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Chapter 1 : Toward Understanding the Molecular Basis of Bacterial Pathogenicity

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Toward Understanding the Molecular Basis of Bacterial Pathogenicity, Page 1 of 2

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Abstract:

This chapter talks about author’s experience in understanding of the molecular basis of bacterial pathogenicity. Observing microbes from individuals with infectious diseases formed the roots of author’s thinking about bacterial pathogenicity. He began his first experiments with the goal of trying to understand the genetic basis of bacterial pathogenicity. Bacterial genetics was still a young field; isolating DNA from bacteria was not a routine procedure. Nevertheless he was able to make some progress in understanding the genetic organization of the chromosome. In parallel, he began experiments on the molecular nature of bacterial plasmids (called episomes in those days), particularly the class of plasmids that encode resistance to antibiotics and that became known as the R factors. Over the years, his laboratory has progressed with the goal of gaining understanding of the genetic and molecular basis of bacterial pathogenicity.

Citation: Falkow S. 2000. Toward Understanding the Molecular Basis of Bacterial Pathogenicity, p 3-10. In Atlas R (ed), Many Faces, Many Microbes. ASM Press, Washington, DC. doi: 10.1128/9781555818128.ch1

Key Concept Ranking

Bacterial Genetics
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Traveler's Diarrhea
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Infectious Diseases
0.40271267
DNA
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Citation: Falkow S. 2000. Toward Understanding the Molecular Basis of Bacterial Pathogenicity, p 3-10. In Atlas R (ed), Many Faces, Many Microbes. ASM Press, Washington, DC. doi: 10.1128/9781555818128.ch1
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Citation: Falkow S. 2000. Toward Understanding the Molecular Basis of Bacterial Pathogenicity, p 3-10. In Atlas R (ed), Many Faces, Many Microbes. ASM Press, Washington, DC. doi: 10.1128/9781555818128.ch1
Permissions and Reprints Request Permissions
Download as Powerpoint

References

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1. Monack, D. M.,, J. Mecsas,, D. Bouley,, and S. Falkow. 1998. Yersinia-induced apoptosis in vivo aids in the establishment of a systemic infection of mice. J. Exp. Med. 188:21272137.
2. Cirillo, D. M.,, R. H. Valdivia,, D. Monack,, and S. Falkow. 1998. Macrophage-dependent induction of the Salmonella pathogenicity island 2 type III secretion system and its role in intracellular survival. Mol. Microbiol. 30:175188.
3. Flnlay, B. B.,, and S. Falkow. 1997. Common themes in microbial pathogenicity revisited. Microbiol. Mol. Biol. Rev. 61:136169.
4. Valdivia, R. H.,, and S. Falkow. 1997. Fluorescence-based isolation of bacterial genes expressed within host cells. Science 277:20072011.
5. Bliska, J. B.,, J. E. Galan,, and S. Falkow. 1993. Signal transduction in the mammalian cell during bacterial attachment and entry. Cell 73:903920.
6. Relman, D. A.,, T. M. Schmidt,, R. R. MacDermott,, and S. Falkow. 1992. Identification of the uncultured bacillus of Whipple's disease. N. Engl. J. Med. 327:293301.
7. Bliska, J. B.,, K. L. Guan,, J. E. Dixon,, and S. Falkow. 1991. Tyrosine phosphate hydrolysis of host proteins by an essential Yersinia virulence determinant. Proc. Natl. Acad. Sci. USA 88:11871191.
8. Relman, D. A.,, J. S. Loutit,, T. M. Schmidt,, S. Falkow,, and L. S. Tompkins. 1990. The agent of bacillary angiomatosis. An approach to the identification of uncultured pathogens. N. Engl. J. Med. 323:15731580.
9. Lee, C. A.,, and S. Falkow. 1990. The ability of Salmonella to enter mammalian cells is affected by bacterial growth state. Proc. Natl. Acad. Sci. USA 87:43044308.
10. Arico, B.,, J. F. Miller,, C. Roy,, S. Stibitz,, D. Monack,, S. Falkow,, R. Gross,, and R. Rappuoli. 1989. Sequences required for expression of Bordetella pertussis virulence factors share homology with prokaryotic signal transduction proteins. Proc. Natl. Acad. Sci. USA 86:66716675.
11. Miller, J. F.,, J. J. Mekalanos,, and S. Falkow. 1989. Coordinate regulation and sensory transduction in the control of bacterial virulence. Science 243:916922.

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