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Chapter 10 : Future Directions of Chlamydial Research

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Future Directions of Chlamydial Research, Page 1 of 2

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Abstract:

The ultimate goals of infectious disease research are to prevent infection, morbidity, and mortality. The spectrum of chronic diseases linked to chlamydial infection falls into two broad categories: (i) those for which the evidence for causality is considered conclusive and (ii) those for which the evidence is insufficient to be considered causal. Whether chronic chlamydial infections can be "cured" with appropriate antibiotic therapy is one of the critical research questions facing the medical community. Intensive preclinical and clinical investigations are under way to develop topical microbicides that will prevent chlamydial infection as well as other sexually transmitted infections, including HIV infection. Chronic chlamydial infection in the upper reproductive tract, or pelvic inflammatory disease (PID), is one of the most serious consequences of this sexually transmitted disease for women. There is an urgent need for rapid, inexpensive, easy-to-use diagnostic tests for chlamydial infection. Data from human and veterinary studies suggest that chlamydial infections probably play an important role in pregnancy outcomes. The potential for chlamydial species to precipitate spontaneous abortion is suggested by manifestations of infection in sheep. Psittacosis has long been recognized as a systemic disease. The infectious agent gains entry through a mucosal surface and disseminates widely. Recent studies of brain tissue from patients with late-onset Alzheimer's disease have resulted in startling findings. Investigators have identified chlamydial nucleic acid sequences in disease plaques from 17 of 19 patients with late-onset Alzheimer's disease; two of these tissue samples also contained viable elementary bodies.

Citation: Hitchcock P. 1999. Future Directions of Chlamydial Research, p 297-311. In Stephens R (ed), Chlamydia. ASM Press, Washington, DC. doi: 10.1128/9781555818203.ch10

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References

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Tables

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Table 1

Consequences of chronic chlamydial infections

Citation: Hitchcock P. 1999. Future Directions of Chlamydial Research, p 297-311. In Stephens R (ed), Chlamydia. ASM Press, Washington, DC. doi: 10.1128/9781555818203.ch10

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