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Chapter 33 : It Came from Chicken Water

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It Came from Chicken Water, Page 1 of 2

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Abstract:

Cathy Squires worked on the regulation of ribosomal RNA (rRNA) synthesis and felt very fortunate to have had excellent students, postdoctoral fellows, and associates to share this project. They applied genetics, biochemistry, molecular biology, and physiology-the patchwork of his training and interests-to their studies of ribosome synthesis. Transcription regulation was studied using gene fusions to characterize a special feature of rRNA synthesis-transcription antitermination. Cell physiology and genetics were also studied as they relate to copies of ribosomal genes. A strain of with no intact chromosomal rRNA operons was successfully constructed. The cell's only source of ribosomal genes is a plasmid. By exchanging coli sequences on the plasmid with those of other microbes, the author and his team were able to manipulate a cell's ribosome content in many unexpected ways and thereby pose novel questions about the cell's translation machinery.

Citation: Squires C. 2000. It Came from Chicken Water, p 258-262. In Atlas R (ed), Many Faces, Many Microbes. ASM Press, Washington, DC. doi: 10.1128/9781555818128.ch33

Key Concept Ranking

Ribosomal RNA
0.64285713
Gene Expression
0.61378926
Escherichia coli
0.5890589
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Citation: Squires C. 2000. It Came from Chicken Water, p 258-262. In Atlas R (ed), Many Faces, Many Microbes. ASM Press, Washington, DC. doi: 10.1128/9781555818128.ch33
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References

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1. Voulgaris, J.,, S. French,, R. Gourse,, C. Squires,, and C. L. Squires. 1999. Increased rrn gene dosage causes intermittent transcription of rRNA in Escherichia coli. J. Bacteriol 181:41704175.
2. O'Connor, M.,, T. Asai,, C. L. Squires,, and A. Dalhberg. 1999. Enhancement of translation by the downstream box does not involve base pairing of mRNA with the penultimate stem sequence of 16S rRNA. Proc. Natl. Acad. Sci. USA 96:89738978.
3. Asai, T.,, D. Zaporojets,, C. Squires,, and C. L. Squires. 1999. An E. coli strain with all chromosomal rRNA operons inactivated: Complete exchange of rRNA genes between bacteria. Proc. Natl. Acad. Sci. USA 96:19711976.
4. Condon, C.,, S. French,, C. Squires,, and C. L. Squires. 1993. Depletion of functional ribosomal RNA operons in Escherichia coli causes increased expression of the remaining intact copies. EMBO J. 12:43054315.
5. Condon, C.,, J. Philips,, Z.-Y. Fu,, C. Squires,, and C. L. Squires. 1992. Comparison of the expression of the seven ribosomal RNA operons in Escherichia coli. EMBO J. 11:41754185.
6. Berg, K.,, C. L. Squires,, and C. Squires. 1989. Ribosomal RNA operon antitermination: Function of leader and spacer region box B-box A sequences and their conservation in diverse microorganisms. J. Mol. Biol. 209:345358.
7. Li, S.,, C. L. Squires,, and C. Squires. 1984. Antitermination of Escherichia coli ribosomal RNA transcription is caused by a control region segment containing lambda nut-like sequences. Cell 38:851860.
8. Barry, G.,, C. Squires,, and C. L. Squires. 1980. Attenuation and processing of the messenger RNA from the rp1JL-rpoBC transcription unit of Escherichia coli. Proc. Natl. Acad. Sci. USA 77:33313335.
9. Bertand, K.,, L. Korn,, F. Lee,, T. Piatt,, C. L. Squires,, C. Squires,, and C. Yanofsky. 1975. New features of the regulation of the tryptophan operon. Science 189:2226.
10. Squires, C. L.,, F. Lee,, and C. Yanofsky. 1975. Interaction of the trp repressor and RNA polymerase with the trp operon. J. Mol. Biol. 92:93111.

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