, R. Erbel,, H. Darius,, G. Gorge,, T. Makowski,, R. Zotz,, S. Mohr-Kahaly,, U. NixdorfF,, M. Drexler,, and J. Meyer. 1991. Prediction of rapid versus prolonged healing of infective endocarditis by monitoring vegetation size. J. Am. Soc. Echocardiogr. 4:465474.
112. Rohmann, S.,, R. Erbel,, H. Darius,, T. Makowski,, P. Jensen,, T. Fischer,, and J. Meyer. 1992. Spontaneous echo contrast imaging in infective endocarditis: a predictor of complications? Int. J. Card. Imaging 8:197207.
113. Rosenberg, R. D.,, and W. C. Aird. 1999. Vascular-bed-specific hemostasis and hypercoagulable states. N. Engl. J. Med. 340:15551564.
114. Schlievert, P. M.,, P. J. Gahr,, A. P. Assimacopoulos,, M. M. Dinges,, J. A. Stoehr,, J. W. Harmala,, H. Hirt,, and G. M. Dunny. 1998. Aggregation and binding substances enhance pathogenicity in rabbit models of Enterococcus faecalis endocarditis. Infect. Immun. 66:218223.
115. Schwan, W. R.,, S. N. Coulter,, E. Y. Ng,, M. H. Langhorne,, H. D. Ritchie,, L. L. Brody,, S. Westbrock-Wadman,, A. S. Bayer,, K. R. Folger,, and C. K. Stover. 1998. Identification and characterization of the PutP proline permease that contributes to in vivo survival of Staphylococcus aureus in animal models. Infect. Immun. 66:567572.
116. Semeraro, N.,, and M. Colucci. 1997. Tissue factor in health and disease. Thromb. Haemost. 78:759764.
117. Shapiro, J. A. 1998. Thinking about bacterial populations as multicellular organisms. Annu. Rev. Microbiol. 52:81104.
118. Soberay, A. H.,, M. C. Herzberg,, J. D. Rudney,, H. K. Nieuwenhuis,, J. J. Sixma,, and U. Seligsohn. 1987. Responses of platelets to strains of Streptococcus sanguis: findings in healthy subjects, Bernard-Soulier, Glanzmann's, and collagen-unresponsive patients. Thromb. Haemost. 57:222225.
119. Sommer, P.,, C. Gleyzal,, S. Guerret,, J. Etienne,, and J. A. Grimaud. 1992. Induction of a putative laminin-binding protein of Streptococcus gordonii in human infective endocarditis. Infect. Immun. 60:360365.
120. Soto, A.,, P. H. McWhinney,, C. C. Kibbler,, and j. Cohen. 1998. Cytokine release and mitogenic activity in the viridans streptococcal shock syndrome. Cytokine 10:370376.
121. Strom, B. L.,, E. Abrutyn,, J. A. Berlin,, J. L. Kinman,, R. S. Feldman,, P. D. Stolley,, M. E. Levison,, O. M. Korzeniowski,, and D . Kaye. 1998. Dental and cardiac risk factors for infective endocarditis. A population-based, casecontrol study. Ann. Intern. Med. 129:761769.
122. Sullam, P. M.,, F. H. Valone,, and J. Mills. 1987. Mechanisms of platelet aggregation by viridans group streptococci. Infect. Immun. 55: 17431750.
123. Sullam, P. M.,, G. A. Jarvis,, and F. H. Valone. 1988. Role of immunoglobulin G in platelet aggregation by viridans group streptococci. Infect. Immun. 56:29072911.
124. Sullam, P. M.,, A. S. Bayer,, W. M. Foss,, and A. L. Cheung. 1996. Diminished platelet binding in vitro by Staphylococcus aureus is associated with reduced virulence in a rabbit model of infective endocarditis. Infect. Immun. 64:49154921.
125. Sullam, P. M.,, W. C. Hyun,, J. Szollosi,, J. F. Dong,, W. M. Foss,, and J. A. Lopez. 1998. Physical proximity and functional interplay of the glycoprotein Ib-DC-V complex and the Fc receptor FcgammaRIIA on the platelet plasma membrane. J. Biol. Chem. 273:53315336.
126. Taha, T. H.,, S. Durrant,, J. Crick,, S. Bowcock,, A. Bradshaw,, and C. M. Oakley. 1991. Hemostatic studies in patients with infective endocarditis: a report on nine consecutive cases with evidence of coagulopathy. Heart Vessels 6: 102106.
127. Valtonen, V.,, A. Kuikka,, and J. Syrjanen. 1993. Thrombo-emboliccomplications in bacteraemic infections. Eur. Heart J. 14(Suppl. K):2023.
128. Viscount, H. B.,, C. L. Munro,, D. Burnette-Curley,, D. L. Peterson,, and F. L. Macrina. 1997. Immunization with FimA protects against Streptococcus parasanguis endocarditis in rats. Infect. Immun. 65:9941002.
129. Vuille, C.,, M. Nidorf,, A. E. Weyman,, and M. H. Picard. 1994. Natural history of vegetations during successful medical treatment of endocarditis. Am. Heart J. 128:12001209.
130. Watson, S. P.,, and j. Gibbins. 1998. Collagen receptor signaling in platelets: extending the role of the ITAM. Immunol. Today 19:260264.
131. Wells, A. U.,, C. C. Fowler,, R. B. Ellis-Pegler,, R. Luke,, S. Hannan,, and D. N. Sharpe. 1990. Endocarditis in the 80s in a general hospital in Auckland, New Zealand. Q. J. Med. 76:753762.
132. Whatmore, A. M.,, V. A. Barcus,, and C. G. Dowson. 1999. Genetic diversity o f the streptococcal competence (com) gene locus. J. Bacteriol. 181:31443154.
133. Wu, T.,, M. R. Yeaman,, and A. S. Bayer. 1994. In vitro resistance to platelet microbicidal protein correlates with endocarditis source among bacteremic staphylococcal and streptococcal isolates. Antimicrob. Agents Chemother. 38:729732.
134. Yeaman, M. R.,, D. C. Norman,, and A. S. Bayer. 1992. Staphylococcus aureus susceptibility to thrombin-induced platelet microbicidal protein is independent of platelet adherence and aggregation in vitro. Infect. Immun. 60:23682374.

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