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Chapter 40 : Mentoring the New Generation of Scientists

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Abstract:

Among the many outstanding teachers, the author acknowledges the extraordinary efforts of Sterling Wallace, an uppergrade school teacher, and Mr. Sanders and Ms. Hope, my high school chemistry and physics and algebra-geometry teachers, respectively. With little to no financial resources, the author initially attended Tuskegee Institute (now Tuskegee University) as a five-year "work-study" student and subsequently transferred to Miles College, a small historically black college in Birmingham. This multiyear experience, along with excellent professors in organic chemistry, biochemistry, genetics, classical structural studies, and histology, afforded the author a productive and enjoyable undergraduate tenure. The author had the distinct pleasure to join the laboratory of Fred Neidhardt as a graduate student, and his research focused on the regulation of amino acid and aminoacyl-tRNA synthetase synthesis in . This was a rare opportunity to learn microbial genetics, biochemistry, and physiology under the supervision of an intellectually demanding, professionally sophisticated, and seasoned mentor. In the spring of 1969, the author joined the faculty of Atlanta University. In a very short period of time, he was soon mentoring a very large pool of graduate students. The most important of the activities in which we engaged was the creation of an intellectual ambiance that was nurturing to the students who came with different preparations, different interests, and different perceptions of their self-worth—they were placed in an environment that simply disallowed those differentials.

Citation: Williams L. 2000. Mentoring the New Generation of Scientists, p 305-312. In Atlas R (ed), Many Faces, Many Microbes. ASM Press, Washington, DC. doi: 10.1128/9781555818128.ch40

Key Concept Ranking

Escherichia coli
0.64141965
Leucine Biosynthesis
0.57615155
Microbial Genetics
0.5492232
Transfer RNA
0.54375005
0.64141965
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Citation: Williams L. 2000. Mentoring the New Generation of Scientists, p 305-312. In Atlas R (ed), Many Faces, Many Microbes. ASM Press, Washington, DC. doi: 10.1128/9781555818128.ch40
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References

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1. Williams, A. L.,, L. S. Williams. 1985. Control of isoleucine-valine biosynthesis in a valine-resistant mutant of Escherichia coli K-12 that simultaneously acquired azaleucine-resistance. Biochem. Biophys. Res. Comm. 131:9941002.
2. Davidson, J. P.,, D. J. Wilson,, and L. S. Williams. 1982. Role of a hisU gene in the control of stable RNA synthesis in Salmonella typhimurium. J.Molec. Biol. 157:237264.
3. Davis, L.,, and L. S. Williams. 1982. Altered regulation of isoleucine-valine biosynthesis in a hisW mutant of Salmonella typhimurium. J. Bacteriol. 151:860866.
4. Fayerman, J. T.,, M. C. Vann,, L. S. Williams,, and H. E. Umbarger. 1979. ilvU, a locus in Escherichia coli affecting the derepression of isoleucyl-tRNA synthetase and the RPC-5 chromatographic profiles of tRNAile and tRNAval. J. Biolog. Chem. 254:94299440.
5. Levinthal, M.,, M. Levinthal,, and L. S. Williams. 1976. The regulation of the ilvADGE operon: evidence for positive control by threonine deaminase. J. Molec. Biol. 102:453465.
6. Fitzgerald, G.,, and L. S. Williams. 1975. Modified penicillin enrichment procedure for the selection of bacterial mutants. J. Bacteriol. 122:345346.
7. Coleman, W., Jr.,, E. L. Kline,, C. S. Brown,, and L. S. Williams. 1975. Regulation of branched-chain aminoacyl-transfer ribonucleic acid synthetases in an ilvDAC deletion strain of Escherichia coli K-12. J. Bacteriol. 121:785793.
8. Jackson, J.,, L. S. Williams,, and H. E. Umbarger. 1974. Regulation of synthesis of the branched-chain amino acids and cognate aminoacyl-transfer ribonucleic acid synthetases of Escherichia coli: A common regulatory element. J. Bacteriol. 120:13801386.
9. Coleman, W. G., Jr.,, and L. S. Williams. 1974. First enzyme of histidine biosynthesis and repression control of histidyl-transfer ribonucleic acid synthetase of Salmonella typhimurium. J. Bacteriol. 120:390393.
10. McGinnis, E.,, A. C. Williams,, and L. S. Williams. 1974. Derepression of synthesis of the aminoacyl-transfer ribonucleic acid synthetases for the branched-chain amino acids of Escherichia coli. J. Bacteriol. 119:554559.
11. Levinthal, M.,, L. S. Williams,, and H. E. Umbarger. 1973. Role of threonine deaminase in the regulation of isoleucine and valine biosynthesis. Nature 246:6568.
12. Archibold, E. R.,, and L. S. Williams. 1973. Regulation of methionyl-transfer ribonucleic acid synthetase formation in Escherichia coli and Salmonella typhimurium. J. Bacteriol. 114:10071013.
13. Williams, A. L.,, D. W. Yem,, E. McGinnis,, and L. S. Williams. 1973. Control of arginine biosynthesis in Escherichia coli: inhibition of arginyl-transfer ribonucleic acid synthetase activity. J. Bacteriol. 115:228234.
14. Williams, A. L.,, and L. S. Williams. 1973. Control of arginine biosynthesis in Escherichia coli: characterization of arginyl-transfer ribonucleic acid synthetase mutants. J. Bacteriol. 113:14331441.
15. Williams, L. S. 1973. Control of arginine biosynthesis in Escherichia coli: role of arginyl-transfer ribonucleic acid synthetase in repression. J. Bacteriol. 113:14191432.
16. Yem, D. W.,, and L. S. Williams. 1973. Evidence for the existence of two arginyl-transfer ribonucleic acid synthetase activities in Escherichia coli. J. Bacteriol. 113:891894.
17. McGinnis, E.,, and L. S. Williams. 1972. Regulation of histidyl-transfer ribonucleic acid synthetase formation in a histidyl-transfer ribonucleic acid synthetase mutant of Salmonella typhimurium. J. Bacteriol. 111:739744.
18. Archibold, E. R.,, and L. S. Williams. 1972. Regulation of synthesis of methionyl-, prolyl-, and threonyl-transfer ribonucleic acid synthetases of Escherichia coli. J. Bacteriol. 109:10201026.
19. McGinnis, E.,, and L. S. Williams. 1972. Role of histidine transfer ribonucleic acid in regulation of synthesis of histidyl-transfer ribonucleic acid synthetase of Salmonella typhimurium. J. Bacteriol. 109:505511.
20. McGinnis, E.,, and L. S. Williams. 1971. Regulation of synthesis of the aminoacyl-transfer ribonucleic acid synthetases for the branched-chain amino acids of Escherichia coli. J. Bacteriol. 108:254262.
21. Yem, D. W.,, and L. S. Williams. 1971. Inhibition of arginyl-transfer ribonucleic acid synthetase activity of Escherichia coli by arginine biosynthetic precursors. J. Bacteriol. 107:589591.
22. Williams, L. S.,, and F. C. Neidhardt. 1969. Synthesis and inactivation of aminoacyl-transfer RNA synthetases during growth of Escherichia coli. J. Mol. Biol. 43:529550.
23. Williams, L. S.,, and M. Freundlich. 1969. Role of valine transfer RNA in control of RNA synthesis in Escherichia coli. Biochim. Biophys. Acta. 179:515517.
24. Chrispeels, M. J.,, R. F. Boyd,, L. S. Williams,, and F. C. Neidhardt. 1968. Modification of valyl tRNA synthetase by bacteriophage in Escherichia coli. J. Mol. Biol. 31:463475.

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