Chapter 1 : Introduction to the Pathogen

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This chapter begins with the history of . By the end of the 19th century three seminal observations had been made regarding . First, the organism had been recovered from lesions in humans and animals, establishing its potential to cause disease. Second, the organism had been recovered from the environment, establishing that it was free-living. Finally, the organism was propagated in the laboratory and shown to cause disease in laboratory animals. Many of the early clinical reports of cryptococcosis included animal experiments with the organism isolated from patients. Examination of by light microscopy reveals yeast-like cells that reproduce by budding and are of variable size. has been extensively studied by electron microscopy, which shows that cells have morphological features typical of eukaryotic cells. There are many reports in the literature of cells with germ tube-like structure, hyphal forms, pseudohyphae, and sporulation. For an extensive discussion of the effect of various environmental conditions on the survival the effect of temperature, pH, sunlight, and moisture are briefly discussed in the chapter.

Citation: Casadevall A, Perfect J. 1998. Introduction to the Pathogen, p 1-27. In . ASM Press, Washington, DC. doi: 10.1128/9781555818241.ch1

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Microtubule Organizing Centers
Systemic Lupus Erythematosus
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Figure 1

Transmission electron micrograph of . The cytoplasm shows typical eukaryotic cellular structures such as a nucleus, mitochondria, and various vesicles. Several vesicles contain low-electron-density material that may be lipid. Note the thick cell wall. N, nucleus; M, mitochondria; V, vacuole; C, cell wall. The arrow indicates a new bud. In this preparation the polysaccharide capsule is not apparent. Magnification, × 12,000. Reprinted with permission from A. Casadevall, Cryptococcosis: the case for immunotherapy. 4(4):2, 1993, Lawrence Della-Corte Publications, Inc.

Citation: Casadevall A, Perfect J. 1998. Introduction to the Pathogen, p 1-27. In . ASM Press, Washington, DC. doi: 10.1128/9781555818241.ch1
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Image of Figure 2
Figure 2

Idealized diagram of a cell based on electron microscopic studies. In cells grown with the appropriate substrate, melanin is found in the cell wall (see chapter 4).

Citation: Casadevall A, Perfect J. 1998. Introduction to the Pathogen, p 1-27. In . ASM Press, Washington, DC. doi: 10.1128/9781555818241.ch1
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1. Al-Doory, Y. 1971. A bibliography of cryptococcosis. Mycopathol Mycol. Appl. 45:260.
2. Al-Doory, Y. 1971. The ultrastructure of Cryptococcus neoformans. Sabouraudia 9:113118.
3. Anandi, V.,, P. G. Babu,, and T. J. John. 1991. Infection due to Cryptococcus neoformans of unusual morphology in a patient with AIDS. Mycoses 34:377379.
4. Anderson, H. W. 1917. Yeast-like fungi in the human intestinal tract. J. Infect. Dis. 21:380383.
5.Anonymous. 1996. Vital events and reportable diseases and conditions, 1976 to 1995. City Health Informatd S. Shtokalko. 1957. Cryptococcus meningitis arrested with Amphotericin B. Ann. Intern. Med. 47:346351.
7. Atkinson, A. J.,, and J. E. Bennett. 1968. Experience with a new skin test antigen prepared from Cryptococcus neoformans. Am. Rev. Respir. Dis. 97:637643.
8. Attal, H. C.,, S. Grover,, M. P. Bansai,, B. S. Chaubey,, and V. K. Joglekar. 1983. Capsule deficient Cryptococcus neoformans: an unusual clinical presentation. J. AssoC. Phys. India 31:4951.
9. Baker, R. D. 1952. Resectable mycotic lesions and acutely fatal mycoses. JAMA 159:15791581.
10. Baker, R. D. 1976. The primary pulmonary lymph node complex of cryptococcosis. Am. J. Clin. Pathol. 65:8392.
11. Baker, R. D.,, and R. K. Haugen. 1955. Tissue changes and tissue diagnosis in cryptococcosis. A study of 26 cases. Am. J. Clin. Pathol. 25:1424.
12. Barlow, D. L. 1923. Primary blasto-mycotic meningitis occurring in a child. Med. J. Aust. 2:302304.
13. Beck, E. M.,, and G. Q. Voyles. 1946. Systemic infection due to Torula Histolytica (Cryptococcus hominis). Arch. Intern. Med. 77:516525.
14. Benbow, E. W.,, and R. W. Stoddardt. 1985. Capsule-deficient Cryptococcus neoformans in AIDS patients. Lancet i:988989.
15. Benham, R. W. 1934. The fungis of blastomycosis and coccidioidal granuloma. Arch. Dermatol. Syph. 30:385400.
16. Benham, R. W. 1935. Cryptococci—their identification by morphology and by serology. J. Infect. Dis. 57:255274.
17. Benham, R. W. 1950. Cryptococcosis and blastomycoses. Ann. N.Y. Acad. Sci. 50:12991314.
18. Benham, R. W. 1956. The genus cryptococcus. Bacteriol. Rev. 20:189201.
19. Benn, J. J.,, P. S. Monro,, and G. Duncan. 1985. Capsule-deficient Cryptococcus neoformans in AIDS patients. Lancet i:989.
20. Bennett, J. E.,, and H. F. Hasenclever. 1965. Cryptococcus neoformans polysaccharide: studies of serologic properties and role in infection. J. Immunol. 94:916920.
21. Bennett, J. E.,, K. J. Kwon-Chung,, and D. H. Howard. 1977. Epidemiologic differences among serotypes of Cryptococcus neoformans. Am.J. Epidemiol. 105:582586.
22. Bergman, F. 1961. Pathology of experimental cryptococcosis. A study of course and tissue response in subcutaneously induced infection in mice. Acta Pathol. Microbiol. Scand. Suppl. 147:1163.
23. Bettin, M. E. 1924. Report of a case of Torula infection. Calif. West. Med. 22:98101.
24. Bhattacharjee, A. K.,, J. E. Bennett,, and C. P. J. Glaudemans. 1984. Capsular polysaccharides of Cryptococcus neoformans. Rev. Infect. Dis. 6:619624.
25. Bhattacharjee, A. K.,, K. J. Kwon-Chung,, and C. P. J. Glaudemans. 1979. The structure of the capsular polysaccharide from Cryptococcus neoformans serotype D. Carbohydr. Res. 73:183192.
26. Bhattacharjee, A. K.,, K. J. Kwon-Chung,, and C. P. J. Glaudemans. 1980. Structural studies on the major, capsular polysaccharide from Cryptococcus neoformans serotype B. Carbohydr. Res. 82:103111.
27. Bhattacharjee, A. K.,, K. J. Kwon-Chung,, and C. P. J. Glaudemans. 1981. Capsular polysaccharides from a parent strain and from a possible, mutant strain of Cryptococcus neoformans serotype A. Carbohydr. Res. 95:237248.
28. Bindford, C. H. 1941. Torulosis of the central nervous system. Review of recent literature and report of a case. Am. J. Clin. Pathol. 11:242251.
29. Blandamer, A.,, and I. Danishefsky. 1966. Investigations on the structure of the capsular polysaccharide from Cryptococcus neoformans type B. Biochim. Biophys. Acta 117:305313.
30. Bloomfield, N.,, M. A. Gordon,, and D. F. Elmendorf, Jr. 1963. Detection of Cryptococcus neoformans antigen in body fluids by latex particle agglutination. ProC. SoC. Exp. Biol. Med. 114:6467.
31. Bodham, C. 1922. Preliminary report on the causal organism of blastomycotic meningitis in Australia. Med. J. Aust. 2:385.
32. Bottone, E. J.,, M. Toma,, B. E. Johansson,, and G. P. Wormsei: 1985. Capsule-deficient Cryptococcus neoformans in AIDS patients. Lancet i:400.
33. Bottone, E. J.,, M. Toma,, B. E. Johansson,, and G. P. Wormser. 1986. Poorly encapsulated Cryptococcus neoformans from patients with AIDS. I. Preliminary observations. AIDS Res. 2:211219.
34. Brewer, G. E.,, and F. C. Wood. 1908. Blastomycosis of the spine. Ann. Surg. 48:889896.
35. Bruatto, M.,, V. Vidotto,, and A. M. Maima. 1992. Growth of Cryptococcus neoformans in a thiamine-free medium. Mycopathologia 119:129132.
36. Buhner, G. S.,, and M. D. Sans. 1967. Cryptococcus neoformans. II. Phagocytosis by human leukocytes. J. Bacteriol. 94:14801483.
37. Buhner, G. S.,, and M. D. Sans. 1968. Cryptococcus neoformans. III. Inhibition of phagocytosis. J. Bacteriol. 95:58.
38. Buhner G. S.,, M. D. Sans,, and C. M. Gunn. 1967. Cryptococcus neoformans. I. Nonencapsulated mutants. J. Bacteriol. 94:14751479.
39. Casadevall, A. 1995. Antibody immunity and invasive fungal infections. Infect. Immun. 63:42114218.
40. Casadevall, A.,, L. Freundlich,, L. Marsh,, and M. D. Scharff. 1992. Extensive allelic variation in Cryptococcus neoformans. J. Clin. Microbiol. 30:10801084.
41. Cassone, A.,, N. Simonetti,, and V. Strippoli. 1974. Wall structure and bud formation on Cryptococcus neoformans. Arch. Microbiol. 95:205212.
42. Cauley, L. K.,, and J. W. Murphy. 1979. Response of congenitally athymic (nude) and phenotypically normal mice to Cryptococcus neoformans infection. Infect. Immun. 23:644r651.
43. Chang, Y. C.,, and K. J. Kwon-Chung. 1994. Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence. Mol. Cell. Biol. 14:49124919.
44. Cherniak, R.,, E. Reiss,, M. E. Slodki,, R. D. Plattner,, and S. O. Blumer. 1980. Structure and antigenic activity of the capsular polysaccharide of Cryptococcus neoformans serotype A. Mol. Immunol. 17:10251032.
45. Cherniak, R., and J. B. Sundstrom. 1994. Polysaccharide antigens of the capsule of Cryptococcus neoformans. Infect. Immun. 62:15071512.
46. Chuck, S. L.,, and M. A. Sande. 1989. Infections with Cryptococcus neoformans in the acquired immunodeficiency syndrome. N. Engl. J. Med. 321:794r799.
47. Cleare, W.,, S. Mukherjee,, E. D. Spitzer,, and A. Casadevall. 1994. Prevalence in Cryptococcus neoformans strains of a polysaccharide epitope which can elicit protective antibodies. Clin. Diagn. Lab. Immunol. 1:737740.
48. Cox, L. B.,, and J. C. Tolhurst 1946. Human Torulosis. Melbourne University Press, Melbourne, Australia.
49. Crone, J. T.,, A. F. DeGroat,, and J. G. Wahlin. 1937. Torula infection. Am. J. Pathol. 13:863879.
50. Cruickshank, J. G.,, R. Cavill,, and M. Jelbert. 1973. Cryptococcus neoformans of unusual morphology. Appl. Microbiol. 25:309312.
51. Currie, B. P.,, and A. Casadevall. 1994. Estimation of the prevalence of cryptococcal infection among HIV infected individuals in New York City. Clin. Infect. Dis. 19:10291033.
52. Cutler, J. E.,, and K. H. Erke. 1971. Ultrastructural characteristics of Coccidioides intimitis, a morphological variant of Cryptococcus neoformans and Podossypha ravenelii. J. Bacteriol. 105:438444.
53. Diamond, R. D.,, J. E. May,, M. Kane,, M. M. Frank,, and J. E. Bennett. 1973. The role of late complement component and the alternate complement pathway in experimental cryptococcosis (37580). ProC. SoC. Exp. Biol. Med. 144:312315.
54. Diamond, R. D.,, J. E. May,, M. C. Kane,, M. M. Frank,, and J. E. Bennett 1974. The role of the classical and alternate complement pathways in host defenses against Cryptococcus neoformans infection. J. Immunol. 112:22602270.
55. Dong, Z. M.,, and J. W. Murphy. 1996. Cryptococcal polysaccharides induce L-selectin shedding and tumor necrosis receptor loss from the surface of human neutrophils. J. Clin. Invest. 97:689698.
56. Dong, Z. M.,, and J. W. Murphy. 1997. Cryptococcal polysaccharide bind to CD18 on human neutrophils. Infect. Immun. 65:557563.
57. Dromer, E.,, A. Varma,, O. Ronin,, S. Mathoulin,, and B. Dupont. 1994. Molecular typing of Cryptococcus neoformans serotype D clinical isolates. J. Clin. Microbiol. 32:23642371.
58. Drouhet, E. 1997. Milestones in the history of Cryptococcus and cryptococcosis. J. Mycol. Med. 7:1027.
59. Drouhet, E.,, and G. Segretain. 1951. Inhibition de la migration leucocytaire in vitro par un polyoside capsulaire de Torulopsis (Cryptococcus) neoformans. Ann. Inst. Pasteur 81:674.
60. Edman, J. C.,, and K. J. Kwon-Chung. 1990. Isolation of the URA5 gene from Cryptococcus neoformans var neoformans and its use as a selective marker for transformation. Mol. Cell. Biol. 10:45834544.
61. Edwards, M. R.,, M. A. Gordon,, E. W. Lapa,, and W. C. Ghiorse. 1967. Micromorphology of Cryptococcus neoformans. J. Bacteriol. 94:766777.
62. Ellis, D.,, and T. J. Pfeiffer. 1992. The ecology of Cryptococcus neoformans. Eur. J. Epidemiol. 8:321325.
63. Ellis, D. H.,, and T. J. Pfeiffer. 1990. Natural habitat of Cryptococcus neoformans var. gattii. J. Clin. Microbiol. 28:16421644.
64. Emanuael, B.,, E. Ching,, A. D. Leiberman,, and M. Goldin. 1961. Cryptococcus meningitis in a child successfully treated with amphotericin B, with a review of the pediatric literature. J. Pediatr. 59:577591.
65. Emmons, C. W. 1951. Isolation of Cryptococcus neoformans from soil. J. Bacteriol. 62:685690.
66. Emmons, C. W. 1960. Prevalence of Cryptococcus neoformans in pigeon habitats. Public Health Rep. 75:362364.
67. Eng, R. H. K.,, E. Bishburg,, S. M. Smith,, and R. Kapila. 1986. Cryptococcal infections in patients with acquired immune deficiency syndrome. Am. J. Med. 81:1923.
68. Erke, K. H., and J. D. Schneidau. 1973. Relationship of some Cryptococcus neoformans hypha-forming strains to standard strains and to other species of yeasts as determined by deoxyribonucleic acid base ratios and homologies. Infect. Immun. 7:941948.
69. Evans, E. D.,, and J. F. Kessel. 1951. The antigenic composition of Cryptococcus neoformans. J. Immunol. 67:109114.
70. Evans, E. E. 1949. An immunologic comparison of twelve strains of Cryptococcus neoformans (Torula histolytica). ProC. SoC. Exp. Biol. Med. 71:644646.
71. Evans, E. E. 1950. The antigenic composition of Cryptococcus neoformans. I. A serologic classification by means of the capsular and agglutination reactions. J. Immunol. 64:423430.
72. Evans, E. E. 1960. Capsular reactions of Cryptococcus neoformans. Ann. N.Y. Acad. Sci. 89:184192.
73. Evans, N. 1922. Torula infection. Report of two cases. Calif. State J. Med. 20:383385.
74. Fan, M.,, L.-L. Chen,, M. A. Ragan,, R. R. Gutell,, J. R. Warner,, B. P. Currie,, and A. Casadevall. 1995. The 5S rRNA and the rDNA intergenic spacer of the two varieties of Cryptococcus neoformans: sequence, structure, and phylogenetic implications. J. Med. Vet. Mycol. 33:215221.
75. Fan, M.,, B. P. Currie,, R. R. Gutell,, M. A. Ragan,, and A. Casadevall. 1994. The 16S-like, 5.8S, and 23S-like rRNAs of the two varieties of Cryptococcus neoformans: sequence, secondary structure, phylogenetic analysis, and restriction fragment polymorphisms. J. Med. Vet. Mycol. 32:163180.
76. Farhi, E.,, G. S. Bulmei>, and J. R. Tacker. 1970. Cryptococcus neoformans. IV. The not-so-encapsulated yeast. Infect. Immun. 1:526531.
77. Farmer, S. G.,, and R. A. Komorowski. 1973. Histologic response to capsule-deficient Cryptococcus neoformans. Arch. Pathol. 96:383387.
78. Fell, J. W.,, C. P. Kurtzman,, and K. J. Kwon-Chung. 1989. Proposal to conserve Cryptococcus (fungi). Taxon 38:151152.
79. Fiskin, A. M.,, M. C. Zalles,, and R. G. Garrison. 1990. Electron cytodiemical studies of Cryptococcus neoformans grown on uric acid and related sources of nitrogen. J. Med. Vet. Mycol. 38:197207.
80. Freed, E. R.,, R. J. Duma,, H. J. Shadomy,, and J. P. Utz. 1971. Meningoencephalitis due to hyphae-forming Cryptococcus neoformans. Am. J. Clin. Pathol. 51:3053.
81. Freeman, W. 1931. Torula infection of the central nervous system. J. Psychol. Neurol. 43:236345.
82. Freeman, W.,, and F. D. Weidman. 1923. Cystic blastomycosis of the cerebral gray matter caused by Torula histolytica Stoddard and Cutler. Arch. Neurol. Psychiatr. 9:589603.
83. Fromtling, R. A.,, and G. S. Bulmen 1985. Capsule-deficient Cryptococcus neoformans in AIDS patients. Lancet i:988.
84. Frothingham, L. 1902. A tumor-like lesion in the lung of a horse caused by a blastomyces (torula). J. Med. Res. 8:3143.
85. Gadebusch, H. H. 1958. Passive immunization against Cryptococcus neoformans. ProC. SoC. Exp. Biol. Med. 98:611614.
86. Gadebusch, H. H. 1961. Natural host resistance to infection with Cryptococcus neoformans. The effect of the properdin system on the experimental disease. J. Infect. Dis. 109:147153.
87. Gadebusch, H. H. 1972. Mechanisms of native and acquired resistance to infection with Cryptococcus neoformans. Crit. Rev. Microbiol. 1:311320.
88. Gordon, M. 1981. Cryptococcal antigen test. JAMA 246:1403.
89. Gordon, M. A.,, and J. Devine. 1970. Filamentation and endogenous sporulation in Cryptococcus neoformans. Sabouraudia 8:227234.
90. Granger, D. L.,, J. R. Perfect,, and D. T. Durack. 1985. Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide. J. Clin. Invest. 76:508516.
91. Graybill, J. R.,, and R. H. Alford. 1974. Cell-mediated immunity in cryptococcosis. Cell. Immunol. 14:1221.
92. Graybill, J. R.,, and D. J. Drutz. 1978. Host defense in cryptococcosis, II. Cryptococcosis in the nude mouse. Cell. Immunol. 40:263274.
93. Graybill, J. R.,, L. Mitchell,, and D. J. Drutz. 1979. Host defense in cryptococcosis, III. Protection of nude mice by thymus transplantation. J. Infect. Dis. 140:546552.
94. Hay, R. J.,, and E. Reiss. 1978. Delayed-type hypersensitivity responses in infected mice elicited by cytoplasmic fractions of Cryptococcus neoformans. Infect. Immun. 22:7279.
95. Hehre, E. J.,, A. S. Carlson,, and D. M. Hamilton. 1949. Crystalline amylose from cultures of a pathogenic yeast (Torula histolytica). J. Biol. Chem. 177:289293.
96. Hirsch, E. E.,, and G. H. Coleman. 1929. Acute miliary torulosis of the lungs. JAMA 92:437438.
97. Hiruma, M.,, and S. Kagawa. 1985. Ultrastructure of Cryptococcus neoformans in the cerebrospinal fluid of a patient with cryptococcal meningitis. Mycopathologia 89:512.
98. Howard, D. H. 1961. Some factors which affect the initiation of growth of Cryptococcus neoformans. J. Bacteriol. 82:430435.
99. Huahua, T.,, J. Rudy,, and C. M. Kunin. 1991. Effect of hydrogen peroxide on growth of Candida, Cryptococcus and other yeasts in simulated blood culture bottles. J. Clin. Microbiol. 29:328332.
100. Ishaq, C. M.,, G. S. Bulmer,, and E G. Felton. 1968. An evaluation of various environmental factors affecting the propagation of Cryptococcus neoformans. Mycopathol. Mycol. Appl. 35:8190.
101. Johns, E. M.,, and C. L. Attaway. 1933. Torula meningitis. Report of a case and review of the literature. Am. J. Clin. Pathol. 3:459465.
102. Kalina, M.,, Y. Kletter,, and M. Aronson. 1974. The interaction of phagocytes and the large-sized parasite Cryptococcus neoformans: cytochemical and ultrastructural study. Cell Tissue Res. 152:165174.
103. Kaufman, L.,, and S. Blumer. 1977. Cryptococcosis: the awakening giant, abstr. 176-182. Proceedings of the Fourth International Conference on the Mycoses. PAHO Scientific Publication No. 356.
104. Keye, J. D.,, and W. E. Magee. 1956. Fungal diseases in a general hospital. Am. J. Clin. Pathol. 26:12351253.
105. Kligman, A. M.,, and F. D. Weidman. 1949. Experimental studies on treatment of human torulosis. Arch. Dermatol. Syph. 60:726741.
106. Knoke, M.,, and G. Schwesinger. 1994. One hundred years ago: the history of cryptococcosis in Greifswald. Medical mycology in the nineteenth century. Mycoses 37:229233.
107. Kozel, T. R. 1996. Activation of the complement system by pathogenic fungi. Clin. Microbiol. Rev. 9:3446.
108. Kozel, T. R., and J. Cazin, Jr. 1972. Immune response to Cryptococcus neoformans soluble polysaccharide. Infect. Immun. 5:3541.
109. Kozel, T. R.,, W. F. Gulley,, and J. Cazin, Jr. 1977. Immune response to Cryptococcus neoformans soluble polysaccharide: immunological unresponsiveness. Infect. Immun. 18:701707.
110a.. Kozel, T. R., and T. G. McGaw. 1979. Opsonization of Cryptococcus neoformans by human immunoglobulin G: role of immunoglobulin G in phagocytosis by macrophages. Infect. Immun. 25:255261.
111. Kwon-Chung, K. J. 1975. A new genus, Filobasidiella, the perfect state of Cryptococcus neoformans. Mycologia 67:11971200.
112. Kwon-Chung, K. J. 1976. A new species of Filobasidiella, the sexual state of Cryptococcus neoformans B and C serotypes. Mycologia 68:942946.
113. Kwon-Chung, K. J. 1976. Morphogenesis of Filobasidiella neoformans, the sexual state of Cryptococcus neoformans. Mycologia 67:821833.
114. Kwon-Chung, K. J.,, and J. E. Bennett. 1984. Epidemiologic differences between the two varieties of Cryptococcus neoformans. Am. J. Epidemiol. 120:123130.
115. Kwon-Chung, K. J.,, and J. E. Bennett,. 1992. Cryptococcosis, p. 397446. In K. J. Kwon-Chung, and J. E. Bennett, (ed.), Medical Mycology. Lea & Febiger, Philadelphia.
116. Kwon-Chung, K. J.,, J. E. Bennett,, and J. C. Rhodes. 1982. Taxonomic studies on Filobasidiella species and their anamorphs. Antonie van Leeuwenhoek 48:2538.
117. Levin, E. A. 1937. Torula infection of the central nervous system. Arch. Intern. Med. 59:667684.
118. Levitz, S. M. 1992. Overview of host defenses in fungal infections. Clin. Infect. Dis. 14(Suppl. 1):S37S42.
119. Levitz, S. M.,, H. L. Mathews,, and J. W. Murphy. 1995. Direct antimicrobial activity by T cells. Immunol. Today 16:387391.
120. Littman, M. L. 1958. Capsule synthesis by Cryptococcus neoformans. Trans. N.Y. Acad. Sci. 20:623648.
121. Littman, M. L. 1959. Cryptococcosis (torulosis). Am. J. Med. 27:976998.
122. Littman, M. L. 1968. Cryptococcosis: current status. Am. J. Med. 45:922932.
123. Littman, M. L.,, and R. Borok. 1968. Relation of the pigeon to cryptococcosis: natural carrier state, heat resistance and survival of cryptococcus neoformans. Mycopathol. Mycol. Appl. 35:329345.
124. Littman, M. L.,, and L. E. Zimmerman. 1956. Cryptococcosis, Torulosis or European Blastomycosis. Grune & Stratton, New York.
125. Lodder, J. 1938. Torulopsis or Cryptococcus? Mycopathologia 1:6267.
126. Longmire, W. P.,, and T. C. Goodwin. 1939. Generalized torula infection. Case report and review with observations on pathogenesis. Bull. Johns Hopkins Hosp. 64:2243.
127. Love, G. L.,, G. D. Boyd,, and D. L. Greer. 1985. Large Cryptococcus neoformans isolated from brain abscess. J. Clin. Microbiol. 22:10681070.
128. Lurie, H. L.,, and H. J. Shadomy. 1971. Morphological variations of a hypha-forming strain of Cryptococcus neoformans (Coward strain) in tissues of mice. Sabouraudia 9:1014.
129. Lurie, H. I.,, H. J. Shadomy,, and W. J. S. Still. 1971. An electron microscopic study of Cryptococcus neoformans (Coward strain). Sabouraudia 9:1516.
130. Macher, A. M.,, J. E. Bennett,, J. E. Gadek,, and M. M. Frank. 1978. Complement depletion in cryptococcal sepsis. J. Immunol. 120:16861690.
131. Mackensie, D. W. R.,, and R. J. Hay. 1985. Capsule-deficient Cryptococcus neoformans in AIDS patients. Lancet i:642.
132. Magruder, R. G. 1939. A report of three cases of Torula infection of the central nervous system J. Lab. Clin. Med. 24:495499.
133. McKendree, C. A.,, and L. H. Cornwall. 1926. Meningo-encephalitis due to torula. Arch. Neurol. Psychiatr. 16:167181.
134. Merrifield, E. H.,, and A. M. Stephen. 1980. Structural investigations of two capsular polysaccharides from Cryptococcus neoformans. Carbohydr. Res. 86:6976.
135. Miller, G. P. G. 1986. The immunology of cryptococcal disease. Semin. Respir. Infect. 1:4552.
136. Mitchell, L. A. 1936. Torulosis. JAMA 106:450452.
137. Mitchell, T. G.,, E. Z. Freedman,, T. J. White,, and J. W. Taylor. 1994. Unique oligonucleotide primers in PCR for identification of Cryptococcus neoformans. J. Clin. Microbiol. 32:253255.
138. Miyazaki, T. 1961. Studies on fungal polysaccharides. I. On the isolation and chemical properties of capsular polysaccharide from Cryptococcus neoformans. Chem. Pharm. Bull. 9:715718.
139. Miyazaki, T. 1961. Studies on fungal polysaccharides. EL On the componental sugars and partial hydrolysis of the capsular polysaccharides from Cryptococcus neoformans. Chem. Pharm. Bull. 9:826829.
140. Miyazaki, T. 1961. Studies on fungal polysaccharides. III. Chemical structure of the capsular polysaccharide from Cryptococcus neoformans. Chem. Pharm. Bull. 9:829833.
141. Mochizuki, T.,, S. Tanaka,, Y. Saito,, and S. Watanabe. 1988. Mitochondrial kinetics during mitosis in Cryptococcus neoformans—an ultrastructure study. Mycoses 32:713.
142. Mochizuki, T.,, S. Tanaka,, and S. Watanabe. 1987. Ultrastructure of the mitotic apparatus in Cryptococcus neoformans. J. Med. Vet. Mycol. 25:223233.
143. Mook, W. H.,, and M. Moore. 1936. Cutaneous torulosis. Arch.Dermatol. Syph. 33:951962.
144. Moore, T. D. E.,, and J. C. Edman. 1993. The alpha-mating type locus of Cryptococcus neoformans contains a peptide pheromone gene. Mol. Cell. Biol. 13:19621970.
145. Moser, S. A.,, L. Friedman,, and A. R. Varraux. 1978. Atypical isolate of Cryptococcus neoformans cultured from sputum of a patient with pulmonary cancer and blastomycosis. J. Clin. Microbiol. 7:316318.
146. Muchmore, H. G.,, F. G. Felton,, S. B. Salvin,, and E. R. Rhoades. 1968. Delayed hypersensitivity to cryptococcin in man. Sabouraudia 6:285288.
147. Murphy, J. A. 1991. Mechanisms of natural resistance to human pathogenic fungi. Anna. Rev. Microbiol. 45:509538.
148. Murphy, J. W.,, and G. C. Cozad. 1972. Immunological unresponsiveness induced by cryptococcal polysaccharide assayed by the hemolytic plaque technique. Infect. Immun. 5:896901.
149. Neilson, J. B.,, R. A. Fromtling,, and G. S. Bulmer. 1981. Pseudohyphal forms of Cryptococcus neoformans: decreased survival in vivo. Mycopathologia 73:5759.
150. Neilson, J. B.,, M. H. Ivey,, and G. S. Bulmer. 1978. Cryptococcus neoformans: pseudohyphal forms surviving culture with Acanthamoeba polyphaga. Infect. Immun. 20:262266.
151. Newberry, W. M.,, J. Walter,, J. W. Chandler,, and F. E. Tosh. 1967. Epidemiologic study of Cryptococcus neoformans. Ann. Intern. Med. 67:727732.
152. Odds, F. C.,, T. De Backer,, G. Dams,, L. Vranckx,, and F. Woestenborghs. 1995. Oxygen as a limiting nutrient for growth of Cryptococcus neoformans. J. Clin. Microbiol 33:995997.
153. Partridge, B. M.,, and H. I. Winner. 1965. Cryptococcus neoformans in bird droppings in London. Lancet i:10601061.
154. Perfect, J. R.,, D. L. Toffaletti,, and T. H. Rude. 1993. The gene encoding phosphoribosylaminoimidazole carboxylase (ADE2) is essential for growth of Cryptococcus neoformans in cerebrospinal fluid. Infect. Immun. 61:44464451.
155. Pierson, P. H. 1917. Torula in man. Report of a case with necropsy findings. JAMA 69:21792181.
156. Polacheck, I. 1991. The discovery of melanin production in Cryptococcus neoformans and its impact on diagnosis and the study of virulence. Zentralbl. Bakteriol. 276:120123.
157. Reeves, D. L.,, E. M. Butt,, and R. W. Hammack. 1941. Torula infection of the lungs and central nervous system. Arch. Intern. Med. 68:5779.
158. Restrepo, B. I.,, and A. G. Barbour. 1989. Cloning of the 18S and 25S rDNAs from the pathogenic fungus Cryptococcus neoformans. J. Bacteriol. 171:55965600.
159. Rosas, A. L.,, and A. Casadevall. 1997. Melanization affects susceptibility of Cryptococcus neoformans to heat and cold. FEMS Microbiol Lett. 153:265272.
160. Ruiz, A.,, J. B. Neilson,, and G. S. Bulmer. 1982. A one year study on the viability of Cryptococcus neoformans in nature. Mycopathologia 77:117122.
161. Rusk, G. Y.,, and F. J. Farnell. 1912. Systemic oidiomycosis. A study of two cases developing terminal oidiomycetic meningitis. Univ. Calif. Publ. Pathol. 2:4758.
162. Saag, M. S.,, and W. E. Dismukes. 1988. Azole antifungal agents: emphasis on new triazoles. Antimicrob. Agents Chemother. 32:18.
163. Sakaguchi, N. 1993. Ultrastructural study of hepatic granulomas induced by Cryptococcus neoformans by quick-freezing and deep-etching method. Virchows Arch. (Cell. Pathol.) 64:5766.
164. Sakaguchi, N.,, T. Baba,, M. Fukuzawa,, and S. Ohno. 1993. Ultrastructural study of Cryptococcus neoformans by quick-freezing and deep-etching method. Mycopathologia 121:133141.
165. Salvin, S. B. 1959. Current concepts of diagnostic serology and skin hypersensitivity in the mycoses. Am. J. Med. 27:97114.
166. Salvin, S. B.,, and R. F. Smith. 1961. An antigen for detection of hypersensitivity to Cryptococcus neoformans (26977). ProC. SoC. Exp. Biol. Med. 108:498501.
167. Sanfelice, F. 1894. Contributo alia morfologia e biologia dei blastomiceti che si sviluppano nei succhi di alcuni frutti. Ann. Igien. 4:463495.
168. Sanfelice, F. 1895. Sull'azione patogena dei blastomiceti. Ann. Inst. Igien. Univ. Roma 5:239262.
169. Schimpff, S. C.,, and J. E. Bennett. 1975. Abnormalities in cell-mediated immunity in patients with Cryptococcus neoformans infection. J. Allergy Clin. Immunol. 55:430441.
170. Schmidt, E. G.,, J. A. Alvarez-De Choudens,, N. McElvain,, F. J. Beardsley,, and S. A. A. Tawab. 1950. A microbiology study of Cryptococcus neoformans. Arch. Biochem. 26:1524.
171. Semerak, C. B. 1928. Torular leptomeningitis. Arch. Pathol. 6:11421145.
172. Shadomy, H. J., 1970. Clamp connections in two strains of Cryptococcus neoformans, p. 6772. In D. G. Ahearn (ed.), Recent Trends in Yeast Research. Georgia State University, Atlanta.
173. Shadomy, H. J.,, and H. I. Lurie. 1971. Histopathological observations in experimental cryptococcosis caused by hypha-producing strain of Cryptococcus neoformans in mice. Sabouraudia 9:69.
174. Shapiro, L. L.,, and J. B. Neal. 1925. Torula meningitis. Arch. Neurol. Psychiatr. 13:174190.
175. Sheppe, W. M. 1924. Torula infection in man. Am. J. Med. Sci. 167:91108.
176. Shields, A.,, and L. Ajello. 1966. Medium for selective isolation of Cryptococcus neoformans. Science 151:208209.
177. Skinner, C. E. 1950. Generic name for imperfect yeasts, cryptococcus or torulopsis? Am. Midland Nat. 43:242250.
178. Smith, F. B.,, and J. S. Crawford. 1930. Fatal granulomatosis of the central nervous system due to a yeast (torula). J. Pathol. Bacteriol. 33:291296.
179. Spickard, A.,, W. T. Butler,, V. Andriole,, and J. P. Utz. 1963. The improved prognosis of cryptococcal meningitis with amphotericin B therapy. Ann. Intern. Med. 58:6683.
180. Stoddard, J. L.,, and E. C. Cutler. 1916. Torula Infection in Man. Waverly Press, The Williams and Wilkins Co., Baltimore.
181. Stoetzner, H.,, and C. Kemmer. 1971. The morphology of Cryptococcus neoformans in human cryptococcosis—a light-, phase contrast, and electron microscopic study. Mycopathol. Mycol. Appl. 45:327335.
182. Stone, W. J.,, and B. F. Sturdivant. 1929. Meningo-encephalitis due to Torula histolytica. Arch. Intern. Med. 44:560575.
183. Sugar, A. M.,, and C. Saunders. 1988. Oral fluconazole as suppressive therapy of disseminated cryptococcosis in patients with acquired immunodeficiency syndrome. Am. J. Med. 85:481489.
184. Swift, H.,, and L. B. Bull. 1917. Notes on a case of systemic blastomycosis-blastomycotic cerebrospinal meningitis. Med. J. Aust. 13:265267.
185. Takeo, K.,, I. Uesaka,, K. Uehira,, and M. Nishiura. 1973. Fine structure of Cryptococcus neoformans grown in vivo as observed by freeze-etching. J. Bacteriol. 113:14491454.
186. Todd, R. L.,, and W. W. Herrmann. 1936. The life cycle of the organism causing yeast meningitis. J. Bacteriol. 32:89103.
187. Toffaletti, D. L.,, T. H. Rude,, S. A. Johnston,, D. T. Durack,, and J. R. Perfect. 1993. Gene transfer in Cryptococcus neoformans by means of Holistic delivery of DNA. J. Bacteriol. 175:14051411.
188. Torack, R. M. 1957. Fungus infections associated with antibiotic and steroid therapy. Am. J. Med. 22:872882.
189. Vanbreuseghem, R.,, and M. Takashio. 1970. An atypical strain of Cryptococcus neoformans (San Felice) Vuillemin 1894. Ann. SoC. Belg. Med. Trop. 50:695702.
190. Van Cutsem, J.,, J. Fransen,, F. Van Gerven,, and P. A. J. Janssen. 1986. Experimental cryptococcosis: ctissemination of Cryptococcus neoformans and dermtropism in guinea pigs. Mykosen 29:561575.
191. Varma, A.,, and K. J. Kwon-Chung. 1989. Restriction fragment polymorphism in mitochondrial DNA of Cryptococcus neoformans. J. Gen. Microbiol. 135:33533362.
192. Varma, A.,, D. Swinne,, F. Staib,, J. E. Bennett,, and K. J. Kwon-Chung. 1995. Diversity of DNA fingerprints in Cryptococcus neoformans. J. Clin. Microbiol. 33:18071814.
193. Vidotto, V.,, S. Aoki,, and G. Campanini. 1996. A vitamin-free minimal synthetic medium for Cryptococcus neoformans. Mycopathologia 133:139142.
194. Walter, J. E.,, and R. W. Atchison. 1966. Epidemiological and immunological studies of Cryptococcus neoformans. J. Bacteriol. 92:8287.
195. Walter, J. E.,, and E. G. Coffee. 1968. Control of Cryptococcus neoformans in pigeon coops by alkalization. Am. J. Epidemiol. 87:173178.
196. Wang, Y.,, and A. Casadevall. 1994. Decreased susceptibility of melanized Cryptococcus neoformans to UV light. Appl. Environ. Microbiol. 60:38643866.
197. Weidman, F. D.,, and W. Freeman. 1924. India ink in the microscopic study of yeast cells. JAMA 83:11631164.
198. Weidman, F. D.,, and H. L. Ratcliffe. 1934. Extensive generalized torulosis in a chetah or hunting leopard (Cynaelurus jubatus). Arch. Pathol. 18:362369.
199. Wilhelmj, C. M. 1925. The primary meningeal form of systemic blastomycosis. Am.J. Med. Sci. 169:712721.
200. Williams, J. R. 1922. A case of systemic blastomycosis. Med. J. Aust. 9:185188.
201. Williamson, J., D. J. F. Silverman,, C. T. Mallak,, and J. D. Christie. 1996. Atypical cytomorphologic appearance of Cryptococcus neoformans. Acta Cytol. 40:363379.
202. Williamson, P. R. 1994. Biochemical and molecular characterization of the diphenol oxidase of Cryptococcus neoformans: identification as a laccase. J. Bacteriol. 176:656664.
203. Wilson, D. E.,, J. E. Bennett,, and J. W. Bailey. 1968. Serologic grouping of Cryptococcus neoformans. ProC. SoC. Exp. Biol. Med. 127:820823.
204. Zerpa, R.,, L. Huicho,, and A. Guillen. 1996. Modified india ink preparation for Cryptococcus neoformans in cerebrospinal fluid specimens. J. Clin. Microbiol. 34:22902291.
205. Zimmerman, L. E.,, and H. Rappaport. 1954. Occurrence of cryptococcosis in patients with malignant disease of reticuloendothelial system. Am. J. Clin. Pathol. 24:10501072.
206. Zuger, A.,, E. Louie,, R. S. Holzman,, M. S. Simberkoff,, and J. J. Rahal. 1986. Cryptococcal disease in patients with the acquired immunodeficiency syndrome: diagnostic features and outcome of treatment. Ann. Intern. Med. 104:234240.
207. Zuger, A.,, M. Shuster,, M. S. Simberkoff,, J. J. Rahal,, and R. S. Holzman. 1988. Maintenance amphotericin B for cryptococcal meningitis in the acquired immunodeficiency syndrome (AIDS). Ann. Intern. Med. 109:592593.


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Table 1

Some names used to refer to and cyptococcosis in the literature

Citation: Casadevall A, Perfect J. 1998. Introduction to the Pathogen, p 1-27. In . ASM Press, Washington, DC. doi: 10.1128/9781555818241.ch1

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