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Chapter 6 : Succumbing to the Mysteries of Microbiology and Immunology

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Abstract:

Researchers determined which cytokines induced the two activated antimicrobial macrophage effector reactions-resistance to infection and intracellular killing-and which cytokines shut down the killing. The author made inroads in the understanding of infections, devised a polymerase chain reaction-based detection system and an attenuated and subunit vaccine, and explored the use of immunomodulation with bacille-Calmette-Guerin (BCG) with great success. In this chapter the author seeks additional philanthropic funds to assist companies and academic investigators in the clinical development of new anti-TB drugs. The path is set for the foundation, and there is great excitement both within the foundation and the research community. Sequella, Inc., is working with investigators in universities around the world and has licensed some innovative, useful products for diagnosis and treatment of tuberculosis (TB). It is currently raising money to fund the development of its products and hopes to have at least one of its new TB products in the marketplace by the year 2001.

Citation: Nacy C. 2000. Succumbing to the Mysteries of Microbiology and Immunology, p 43-50. In Atlas R (ed), Many Faces, Many Microbes. ASM Press, Washington, DC. doi: 10.1128/9781555818128.ch6

Key Concept Ranking

White Blood Cells
0.60711765
Immune Systems
0.55404097
Clinical Immunology
0.5286238
0.60711765
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Citation: Nacy C. 2000. Succumbing to the Mysteries of Microbiology and Immunology, p 43-50. In Atlas R (ed), Many Faces, Many Microbes. ASM Press, Washington, DC. doi: 10.1128/9781555818128.ch6
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References

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1. Sim, B. K. L.,, M. O’Reilly,, H. Liang,, A. H. Fortier,, W. He,, J. W. Madsen,, R. Lapcevich,, and C. A. Nacy. 1997. Recombinant human AngiostatinTM protein: An antiangiogenic protein with inhibitory activity against experimental metastatic cancer. Cancer Res. 57:13291334.
2. Dijkstra, J.,, G. M. Swartz,, J. J. Raney,, J. Aniagolu,, L. Toro,, C. A. Nacy,, and S. J. Green. 1996. Interaction of anti-cholesterol antibodies with human lipoproteins. J. Immunol. 157:20062013.
3. Robledo, S.,, D. Leiby,, C. Nacy,, L. Toro,, L. Valderrama,, and N. Saravia. 1996. Cytokine induction, differentiation antigen, and adhesion molecule expression in human mononuclear phagocytes infected with Leishmania (viannia). FASEB J. 10:10601067.
4. James, S. L.,, and C. Nacy. 1993. Effector functions of activated macrophages against parasites. Curr. Opin. Immunol. 5:518523.
5. Mock, B.,, J. Blackwell,, J. Hilgers,, M. Potter,, and C. Nacy. 1993. Genetic-control of Leishmania-major infection in congenic, recombinant inbred and F2 populations of mice. European J. Immunogen. 20:335348.
6. Leiby, D. A.,, R. D. Schreiber,, and C. A. Nacy. 1993. IFN-γ produced in vivo during the first two days is critical for resolution of murine Leishmania major infections. Microb. Path. 14:495500.
7. Fortier, A. H.,, T. Polsinelli,, S. J. Green,, and C. A. Nacy. 1992. Activation of macrophages to kill Francisella tularensis: Identification of effector cells, activation cytokines, and effector molecules. Infect. Immun. 60:817825.
8. Mellouk, S.,, S. J. Green,, C. A. Nacy,, and S. L. Hoffman. 1991. Destruction of Plasmodium berghei sporozoites by hepatocytes involves nitric oxides. J. Immunol. 146:39713976.
9. Davis, C. E.,, M. Belosevic,, M. S. Meltzer,, and C. A. Nacy. 1988. Regulation of macrophage antimicrobial activities: Cooperation of lymphokines for induction of resistance to infection. J. Immunol. 141:627635.
10. Mock, B. A.,, A. H. Fortier,, M. Potter,, J. Blackwell,, and C. A. Nacy. 1985. Genetic control of systemic Leishmania major infection: Identification of subline differences for susceptibility to disease. Curr. Top. Microbiol. Immunol. 122:115121.
11. Haverly, A. L.,, M. G. Pappas,, R. R. Henry,, and C. A. Nacy. 1983. In vitro macrophage antimicrobial activities and in vivo susceptibility to Leishmania tropica infection. Adv. Exper. Med. Biol. 162:433439.

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