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Chapter 7 : Pathogenicity Islands and the Evolution of Salmonella Virulence

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Pathogenicity Islands and the Evolution of Salmonella Virulence, Page 1 of 2

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Abstract:

This chapter discusses the structure and function of -specific DNA segments that play a role in virulence. SPI-1 is a 40-kb DNA segment located at 63 min on the serovar Typhimurium chromosome. It is flanked by two housekeeping genes, and , and this distinguishes it from other pathogenicity islands (PAIs), which are typically adjacent to tRNA genes. The SpaN and SpaO proteins are required for secretion of all substrates by the SPI-1 secretory system, and thus they can be considered part of the export apparatus. At least six proteins are translocated into cultured epithelial cells by the SPI-1 secretion system. The major role of SPI-1 is to govern bacterial entry into nonphagocytic cells. However, SPI-1 genes have also been implicated in inflammation and macrophage apoptosis. SPI-1 genes are organized in several transcriptional units: , , , , the operon that might extend through ,a large operon including genes from through , and invH. SPI- 2 was introduced later in the evolution of and conferred upon the microorganism the ability to proliferate within host cells and to cause systemic disease. Other - specific sequences may specify host range, govern other aspects of infection, or mediate growth in nonhost environments.

Citation: Groisman E, Blanc-Potard A, Uchiya K. 1999. Pathogenicity Islands and the Evolution of Salmonella Virulence, p 127-150. In Kaper J, Hacker J (ed), Pathogenicity Islands and Other Mobile Virulence Elements. ASM Press, Washington, DC. doi: 10.1128/9781555818173.ch7

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Physical and genetic map of the SPI-1 PAI of

Citation: Groisman E, Blanc-Potard A, Uchiya K. 1999. Pathogenicity Islands and the Evolution of Salmonella Virulence, p 127-150. In Kaper J, Hacker J (ed), Pathogenicity Islands and Other Mobile Virulence Elements. ASM Press, Washington, DC. doi: 10.1128/9781555818173.ch7
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Figure 2

Model for transcriptional control of invasion genes by regulatory proteins encoded within and outside SPI-1.

Citation: Groisman E, Blanc-Potard A, Uchiya K. 1999. Pathogenicity Islands and the Evolution of Salmonella Virulence, p 127-150. In Kaper J, Hacker J (ed), Pathogenicity Islands and Other Mobile Virulence Elements. ASM Press, Washington, DC. doi: 10.1128/9781555818173.ch7
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Image of Figure 3
Figure 3

Physical and genetic map of the SPI-2 PAI of

Citation: Groisman E, Blanc-Potard A, Uchiya K. 1999. Pathogenicity Islands and the Evolution of Salmonella Virulence, p 127-150. In Kaper J, Hacker J (ed), Pathogenicity Islands and Other Mobile Virulence Elements. ASM Press, Washington, DC. doi: 10.1128/9781555818173.ch7
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Tables

Generic image for table
Table 1

Salmonella PAIs

Citation: Groisman E, Blanc-Potard A, Uchiya K. 1999. Pathogenicity Islands and the Evolution of Salmonella Virulence, p 127-150. In Kaper J, Hacker J (ed), Pathogenicity Islands and Other Mobile Virulence Elements. ASM Press, Washington, DC. doi: 10.1128/9781555818173.ch7

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