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Chapter 8 : Human Immunity to Chlamydiae

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Human Immunity to Chlamydiae, Page 1 of 2

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Abstract:

This chapter addresses the question of and data for natural immunity to chlamydial infection, focusing on data on infections in humans. It summarizes the limited information on immunity to human infection, and discusses the basis of individual susceptibility to chlamydial infection and disease with reference to chlamydial immunity. The relationships between determinants for host susceptibility to infection, persistence of infection, and propensity to cause disease are highlighted in this chapter. The chapter also discusses of the role that immune evasion mechanisms have on interventions such as vaccines. Chlamydiae are surprisingly susceptible to inactivation by humoral and cellular innate defenses. Results from several observations suggested that major outer membrane protein (MOMP)-specific T CD4 T cells are important in immunity to infection and disease and that Hsp60-specific T-like CD4 T cells are associated with the pathological sequelae of persistent chlamydial infection. The authors suggest that Fc-receptor-mediated cell entry enhanced susceptibility to chlamydial infection. A complex web of host and pathogen determinants appears to constrain the outcome of chlamydial infection. Infection with induces strong serum antibody responses. At the population level, serum antibodies are principally acquired between ages 5 and 14 years, with approximately 50 to 75% of adults having antibody to . Both peripheral blood and synovial fluid mononuclear cells have been successfully used in lymphoproliferation assays.

Citation: Brunham R. 1999. Human Immunity to Chlamydiae, p 211-238. In Stephens R (ed), Chlamydia. ASM Press, Washington, DC. doi: 10.1128/9781555818203.ch8

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References

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1. Abbas, A. K.,, K. M. Murphy,, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383:787793.
2. Allen, J. E.,, R. M. Locksley,, and R. S. Stephens. 1991. A single peptide from the major outer membrane protein of Chlamydia trachomatis elicits T cell help for the production of antibodies to protective determinants. J. Immunol 147:674679.
3. Amann, R.,, N. Springer,, W. Schönhuber,, W. Ludwig,, E. N. Schmid,, K.-D. Muller,, and R. Michel. 1997. Obligate intracellular bacterial parasites of acanthamoebae related to Chlamydia spp. Appi Environ. Microbiol 63:115121.
4. Anderson, R. M.,, C. A. Donnelly,, and S. Gupta. 1997. Vaccine design, evaluation, and community-based use for antigenically variable infectious agents. Lancet 350:14661470.
5. Arno, J. N.,, B. P. Katz,, R. McBride,, G. A. Carty,, B. E. Batteiger,, V. A. Caine,, and R. B. Jones. 1993. Age and clinical immunity to infections with Chlamydia trachomatis. Sex. Transm. Dis. 21:4752.
6. Arno, J. N.,, V. A. Ricker,, K. E. Batteiger,, B. P. Katz,, V. A. Caine,, and R. B. Jones. 1990. Interferon-g in endocervical secretions of women infected with Chlamydia trachomatis. J. Infect. Dis. 162:13851389.
7. Baehr, W.,, Y.-X. Zhang,, T. Joseph,, H. Su,, F. E. Nano,, K. D. E. Everett,, and H. D. Caldwell. 1988. Mapping antigenic domains expressed by Chlamydia trachomatis major outer membrane protein genes. Proc. Natl. Acad. Sci. USA 85:40004004.
8. Bailey, R.,, A. Fowler,, R. Peeling,, D. Mabey,, H. Whittle,, and A. Jepson,. 1998. Lymphoproliferative responses to C. trachomatis EBs in a Gambian twin population: estimating the role of host genetic factors, p. 474477. In R. S. Stephens,, G. I. Byrne,, G. Christiansen,, I. N. Clarke,, J. T. Grayston,, R. G. Rank,, G. L. Ridgway,, P. Saikku,, J. Schachter,, and W. E. Stamm (ed.), Chlamydial Infections. Proceedings of the Ninth International Symposium on Human Chlamydial Infection. International Chlamydia Symposium, San Francisco, Calif..
9. Bailey, R. L.,, M. J. Holland,, H. C. Whittle,, and D. C. W. Mabey. 1995. Subjects recovering from human ocular chlamydial infection have enhanced lymphoproliferative responses to chlamydial antigens compared with those of persistently diseased controls. Infect. Immun. 63:389392.
10. Bailey, R. L.,, M. Kajbaf,, H. C. Whittle,, M. E. Ward,, and D. C. W. Mabey. 1993. The influence of local antichlamydial antibody on the acquisition and persistence of human ocular chlamydial infection: IgG antibodies are not protective. Epidemiol. Infect. 111:315324.
11. Bailey, R.,, C. Osmond,, D. C. W. Mabey,, H. C. Whittle,, and M. E. Ward. 1989. Analysis of the household distribution of trachoma in a Gambian village using a Monte Carlo simulation procedure. Int. J. Epidemiol. 18:944951.
12. Banchereau, J.,, and R. M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392: 245252.
13. Bard, J.,, and D. Levitt. 1984. Chlamydia trachomatis stimulates human peripheral blood B lymphocytes to proliferate and secrete polyclonal immunoglobulins in vitro. Infect. Immun. 43:8492.
14. Bard, J.,, and D. Levitt 1986. Chlamydia trachomatis (L2 serovar) binds to distinct subpopulations of human peripheral blood leukocytes. Clin. Immunol Immunopathol. 38:150160.
15. Barenfanger, J.,, and A. B. MacDonald. 1974. The role of immunoglobulin in the neutralization of trachoma infectivity. J. Immunol. 113:16071617.
16. Barnes, R. R.,, C. P. Katz,, R. T. Rolfs,, B. Batteiger,, V. Caine,, and R. B. Jones. 1990. Quantitative culture of endocervical Chlamydia trachomatis. J. Clin. Microbiol. 28:774780.
17. BartI, S.,, D. Baltimore,, and I. L. Weissman. 1994. Molecular evolution of the vertebrate immune system. Proc. Natl. Acad. Sci. USA 91:1076910770.
18. Bas, S.,, R. Griffais,, T. K. Kvien, , A. Glennâs,, K. Melby,, and T. L. Vischer. 1995. Amplification of plasmid and chromosome Chlamydia DNA in synovial fluid of patients with reactive arthritis and undifferentiated seronegative oligoarthropathies. Arthritis Rheum. 38:10051013.
19. Batteiger, B. E.,, R. G. Rank,, P. M. Bavoil,, and L. S. F. Soderberg. 1993. Partial protection against genital reinfection by immunization of guinea-pigs with isolated outer-membrane proteins of the chlamydial agent of guinea-pig inclusion conjunctivitis. J. Gen. Microbiol. 139:29652972.
20. Beatty, W. L.,, G. I. Byrne,, and R. P. Morrison. 1993. Morphological and antigenic characterization of interferon-g mediated persistent Chlamydia trachomatis infection in vitro. Proc. Natl. Acad. Sci. USA 90:39984002.
21. Beatty, W. L.,, R. P. Morrison,, and G. I. Byrne. 1994. Persistent chlamydiae: from cell culture to a paradigm for chlamydial pathogenesis. Microbiol. Rev. 58:686699.
22. Bianchi, A.,, C. Dosquet,, S. Henry,, M.-C. Couderc,, F. Ferchal,, and C. Scieux. 1997. Chlamydia trachomatis growth stimulates interleukin 8 production by human monocytic U-937 cells. Infect. Immun. 65:24342436.
23. Bix, M.,, and R. M. Locksley. 1998. Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells. Science 281:13521354.
24. Black, C. M.,, C. E. Farshy,, R. C. Barnes,, D. C. Bosse,, J. K. A. Nicholson,, and E. W. Ades. 1992. Regulation of class I MHC expression by chlamydial infection: a possible means to evade immune response. Med. Microbiol. Lett. 1:127134.
25. Blanchard, J.,, H. Armenian,, R. Peeling,, P. Poulter-Friesen,, C. Shen,, and R. C. Brunham,. 1998. The relationship between Chlamydia pneumoniae infection and abdominal aortic aneurysm, p. 207210. In R. S. Stephens,, G. I. Byrne,, G. Christiansen,, I. N. Clarke,, J. T. Grayston,, R. G. Rank,, G. L. Ridgway,, P. Saikku,, J. Schachter,, and W. E. Stamm (ed.), Chlamydial Infections. Proceedings of the Ninth International Symposium on Human Chlamydial Infection. International Chlamydia Symposium, San Francisco, Calif..
26. Bobo, L.,, N. Novak,, H. Mkocha,, S. Vitale,, S. West,, and T. C. Quinn. 1996. Evidence for a predominant proinflammatory conjunctival cytokine response in individuals with trachoma. Infect. Immun. 64: 32733279.
27. Bobo, L. D.,, N. Novak,, B. Muñoz,, Y.-H. Hsieh,, T. C. Quinn,, and S. West. 1997. Severe disease in children with trachoma is associated with persistent Chlamydia trachomatis infection. J. Infect. Dis. 176:15241530.
28. Bomsel, M.,, M. Heyman,, H. Hocini,, S. Lagaye,, L. Belec,, C. Dupont,, and C. Desgranges. 1998. Intracellular neutralization of HIV transcytosis across tight epithelial barriers by anti-HIV envelope protein dlgA or IgM. Immunity 9:277287.
29. Braun, J.,, S. Laitko,, J. Treharne,, U. Eggens,, P. Wu,, A. Distler,, and J. Sieper. 1994. Chlamydia pneumoniae: a new causative agent of reactive arthritis and undifferentiated oligoarthritis. Ann. Rheum. Dis. 53:100105.
30. Brunham, R.,, B. Irwin,, W. E. Stamm,, and K. K. Holmes. 1980. Epidemiological and clinical correlates of Chlamydia trachomatis and Neisseria gonorrhoeae infection among women attending a clinic for sexually transmitted diseases. Clin. Res. 28:47A. (Abstract.)
31. Brunham, R. C., 1994. Vaccine design for the prevention of Chlamydia trachomatis infection, p. 7382. In J. Orfila,, G. I. Byrne,, M. A. Chernesky,, J. T. Grayston,, R. B. Jones,, G. L. Ridgway,, P. Saikku,, J. Schachter,, W. E. Stamm,, and R. S. Stephens (ed.), Chlamydial Infections. Proceedings of the Eighth International Symposium on Human Chlamydial Infections. Società Editrice Esculapio, Bologna, Italy.
32. Brunham, R. C,, J. Kimani,, J. Bwayo,, G. Maitha,, I. Maclean,, C. Yang,, C. Shen,, S. Roman,, N. J. D. Nagelkerke,, M. Cheang,, and F. A. Plummer. 1996. The epidemiology of Chlamydia trachomatis within a sexually transmitted diseases core group. J. Infect. Dis. 173:950956.
33. Brunham, R. C.,, D. H. Martin,, T. W. Hubbard,, C.-C. Kuo,, C. W. Critchlow,, L. D. Cíes,, D. A. Eschenbach,, and K. K. Holmes. 1983a. Depression of the lymphocyte transformation response to microbial antigens and to phytohemagglutinin during pregnancy. J. Clin. Invest. 72:16291638.
34. Brunham, R. C.,, C.-C. Kuo,, L. Cles,, and K. K. Holmes. 1983b. Correlation of host immune response with quantitative recovery of Chlamydia trachomatis from the human endocervix. Infect. Immun. 39: 14911494.
35. Brunham, R. C.,, D. H. Martin,, C.-C. Kuo,, S.-P. Wang,, C. E. Stevens,, T. Hubbard,, and K. K. Holmes. 1981. Cellular immune response during uncomplicated genital infection with Chlamydia trachomatis in humans. Infect. Immun. 34:98104.
36. Brunham, R. C.,, and R. W. Peeling. 1994. Chlamydia trachomatis antigens: role in immunity and pathogenesis. Infect. Agents Dis. 3:218233.
37. Brunham, R. C.,, R. Peeling,, I. Maclean,, M. L. Kosseim,, and M. Paraskevas. 1992. Chlamydia trachomatis-associated ectopic pregnancy: serologic and histologic correlates. J. Infect. Dis. 165:10761081.
38. Brunham, R. C.,, F. A. Plummer,, and R. S. Stephens. 1993. Bacterial antigenic variation, host immune response, and pathogen-host coevolution. Infect. Immun. 61:22732276.
39. Brunham, R.,, C. Yang,, I. Maclean,, J. Rimani,, G. Maitha,, and F. Plummer. 1994. Chlamydia trachomatis from individuals in a sexually transmitted disease core group exhibit frequent sequence variation in the major outer membrane protein (ompl ) gene. J. Clin. Invest. 94:458463.
40. Burd, E. M.,, K. F. Tabbara,, A. M. Nasr,, and P. B. Taylor. 1988. Conjunctival lymphocyte subsets in trachoma. Int. Ophthalmol. 12:5357.
41. Burns, J. W.,, M. Siadat-Pajouh,, A. A. Krishnaney,, and H. B. Greenberg. 1996. Protective effect of rotavirus VP6-specific IgA monoclonal antibodies that lack neutralizing activity. Science 272:104107.
42. Caldwell, H. D.,, J. Kromhout,, and J. Schachten 1981. Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatis .Infect. Immun. 31:11611176.
43. Campbell, L. A.,, D. L. Patton,, D. E. Moore,, A. L. Cappuccio,, B. A. Mueller,, and S.-P. Wang. 1993. Detection of Chlamydia trachomatis deoxyribonucleic acid in women with tubal infertility. Fértil. Steril. 59:4550.
44. Conway, D. J.,, M. J. Holland,, R. L. Bailey,, A. E. Campbell,, O. S. M. Mahdi,, R. Jennings,, E. Mbena,, and D. C. W. Mabey. 1997. Scarring trachoma is associated with polymorphism in the tumor necrosis factor alpha (TNF-a) gene promoter and with elevated TNF-a levels in tear fluid. Infect. Immun. 65:10031006.
45. Conway, D. J.,, M. J. Holland,, A. E. Campbell,, R. L. Bailey,, P. Krausa,, R. W. Peeling,, H. C. Whittle,, and D. C. W. Mabey. 1996. HLA class I and II polymorphisms and trachomatous scarring in a Chlamydia trachomatis-endemic population. J. Infect. Dis. 174:643646.
46. Cox, R. L.,, C.-C. Kuo,, J. T. Grayston,, and L. A. Campbell. 1988. Deoxyribonucleic acid relatedness of Chlamydia sp. strain TWAR to Chlamydia trachomatis and Chlamydia psittaci. Int. J. Syst. Bac teriol. 38:265268.
47. Critchlow, C. W.,, P. Woiner-Hanssen,, D. A. Eschenbach,, N. B. Kiviat,, L. A. Koutsky,, C. E. Stevens,, and K. K. Holmes. 1995. Determinants of cervical ectopia and of cervicitis: age, oral contraception, specific cervical infection, smoking, and douching. Am. J. Obstet. Gynecol 173:534543.
48. Cunningham, D. S. 1995. Immune response characteristics in women with chlamydial genital tract infection. Gynecol Obstet. Invest. 39:5459.
49. Dahlén, G. H.,, J. Boman,, L. Slunga Birgander,, and B. Lindblom. 1995. Lp(a) lipoprotein, IgG, IgA and IgM antibodies to Chlamydia pneumoniae and HLA class II genotype in early coronary artery disease. Atherosclerosis 114:165174.
50. Danesh, J.,, R. Collins,, and R. Peto. 1997. Chronic infections and coronary heart disease: is there a link? Lancet 350:430436.
51. Dean, D.,, E. Oudens,, G. Bolan,, N. Padian,, and J. Schachten 1995. Major outer membrane protein variants of Chlamydia trachomatis are associated with severe upper genital tract infections and histopathology in San Francisco. J. Infect. Dis. 172:10131022.
52. Dunlop, E. M., C. A. Garner,, S. Darougar,, J. D. Treharae,, and R. M. Woodland. 1989. Colposcopy, biopsy, and cytology results in women with chlamydial cervicitis. Genitourin. Med. 65:2231.
53. Ebert, D. 1998. Experimental evolution of parasites. Science 282:14321435.
54. El-Asrar, A. M. A.,, J. J. van den Oord,, K. Geboes,, L. Missotten,, M. H. Emarah,, and V. Desmet. 1989. Immunopathology of trachomatous conjunctivitis. Br. J. Ophthalmol 73:276282.
55. Falsey, A. R.,, and E. E. Walsh. 1993. Transmission of Chlamydia pneumoniae. J. Infect. Dis. 168:493496.
56. Fan, T.,, H. Lu,, H. Hu,, L. Shi,, G. A. McClarty,, D. M. Nance,, A. H. Greenberg,, and G. Zhong. 1998. Inhibition of apoptosis in Chlamydia-infected cells: blockade of mitochondrial cytochrome c release and caspase activation. J. Exp. Med. 187:487496.
57. Fryer, R. H.,, E. P. Schwobe,, M. L. Woods,, and G. M. Rodgers. 1997. Chlamydia species infect human vascular endothelial cells and induce procoagulant activity. J. Invest. Med. 45:168174.
58. Gaydos, C. A.,, T. C. Quinn,, L. D. Bobo,, and J. J. Eiden. 1992. Similarity of Chlamydia pneumonia strains in the variable domain IV region of the major outer membrane protein gene. Infect. Immun. 60:53195323.
59. Gaydos, C. A.,, J. T. Summersgill,, N. N. Sahney,, J. A. Ramirez,, and T. C. Quinn. 1996. Replication of Chlamydia pneumoniae in vitro in human macrophages, endothelial cells, and aortic artery smooth muscle cells. Infect. Immun. 64:16141620.
60. Ghaem-Maghami, S.,, R. L. Bailey,, D. C. W. Mabey,, P. E. Hay,, O. S. M. Mahdi,, H. M. Joof,, H. C. M. Whittle,, M. E. Ward,, and D. J. M. Lewis. 1997. Characterization of B-cell responses to Chlamydia trachomatis antigens in humans with trachoma. Infect. Immun. 65:49584964.
61. Ghaem-Maghami, S.,, P. E. Hay,, and D. J. M. Lewis. 1996. Antigen and isotype specificity of human B cell responses in immunopathogenesis of genital Chlamydia trachomatis infection. Infect. Dis. Ob-stet. Gynecol. 4:179180.
62. Ghosh, S.,, M. J. May,, and E. B.. Kopp. 1998. NF-κB and rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16:225260.
63. Gorham, J. D.,, M. L. Güler,, R. G. Steen,, A. J. Mackey,, M. J. Daly,, K. Frederick,, W. F. Dietrich,, and K. M. Murphy. 1996. Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses. Proc. Natl. Acad. Sci. USA 93:1246712472.
64. Grayston, J. T.,, C.-C. Kuo,, S.-P. Wang,, and J. Altman. 1986. A new Chlamydia psittaci strain, TWAR, isolated in acute respiratory tract infections. N. Engl. J. Med. 315:161168.
65. Grayston, J. T.,, and S.-P. Wang. 1978. The potential for vaccine against infection of the genital tract with Chlamydia trachomatis. Sex. Transm. Dis. 5:7377.
66. Grayston, J. T.,, S.-P. Wang,, L.-J. Yeh,, and C.-C. Kuo. 1985. Importance of reinfection in the pathogenesis of trachoma. Rev. Infect. Dis. 7:717725.
67. Gupta, S.,, N. Ferguson,, and R. Anderson. 1998. Chaos, persistence, and evolution of strain structure in antigenically diverse infectious agents. Science 280:912915.
68. Hackstadt, T.,, E. R. Fisher,, M. A. Scidmore,, D. D. Rockey,, and R. A. Heinzen. 1997. Origins and functions of the chlamydial inclusion. Trends Microbiol. 5:288293.
69. Hahn, D. L.,, R. W. Dodge,, and R. Golubjatnikov. 1991. Association of C. pneumoniae (strain TWAR) infection with wheezing, asthmatic bronchitis, and adult-onset asthma. JAMA 266:225230.
70. Halme, S.,, P. Saikku,, and H.-M. Surcel. 1997. Characterization of Chlamydia pneumoniae antigens using human T cell clones. Scand. J. Immunol. 45:378384.
71. Hanna, L.,, L. Schmidt,, M. Sharp,, D. P. Stites,, and E. Jawetz. 1979. Human cell-mediated immune responses to chlamydial antigens. Infect. Immun. 23:412417.
72. Harrison, H. R.,, D. Phil,, M. Costin,, J. B. Meder,, L. M. Bownds,, D. A. Sim,, M. Lewis,, and E. R. Alexander. 1985. Cervical Chlamydia trachomatis infection in university women: relationship to history, contraception, ectopy, and cervicitis. Am. J. Obstet. Gynecol. 153:244251.
73. Harshbarger, J. C.,, S. C. Chang,, and S. V. Otto. 1997. Chlamydiae (with phages), mycoplasmas, and rickettsiae in Chesapeake Bay bivalves. Science 196:666668.
74. Hatch, T. P.,, D. W. Vance, Jr.,, and E. Al-Hossainy. 1981. Identification of a major envelope protein in Chlamydia spp. J. Bacteriol. 146:426429.
75. Heinemann, M.,, M. Susa,, U. Simnacher,, R. Marre,, and A. Essig. 1996. Growth of Chlamydia pneumoniae induces cytokine production and expression of CD 14 in a human monocytic cell line. Infect. Immun. 64:48724875.
76. Herre, E. A. 1995. Factors affecting the evolution of virulence: nematode parasites of fig wasps as a case study. Parasitology 111:S179S191.
77. Hess, C. B.,, T. R. Jerrells,, T. Hackstadt,, G. R. Klimpel,, and D. W. Niesel. 1992. Obligate intracellular bacteria induce interferon a/b production in fibroblasts. Immunol. Infect. Dis. 2:1316.
78. Hillis, S. D.,, L. M. Owens,, P. A. Marchbanks,, L. E. Amsterdam,, and W. R. Mackenzie. 1997. Recurrent chlamydial infections increase the risks of hospitalization for ectopic pregnancy and pelvic inflammatory disease. Am. J. Obstet. Gynecol. 176:103107.
79. Hobson, D.,, P. Karayiannis,, R. E. Byng,, E. Rees,, I. A. Tait,, and J. A. Davies. 1980. Quantitative aspects of chlamydial infection of the cervix. Br. J. Wener. Dis. 56:156162.
80. Holland, M. J.,, R. L. Bailey,, D. J. Conway,, F. Culley,, G. Miranpuri,, G. I. Byrne,, H. C. Whittle,, and D. C. W. Mabey. 1996. T helper type-1 (Thl)-Th2 profiles of peripheral blood mononuclear cells (PBMC); responses to antigens of Chlamydia trachomatis in subjects with severe trachomatous scarring. Clin. Exp. Immunol. 105:429435.
81. Holland, M. J.,, R. L. Bailey,, L. J. Hayes,, H. C. Whittle,, and D. C. W. Mabey. 1993. Conjunctival scarring in trachoma is associated with depressed cell-mediated immune responses to chlamydial antigens. J. Infect. Dis. 168:15281531.
82. Holland, M. J.,, R. L. Bailey,, H. C. Whittle,, and D. C. W. Mabey,. 1994. Expression of cytotoxicity by PBL stimulated with autologous primary fibroblasts infected with LÍ C. trachomatis, p. 103. In J. Orfila,, G. I. Byrne,, M. A. Chernesky,, J. T. Grayston,, R. B. Jones,, G. L. Ridgway,, P. Saikku,, J. Schachter,, W. E. Stamm,, and R. S. Stephens (ed.), Chlamydial Infections. Proceedings of the Eighth International Symposium on Human Chlamydial Infections. Società Editrice Esculapio, Bologna, Italy.
83. Holland, M. J.,, D. J. Conway,, T. J. Blanchard,, O. M. S. Mand,, R. L. Bailey,, H. C. Whittle,, and D. C. W. Mabey. 1997. Synthetic peptides based on Chlamydia trachomatis antigens identify cytotoxic T lymphocyte responses in subjects from a trachoma-endemic population. Clin. Exp. Immunol. 107: 4449.
84. Iezzi, G.,, K. Karjalainen,, and A. Lanzavecchia. 1998. The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity 8:8995.
85. Iijima, Y.,, N. Miyashita,, T. Kishimoto,, Y. Kanamoto,, R. Soejima,, and A. Matsumoto. 1994. Characterization of Chlamydia pneumoniae species-specific proteins immunodominant in humans. J. Clin. Microbiol. 32:583588.
86. Ingalls, R. R.,, P. A. Rice,, N. Qureshi,, K. Takayama,, J. Shin Lin,, and D. T. Golenbock. 1995. The inflammatory cytokine response to Chlamydia trachomatis infection is endotoxin mediated. Infect. Immun. 63:31253130.
87. Jawetz, E.,, L. Rose,, L. Hanna,, and P. Thygeson. 1965. Experimental inclusion conjunctivitis in man. JAMA 194:150162.
88. Johansson, M.,, K. Schön,, M. Ward,, and N. Lycke. 1997. Genital tract infection with Chlamydia trachomatis fails to induce protective immunity in gamma interferon receptor-deficient mice despite a strong local immunoglobulin A response. Infect. Immun. 65:10321044.
89. Johnson, A. P.,, M. F. Osborn,, S. Rowntree,, B. J. Thomas,, and D. Taylor-Robinson. 1983. A study of inactivation of Chlamydia trachomatis by normal human serum. Br. J. Wener. Dis. 59:369372.
90. Katz, B. P.,, B. E. Batteiger,, and R. B. Jones. 1987. Effect of prior sexually transmitted disease on the isolation of Chlamydia trachomatis. Sex. Transm. Dis. 14:160164.
91. Rimani, J.,, I. W. Maclean,, J. J. Bwayo,, K. MacDonald,, J. Oyugi,, G. M. Maitha,, R. W. Peeling,, M. Cheang,, N. J. D. Nagelkerke,, F. A. Plummer,, and R. C. Brunham. 1996. Risk factors for Chlamydia trachomatis pelvic inflammatory disease among sex workers in Nairobi, Kenya. J. Infect. Dis. 173: 14371444.
92. King, C.,, J. Davies,, R. Mueller,, M.-S. Lee,, T. Krahl,, B. Yeung,, E. O'Connor,, and N. Sarvetnick. 1998. TGF-/31 alters APC preference, polarizing islet antigen responses toward a Th2 phenotype. Immunity 8:601613.
93. Kiviat, N. B.,, J. A. Paavonen,, J. Brockway,, C. W. Critchlow,, R. C. Brunham,, C. E. Stevens,, W. E. Stamm,, C. C. Kuo,, T. DeRouen,, and K. K. Holmes. 1985. Cytologic manifestations of cervical and vaginal infections: epithelial and inflammatory cellular changes. JAMA 253:989996.
94. Kiviat, N. B.,, J. A. Paavonen,, P. W0lner-Hanssen,, C. W. Critchlow,, W. E. Stamm,, J. Douglas,, D. A. Eschenbach,, L. A. Corey,, and K. K. Holmes. 1990a. Histopathology of endocervical infection caused by Chlamydia trachomatis, herpes simplex virus, Trichomonas vaginalis, and Neisseria gonorrhoeae. Hum. Pathol. 21:831837.
95. Kiviat, N. B.,, P. W0lner-Hanssen,, D. A. Eschenbach,, J. N. Wasserheit,, J. A. Paavonen,, T. A. Bell,, C. W. Critchlow,, W. E. Stamm,, D. E. Moore,, and K. K. Holmes. 1990b. Endometrial histopathology in patients with culture-proved upper genital tract infection and laparoscopically diagnosed acute salpingitis. Am. J. Surg. Pathol. 14:167175.
96. Kondo, L.,, L. Hanna,, and H. Keshishyan. 1973. Reduction in chlamydial infectivity by lysozyme. Proc. Soc. Exp. Biol. Med. 142:131132.
97. Kuo, C.-C.,, and J. T. Grayston. 1990. A sensitive cell line, HL cells, for isolation and propagation of Chlamydia pneumoniae strain TWAR. J. Infect. Dis. 162:755758.
98. Kuo, C.-C.,, J. T. Grayston,, L. A. Campbell,, Y. A. Goo,, R. W. Wissler,, and E. P. Benditt. 1995a. Chlamydia pneumoniae (TWAR) in coronary arteries of young adults (15-34 years old). Proc. Natl. Acad. Sci. USA 92:69116914.
99. Kuo, C.-C.,, L. A. Jackson,, L. A. Campbell,, and J. T. Grayston. 1995b. Chlamydia pneumonia (TWAR). Clin. Microbiol. Rev. 8:451461.
100. Lee, C. K.,, and J. W. Moulder. 1981. Persistent infection of mouse fibroblasts (McCoy cells) with a trachoma strain of Chlamydia trachomatis. Infect. Immun. 32:822829.
101. Leinonen, M.,, E. Linnanmâki,, K. Mattila,, M. S. Nieminen,, V. Valtonen,, M. Leirisalo-Repo,, and P. Saikku. 1990. Circulating immune complexes containing chlamydial lipopolysaccharide in acute myocardial infarction. Microb. Pathog. 9:6773.
102. Levitt, D.,, R. W. Newcomb,, and M. O. Beem. 1983. Excessive numbers and activity of peripheral blood T cells in infants with Chlamydia trachomatis pneumonia. Clin. Immunol. Immunopathol. 29: 424432.
103. Linnanmâki, E.,, M. Leinonen,, K. Mattila,, M. S. Nieminen,, V. Valtonen,, and P. Saikku. 1993. Chlamydia pneumoniae-speciñc circulating immune complexes in patients with chronic coronary heart disease. Circulation 87:11301134.
104. Mabey, D.,, and R. Bailey. 1996. Immunity to Chlamydia trachomatis: lessons from a Gambian village. J. Med. Microbiol. 45:12.
105. Mabey, D. C. W.,, M. J. Holland,, N. D. Viswalingam,, B. T. Goh,, S. Estreich,, A. Macfarlane,, H. M. Dockrell,, and J. D. Treharne. 1991a. Lymphocyte proliferative responses to chlamydial antigens in human chlamydial eye infections. Clin. Exp. Immunol. 86:3742.
106. Mabey, D. C. W.,, R. L. Bailey,, D. Dunn,, D. Jones,, J. H. D. Williams,, H. M. Whittle,, and M. E. Ward. 1991b. Expression of MHC class II antigens by conjunctival epithelial cells in trachoma: implications concerning the pathogenesis of blinding disease. J. Clin. Pathol. 44:285289.
107. Mabey, D. C. W.,, R. L. Bailey,, M. E. Ward,, and H. M. Whittle. 1992. A longitudinal study of trachoma in a Gambian village: implications concerning the pathogenesis of chlamydial infection. Epidemiol. Infect. 108:343351.
108. Manor, E.,, and I. Sarov. 1986. Fate of Chlamydia trachomatis in human monocytes and monocyte-derived macrophages. Infect. Immun. 54:9095.
109. Marrack, P.,, and J. Kappler. 1994. Subversion of the immune system by pathogens. Cell 76:323332.
110. Marsh, D. G.,, J. D. Neely,, D. R. Breazeale,, B. Ghosh,, L. R. Freidhoff,, E. Ehrlich-Kautzky,, C. Schou,, G. Krishnaswamy,, and T. H. Beaty. 1994. Linkage analysis of IIA and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 264:11521156.
111. Martin, D. H.,, S. Pollock,, C. -C Kuo,, S.-P. Wang,, R. C. Brunham,, and K. K. Holmes. 1984. Chlamydia trachomatis infections in men with Reiter's syndrome. Ann. Intern. Med. 100:207213.
112. Megran, D. W.,, H. G. Stiver,, and W. R. Bowie. 1985. Complement activation and stimulation of chemotaxis by Chlamydia trachomatis. Infect. Immun. 49:670673.
113. Menta, S. J.,, R. D. Miller,, J. A. Ramirez,, and J. T. Summersgill. 1998. Inhibition of Chlamydia pneumoniae replication in HEp-2 cells by interferon-g: role of tryptophan catabolism. J. Infect. Dis. 177:13261331.
114. Melgosa, M. P.,, C.-C. Kuo,, and L. A. Campbell. 1991. Sequence analysis of the major outer membrane protein gene of Chlamydia pneumoniae. Infect. Immun. 59:21952199.
115. Merigan, T. C, and L. Hanna. 1966. Characteristics of interferon induced in vitro and in vivo by a TRIC agent (31151). Proc. Soc. Exp. Biol. Med. 122:421424.
116. Molestina, R. E.,, D. Dean,, R. D. Miller,, J. A. Ramirez,, and J. T. Summersgill. 1998. Characterization of a strain of Chlamydia pneumoniae isolated from a coronary atheroma by analysis of the ompl gene and biological activity in human endothelial cells. Infect. Immun. 66:13701376.
117. Moller, B. R.,, L. Weström,, S. Ahrons,, K. T. Ripa,, L. Svensson,, C. von Mecklenburg,, H. Henrikson,, and P. A. Màrdh. 1979. Chlamydia trachomatis infection of the fallopian tubes. Br. J. Verier. Dis. 55:422428.
118. Morrison, R. P.,, D. S. Manning,, and H. D. Caldwell,. 1992. Immunology of Chlamydia trachomatis infections: immunoprotective and immunopathogenetic responses, p. 5784. In T. C. Quinn (ed.), Sexually Transmitted Diseases, vol. 8. Raven Press, Ltd., New York, N.Y..
119. Moulder, J. W.,, N. J. Levy,, and L. P. Schulman. 1980. Persistent infection of mouse fibroblasts (L cells) with Chlamydia psittaci: evidence for a cryptic chlamydial form. Infect. Immun. 30:874883.
120. Nichols, R. L.,, R. E. Oertley,, C. E. O. Fraser,, A. B. MacDonald,, and D. E. McComb. 1973. Immunity to chlamydial infections of the eye. VI. Homologous neutralization of trachoma infectivity for the owl monkey conjunctivae by eye secretions from humans with trachoma. J. Infect. Dis. 127:429432.
121. Nowak, M. A.,, and R. M. May. 1994. Superinfection and the evolution of parasite virulence. Proc. R. Soc. London Ser. B 255:8189.
122. Numazaki, K.,, K. Suzuki,, and S. Chiba. 1995. Replication of Chlamydia trachomatis and C. pneumoniae in the human monocytic cell line U-937. J. Med. Microbiol. 42:191195.
123. Ojcius, D. M.,, Y. Bravo de Alba,, J. M. Kanellopoulos,, R. A. Hawkins,, K. A. Kelly,, R. G. Rank,, and A. Dautry-Varsat. 1998. Internalization of Chlamydia by dendritic cells and stimulation of Chlamydia-specific T cells. J. Immunol. 160:12971303.
124. Onsrud, M.,, and E. Qvigstad. 1984. Natural killer cell activity after gynecologic infections with Chlamydia. Acta Obstet. Gynecol. Scand. 63:613615.
125. Ortiz, L.,, K. P. Demick,, J. W. Petersen,, M. Polka,, R. A. Rudersdorf,, B. Van der Pol,, R. Jones,, M. Angevine,, and R. De Mars. 1996. Chlamydia trachomatis major outer membrane protein (MOMP) epitopes that activate HLA class I-restricted II cells from infected humans. J. Immunol. 157:45544567.
126. Osser, S.,, and K. Persson. 1984. Postabortal pelvic infection associated with Chlamydia trachomatis and the influence of humoral immunity. Am. J. Obstet. Gynecol. 150:699703.
127. Paavonen, J.,, E. Vesterinen,, B. Meyer,, and E. Saksela. 1982. Colposcopie and histologic findings in cervical chlamydial infection. Obstet. Gynecol. 59:712714.
128. Pal, S.,, I. Theodor,, E. M. Peterson,, and L. M. De La Maza. 1997. Immunization with an acellular vaccine consisting of the outer membrane complex of Chlamydia trachomatis induces protection against a genital challenge. Infect. Immun. 65:33613369.
129. Patton, D. L.,, M. Askienazy-Elbhar,, J. Henry-Suchet,, S.-P. Wang,, and C.-C. Kuo. 1994. Detection of Chlamydia trachomatis in fallopian tube tissue in women with postinfectious tubal infertility. Am. J. Obstet. Gynecol. 171:95101.
130. Punnonen, R.,, P. Terho,, V. Nikkanen,, and O. Meurman. 1979. Chlamydial serology in infertile women by immunofluorescence. Fértil. Steril 31:656659.
131. Puolakkainen, M.,, E. Vesterinen,, E. Purola,, P. Saikku,, and J. Paavonen. 1986. Persistence of chlamydial antibodies after pelvic inflammatory disease. J. Clin. Microbiol. 23:924928.
132. Qvigstad, E.,, S. Digranes,, and E. Thorsby. 1983a. Antigen-specific proliferative human T-lymphocyte clones with specificity for Chlamydia trachomatis. Scand. J. Immunol. 18:291297.
133. Qvigstad, E.,, G. Gaudernack,, and E. Thorsby. 1984a. Antigen-specific T cell clones restricted by DR, DRw53 (MT), or DP (SB) class II HLA molecules, inhibition studies with monoclonal HLA-specific antibodies. Hum. Immunol. 11:207217.
134. Qvigstad, E.,, and H. Hirschberg. 1984. Lack of cell-mediated cytotoxicity towards Chlamydia trachomatis infected target cells in humans. APMIS 92:153159.
135. Qvigstad, E.,, M. Onsrud,, and K. Skaug. 1984b. Letter to the editor. Br. J. Vener. Dis. 60:132.
136. Qvigstad, E.,, K. Skaug,, and H. Hirschberg. 1985. Characterization of Chlamydia trachomatis serotypes by human T-lymphocyte clones. Scand. J. Immunol. 21:215220.
137. Qvigstad, E.,, K. Skaug,, and E. Thorsby. 1983b. Proliferative human T cell responses to Chlamydia trachomatis in vitro. APMIS 91:203209.
138. Qvigstad, E.,, and E. Thorsby. 1983. Class-T HLA restriction of antigen-specific human T-lymphocyte clones. Scand. J. Immunol. 18:299306.
139. Ràsànen, L.,, M. Lehtinen,, M. Lehto,, J. Paavonen,, and P. Leinikki. 1986. Polyclonal response of human lymphocytes to Chlamydia trachomatis. Infect. Immun. 54:2831.
140. Rasmussen, S. J.,, L. Eckmann,, A. J. Quayle,, L. Shen,, Y.-X. Zhang,, D. J. Anderson,, J. Fierer,, R. S. Stephens, and M. F. Kagnoff. 1997. Secretion of proinflammatory cytokines by epithelial cells in response to chlamydial infection suggests a central role for epithelial cells in chlamydial pathogenesis. J. Clin. Invest. 99:7787.
141. Reacher, M. H.,, J. Pe'er,, P. A. Rapoza,, J. A. Whittum-Hudson,, and H. R. Taylor. 1991. T cells and trachoma: their role in cicatricial disease. Ophthalmology 98:334341.
142. Rhinehart-Jones, T. R.,, A. H. Fortier,, and K. L. Elkins. 1994. Transfer of immunity against lethal murine Francisella infection by specific antibody depends on host gamma interferon and T cells. Infect. Immun. 62:31293137.
143. Rothermel, C. D.,, J. Schachter,, P. Lavrich,, E. C. Lipsitz,, and T. Francus. 1989. Chlamydia tra-chomatis-máuctá production of interleukin-1 by human monocytes. Infect. Immun. 57:27052711.
144. Saikku, P.,, K. Mattila,, M. S. Nieminen,, J. K. Huttunen,, M. Leinonen,, M.-R. Ekman,, P. H. Makelâ,, and V. Valtonen. 1988. Serological evidence of an association of a novel Chlamydia, TWAR, with chronic coronary heart disease and acute myocardial infarction. Lancet ii:983985.
145. Salari, S. H.,, and M. E. Ward. 1981. Polypeptide composition of Chlamydia trachomatis. J. Gen. Microbiol 123:197207.
146. Sieper, J.,, G. Kingsley,, A. Palacios-Boix,, C. Pitzalis,, J. Treharne,, R. Hughes,, A. Keat,, and G. S. Panayi. 1991. Synovial T lymphocyte-specific immune response to Chlamydia trachomatis in Reiter's disease. Arthritis Rheum. 34:588598.
147. Stagg, A. J.,, W. A. J. Elsley,, M. A. Pickett,, M. E. Ward,, and S. C. Knight. 1993. Primary human T-cell responses to the major outer membrane protein of Chlamydia trachomatis. Immunology 79: 19.
148. Stephens, R. S., 1989. Antigenic variation of Chlamydia trachomatis, p. 5162. In J. W. Moulder (ed.), Intracellular Parasitism. CRC Press, Inc., Boca Raton, Fla..
149. Stephens, R. S.,, S. Kalman,, C. Lammel,, J. Fan,, R. Marathe,, L. Aravind,, W. Mitchell,, L. Olinger,, R. Tatusov,, Q. Zhao,, E. V. Koonin,, and R. W. Davis. 1998. Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis. Science 282:754759.
150. Stephens, R. S.,, G. Mullenbach,, R. Sanchez-Pescador,, and N. Agabian. 1986. Sequence analysis of the major outer membrane protein gene from Chlamydia trachomatis serovar L2. J. Bacteriol. 168: 12771282.
151. Stephens, R. S.,, R. Sanchez-Pescador,, E. A. Wagar,, C. Inouye,, and M. S. Urdea. 1987. Diversity of Chlamydia trachomatis major outer membrane protein genes. J. Bacteriol. 169:38793885.
152. Storz, J., 1988. Overview of animal diseases induced by chlamydial infections, p. 167192. In A. L. Barron (ed.), Microbiology of Chlamydia. CRC Press, Inc., Boca Raton, Fla..
153. Su, H.,, and H. D. Caldwell. 1995. Kinetics of chlamydial antigen processing and presentation to T cells by paraformaldehyde-fixed murine bone marrow-derived macrophages. Infect. Immun. 63:946953.
154. Su, H.,, R. Messer,, W. Whitmire,, E. Fischer,, J. C.. Portis, and H. D. Caldwell. 1998. Vaccination against chlamydial genital tract infection after immunization with dendritic cells pulsed ex vivo with nonviable chlamydiae. J. Exp. Med. 188:809818.
155. Su, H.,, G. J. Spangrude,, and H. D. Caldwell. 1991. Expression of Fc gamma RIII on HeLa 229 cells: possible effect on in vitro neutralization of Chlamydia trachomatis. Infect. Immun. 59:38113814.
156. Summersgill, J. T.,, N. N. Sahney,, C. A. Gaydos,, T. C. Quinn,, and J. A. Ramirez. 1995. Inhibition of Chlamydia pneumoniae growth in HEp-2 cells pretreated with gamma interferon and tumor necrosis factor alpha. Infect. Immun. 63:28012803.
157. Surcel, H. M.,, H. Syrjâlâ,, M. Leinonen,, P. Saikku,, and E. Herva. 1993. Cell-mediated immunity to Chlamydia pneumoniae measured as lymphocyte blast transformation in vitro. Infect. Immun. 61:21962199.
158. Swanson, A. F.,, R. A. B. Ezekowitz,, A. Lee,, and C.-C. Kuo. 1998. Human mannose-binding protein inhibits infection of HeLa cells by Chlamydia trachomatis. Infect. Immun. 66:16071612.
159. Taylor, H. R. 1990. Development of immunity to ocular chlamydial infection. Am. J. Trop. Med. Hyg. 42:358364.
160. Taylor-Robinson, D.,, C. B. Gilroy,, B. J. Thomas,, and A. C. S. Keat. 1992. Detection of Chlamydia trachomatis DNA in joints of reactive arthritis patients by polymerase chain reaction. Lancet 340:8182.
161. Treharae, J. D.,, K. T. Ripa,, R-A. Mardh,, L. Svensson,, L. Weström,, and S. Darougar. 1979. Antibodies to Chlamydia trachomatis in acute salpingitis. Br. J. Verier. Dis. 55:2629.
162. Turner, V. M.,, S. K. West,, B. Muñoz,, S. J. Katala,, H. R. Taylor,, N. Halsey,, and B. B. O. Mmbaga. 1993. Risk factors for trichiasis in women in Kongwa, Tanzania: a case-control study. Int. J. Epidemiol. 22:341347.
163. Vaahtoranta-Lehtonen, H. H.,, O.-P. J. Lehtonen,, Y. Forsten, O. H. Meurman, and K. M. Saari. 1993. Tear znti-Chlamydia antibodies in males with chlamydial urethritis. Ophthalmic Res. 25:2329.
164. van Westreenen, M.,, A. Pronk,, R. J. A. Diepersloot,, P. G. de Groot,, and P. Leguit. 1998. Chlamydia trachomatis infection of human mesothelial cells alters proinflammatory, procoagulant, and fibrinolytic responses. Infect. Immun. 66:23532355.
165. Wang, S.-P.,, D. A. Eschenbach,, K. K. Holmes,, G. Wager,, and T. J. Grayston. 1980. Chlamydia trachomatis infection in Fitz-Hugh-Curtis syndrome. Am. J. Obstet. Gynecol. 138:10341038.
166. Wang, S.-P.,, and J. T. Grayston. 1974. Human serology in Chlamydia trachomatis infection with microimmunofluorescence. J. Infect. Dis. 130:388397.
167. West, S. K.,, B. Muñoz,, M. Lynch,, A. Kayongoya,, B. B. O. Mmbaga,, and H. R. Taylor. 1996. Risk factors for constant, severe trachoma among preschool children in Kongwa, Tanzania. Am. J. Epidemiol. 143:7378.
168. Woese, C. R. 1987. Bacterial evolution. Microbiol. Rev. 51:221271.
169. Yang, C.-L.,, I. Maclean,, and R. C. Brunham. 1993. DNA sequence polymorphism of the Chlamydia trachomatis ompl gene. J. Infect. Dis. 168:12251230.
170. Yang, X.,, and R. C. Brunham. 1998a. Gene knockout T cell-deficient mice demonstrate that T cells play an important role in the initiation of T cell responses to Chlamydia trachomatis (mouse pneumonitis) lung infection. J. Immunol. 161:14391446.
171. Yang, X.,, and R. C. Brunham. 1998b. T lymphocyte immunity in host defence against Chlamydia trachomatis and its implication for vaccine development. Can. J. Infect. Dis. 9:99108.
172. Yi, Y.,, X. Yang,, and R. C. Brunham. 1997. Autoimmunity of heat shock protein 60 and antigen-specific production of interleukin-10. Infect. Immun. 65:16691674.
173. Yong, E. C.,, E. Y. Chi,, W.-J. Chen,, and C.-C. Kuo. 1986. Degradation of Chlamydia trachomatis in human polymorphonuclear leukocytes: an ultrastructural study of peroxidase-positive phagolysosomes. Infect. Immun. 53:427431.
174. Yong, E. C.,, E. Y. Chi,, and C.-C. Kuo. 1987. Differential antimicrobial activity of human mononuclear phagocytes against the human biovars of Chlamydia trachomatis. J. Immunol. 139:12971302.
175. Zhang, D.-J.,, H. Fan,, G. McClarty,, and R. C. Brunham. 1995. Identification of the Chlamydia trachomatis RecA-encoding gene. Infect. Immun. 63:676680.
176. Zhang, D.-J.,, X. Yang,, J. Berry,, C. Shen,, G. McClarty,, and R. C. Brunham. 1997. DNA vaccination with the major outer-membrane protein gene induces acquired immunity to Chlamydia trachomatis (mouse pneumonitis) infection. J. Infect. Dis. 176:10351040.
177. Zhang, D.,, X. Yang,, C. Shen,, and R. C. Brunham,. 1998. The immune responses following intramuscular DNA immunization with the MOMP gene of Chlamydia trachomatis, p. 442445. In R. S. Stephens,, G. I. Byrne,, G. Christiansen,, I. N. Clarke,, J. T. Grayston,, R. G. Rank,, G. L. Ridgway,, P. Saikku,, J. Schachter,, and W. E. Stamm (ed.), Chlamydial Infections. Proceedings of the Ninth International Symposium on Human Chlamydial Infection. International Chlamydia Symposium, San Francisco, Calif..
178. Zhong, G.,, and R. C. Brunham. 1991. Antigenic determinants of the chlamydial major outer membrane protein resolved at a single amino acid level. Infect. Immun. 59:11411147.
179. Zhong, G.,, and R. C. Brunham. 1992. Antibody responses to the chlamydial heat shock proteins Hsp60 and Hsp70 are H-2 linked. Infect. Immun. 60:31433149.
180. Zhong, G.,, and R. C. Brunham. 1998. Chlamydial resistance to host defense mechanisms: inhibition of host cell apoptosis. Sci. Med. 5:3847.

Tables

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Table 1

Association of submucosal lymphoid follicle formation with l cervicitis and endometritis

Citation: Brunham R. 1999. Human Immunity to Chlamydiae, p 211-238. In Stephens R (ed), Chlamydia. ASM Press, Washington, DC. doi: 10.1128/9781555818203.ch8

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