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Chapter 25 : Gene Transfer out of the Microbial World

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Gene Transfer out of the Microbial World, Page 1 of 2

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Abstract:

The study of transformation might be more fruitful than a continuation of the investigation on . This was an important decision for a postdoc who would be looking for a job in a few years. Joshua and Esther Lederberg determined that genes of tryptophan synthesis were closely linked to a gene of histidine biosynthesis. More extensive analysis of this region demonstrated that additional genes of aromatic acid biosynthesis were closely linked to each other and to the locus. They also identified a new form of allosteric inhibition of aromatic acid synthesis and published a number of papers on the genetics, biochemistry, and regulation of the pathway. The author also focused on studying the mechanism by which donor DNA is taken up by competent cells of . The author also focused on and the disease that it caused in plants, crown gall tumors, for a number of reasons, all of which seem to have crystallized simultaneously. From the very beginning, Joshua and Esther Lederberg believed that Schilperoort was correct in concluding that DNA was transferred from into plant cells. Using techniques of DNA-DNA hybridization, they demonstrated that many strains of that were not lysogenic for this phage nevertheless caused crown gall tumors.

Citation: Nester E. 2000. Gene Transfer out of the Microbial World, p 196-204. In Atlas R (ed), Many Faces, Many Microbes. ASM Press, Washington, DC. doi: 10.1128/9781555818128.ch25

Key Concept Ranking

Aromatic Amino Acid Biosynthesis
0.503628
Bacterial Genetics
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Citation: Nester E. 2000. Gene Transfer out of the Microbial World, p 196-204. In Atlas R (ed), Many Faces, Many Microbes. ASM Press, Washington, DC. doi: 10.1128/9781555818128.ch25
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Citation: Nester E. 2000. Gene Transfer out of the Microbial World, p 196-204. In Atlas R (ed), Many Faces, Many Microbes. ASM Press, Washington, DC. doi: 10.1128/9781555818128.ch25
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References

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1. Stephens, K. M.,, C. Roush,, and E. Nester. 1995. Agrobacterium tumefaciens VirB11 protein requires a consensus nucleotide-binding site for function in virulence. J. Bacteriol. 177:2736.
2. Toro, N.,, A. Datta,, M. Yanofsky,, and E. Nester. 1988. Role of the overdrive sequence in T-DNA border cleavage in Agrobacterium. Proc. Natl. Acad. Sci. USA 85:85588562.
3. Das, A.,, S. Stachel,, P. Ebert,, P. Allenza,, A. Montoya,, and E. Nester. 1986. Promoters of Agrobacterium tumefaciens Ti-plasmid virulence genes. Nucleic Acids Res. 14:13551364.
4. Yanofsky, M.,, A. Montoya,, V. Knauf,, B. Lowe,, M. Gordon,, and E. Nester. 1985. Limited-host-range plasmid of Agrobacterium tumefaciens: Molecular and genetic analyses of transferred DNA. J. Bacteriol. 163:341348.
5. Douglas, C.,, W. Halperin,, M. Gordon,, and E. Nester. 1985. Specific attachment of Agrobacterium tumefaciens to bamboo cells in suspension cultures. J. Bacteriol. 161:764766.
6. Knauf, V.,, M. Yanofsky,, A. Montoya,, E. Nester. 1984. Physical and functional map of an Agrobacterium tumefaciens tumor-inducing plasmid that confers a narrow host range. J. Bacteriol. 160:564568.
7. Lichtenstein, C.,, H. Klee,, A. Montoya,, D. Garfinkel,, S. Fuller,, C. Flores,, E. Nester,, and M. Gordon. 1984. Nucleotide sequence and transcript mapping of the tmr gene of the pTiA6NC octopine Ti-plasmid: a bacterial gene involved in plant tumorigenesis. J. Molec. Appl. Gen. 2:354362.
8. Klee, H.,, A. Montoya,, F. Horodyski,, C. Lichtenstein,, D. Garfinkel,, S. Fuller,, C. Flores,, J. Peschon,, E. Nester,, and M. Gordon. 1984. Nucleotide sequence of the tms genes of the pTiA6NC octopine Ti plasmid: two gene products involved in plant tumorigenesis. Proc. Natl. Acad. Sci. USA 81:17281732.
9. Huang, L.,, M. Nakatsukasa,, and E. Nester. 1974. Regulation of aromatic amino acid biosynthesis in Bacillus subtilis 168. Purification, characterization, and subunit structure of the bifunctional enzyme 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase-chorismate mutase. J. Biol. Chem. 249:44674472.

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