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Chapter 9 : Pathogenicity Islands and Other Mobile Virulence Elements of Vibrio cholerae

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Abstract:

Cholera is acquired by ingesting food or water contaminated with the bacterium . The genome contains a variety of potentially mobile genetic elements including plasmids, bacteriophages, and pathogenicity islands (PAIs), which are reviewed in this chapter. The chapter describes recent exciting and provocative discoveries that the PAIs in epidemic can be acquired by horizontal gene transfer by bacteriophages. The genes encoding the most important virulence factors, cholera enterotoxin (CT) and the toxin-coregulated pilus (TCP), are not usually present in strains that are commonly isolated from the environment. All epidemic strains of contain ctxAB genes, which encode CT. The major protein forming the pilus structure (TcpA) is encoded by the tcpA gene and is 20.5 kDa in size. The determination of the genomic sequence of will undoubtedly reveal additional virulence factors, PAIs, and other mobile virulence elements. The recent findings described in the chapter should lead to future studies that will help us understand the emergence, pathogenesis, and spread of cholera, a disease which still surprises and challenges us after a century of study.

Citation: Karaolis D, Kaper J. 1999. Pathogenicity Islands and Other Mobile Virulence Elements of Vibrio cholerae, p 167-187. In Kaper J, Hacker J (ed), Pathogenicity Islands and Other Mobile Virulence Elements. ASM Press, Washington, DC. doi: 10.1128/9781555818173.ch9

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Mobile Genetic Elements
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Outer Membrane Proteins
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Type IV Pili
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Linear Double-Stranded DNA
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Horizontal Gene Transfer
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Figure 1

Schematic map of the CTXΦ genome integrated in the chromosome.

Citation: Karaolis D, Kaper J. 1999. Pathogenicity Islands and Other Mobile Virulence Elements of Vibrio cholerae, p 167-187. In Kaper J, Hacker J (ed), Pathogenicity Islands and Other Mobile Virulence Elements. ASM Press, Washington, DC. doi: 10.1128/9781555818173.ch9
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Image of Figure 2
Figure 2

Schematic map of the VPIΦ genome integrated in the chromosome.

Citation: Karaolis D, Kaper J. 1999. Pathogenicity Islands and Other Mobile Virulence Elements of Vibrio cholerae, p 167-187. In Kaper J, Hacker J (ed), Pathogenicity Islands and Other Mobile Virulence Elements. ASM Press, Washington, DC. doi: 10.1128/9781555818173.ch9
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