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Chapter 10 : Animal Models and Veterinary Aspects of Cryptococcosis

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Abstract:

has been reported to cause infection in a wide variety of mammalian hosts. The clinical history of both natural and experimental animal cryptococcosis began over 100 years ago with the initial description of the pathogenic yeast. It was at this time in the late 19th century that experimental animal models of cryptococcosis were first used. Several pathological findings in this study were of further interest. Mice are extremely attractive for the study of cryptococcosis for two very important reasons. First, they provide both a very uniform set of immune responses and a wide variety of these responses in a series of inbred strains. The second reason that mice are attractive for the study of cryptococcosis is the ability to immunologically alter them, either genetically or through immunological reagents. Mouse models have also been used to dissect the importance of specific cell-mediated immunity in cryptococcosis. The rabbit is an interesting model for the study of cryptococcosis and has both positive and negative features for the study of cryptococcal pathogenesis. Although much of the discussion on animal model systems has emphasized the four major models, has also been inoculated into other animals.

Citation: Casadevall A, Perfect J. 1998. Animal Models and Veterinary Aspects of Cryptococcosis, p 325-350. In . ASM Press, Washington, DC. doi: 10.1128/9781555818241.ch10

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References

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1. Allen, V. K.,, and L. Lowbeer. 1945. Rectal ulcers with perirectal fistula as a port of entrance for Toruda encephalitis. South. Med. J. 38: 564 569.
2. Baro, T.,, J. M. Torres-Rodriquez,, M. Hermosa de Mendoza,, Y. Morera,, and C. Alia. 1998. First identification of autochthonous Cryptococcus neoformans var. gattii isolated from goats with predominantly severe pulmonary disease in Spain. J. Clin. Microbiol. 36: 458 461.
3. Barrie, M. T.,, and C. K. Stadler. 1995. Successful treatment of Cryptococcus neoformans infection in an Allen’s swamp monkey ( Allenopithecus nigroviridis) using fluconazole and flucytosine. J. Zool. Wildlife Med. 26: 109 114.
4. Barron, C. N. 1955. Cryptococcosis in animals. J. Am. Vet. Med. Assoc. 127: 125 132.
5. Barton, M. D.,, and I. Knight 1972. Cryptococcal meningitis of a horse. Aust. Vet. J. 48: 534.
6. Beehler, B. A. 1982. Oral therapy for nasal cryptococcosis in a cheetah. J. Am. Vet. Med. Assoc. 181: 1400 1401.
7. Bennett, J. E.,, W. Dismukes,, R. J. Duma,, G. Medoff,, M. A. Sande,, H. Gallis,, J. Leonard,, B. T. Fields,, M. Bradshaw,, H. Haywood,, Z. A. McGee,, T. R. Cate,, C. G. Cobbs,, J. F. Warner,, and D. W. Ailing. 1979. A comparison of amphotericin B alone and combined with flucytosine in the treatment of cryptococcal meningitis. N. Engl. J. Med. 301: 126 131.
8. Bergman, F. 1966. Effect of temperature on intratesticular cryptococcal infection in rabbits. Sabouraudia 5: 54 58.
9. Betty, M. J. 1977. Spontaneous cryptococcal meningitis in a group of guinea pigs caused by a hyphae-producing strain, J. Comp. Pathol. 87: 377 382.
10. Bistner, S.,, A. DeLahunta,, and M. Lorenz. 1971. Generalized cryptococcosis in a dog. Cornell Vet. 61: 440 457.
11. Blovin, P.,, and R. M. Cello. 1980. Experimental ocular cryptococcosis. Invest. Ophthalmol. Visual Sci. 19: 21 30.
12. Bollinger, A.,, and E. S. Finckh. The prevalence of cryptococcosis in thekoala ( Phascolarctos cinereus). Med. J. Aust. 14: 545 547.
13. Bonacini, M.,, J. Nussbaum,, and C. Ahluwalia. 1990. Gastrointestinal, hepatic and pancreatic involvement with Cryptococcus neoformans in AIDS. J. Clin. Gastroenterol. 12: 296 297.
14. Boulton, C. H.,, and L. Williamson. 1984. Cryptococcal granuloma associated with jejunal intussusception in a horse. J. Equine Vet. Sci. 16: 548 551.
15. Bovee, K. C.,, J. D. Conroy,, and S. A. Rosenthal. 1966. Cryptococcosis in a dog and treatment with amphotericin B. J. Am. Vet. Med. Assoc. 149: 49 55.
16. Buchanan, K. L.,, and J. W. Murphy. 1994. Regulation of cytokine production during the expression phase of the anticryptococcal delayed-type hypersensitivity response. Infect. Immun. 62: 2930 2939.
17. Cabanes, F. J.,, M. L. Abarca,, R. Bonavia,, M. R. Bragulat,, G. Castella,, and L. Ferrer. 1995. Cryptococcosis in a cat seropositive for feline immunodeficiency virus. Mycoses 38: 131 133.
18. Carter, H. S.,, and J. L. Young. 1950. Note on the isolation of Cryptococcus neoformans from a sample of milk. J. Pathol. Bacteriol. 62: 271 273.
19. Cauley, L. K.,, and J. W. Murphy. 1979. Response of congenital athymic (nude) and phenotypically normal mice to Cryptococcus neoformans infection. Infect. Immun. 23: 644 651.
20. Chang, Y. C.,, and K. J. Kwon-Chung. 1994. Complementation of a capsule-deficiency mutation of Cryptococcus neoformans restores its virulence. Mol. Cell. Biol. 14: 4912 4919.
21. Chapman, H. M.,, W. F. Robinson,, J. R. Bolton,, and J. R Robertson. 1990. Cryptococcus neoformans infection in goats. Aust. Vet. J. 67: 263 265.
22. Clemons, K. V.,, R. Azzi,, and D. A. Stevens. 1996. Experimental systemic cryptococcosis in SCID mice. J. Med. Vet. Mycol. 34: 331 335.
23. Clipsham, R. C.,, and J. O. Britt, Jr. 1983. Disseminated cryptococcosis in a macaw. J. Am. Vet. Med. Assoc. 183: 1303 1305.
24. Collett, M. G.,, A. S. Doyle,, F. Reyers,, T. Kruse,, and B. Fabian. 1987. Fatal disseminated cryptococcosis and concurrent ehrlichiosis in a dog. J. South Afr. Vet. Assoc. 58: 197 202.
24a. Cox, G. M.,, and J. R. Perfect. Unpublished data.
25. Crose, E.,, C. J. Marin-Kelle,, and C. Striegel. 1968. The use of tissue cultures in the identification of Cryptococcus neoformans from Columbia bats. Sabouraudia 6: 127 132.
26. Curtis, A. J. 1951. A case of torulosis in a domestic cat. Aust. J. Med. Tech. 1: 71.
27. Curtis, F. 1895. Note sur un nouveau parasite humain, megalococcus myxoides, trouvé dans un néoplasme de la région inguino-crurole. C.R. Soc. Biol. (Paris) 1895: 715 718.
28. Curtis, F. 1896. Contribution a l’étude de la saccharomycose humaine. Ann. Inst. Pasteur 10: 449 468.
29. Daly, J. S.,, K. A. Porter,, F. K. Chong,, and R. J. Robillard. 1990. Disseminated non-meningeal gastrointestinal cryptococcal infection in an HIV-negative patient. Am. J. Gastroenterol. 85: 1421 1424.
30. Denning, D.W.,, R. M. Tucker,, J. S. Hostetler,, S. Gill,, and D. A. Stevens,. 1990. Oral itraconazole therapy of cryptococcal meningitis and cryptococcosis in patients with AIDS, p. 305 324. In H. Vanden Bossche (ed.), Mycoses in AIDS Patients. Plenum Press, New York.
31. Diamond, R. D. 1977. Effects of stimulation and suppression of cell-mediated immunity on experimental cryptococcosis. Infect. Immun. 17: 187 194.
32. Diamond, R. D.,, J. E. May,, and M. A. Kane. 1974. The role of the classical and alternative complement pathways in host defense against Cryptococcus neoformans infection. J. Immunol. 112: 2260 2270.
33. Dixon, D. M.,, and A. Polak. 1986. In vivo and in vitro studies with an atypical, rhinotrophic isolate of Cryptococcus neoformans. Mycopathologia 96: 33 40.
34. Dromer, F.,, C. Perronne,, J. Borge,, J. L. Vilde,, and P. Yeni. 1989. Role of IgG and complement component C5 in the initial course of experimental cryptococcosis. Clin. Exp. Immunol. 78: 412 417.
35. Duke, S. S.,, and R. A. Fromtling. 1984. Effects of diethyl-stilbestrol and cyclophosphamide on the pathogenesis of experimental Cryptococcus neoformans infections. J. Med. Vet. Mycol. 22: 125 135.
36. Duperval, R., R E. Hermans, N. S. Brewer, and G. D. Roberts. 1977. Cryptococcosis, with emphasis on the significance of isolation of Cryptococcus neoformans from the respiratory tract. Chest 72: 13 19.
37. Emmons, C. W. 1955. Saprophytic sources of Cryptococcus neoformans associated with the pigeon. Am. J. Hyg. 62: 227 232.
38.Ensley, R K., C. E. Davis, M. P. Anderson, and K. C. Fletcher. 1979. Cryptococcosis in a male Beccari’s crowned pidgeon. J. Am. Vet. Med. Assoc. 175: 992994.
39. Faggi, E.,, G. Gargani,, C. Pizzirani,, S. Pizzirani,, and N. Saponetto. 1993. Cryptococcosis in domestic mammals. Mycoses 36: 165 170.
40. Felton, F. G.,, W. E. Maldonado,, H. G. Muchmore,, and E. R. Rhoades. 1966. Experimental cryptococcal infection in rabbits. Am. Rev. Respir. Dis. 94: 589 594.
41. Fen wick, B.,, K. Takushita,, and A. Wong. 1985. A moluccan cockatoo with disseminated cryptococcosis. J. Am. Vet. Med. Assoc. 187: 1218 1219.
42. Flatland, B.,, R. T. Greene,, and M. R. Lappin. 1996. Clinical and serologic evaluation of cats with cryptococcosis. J. Am. Vet. Med. Assoc. 209: 1110 1113.
43. Fromtling, R. A.,, G. K. Abruzzo,, and A. Ruiz. 1988. Cryptococcus neoformans: a central nervous system isolate from an AIDS patient that is rhinotropic in a normal mouse model. Mycopathologia 102: 72 86.
44. Frothingham, L. 1902. A tumor-like lesion in the lung of a horse caused by a blastomyces (torula). J. Med. Res. 3: 31 43.
45. Fujita, N. 1983. Experimental hematogenous endophthalmitis due to Cryptococcus neoformans. Invest. Ophthalmol. Visual Sci. 24: 368 375.
46. Gadebusch, H. H.,, and P. W. Gikas. 1965. The effect of cortisone upon experimental pulmonary cryptococcosis. Am. Rev. Respir. Dis. 92: 64 74.
47. Gales, N.,, G. Wallace,, and J. Dickson. 1985. Pulmonary cryptococcosis in a striped dolphin ( Stenella coeruleoalba). J. Wildlife Dis. 21: 443 446.
48. Gelatt, K. N.,, L. D. McGill,, and V. Perman. 1973. Ocular and systemic cryptococcosis in a dog. J. Am. Vet. Med. Assoc. 162: 370 375.
49. Gerds-Grogan, S.,, and B. Dayrell-Hart. 1997. Feline cryptococcosis: a retrospective evaluation. J. Am. Anim. Hosp. Assoc. 33: 118 122.
50. Goldman, D.,, S. C. Lee,, and A. Casadevall. 1994. Pathogenesis of pulmonary Cryptococcus neoformans infection in the rat. Infect. Immun. 62: 4755 4761.
51. Graybill, J. R.,, and D. J. Drutz. 1978. Host defense in cryptococcosis. II. Cryptococcosis in the nude mouse. Cell. Immunol. 40: 263 274.
52. Graybill, J. R.,, and L. Mitchell. 1978. Cyclophosphamide effects on murine cryptococcosis. Infect. Immun. 21: 674 677.
53. Green, J. R.,, and G. S. Bulmer. 1979. Gastrointestinal inoculation of Cryptococcus neoformans in mice. Sabouraudia 17: 233 240.
54. Greenlee, P. G.,, and E. Stephena. 1984. Meningeal cryptococcosis and ingestive cardiomyopathy in a ferret. J. Am. Vet. Med. Assoc. 184: 840 841.
55. Griner, L. A.,, and H. A. Walch. 1978. Cryptococcosis in Columbiformes at the San Diego Zoo. J. Wildlife Dis. 14: 389 394.
56. Hidore, M. R.,, and J. W. Murphy. 1986. Natural cellular resistance of beige mice against Cryptococcus neoformans. J. Immunol.. 137: 3624 3631.
57. Hubert, B. J.,, C. R. Huxtable,, and S. E. Pawley. 1980. Cryptococcal pneumonia in a horse. Aust. Vet. J. 56: 391 392.
58. Hill, F. I.,, A. J. Woodgyer,, and M. A. Lintott. 1995. Cryptococcosis in a North Island brown kiwi ( Apteryx australis mantelli) in New Zealand. J. Med. Vet. Mycol. 33: 305 309.
59. Hill, J. O. 1992. CD4+ T cells cause multinucleated giant cells to form around Cryptococcus neoformans and confine the yeast within the primary site of infection in the respiratory tract. J. Exp. Med. 175: 1685 1695.
60. Hill, J. O.,, and K. M. Aquirre. 1994. CD4+ T cell-dependent acquired state of immunity that protects the brain against Cryptococcus neoformans. J. Immunol. 152: 2344 2350.
61. Hill, J. O.,, and P. C. Dunn. 1993. A T-cell independent protective response against Cryptococcus neoformans expressed at the primary site of infection in the lung. Infect. Immun. 61: 5302 5308.
62. Holzworth, J. 1952. Cryptococcosis in a cat. Cornell Vet. 42: 12 15.
63. Huffnagle, G. B.,, M. F. Lipscomb,, J. A. Lovchik,, K. A. Hoag,, and N. E. Street. 1994. The role of CD4+ and CD8+ T cells in the protective inflammatory response to a pulmonary cryptococcal infection. J. Leukocyte Biol. 55: 35 42.
64. Huffnagle, G. B.,, J. L. Yates,, and M. F. Lipscomb. 1991. T cell-mediated immunity in the lung: a Cryptococcus neoformans pulmonary infection model using SCID and athymic nude mice. Infect. Immun. 59: 1423 1433.
65. Hutto, J. O.,, C. S. Bryan,, F. L. Greene,, C. J. White,, and J. I. Gallin. 1988. Cryptococcosis of the colon resembling Crohn’s disease in a patient with hyperimmunoglobulin E-recurrent infection (Job’s) syndrome. Gastroenterology 94: 808 812.
66. Jacobs, D. H.,, A. M. Mâcher,, R. Handler,, J. E. Bennett,, M. J. Collern,, and J. I. Gallin. 1984. Esophageal cryptococcosis in a patient with the hyperimmunoglobulin E-recurrent infection (Job’s) syndrome. Gastroenterology 87: 201 203.
67. Jacobs, G. J.,, L. Medleau,, C. Calvert,, and J. Brown. 1997. Cryptococcal infection in cats: factors influencing treatment outcome, and results of sequential serum antigen titers in 35 cats. J. Vet. Intern. Med. 11: 1 4.
68. Kligman, A. M.,, A. P. Crane,, and R. F. Norris. 1951. Effect of temperature on survival of chick embryos infected intravenously with Cryptococcus neoformans ( Torula histolytica). Am. J. Med. Sci. 221: 273 278.
69. Kligman, A. M.,, and F. D. Weidman. 1949. Experimental studies on treatment of human torulosis. Arch. Dermatol. Syph. 60: 726 741.
70. Kock, N. D.,, E. P. Lane,, F. Rowbotham,, A. Pawandiwa,, and F. W. Hill. 1991. Concurrent systemic cryptococcosis and haemangiosarcoma in a dog. J. Comp. Pathol. 104: 117 120.
71. Krick, J. A. 1981. Familial cryptococcal meningitis. J. Infect. Dis. 143: 133.
72. Kuttin, E. S.,, M. Feldman,, A. Nyska,, B. A. Weissman,, J. Muller,, and H. B. Levine. 1988. Cryptococcosis of the nasophauynx in mice and rats. Mycopathologia 101: 99 104.
73. Lichtensteiger, C. A.,, and L. E. Hilf. 1994. Atypical cryptococcal lymphadenitis in a dog. Vet. Pathol. 31: 493 496.
74. Lim, T. S.,, J. W. Murphy,, and L. K. Cauley. 1980. Host etiological agent interactions in intranasally and intraperitoneally induced cryptococcosis in mice. Infect. Immun. 29: 633 641.
75. Littman, M. L.,, and R. Borok. 1968. Relation of the pigeon to cryptococcosis: natural carrier state, heat resistance and survival of Cryptococcus neoformans. Mycopathologia 35: 329 345.
76. Littman, M. L.,, R. Borok,, and T. J. Dalton. 1965. Experimental avian cryptococcosis. Am. J. Epidemiol. 82: 197 207.
77. Littman, M. L.,, and L. E. Zimmerman. 1956. Cryptococcosis, Torulosis or European Blastomycosis, p. 38 46. Grune and Stratton, New York.
78. Lodge, J. K.,, E. Jackson-Machelski,, D. L. Toffaletti,, J. R. Perfect,, and J. I. Gordon. 1994. Targeted gene replacement demonstrates that myristoyl CoA: protein N-myristoyl-transferase is essential for the viability of Cryptococcus neoformans. Proc. Natl. Acad. Sci. USA 91: 12008 12012.
79. Louria, D. B.,, N. Fallon,, and H. G. Browne. 1960. The influence of cortisone on experimental fungus infections in mice. J. Clin. Invest. 39: 1435 1449.
80. Lovchik, J.,, J. Wilder,, M. F. Lipscomb,, R. Riblet,, and R. C. Lyons. 1996. The clearance rate of a pulmonary cryptococcal infection is determined by a gene on chromosome 12, abstr. 2:15. 3rd International Conference on Cryptococcus and Cryptococcosis, Paris.
81. Lutsky, I.,, and J. Brodish. 1964. Experimental canine cryptococcosis. J. Infect. Dis. 114: 273 276.
82. MacDonald, D. W.,, and H. C. Stretch. 1982. Canine cryptococcosis associated with prolonged corticosteriod therapy. Can. J. Vet. Res. 23: 200 202.
83. Malik, R.,, E. Dill-Mackey,, P. Martin,, D. I. Wigney,, D. B. Muir,, and D. N. Love. 1995. Cryptococcis in dogs: a retrospective study of 20 consecutive cases. J. Med. Vet. Mycol. 33: 291 297.
84. Malik, R.,, D. I. Wigney,, D. B. Muir,, D. J. Gregory,, and D. N. Love. 1992. Cryptococcosis in cats: clinical and mycological assessment of 29 cases and evaluation of treatment using orally administered fluconazole. J. Med. Vet. Mycol. 30: 133 144.
85.Malik, R, D. I. Wigney, D. B. Muir, and D. N. Love. 1997. Asymptomatic carriage of Cryptococcus neoformans in the nasal cavity of dogs and cats. J. Med. Vet. Mycol. 35: 2731.
86.Mancianti, E, C. Giannelli, M. Bendinelli, and A. Poli. 1992. Mycological findings in feline immunodeficiency virus-infected cats. J. Med. Vet. Mycol. 30: 257259.
87. Marcato, P. S. 1966. A case of Hodgkin’s disease associated with cryptococcosis in a dog. J. Small Anim. Pract. 7: 649 650.
88. Marquis, G.,, S. Montplaisir,, and M. Pelletier. 1985. Genetic resistance to murine cryptococcosis: the beige mutation (Chediak-Higashi syndrome) in mice. Infect. Immun. 47: 288 293.
89. Marquis, G.,, S. Montplaisir,, M. Pelletier,, S. Mousseau,, and P. Auger. 1985. Genetic resistance to murine cryptococcosis: increased susceptibility in the CBA/N XID mutant strain of mice. Infect. Immun. 47: 282 287.
90. McGrath, J. T. 1954. Cryptococcosis of the central nervous system in domestic animals. Am. J. Pathol. 30: 651.
91. McNamara, T. S., R A. Cook, J. L. Behler, L. Ajello, and A. A. Padhye. 1994. Cryptococcosis in a common anaconder (Eunectes murinus). J. Zool. Wildlife Med. 25: 128 132.
92. Medleau, L.,, C. E. Greene,, and P. M. Rakich. 1990. Evaluation of ketoconazole and itraconazole for treatment of disseminated cryptococcosis in cats. Am. J. Vet. Res. 51: 1454 1458.
93. Medleau, L.,, G. J. Jacobs,, and M. A. Marks. 1995. Itraconazole for the treatment of cryptococcosis in cats. J. Vet. Intern. Med. 9: 39 42.
94. Mehrotra, B. S. 1983. Cryptococcal mastitis in dairy animals. Mykosen 26: 615 616.
95. Mendoza, M. H.,, A. M. Garcia,, and L. Vizcaino. 1984. Spontaneous cryptococcosis in a pigeon. Arch. Zootech. 33: 27 41.
96. Meyer, K. F. 1914. A pathogenic blastomyces from the horse. Proc. Pathol. Soc. Phil. 16: 28.
97. Migaki, G.,, R. D. Gunnels,, and H. W. Casey. 1978. Pulmonary cryptococcosis in an Atlantic bottlenosed dolphin ( Tursiops truncatus). Lab. Anim. Sci. 28: 603 606.
97a.. Mitchell, T. G.,, and J. R. Perfect 1995. Cryptococcosis in the era of AIDS—100 years after the discovery of Cryptococcus neoformans. Clin. Microbiol. Rev. 8: 515 548.
98. Miyake, T.,, T. Veda,, and Y. Matsuura. 1978. A case of cryptococcosis in a sooty mangabey, Cercocebus torquatus atys. J. Jpn. Assoc. Zool. Gardens Aquariums 20: 4 6.
99. Mody, C. H.,, G. H. Chen,, C. Jackson,, J. L. Curtis,, and G. B. Toews. 1994. In vivo depletion of murine CD8 positive T-cells impairs survival during infection with a highly virulent strain of Cryptococcus neoformans. Mycopathologia 125: 7 17.
100. Mody, C. H.,, M. F. Lipscomb,, N. E. Street,, and -G. B. Toews. 1990. Depletion of CD4+ (L3T4+) lymphocytes in vivo impairs murine host defenses to Cryptococcus neoformans. J. Immunol. 144: 1472 1477.
101. Mody, C. H.,, G. B. Toews,, and M. F. Lipscomb. 1988. Cyclosporin A inhibits the growth of Cryptococcus neoformans in a murine model. Infect. Immun. 56: 7 12.
102. Mody, C. H.,, G. B. Toews,, and M. F. Lipscomb. 1989. Treatment of murine cryptococcosis with cyclosporin-A in normal and athymic mice. Am. Rev. Respir. Dis. 139: 8 13.
103. Nishimura, K.,, and M. Miyaji. 1979. Histopathological studies on experimental cryptococcosis in nude mice. Mycopathologia 68: 143 153.
104. Odom, A.,, M. Del Poeta,, J. Perfect,, and J. Heitman. 1997. The immunosuppressant FK506 and its non-immunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein. Antimicrob. Agents Chemother. 41: 156 161.
105. Odom, A.,, S. Muir,, E. Lim,, D. L. Toffaletti,, J. R. Perfect,, and J. Heitman. 1997. Calcineurin is required for virulence of Cryptococcus neoformans. EMBO J. 16: 2576 2589.
106. Pal, M. 1991. Feline meningitis due to Cryptococcus neoformans var. neoformans and review of feline cryptococcosis. Mycoses 34: 313 316.
107. Pal, M.,, G. D. Dube,, and B. S. Mehrota. 1984. Pulmonary cryptococcosis in a rhesus monkey (macaca mulatta). Mykosen 27: 309 312.
108. Pal, M.,, K. Ono,, R. Goitsuka,, and A. Hasegawa. 1990. Isolation of Cryptococcus neoformans var. neoformans from canine otitis. Mycoses 33: 465 467.
108a.. Perfect, J. R. Unpublished data.
109. Perfect, J. R. 1990. Fluconazole therapy for experimental cryptococcosis and candidiasis in the rabbit. Rev. Infect. Dis. 12(Suppl. 3): 299 302.
110. Perfect, J. R.,, and D. T. Durack. 1985. Effects of cyclosporine in experimental cryptococcal meningitis. Infect. Immun. 50: 22 26.
111. Perfect, J. R.,, and D. T. Durack. 1985. Chemotactic activity of cerebrospinal fluid in experimental cryptococcal meningitis. J. Med. Vet. Mycol. 23: 37 45.
112. Perfect, J. R.,, and D. T. Durack. 1985. Comparison of amphotericin B and N-D-ornithyl amphotericin B methyl ester in experimental crytococcal meningitis and Candida albicans endocarditis with pyelonephritis. Antimicrob. Agents Chemother. 28: 751 755.
113. Perfect, J. R.,, M. M. Hobbs,, D. L. Granger,, and D. T. Durack. 1988. Cerebrospinal fluid macrophage cytotoxicity: in vitro and in vivo correlation. Infect. Immun. 56: 849 854.
114. Perfect, J. R.,, S. D. R. Lang,, and D. T. Durack. 1981. Influence of agglutinating antibody in experimental cryptococcal meningitis. Br. J. Exp. Pathol. 62: 595 599.
115. Perfect, J. R.,, S. D. R. Lang,, and D. T. Durack. 1980. Chronic cryptococcal meningitis: a new experimental model in rabbits. Am. J. Pathol. 101: 177 194.
116. Perfect, J. R.,, and T. H. Rude. 1993. Identifying Cryptococcus neoformans by differential expression at the site of infection, abstr. L3, p. 24. 2nd International Conference on Cryptococcus and Cryptococcosis, Milan.
117. Perfect, J. R.,, D. V. Savani,, and D. T. Durack. 1986. Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and Candida pyelonephritis in rabbits. Antimicrob. Agents Chemother. 29: 579 583.
118. Perfect, J. R.,, D. L. Toffaletti,, and T. H. Rude. 1993. The gene encoding for phosphori-bosylaminoimidazole carboxylase (ADE2) is essential for growth of Cryptococcus neoformans in cerebrospinal fluid. Infect. Immun. 61: 4446 4451.
119. Perfect, J. R.,, and K. A. Wright. 1994. Amphotericin B lipid complex in the treatment of experimental cryptococcal meningitis and disseminated candidiasis. J. Antimicrob. Chemother. 33: 73 81.
120. Perfect, J. R.,, K. A. Wright,, M. M. Hobbs,, and D. T. Durack. 1989. Treatment of experimental cryptococcal meningitis and disseminated candidiasis with SCH 39304. Antimicrob. Agents Chemother. 33: 1735 1740.
121. Petrites-Murphy, M. B.,, L. A. Robbins,, J. M. Donahue,, and B. Smith. 1996. Equine cryptococcal endometritis and placentitis with neonatal cryptococcal pneumonia. J. Vet. Diagn. Invest. 8: 383 386.
122. Pounden, W. D.,, J. M. Amberson,, and R. F. Jaeger. 1952. A severe mastitis problem associated with Cryptococcus neoformans in a large dairy herd. Am. J. Vet. Res. 13: 121 128.
123. Ramadan, R. D.,, A. A. Faged,, and A. M. El-Hassan. 1989. Cryptococcosis in a camel ( Camelus dromedanus). Vet. Med. J. Giza 37: 77 82.
124. Ramos-Vara, J. A.,, L. Ferrer,, and J. Visa. 1994. Pathological findings in a cat with cryptococcosis and feline immunodeficiency virus infection. Histol. Histopathol. 9: 305 308.
125. Rebhun, W. C, and N. J. Edwards. 1977. Cryptococcosis involving the orbit of a dog. Vet. Med. Small Anim. Clin. 72: 1447 1450.
126.Reiss, E, and G. Szilagyi. 1965. Ecology of yeast-like fungi in a hospital population. Arch. Dermatol. 91: 611614.
127. Rhodes, J. C. 1985. Contribution of complement component C5 to the pathogenesis of experimental murine cryptococcosis. Sabouraudia 23: 225 234.
128. Rhodes, J. C, L. S. Wicker, and W. J. Urba. 1980. Genetic control of susceptibility to Cryptococcus neoformans in mice. Infect. Immun. 29: 494 499.
129. Rippon, J. W. 1988. Medical Mycology. The Pathogenic Fungi and the Pathogenic Actinomycetes. W.B. Saunders, Philadelphia.
130. Rosskopf, W. J., Jr.,, and R. W. Woespel. 1984. Cryptococcosis in a thick-billed parrot. Avian/Exotic Pract. 1: 14 18.
131.Roussilhon, C, J. . Postal, and P. Rauisse. 1987. Spontaneous cryptococcosis of a squirrel monkey ( Saimiri sciureus) in French Guyana. J. Med. Primatol. 16: 3947.
132. Ruiz, A.,, J. B. Neilson,, and G. S. Bulmer. 1982. Control of cryptococcus in nature by biotic factors. Sabouraudia 20: 21 29.
133. Saag, M. S.,, W. G. Powderly,, G. A. Cloud,, P. Robinson,, M. H. Grieco,, P. K. Sharkey,, S. E. Thompson,, A. Sugar,, C. U. Tuazon,, J. F. Fisher,, N. Hyslop,, J. M. Jacobson,, R. Hafner,, and W. F. Dismukes. 1992. Comparison of amphotericin B with fluconazole in the treatment of acute AIDS-associated cryptococcal meningitis. N. Engl. J. Med. 326: 83 89.
134. Saez, H.,, J. Rinjard,, and M. R. Battesti. 1978. Cryptococcosis in a fennec, Fennecus zerda. Characteristics and differentiation of Cryptococcus neoformans. Bull. Soc. Fr. Mycol. Med. 7: 69 72.
135. Salkowski, C. A.,, and E. Balish. 1990. Pathogenesis of Cryptococcus neoformans in congenitally immunodeficient beige athymic mice. Infect. Immun. 58: 3300 3306.
136. Salkowski, C. A.,, and E. Balish. 1991. Inflammatory responses to cryptococcosis in congenitally athymic mice. J. Leukocyte Biol. 49: 533 541.
137. Salkowski, C. A.,, and E. Balish. 1991. Cutaneous cryptococcosis in athymic and beige-athymic mice. Infect. Immun. 59: 1785 1789.
138. Salkowski, C. A.,, and E. Balish. 1991. Cryptococcosis in beige mice: the effect of congenital defects in innate immunity on susceptibility. Can. J. Microbiol. 37: 128 135.
139. Salkowski, C. A.,, K. F. Bartizal, Jr.,, M. J. Balish,, and E. Balish. 1987. Colonization and pathogenesis of Cryptococcus neoformans in gnotobiotic mice. Infect. Immun. 55: 2000 2005.
140. Sanfelice, F. 1894. Uber eine neuen Pathogenen Blastomyceten welcher innerhalb der Gewebe unter Bildung, kalkartig aussehender massendegeneriert. Zentralbl. Baktenol. Parasitol. Infekt. Hyg. 18: 521 526.
141. Sanfelice, F. 1895. Sull’azione patogena dei blastomiceti. Ann. Ig. 5: 239 262.
142. Scott, E. A.,, J. R. Duncan,, and J. E. McCormack. 1974. Cryptococcosis involving the postorbital area and frontal sinus in a horse. J. Am. Vet. Med. Assoc. 165: 626 627.
143. Seibold, H. R.,, C. S. Roberts, and E. M. Jordan. 1953. Cryptococcosis in a dog. J. Am. Vet. Med. Assoc. 122: 213 215.
144. Sethi, K. K.,, H. S. Randhawa,, S. Abraham,, and R. Viswanathan. 1967. Primary pulmonary canine cryptococcosis. Indian J. Chest Dis. 9: 222 224.
145. Sethi, K. K.,, and J. Schwartz. 1966. Experimental ocular cryptococcosis in pigeons. Am. J. Ophthalmol. 62: 95 98.
146. Siman, J.,, R. E. Nichols,, and E. V. Morse. 1953. An outbreak of bovine cryptococcosis. J. Am. Vet. Med. Assoc. 122: 31 35.
147. Singh, M.,, P. P. Gupta,, J. S. Rana,, and S. K. Jand. 1994. Clinico-pathological studies on experimental cryptococcal mastitis in goats. Mycopathologia 126: 147 155.
148. Skulski, G.,, and W. S. C. Symmers. 1954. Actiomycesis and torulosis in the ferret (Mustek furo). J. Comp. Pathol. Ther. 64: 306 311.
149. Sly, D. L.,, W. T. London,, A. E. Palmer,, and J. M. Rice. 1977. Disseminated cryptococcosis in a Patas monkey (Erythrocebus patas). Lab. Anim. Sci. 27: 694 699.
150. Smith, G. W.,, W. H. Mosberg,, L. O. J. Manganiello,, and J. A. Alvarez de Choudens. 1953. Torulosis of the central nervous system in the laboratory animal. Bull. Sch. Med. 38: 32 41.
151. Spencer, A.,, C. Ley,, P. Canfield,, P. Martin,, and R. Perry. 1993. Meningeocephalitis in a koala (Phascolarctos cinereus) due to Cryptococcus neoformans var gattii infection. J. Zool. Wildlife Med. 24: 519 22.
152. Staib, F. 1962. Cryptococcus neoformans beim Kanarienvogel. Zentralbl. Baktenol. 185: 129 134.
153. Staib, F.,, W. Weller,, S. Brem,, R. Schindlmayr,, and E. Schmittdial. 1985. A Cryptococcus neoformans strain from the brain of a wildlife fox ( Vulpes vulpes) suspected of rabies: mycological observations and comments. Zentralbl. Baktenol. Mikrobiol. Hyg. 260: 566 571.
154. Stoddard, J. L.,, and E. C. Cutler. 1916. Torula Infection in Man, p. 1 98. Monograph no. 6. Rockefeller Institute for Medical Research, New York.
155. Strippoli, V.,, N. Simonetti,, and A. Cassone. 1978. Effect of a tetracycline antibiotic on experimental pathogenicity of Cryptococcus neoformans. Chemotherapy 24: 290 296.
156. Swinne, D.,, K. Kayembe,, and M. Niyimi. 1986. Isolation of saprophytic Cryptococcus neoformans var. neoformans in Kinshasa, Zaire. Ann. Soc. Belg. Med. Trop. 66: 57 61.
157. Swinne-Desgain, D. 1976. Cryptococcus neoformans in the crops of pigeons following its experimental administration. Sabouraudia 14: 313 317.
158. Takos, M. J. 1956. Experimental cryptococcosis produced by the ingestion of virulent organisms. N. Engl. J. Med. 254: 598 601.
159. Takos, M. J.,, and N. W. Elton. 1953. Spontaneous cryptococcosis of marmoset monkeys in Panama. Arch. Pathol. Lab. Med. 55: 403 407.
160. Tell, L.,, and M. Bush. 1993. Cryptococcosis in tree shrews (tupaia tana and tupaia minor) and elephant shrews (macroscelides proboscides), p. 49 50. Proc. Am. Assoc. Zoo Vet.
161. Tell, L. A.,, D. K. Nichols,, W. P. Fleming,, and M. Bush. 1997. Cryptococcus in tree ( Tupaia tana and Tupaia minor) and elephant shrews ( Macroscelides proboscides). J. Zool. Wildlife Med. 28: 175 181.
162. Tortelly, R.,, A. Grune,, G. M. D. Paiva,, and M. D. Rossi. 1979. Spontaneous cryptococcosis in the laboratory mouse. Cientifica Brazil 6: 125 127.
163. Van Cutsem, J.,, J. Fransen,, F. Van Gerven,, and P. A. J. Janssen. 1986. Experimental cryptococcosis: dissemination of Cryptococcus neoformans and dermatropism in guinea pigs. Mykosen 29: 561 575.
164. Van der Gaag, L.,, M. H. van Niel,, B. E. Belshaw,, and W. T. Wolvekamp. 1991. Gastric granulomatous cryptococcosis mimicking gastric carcinoma in a dog. Vet. Q. 13: 185 190.
165. Vuillemin, P. 1901. Les blastomycetes pathogenes. Rev. Gen. Sci. Pures Appl. 12: 732 751.
166. Walker, C.,, R. Malik,, and P. J. Canfield. 1995. Analysis of leucocytes and lymphocytes in cats with naturally-ocaimng cryptococcosis, but differing feline immunodeficiency virus status. Aust. Vet. J. 72: 93 97.
167. Weidman, F. D.,, and H. L. Ratcliffe. 1934. Extensive generalized torulosis in a cheetah or hunting leopard ( Crynaelurus jabatus). Arch. Pathol. 18: 362 369.
168. Weiss, C.,, I. H. Perry,, and M. C. Sheury. 1948. Infections of the human eye with Cryptococcus neoformans: a clinical and experimental study with a new diagnostic method. Arch. Ophthalmol. 39: 739 751.
169. Weitzman, I.,, P. Bonaparte,, V. Guevin,, and M. Crist. 1973. Cryptotoccosis in a field mouse. Sabouraudia 11: 77 79.
170. Welsh, R. D.,, and E. L. Stair. 1995. Cryptococcal meningitis in horse. J. Equine Vet. Sci. 15: 80 82.
171. Yinnon, A. M.,, B. Rudensky,, E. Sagi,, G. Brever,, C. Brautbar,, I. Polacheck,, and J. Halevy. 1997. Invasive cryptococcosis in a family with epidermodysplasia verruciformis and idiopathic CD4 cell depletion. Clin. Infect. Dis. 25: 1252 1253.

Tables

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Table 1

Cryptococcosis in mammals (natural infection)

Citation: Casadevall A, Perfect J. 1998. Animal Models and Veterinary Aspects of Cryptococcosis, p 325-350. In . ASM Press, Washington, DC. doi: 10.1128/9781555818241.ch10
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Table 2

Animal model characteristics for cryptococcosis of the four major species

Abbreviations: MNCs, mononuclear cells; NK, natural killer cells; PMNs, polymorphonuclear cells.

There are numerous references in the literature in which a variety of mouse strains were used, from outbred Swiss mice to a series of inbred strains.

Citation: Casadevall A, Perfect J. 1998. Animal Models and Veterinary Aspects of Cryptococcosis, p 325-350. In . ASM Press, Washington, DC. doi: 10.1128/9781555818241.ch10
Generic image for table
Table 3

Advantages and disadvantages of the primary animal models for cryptococosis

Citation: Casadevall A, Perfect J. 1998. Animal Models and Veterinary Aspects of Cryptococcosis, p 325-350. In . ASM Press, Washington, DC. doi: 10.1128/9781555818241.ch10

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