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Chapter 13 : Human Cryptococcosis

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Abstract:

In the first 100 years of clinical cases of , the infection was described in most organs of the human and animal host. The clinical presentations of human cryptococcosis may be varied, and because of the variety of signs and symptoms, clinical diagnosis without laboratory studies can be difficult at times in both high- and low-risk patients. Clinical manifestations by organ system and demonstrates the breadth of clinical signs attributed to such as central nervous system (CNS), lung and skin. The relative differences in frequency of clinical symptoms and findings are compared in patients with or without human immunodeficiency virus (HIV) infection. A new factor in liver transplants has been the use of tacrolimus and its possible effect on cryptococcosis. It is known that all the immunophilins (cyclosporine, tacrolimus, and sirolimus) have anticryptococcal activity in vitro, but the effect of these medications on human cryptococcosis in this group remains uncertain. A review of pulmonary infections in immunocompromised patients prior to the AIDS epidemic described 34 of 41 patients with pulmonary cryptococcosis who had an underlying immunocompromised condition other than HIV. The most common radiographic findings (in order of frequency of occurrence) were alveolar or interstitial infiltrates, single or multiple-coin lesions, masses, cavitary lesions, and pleural effusions. A clinical principle emphasized in this study is that immunocompromised patients with pulmonary cryptococcosis frequently have disseminated infection and always require antifungal therapy. In animals, strains have been identified that appear to localize/produce infection directly in skin tissue.

Citation: Casadevall A, Perfect J. 1998. Human Cryptococcosis, p 407-456. In . ASM Press, Washington, DC. doi: 10.1128/9781555818241.ch13

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References

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1. Aberg, J. A.,, and W. G. Powderly. 1997. Cryptococcosis. Adv. Pharmacol 37: 215 251.
2. Aitken, G. W.,, and E. M. Symonds. 1962. Cryptococcal meningitis in pregnancy treated with amphotericin B. Br. J. Obstet. Gynaecol 69: 677 679.
3. Alfonso, F.,, L. Gallo,, B. Winkler,, and M. J. Suhrhand. 1994. Fine needle aspiration cytology of peripheral lymph node cryptococcosis: a report of three cases. Acta Cytol. 38: 459 462.
4. Allcock, E. A. 1961. Torulosis. J. Bone Joint Surg. 43: 71 76.
5. Allen, V. K.,, and L. Lowbeer. 1945. Rectal ulcers with perirectal fistula as a port of entrance for Torula encephalitis. South. Med. J. 38: 564 569.
6. Allende, M.,, P. A. Pizzo,, M. Horowitz,, H. I. Pass,, and T. J. Walsh. 1993. Pulmonary cryptococcosis presenting as metastases in children with sarcomas. Pediatr. Infect. Dis. J. 12: 240 243.
7. Alonso-Villaverde, C.,, S. Hernandez-Flix,, R. Tomas,, and L. Masana. 1992. Occurrence of pneumothorax and pneumomediastinum in a patient with AIDS and pulmonary infection caused by Pneumocystis carinii and Cryptococcus neoformans. Reo. Clin. Esp. 191: 397 398.
8. Al-Rasheed, S. A.,, and I. M. Al-Fawaz. 1990. Cryptococcal meningitis in a child with systemic lupus erythematosus. Ann. Trop. Paediatr. 10: 323 326.
9. Andreula, C. E.,, N. Burdi,, and A. Carella. 1993. CNS cryptococcosis in AIDS: spectrum of MR findings. J. Comput. Assist. Tomogr. 17: 438 441.
10. Antony, S. A.,, and S. J. Antony. 1995. Primary cutaneous cryptococcus in nonimmunocompromised patients. Cutis 56: 96 98.
11. Armonda, R. A.,, J. M. Fleckenstein,, B. Brandvold,, and S. L. Dndra. 1993. Cryptococcal skull infection: a case report with review of the literature. J. Neurosurg. 32: 1034 1036.
12. Atkinson, A. J.,, and J. E. Bennett. 1968. Experience with a new skin test antigen prepared from Cryptococcus neoformans. Am. Rev. Respir. Dis. 97: 637 643.
13. Bahls, E.,, and S. M. Sumi. 1986. Cryptococcal meningitis and cerebral toxoplasmosis in a patient with acquired immune deficiency syndrome. J. Neurol. Neurosurg. Psychiatr. 49: 328 330.
14. Baird, R. W.,, and A. S. Garfield. 1994. Cavitation in an immunocompetent man. Am. J. Med. 97: 309 311.
15. Baker, R. D. 1976. The primary pulmonary lymph node complex of cryptococcosis. Am. J. Clin. Pathol 65: 83 92.
16. Baker, R. D.,, and R. K. Haugen. 1955. Tissue changes and tissue diagnosis of cryptococcosis: a study of 26 cases. Am. J. Pathol. 25: 14.
17. Banerjee, U.,, K. Gupta,, and P. Venugopal. 1997. A case of prosthetic valve endocarditis caused by Cryptococcus neoformans var. neoformans. J. Med. Vet. Mycol. 35: 139 141.
18. Barber, B. A.,, J. M. Crotty,, R. G. Washburn, and R S. Pegram. 1995. Cryptococcus neoformans myositis in a patient with AIDS. Clin. Infect. Dis. 21: 1510 1511.
19. Bayer, A. S.,, C. Choi,, and D. B. Tillman. 1980. Fungal arthritis. V. Cryptococcal and histoplasmal arthritis. Semin. Arthritis Rheum. 9: 218.
20. Beeson, R. B. 1952. Cryptococcic meningitis of nearly sixteen years' duration. Arch. Intern. Med. 89: 797 801.
21. Behrman, R. E.,, J. R. Masci, and R Nicholas. 1990. Cryptococcal skeletal infections: case report and review. Rev. Infect. Dis. 12: 181 190.
22. Bennett, J. E. 1981. Cryptococcal skin test antigen: preparation variables and characterization. Infect. Immun. 32: 373 380.
23. Bennington, J. L.,, S. L. Haber,, and N. L. Morgenstern. 1964. Increased susceptibility to cryptococcosis following steroid therapy. Dis. Chest 45: 262.
24. Berger, S. A.,, D. A. Waitman,, and R. Baruch. 1992. Coulter counter identifies Cryptococcus neoformans as leukocytes. A case of pseudopleocytosis. Am. J. Clin. Pathol. 97: 663 664.
25. Bernard, G.,, R. C. Gryschek,, A. J. Duarte,, and M. A. Shikanai-Yasuda. 1996. Cryptococcosis as an opportunistic immunodeficiency secondary to paracoccidioidomycosis. Mycopathologia 133: 65 69.
26. Beyt, B. E.,, and S. R. Waitman. 1978. Cryptococcal endophthalmitis after corneal transplantation. N. Engl J. Med. 298: 825 826.
27. Birkmann, L. W.,, and D. R. Bennett. 1988. Meningoencephalitis following evaluation for cryptococcal endophthalmitis. Ann. Neurol 4: 476 477.
28. Bisseru, B.,, A. Bajaj,, R. H. Carruthers,, and H. N. Chhabra. 1983. Pulmonary and bilateral retinochoroidal cryptococcosis. Br. J. Opthalmol 67: 157 161.
29. Blackie, J. D.,, G. Danta,, T. Sorrell,, and P. Collignon. 1985. Ophthalmological complications of cryptococcal meningitis. Clin. Exp. Neurol 21: 263.
30. Blanc, M.,, R. Leuenberger,, and G. Favez. 1982. Cryptococcose pulmonaire invasive isolé. Presentation d'un cas. Schweiz. Med. Wochenschr. 112: 421 424.
31. Blocker, K. S.,, J. A. Weeks,, and R. C. Noble. 1987. Cutaneous cryptococcal infection presenting as valvular lesion. Genitourin. Med. 63: 341 343.
32. Boden, W. E.,, A. Fisher,, A. Medeiros,, I. Benham,, and M. T. McEnany. 1983. Biopros-thetic endocarditis due to Cryptococcus neoformans. J. Cardiovasc. Surg. 24: 164 166.
33. Bohne, T.,, A. Sander,, A. Pfister-Wartha,, and E. Schopf. 1996. Primary cutaneous cryptococcosis following trauma of the right forearm. Mycoses 39: 457 459.
34. Bonacini, M.,, J. Nussbaum,, and C. Ahluwalia. 1990. Gastrointestinal, hepatic and pancreatic involvement with Cryptococcus neoformans in AIDS. J. Clin. Gastroenterol 12: 296 297.
35. Borton, L.K.,, and B. U. Wintroub. 1984. Disseminated cryptococcosis presenting as herpetiform lesions in a homosexual man with acquired immunodeficiency syndrome. J. Am. Acad. Dermatol 10: 387 390.
36. Bosch, X.,, R. Ramon,, J. Font,, X. Alemary,, and A. Coca. 1994. Bilateral cryptococcosis of the hip. A case report, J. Bone Joint Surg. 76: 1234 1238.
37. Bottone, E. J.,, I. F. Salkin,, N. J. Hurd,, and G. P. Wormser. 1987. Serogroup distribution of Cryptococcus neoformans in patients with AIDS. J. Infect. Dis. 156: 242.
38. Bottone, E. J.,, M. Toma,, B. E. Johansson,, and G. P. Wormser. 1985. Capsule-deficient Cryptococcus neoformans in AIDS patients. Lancet ii: 553.
39. Bozzette, S. A. 1993. The management of cryptococcal disease in patients with AIDS. Curr. Clin. Top. Inject. Dis. 13: 250 268.
40. Braman, R. T. 1981. Cryptococcosis (torulopsis) of prostate. Urology 17: 284 286.
41. Braun, D. K.,, D. A. Janssen,, J. R. Marcus,, and C. A. Kauffman. 1994. Cryptococcal infection of a prosthetic dialysis fistula. Am. J. Kidney Dis. 24: 864 867.
42. Britt, R. H.,, D. R. Enzmann,, and J. S. Remington. 1981. Intracranial infection in cardiac transplant recipients. Ann. Neurol. 9: 107.
43. Brivet, E.,, J. Livartowski,, P. Herve,, B. Rain,, and J. Dormont. 1987. Pericardial cryptococcal disease in acquired immunodeficiency syndrome. Am. J. Med. 82: 1273.
44. Buschke, A. 1895. Ueber eine durch Coccidien hemorgerufene Krankheit des Men-schen. Dtsch. Med. Wochenschr. 21: 14.
45. Busse, O. 1894. Ueber parasitâre Zelleinschulusse and ihre Zuchtung. Int. J. Med. Microbiol. 16: 175 180.
46. Cameron, M. L.,, J. A. Bartlett,, H. A. Gallis,, and H. A. Waskin. 1991. Manifestations of pulmonary cryptococcosis in patients with acquired immunodeficiency syndrome. Rev. Infect. Dis. 13: 64 67.
47. Campbell, G. D. 1966. Primary pulmonary cryptococcosis. Am. Rev. Respir. Dis. 94: 236 243.
48. Campbell, G. D.,, R. D. Currier,, and J. E. Busey. 1981. Survival in untreated cryptococcal meningitis. Neurology 31: 1154 1157.
49. Carter, E. A.,, D. W. Henderson,, J. McBride,, and M. R. Sage. 1992. Case report: complete lung collapse: an unusual presentation of cryptococcosis. Clin. Radiol. 46: 292 294.
50. Cary, C. F.,, L. Mueller,, C. L. Fotopoulos,, and L. Dall. 1991. Bronchitis obliterans-organizing pneumonia associated with Cryptococcus neoformans infection. Rev. Infect. Dis. 13: 1253 1254.
51. Casadevall, A. J.,, J. Mukherjee,, R. Ruong,, and J. R. Perfect. 1994. Management of Cryptococcus neoformans contaminated needle injuries. Clin. Infect. Dis. 19: 951 953.
52. Castaldo, P. 1991. Clinical spectrum of fungal infections after orthotopic liver transplantation. Arch. Surg. 126: 149.
53. Castavon-Olivares, L. R.,, R. Lopez-Martinez,, G. Barriga-Angulo,, and C. Rios-Rosas. 1997. Cryptococcus neoformans var. gattii in an AIDS patient: first observation in Mexico. J. Med. Vet. Mycol. 35: 57 59.
54. Castillo, J. L. M.,, G. Del Negro,, and E. Heins-Vaccari. 1986. Primary cutaneous cryptococcosis. Mycopathologia 96: 25 28.
55. Cawley, E. P.,, R. H. Grekin,, and A. C. Curtis. 1950. Torulosis, a review of the cutaneous and adjoining mucous membrane manifestations. J. Invest. Dermatol. 14: 327 341.
56. Chechani, V.,, and S. L. Kamholz. 1990. Pulmonary manifestations of disseminated cryptococcosis in patients with AIDS. Chest 98: 1060 1066.
57. Chen, C. K.,, D. Y. Chang,, S. C. Chang,, E. F. Lee,, S. C. Huang,, and S. N. Chow. 1993. Cryptococcal infection of the vagina. Obstet. Gynecol. 81: 867 869.
58. Chen, C. P.,, and K. G. Wang. 1996. Cryptococcal meningitis in pregnancy. Am. J. Perinatol. 13: 35 36.
59. Chernik, N. L.,, D. Armstrong,, and J. B. Posner. 1973. Central nervous system infections in patients with cancer. Medicine 52: 563 581.
60. Chiewchanvit, S.,, B. Chuaychoo,, and P. Mahanupab. 1994. Disseminated cryptococcosis presenting as molluscum-like lesions in three male patients with acquired immunodeficiency syndrome. J. Med. Assoc. Thai. 77: 322 326.
61. Chleboun, J.,, and S. Nade. 1977. Skeletal cryptococcosis. J. Bone Joint Surg. 59: 509 514.
62. Cholasani, N.,, C. M. Wilcox,, H. T. Hunter,, and D. A. Schwartz. 1997. Endoscopic features of gastroduodenal cryptococcosis in AIDS. Gastrointest. Endose. 45: 315 317.
63. Chotmongkol, V.,, and S. Siricharoensang. 1991. Cryptococcal meningitis in pregnancy: a case report. J. Med. Assoc. Thai. 74: 421 422.
64. Chotmongkol, V.,, and A. Sookprasert. 1992. Itraconazole in cryptococcal meningitis in pregnancy: a case report. J. Med. Assoc. Thai. 75: 606 608.
65. Christoph, I. 1990. Pulmonary Cryptococcus neoformans and disseminated Nocardia brasiliensis in an immunocompromised host. N.C. Med. J. 51: 219 220.
66. Chuck, S. L.,, and M. A. Sande. 1989. Infections with Cryptococcus neoformans in the acquired immunodeficiency syndrome. N. Engl. J. Med. 321: 794 799.
67. Claman, H. N. 1972. Corticosteroids and lymphoid cells. N. Engl. J. Med. 287: 388.
68. Clark, R. A.,, D. Greer,, W. Atkinson,, G. T. Valainis,, and N. Hyslop. 1990. Spectrum of Cryptococcus neoformans infection in 68 patients infected with acquired immunodeficiency virus. Rev. Infect. Dis. 12: 768 777.
69. Clark, R. A.,, D. L. Greer,, G. T. Valainis,, and N. E. Hyslop. 1990. Cryptococcus neoformans pulmonary infection in HIV-1-infected patients, J. Acquired Immune Defic. Syndr. 3: 480 485.
70. Cobcroft, R.,, H. Kronenberg,, and I. Wilkinson. 1978. Cryptococcus in bagpipes. Lancet i: 1368 1369.
71. Cohen, D. B.,, and B. J. Glasgow. 1993. Bilateral optic nerve cryptococcosis in sudden blindness in patients with acquired immune deficiency syndrome. Ophthalmology 100: 1689 1694.
72. Cohen, I. 1985. Isolated pulmonary cryptococcosis in a young adolescent. Pediatr. Infect. Dis. J. 4: 416 419.
73. Colavecchio, A.,, G. Cannatelli,, F. Dubini,, and L. Riviera. 1993. Bone marrow cryptococcosis as the first manifestation of AIDS. Pathologica 85: 411 415.
74. Collins, J. V.,, D. Tong,, and R. G. Bucknel. 1972. Cryptococcal meningitis as a complication of systemic lupus erythematosus treated with systemic corticosteroids. Post-grad. Med. J. 48: 52.
75. Collins, P.,, A. Gelhom,, and J. R. Trimble. 1951. The coincidence of cryptococcus and diseases of the reticuloendothelial and lymphatic systems. Cancer 4: 883.
76. Colmers, R. A.,, W. Imiger,, and D. H. Steinberg. 1967. Cryptococcus neoformans endocarditis cured by amphotericin B. JAMA 199: 762.
77. Conçus, A. P.,, R. F. Helfand,, M. J. Imber,, S. A. Lerner,, and R. J. Sharpe. 1988. Cutaneous cryptococcosis mimicking Molluscum contagiosum in a patient with AIDS. J. Infect. Dis. 158: 897 898.
78. Conti, D. J.,, N. E. Tolkoff-Rubin,, and G. P. Baker, Jr. 1989. Successful treatment of invasive fungal infections with fluconazole in organ transplant recipients. Transplantation 48: 692 695.
79. Cornell, S. H.,, and C. G. Jacoby. 1982. The varied computed tomographic appearance of intracranial cryptococcosis. Radiology 143: 703 707.
80. Corpe, R. F.,, and L. H. Parr. 1953. Pulmonary torulosis complicating pulmonary tuberculosis treated by resection. J. Thorac. Cardiovasc. Surg. 27: 392 398.
81. Crotty, J. M. 1965. Systemic mycotic infections in Northern Territory Aborigines. Med. J. Aust. 1: 184 186.
82. Crump, J. R.,, S. G. Elner,, V. M. Elner,, and C. A. Kauffman. 1992. Cryptococcal endophthalmitis: case report and review. Clin. Infect. Dis. 14: 1069 1073.
83. Curole, D. N. 1981. Cryptococcal meningitis in pregnancy. J. Reprod. Med. 26: 317 319.
84. Curtis, P. H.,, J. A. Haller,, and E. de Juan. 1995. An unusual case of cryptococcal endophthalmitis. Retina 15: 300 304.
85. Dabe, S. S.,, and R. A. Fromtling. 1984. Effects of diethylstibestrol and cyclophosphamide on pathogenesis of experimental Cryptococcus neoformans infections. J. Med. Vet. Mycol. 22: 125.
86. Dalgleish, A. G. 1981. Concurrent hydatid disease and cryptococcosis in a 16-year-old girl. Med. J. Aust. 2: 144 145.
87. Davies, S. E.,, and G. A. Sarosi. 1987. Role of serodiagnostic tests and skin tests in the diagnosis of fungal disease. Clin. Chest Med. 8: 135 146.
88. Dean, J. L.,, J. E. Wolfe,, A. C. Ranzini,, and M. A. Laughlin. 1994. Use of amphotericin B during pregnancy: case report and review. Clin. Infect. Dis. 18: 364 368.
89. deLalla, E.,, A. Vaglia,, M. Franzettí,, V. Manfrin,, G. P. PeUizer,, and P. Fabris. 1993. Cryptococcal pleural effusion as first indicator of AIDS: a case report. Infection 21: 192.
90. Denning, D. W.,, R. W. Armstrong,, M. Fishman,, and D. A. Stevens. 1991. Endophthalmitis in a patient with disseminated cryptococcosis and AIDS who was treated with itraconazole. Rev. Infect. Dis. 13: 1126 1130.
91. Denning, D. W.,, R. W. Armstrong,, B. H. Lewis,, and D. A. Stevens. 1991. Elevated cerebrospinal fluid pressures in patients with cryptococcal meningitis and acquired immunodeficiency syndrome. Am. J. Med. 91: 267 272.
92. Desmet, P.,, K. D. Kayembe,, and C. DeVroey. 1989. The value of cryptococcal serum antigen screening among HIV positive AIDS patients in Kinshasa, Zaire. AIDS 3: 77 78.
93. Diamond, R. D. 1977. Effects of stimulation and suppression of cell-mediated immunity on experimental cryptococcosis. Infect. Immun. 17: 187 194.
94. Diamond, R.D.,, and J. E. Bennett1974. Prognostic factors in cryptococcal meningitis, a studyof 111 cases. Ann. Intern. Med. 80: 176 181.
95. Diamond, R.D.,, and S. M. Levitz,. 1988. Cryptococcusneoformans pneumonia, p. 457 471. In J. E. Pennington (ed.), Respiratory Infections: Diagnosis and Management. Raven Press, New York.
96. Dismukes, W. E. 1988. Cryptococcal meningitis in patients with AIDS. J. Infect. Dis. 157: 624 628.
97. Doft, B.H.,, and V. T. Curtin. 1982. Combined ocular infectionwith cytomegalovirus and cryptococcosis. Arch. Ophthalmol. 100: 1800 1803.
98. Douketis, J. O.,, and S. Kesten. 1993. Miliary pulmonary cryptococcosis in a patient with the acquired immunodeficiency syndrome. Thorax 48: 402 403.
99. Driver, J. A.,, C. A. Saunders,, B. Heinze-Lacey,, and A. M. Sugar. 1995. Cryptococcal pneumonia in AIDS: is cryptococcal meningitis preceded by clinically recognizable pneumonia? J. Acquired Immune Defic. Syndr. Hum. Retrovirol. 9: 168 171.
100. Dromer, F.,, S. Mathoulin,, B. Dupont,, and A. Laporte. 1996. Epidemiology of cryptococcus in France: a 9-year survey. Clin. Infect. Dis. 23: 82 90.
101. Dromer, F.,, S. Mathoulin,, B. Dupont,, L. Letenneur,, and O. Ronin. 1996. Individual and environmental factors associated with infection due to Cryptococcus neoformans serotype D. Clin. Infect. Dis. 23: 91 96.
102. Dubois, E. L. 1976. Lupus Erythematosus. University of Southern California Press, Los Angeles.
103. Duperval, R.,, P. E. Hermans,, N. S. Brewer,, and G. D. Roberts. 1977. Cryptococcosis, with emphasis on the significance of isolation of Cryptococcus neoformans from the respiratory tract. Chest 72: 13 19.
104. Edwards, V. E.,, J. M. Sutherland,, and J. H. Tyrer. 1970. Cryptococcosis of the central nervous system. J. Neurol. Neurosurg. Psychiatr. 33: 415 425.
105. Ellis, D. H.,, and T. J. Pfeiffer. 1990. Natural habitat of Cryptococcus neoformans var. gattii. J. Clin. Microbiol. 28: 1642 1644.
106. Ellner, J. J.,, and J. E. Bennett. 1976. Chronic meningitis. Medicine 55: 341 369.
107. Ely, E. W.,, J. E. Peacock,, E. F. Haponik,, and R. G. Washburn. 1998. Cryptococcal pneumonia complicating pregnancy: case series and review of 24 published cases of cryptococcosis during pregnancy. Medicine, in press.
108. Emmanuel, B.,, E. Ching,, A. D. Lieberman,, and M. Goldin. 1961. Cryptococcus meningitis in a child successfully treated with amphotericin B with a review of the pediatric literature. J. Pediatr. 59: 577 591.
109. Emmons, W. W.,, S. Luchsinger,, and L. Miller. 1995. Progressive pulmonary cryptococcosis in a patient who is immunocompetent. South. Med. J. 88: 657 660.
111. Eng, R. H. K.,, E. Bishburg,, S. M. Smith,, and R. Kapila. 1986. Cryptococcal infections in patients with acquired immune deficiency syndrome. Am. J. Med. 81: 19 23.
112. Ennis, D. M.,, and M. S. Saag. 1993. Cryptococcal meningitis in AIDS. Hosp. Pract. 28: 99 112.
113. Epstein, R.,, R. Cole,, and K. K. Hunt. 1972. Pleural effusion secondary to pulmonary cryptococcosis. Chest 61: 296.
114. Falconer, H.,, S. I. Terry,, and H. Spencer. 1980. Cryptococcosis in the West Indies. West Indian Med. J. 29: 142.
115. Feigin, D. S. 1983. Pulmonary cryptococcosis: radiologie-pathologie correlates of its three forms. Am. J. Roentgenol. 141: 1263 1272.
116. Feldman, R. 1959. Cryptococcosis (torulosis) of the central nervous system treated with amphotericin B during pregnancy. South. Med. J. 52: 1415 1417.
117. Fera, G.,, N. Semeraro,, V. De Mitrio,, and O. Schiraldi. 1993. Disseminated intravascular coagulation associated with disseminated cryptococcosis in a patient with acquired immunodeficiency syndrome. Infection 21: 171 173.
118. Fink, J. N.,, J. J. Barboriak,, and L. Kaufman. 1968. Cryptococcal antibodies in pigeon Breeder's disease. J. Allergy Clin. Immunol. 41: 297 301.
119. Finke, R.,, E. S. Strobel,, T. Kroepelin,, J. Guzman,, P. J. Klein,, H. E. Schaefer,, R. Kappe,, and J. Muller. 1988. Disseminated cryptococcosis in a patient with malignant lymphoma. Mycoses 31: 102 108.
120. Finley, R. W.,, J. D. Cleary,, J. Goolsby,, and S. W. Chapman. 1995. Fluconazole penetration into the human prostate. Antimicrob. Agents Chemother. 39: 553 555.
121. Fisher, D.,, J. Burrow,, D. Lo,, and B. Currie. 1993. Cryptococcus neoformans in tropical northern Australia: predominantly variant gattii with good outcome. Aust. N.Z. J. Med. 23: 678 682.
122. Frisch, M.,, and D. R. Gnepp. 1995. Primary cryptococcal infection of the larynx: report of a case. Otolaryngol. Head Neck Surg. 113: 477 480.
123. Fromtling, R. A.,, G. K. Abruzzo,, and G. S. Bulmer. 1986. Cryptococcus neoformans: comparisons of in vitro antifungal susceptibilities of serotypes AD and BC. Mycopathologia 94: 27 30.
124. Gadebusch, H. H.,, and P. W. Gikas. 1965. The effect of cortisone upon experimental pulmonary cryptococcosis. Am. Rev. Respir. Dis. 92: 64 74.
125. Gal, A. A.,, S. Evans,, and P. R. Meyer. 1987. The clinical laboratory evaluation of cryptococcal infections in the Acquired Immunodeficiency Syndrome. Diagn. Microbiol. Infect. Dis. 7: 249 254.
126. Gal, A. A.,, M. N. Koss,, J. Hawkins,, S. Evans,, and H. Einstein. 1986. The pathology of pulmonary cryptococcal infections in the acquired immunodeficiency syndrome. Arch. Pathol Lab. Med. 110: 502 507.
127. Gallis, H. A.,, R. A. Betman,, and T. R. Cate. 1975. Fungal infection following renal transplantation. Arch. Intern. Med. 135: 1163 1172.
128. Gandhi, S. A.,, A. A. McMeeking,, D. Friedberg,, and R. S. Holzman. 1996. Cryptococcal choroiditis in a patient with AIDS: case report and review. Clin. Infect. Dis. 23: 1193 1194.
129. Gantz, J. A.,, J. A. Nuetzel,, and J. B. Keller. 1958. Cryptococcal meningitis treated with amphotericin B. Arch. Intern. Med. 102: 795 800.
130. Garcia, C. A.,, L. A. Weisberg,, and W. S. J. LaCorte. 1985. Cryptococcal intracerebral mass lesions: CT pathologic considerations. Neurology 35: 731 734.
131. Garrity, J. A.,, D. C. Herman,, R. Imes,, R. Fries,, C. F. Hughes,, and R. J. Campbell. 1993. Optic nerve sheath decompression for visual loss in patients with acquired immunodeficiency syndrome and cryptococcal meningitis with papilledema. Am. J. Ophthalmol. 116: 472 478.
132. Gavai, M.,, S. Gaur,, and L. D. Frenkel. 1995. Successful treatment of cryptococcosis in a premature neonate. Pediatr. Infect. Dis. J. 14: 1009 1010.
133. Gendel, B. R.,, M. Ende,, and S. L. Norman. 1950. Cryptococcosis: a review with special reference to apparent association with Hodgkin's disease. Am. J. Med. 9: 343.
134. Gerbeaux, J.,, A. Baculard,, and G. Tournier. 1975. Partial cell-mediated immune deficiency in a child with chronic mucocutaneous candidiasis: intercurrent meningeal and pulmonary cryptococcosis. Ann. Intern. Med. 126: 615 625.
135. Gerstenhaber, B. J.,, B. Weiner,, R. Morecki,, R. Bernstein,, and S. Luftschein. 1977. "Allergic" cryptococcal pneumonia. Lung 154: 195 199.
136. Glaser, J. B.,, and A. Garden. 1985. Inoculation of cryptococcosis without transmission of the acquired immunodeficiency syndrome. N. Engl. J. Med. 313: 264.
137. Glassman, S. J.,, and M. J. Hale. 1995. Cutaneous cryptococcosis and Kaposi's sarcoma occurring in the same lesions in a patient with the acquired immunodeficiency syndrome. Clin. Exp. Dermatol. 20: 480 486.
138. Gloster, H. M.,, R. A. Swerlick,, and A. R. Solomon. 1994. Cryptococcal cellulitis in a diabetic kidney transplant patient. J. Am. Acad. Dermatol. 30: 1025 1026.
139. Glynn, M. J.,, G. Duckworth,, J. A. Ridge,, W. J. Grange,, and D. D. Gibbs. 1994. Cryptococcal spondylitis: solitary infective bone lesions are not always tuberculous. Br. J. Rheumatol. 33: 1085 1086.
140. Goenka, M. K.,, S. Mehta,, S. K. Yachha,, B. Nagi,, A. Chakraborty,, and A. K. Malik. 1995. Hepatic involvement culminating in cirrhosis in a child with disseminated cryptococcosis, J. Clin. Gastroenterol. 20: 57 60.
141. Goldman, M.,, and J. C. Pottage, Jr. 1995. Cryptococcal infection of the breast. Clin. Infect. Dis. 21: 1166 1169.
142. Goldstein, E.,, and O. N. Rombo. 1962. Cryptococcal infection following steroid therapy. Ann. Intern. Med. 56: 114.
143. Gonyea, E. F. 1973. Cisternal puncture and cryptococcal meningitis. Arch. Neurol. 28: 200 201.
144. Gonzalez, C.,, D. Shetty,, L. L. Lewis,, B. U. Mueller,, P. A. Pizzo,, and T. J. Walsh. 1996. Cryptococcosis in human immunodeficiency virus-infected children. Pediatr. Infect. Dis. J. 15: 796 800.
145. Goonetilleke, A. K.,, K. Kraus,, D. N. Slater,, D. Deu,, M. L. Wood,, and G. S. Basran. 1995. Primary cutaneous cryptococcosis in an immunocompromised pigeon keeper. Br. J. Dermatol. 133: 650 652.
146. Gosling, H. R.,, and W. S. Gilmer. 1956. Skeletal cryptococcosis: report of a case and review of the literature. J. Bone Joint Surg. 38A: 660 668.
147. Gupta, S.,, and U. U. Deshmukh. 1996. Cryptococcemia and meningococcemia in a post partum woman. J. Assoc. Physicians India 44: 339 341.
148. Gurevitz, O.,, A. Goldschmied-Reuven,, C. Block,, J. Kopolovic,, Z. Farfel,, and D. Hassin. 1994. Cryptococcus neoformans vertebral osteomyelitis. J. Med. Vet. Mycol. 32: 315 318.
149. Hamann, I. D.,, R. J. Gillespie,, and J. K. Ferguson. 1997. Primary cryptococcal cellulitis caused by Cryptococcus neoformans var. gattii in an immunocompetent host. Australas. J. Dermatol. 38: 29 32.
150. Hammerman, K. J.,, K. E. Powell,, C. S. Christianson,, P. M. Huggin,, H. W. Larsh,, J. R. Vivas,, and F. E. Tosh. 1973. Pulmonary cryptococcosis: clinical forms and treatment. A Center for Disease Control Cooperative Mycoses Study. Am. Rev. Respir. Dis. 108: 1116 1123.
151. Hammerschlag, M. R.,, J. Domingo,, J. O. Haller,, and D. Papayanopulos. 1982. Cryptococcal osteomyelitis. Report of a case and review of the literature. Clin. Pediatr. 21: 109 112.
152. Hardy, R. E.,, C. Cummings,, F. Thomas,, and D. Harrison. 1986. Cryptococcal pneumonia in a patient with Sickle Cell disease. Chest 89: 892 894.
153. Hedderwick, S. A.,, H. F. Bonilla,, S. F. Bradley,, and C. A. Kauffman. 1997. Opportunisticinfections in patients with temporal arteritis treated with corticosteroids. J. Am. Geriatr. Soc. 45: 334r 337.
154. Henderson, D. K.,, J. E. Edwards,, W. E. Dismukes,, and J. E. Bennett. 1981. Meningitis produced by different serotypes of Cryptococcus neoformans, abstr. 11. Abstr. 81st Annu. Meet. Am. Soc. Microbiol. 1981. American Society for Microbiology, Washington, D.C.
155. Henson, D. J.,, and A. R. Hill. 1984. Cryptococcal pneumonia: a fulminant presentation. Am. J. Med. 228: 221.
156. Hibberd, P.L.,, and R. H. Rubin. 1994. Clinical aspects of fungalinfection in organ transplant recipients. Clin. Infect. Dis. 19( Suppl. 1): S33 S40.
157. High, K. P. 1994. The antimicrobial activities of cyclosporine, FK506, and rapamycin. Transplantation 57: 1689.
158. Hung, P. C.,, H. S. Wang,, M. L. Chou,, P. C. Sun,, and S. C. 0. 1995. Cerebral cryptococcosis in a child. Acta Paediatr. Sin. 36: 131 135.
159. Hunt, K. K. , Jr.,, R. W. Enquist,, and T. E. Bowen. 1976. Multiple pulmonary nodules with central cavitation. Chest 69: 529 530.
160. Hurd, D. D.,, D. B. Staub,, R. L. Roelofs,, and L. P. Dehner. 1989. Profound muscle weakness as the presenting feature of disseminated cryptococcal infection. Rev. Infect. Dis. 11: 970 974.
161. Huth, R. G. 1994. Concomitant systemic cryptococcosis and coccidioidomycosis in a patient with AIDS. Clin. Infect. Dis. 18: 262 263.
162. Hutto, J. O.,, C. S. Bryan,, F. L. Greene,, C. J. White,, and J. I. Gallin. 1988. Cryptococcosis of the colon resembling Crohn's disease in a patient with hyperimmunoglobulin E-recurrent infection (Job's) syndrome. Gastroenterology 94: 808 812.
163. Iitaka, K.,, P. T. McEnery,, and C. D. West. 1978. Successful renal transplantation after generalized cryptococcosis. J. Pediatr. 92: 422 423.
164. Ingram, C. W.,, H. B. Haywood,, V. M. Morris,, R. L. Allen,, and J. R. Perfect. 1993. Cryptococcal ventricular peritoneal shunt infection: clinical and epidemiological evaluation of two closely associated cases. Infect. Immun. 4: 719 722.
165. Inoue, N.,, T. Uozumi,, T. Yamamoto,, T. Ohishi,, Y. Murai,, M. Murakami,, and H. Yoshimatsu. 1984. Treatment of cryptococcal meningitis with pulmonary granuloma. J. Neurol 231: 109 111.
166. Isaacson, J. E.,, and M. A. Frable. 1996. Cryptococcosis of the larynx. Otolaryngol Head Neck Surg. 114: 106 109.
167. Iseki, M.,, M. Anzo,, N. Yamashita,, and N. Matsuo. 1994. Hyper-IgM immunodeficiency with disseminated cryptococcosis. Acta Paediatr. 83: 780 782.
168. Jacobs, D. H.,, A. M. Mâcher,, R. Handler,, J. E. Bennett,, M. J. Collern,, and J. I. Gallin. 1984. Esophageal cryptococcosis in a patient with the hyperimmunoglobulin E-recurrent infection Gob's) syndrome. Gastroenterology 87: 201 203.
169. Jensen, W. A.,, R. M. Rose,, S. M. Hammer,, and A. W. Karchmer. 1985. Serologic diagnosis of focal pneumonia caused by Cryptococcus neoformans. Am. Rev. Respir. Dis. 132: 189 191.
170. Jimenez-Lucho, V.,, R. del Busto,, and E. J. Fisher. 1985. Disseminated cryptococcosis with muscular involvement. J. Infect. Dis. 151: 567.
171. Johnston, S. R.,, E. L. Corbett,, O. Foster,, S. Ash,, and J. Cohen. 1992. Raised intracranial pressure and visual complications in AIDS patients with cryptococcal meningitis. J. Infect 24: 185 189.
172. Jones, I.,, E. Nassua,, and P. Smith. 1965. Cryptococcosis of the heart. Br. Heart J. 27: 462 464.
173. Jones, J. M.,, and W. A. Craig. 1983. Cryptococcal meningitis: resulution eight months after antifungal therapy. South. Med. J. 76: 1567 1569.
174. Kahn, F. W.,, D. M. England,, and J. M. Jones. 1985. Solitary pulmonary nodule due to Cryptococcus neoformans and Mycobacterium tuberculosis. Am. J. Med. 78: 677 681.
175. Kanj, S. S.,, K. Welty-Wolf,, J. Madden,, V. Tapson,, M. A. Baz,, R. D. Davis,, and J. R. Perfect. 1996. Fungal infections in lung and heart-lung transplant recipients, report of 9 cases and review of the literature. Medicine 75: 142 156.
176. Kaplan, M. H.,, P. P. Rosen,, and D. Armstrong. 1977. Cryptococcus in a cancer hospital. Cancer 39: 2265 2274.
177. Karo, Y. T.,, and C. Brunnemer. 1994. Initial diagnosis of disseminated cryptococcosis and acquired immunodeficiency syndrome by fine needle aspiration of the thyroid. A case report. Acta Cytol. 38: 427 430.
178. Kauffman, C. A.,, A. G. Bergman,, P. J. Severance,, and K. D. McClatchey. 1981. Detection of cryptococcal antigen. Comparison of two latex agglutination tests. Am. J. Clin. Pathol. 75: 106 109.
179. Kent, T. H.,, and J. M. Layton. 1962. Massive pulmonary cryptococcosis. Am. J. Clin. Pathol. 38: 596 604.
180. Kerkering, T. M.,, R. J. Duma,, and S. Shadomy. 1981. The evolution of pulmonary cryptococcosis, clinical implications from a study of 41 patients with and without compromising host factors. Ann. Intern. Med. 94: 611 616.
181. Kershnev, J. E.,, M. B. Ridley,, and J. N. Greene. 1995. Laryngeal cryptococcus treatment with oral fluconazole. Arch. Otolaryngol. Head Neck Surg. 121: 1193 1195.
182. Kestelyn, P.,, H. Taelman,, J. Bogaerts,, A. Kagme,, M. Abdel Aziz,, J. Batungwanayo,, A. M. Stevens,, and P. Van de Perre. 1993. Ophthalmic manifestations of infections with Cryptococcus neoformans in patients with the acquired immunodeficiency syndrome. Am. J. Ophthalmol. 116: 721 727.
183. Khan, M.A.,, and S. Sban1975. Cryptococcal meningitis in steroid-treated systemiclupus erythematosus. Postgrad. Med. J. 5: 660 662.
184. Khardori, N.,, F. Butt,, and K. V. I. Rolston. 1988. Pulmonary cryptococcosis in AIDS. Chest 93: 1319 1320.
185. Khoury, M. B.,, J. D. Godwin,, C. E. Ravin,, H. A. Gallis,, R. A. Halvorsen,, and C. E. Putnam. 1984. Thoracic cryptococcosis: Immunologic competence and radiologic appearance. Am. J. Roentgenol. 141: 893 896.
186. Kida, M.,, C. R. Abramowsky,, and C. Santoscoy. 1989. Cryptococcosis of the placenta in a woman with acquired immunodeficiency. Hum. Pathol. 20: 920 921.
187. Kim, J. S.,, B. I. Choi,, and H. C. Han. 1994. Cryptococcal cholangiohepatitis with intraductal cryptococcoma. Am. J. Roentgenol. 163: 995 996.
188. Knudsen, J.D.,, L. Jensen,, T. L. Sorensen,, T. Jensen,, H. Kjersem,, J. Stenderup,, and C. Pederson. 1997. Cryptococcosis in Denmark: an analysis of 28 cases in 1988-1993. Scand. J. Infect. Dis. 29: 51 55.
189. Kovacs, J. A.,, A. A. Kovacs,, M. Polis,, W. C. Wright,, V. J. Gill,, C. U. Tuazon,, E. P. Gelmann,, H. C. Lane,, R. Longfield,, G. Overturf,, A. M. Macher,, A. S. Fauci,, J. E. Parrillo,, J. E. Bennett,, and H. Masur. 1985. Cryptococcosis in the acquired immunodeficiency syndrome. Ann. Intern. Med. 103: 533 538.
190. Kramer, M.,, M. L. Corrado,, V. Bacci,, A. C. Carter,, and S. H. Landesman. 1983. Pulmonary cryptococcosis and Cushing's syndrome. Ann. Intern. Med. 143: 2179 2180.
191. Kromminger, R.,, F. Sthib,, V. Thalmann,, G. Jautzke,, M. Seibold,, H. Hochrein,, H. Witt,, and H. Burger. 1990. Osteomyelitis due to Cryptococcus neoformans in advanced age. Case report and review of the literature. Mycoses 33: 157 166.
192. Kumlin, U.,, L. G. Elmquist,, M. Granlund,, B. Olsen,, and A. Tarnvik. 1997. CD4 lymphopenia in a patient with cryptococcal osteomyelitis. Scand. J. Infect. Dis. 29: 205 206.
193. Kupf er, C.,, and E. McCrane. 1974. A possible cause of decreased vision in cryptococcal meningitis. Invest. Ophthalmol. Visual Sci. 13: 801.
194. Lalonde, R. G.,, R. Rene,, and M. A. Wainberg. 1993. Opportunistic infections and CD4+ T-lymphocytopenia without HIV infection: report of two cases. Can. Med. Assoc. J. 149: 179 182.
195. Lamantia, L.,, A. Salmaggi,, L. Tajoli,, D. Cerrato,, E. Lamperti,, A. Nespolo,, and E. Bussone. 1986. Cryptococcal meningoencephalitis: intrathecal immunological response. J. Neurol. 233: 362 366.
196. Lambertus, M. W.,, M. B. Goetz,, A. R. Murthy,, and G. E. Mathisen. 1990. Complications of corticosteroid therapy in patients with the acquired immunodeficiency syndrome and Pneumocystis carinii pneumonia. Chest 98: 38 43.
197. Larsen, R. A.,, S. Bozzette,, A. McCutchan,, J. Chiu,, M. A. Leal,, and D. D. Richman. 1989. Persistent Cryptococcus neoformans infection of the prostate after successful treatment of meningitis. Ann. Intern. Med. 111: 125 128.
198. Law, K. F.,, C. P. Aranda,, R. L. Smith,, K. A. Berkowitz,, M. M. Ittman,, and M. L. Lewis. 1993. Pulmonary cryptococcosis mimicking methotrexate pneumonitis. J. Rheumatol. 20: 872 873.
199. Lee, B. E.,, M. Feinberg,, J. J. Abraham,, and A. R. Murthy. 1992. Congenital malformation in an infant bom to a woman treated with fluconazole. Pediatr. Infect. Dis. J. 11: 1062 1064.
200. Lee, Y.T.,, N. W. Leung,, R. Kay,, and H. K. Ng. 1997. Subdural effusion in chroniccryptococcal meningitis in a cirrhotic patient. Int. J. Clin.Pract. 51: 254r 255.
201. Leggiadro, R. J.,, F. F. Barrett,, and W. T. Hughes. 1992. Extrapulmonary cryptococcosis in immunocompromised infants and children. Pediatr. Infect. Dis. J. 11: 43 47.
202. Leggiadro, R. J.,, M. W. Kline,, and W. T. Hughes. 1991. Extrapulmonary cryptococcosis in children with AIDS. Pediatr. Infect. Dis. J. 10: 658 662.
203. Lehmann, R. F.,, R. J. Morgan,, and E. H. Freimer. 1984. Infection with Cryptococcus neoformans var. gattii leading to a pulmonary cryptococcoma and meningitis, J. Infect. 9: 301 306.
204. Levitz, S. M. 1982. The ecology of Cryptococcus neoformans and the epidemiology of cryptococcosis. Rev. Infect. Dis. 53: 283 292.
205. Lewis, J. L.,, and S. Rabinovich. 1972. The wide spectrum of cryptococcal infections. Am. J. Med. 53: 315 322.
206. Lewis, N.,, J. Lipstick,, and C. Cammarosano. 1985. Cryptococcal myocarditis in acquired immune deficiency syndrome. Am. J. Cardiol. 55: 1240.
207. Lipson, B. K.,, W. R. Freeman,, and J. Beniz. 1989. Optic neuropathy associated with cryptococcal arachnoiditis in AIDS patients. Am. J. Ophthalmol. 107: 523 527.
208. Littman, M.L.,, and L. E. Zimmerman. 1956. Cryptococcosis, Torulosis or European Blastomycosis, p. 38 46. Grune and Stratton, New York.
209. Lo, D. 1976. Cryptococcosis in the Northern Territory. Med. J. Aust. 2: 825 828.
210. Loerinc, A. M.,, E. J. Bottone,, L. J. Finkel,, and A. S. Teirstein. 1988. Primary cryptococcal pneumonia mimicking Pneumocystis carinii pneumonia in a patient with AIDS. Mí. Sinai J. Med. 55: 181 186.
211. Lombardo, T. A.,, A. S. Rabson,, and H. T. Dodge. 1957. Mycotic endocarditis. Am. J. Med. 22: 664.
212. Long, J. A.,, J. R. Herdt,, G. DiChiro,, and H. R. Cramer. 1980. Cerebral mass lesions in torulosis demonstrated by computer tomography. J. Comput. Assist. Tomogr. 4: 766 769.
213. Long, R. F.,, S. V. Berens,, and G. R. Shambhag. 1972. Case reports. An unusual manifestation of pulmonary cryptococcosis. Br. J. Radiol. 45: 757 759.
214. Lucatorto, F.,, and L. R. Eversole. 1993. Deep mycoses and palatal perforation with granulomatous pansinusitis in acquired immunodeficiency syndrome: a case report. Quintessence Int. 24: 743 748.
215. Lui, H.,, W. A. McLeod,, and W. S. Wood. 1993. An ulcerated plaque in a gay man. Cutaneous cryptococcosis. Arch. Dermatol. 129: 499 502.
216. Mabee, C.L.,, S. W. Mabee,, R. B. Kirkpatrick,, and S. L. Koletar. 1995. Cirrhosis: a risk factorfor cryptococcal peritonitis. Am. J. Gastroenterol. 90: 2042 2045.
217. Mahida, P.,, R. Morar,, M. A. Goolam,, E. Song,, J. P. Tissandie,, and C. Feldman. 1996. Cryptococcosis: an unusual cause of endobronchial obstruction. Eur. Respir. J. 9: 837 839.
218. Majid, A. A. 1989. Clinical notes. Surgical resection of pulmonary cryptococcomas in the presence of cryptococcal meningitis. J. R. Coll. Surg. Edinb. 34: 332 333.
219. Malabonga, V. M.,, and S. L. Kamholz. 1991. Utility of bronchoscopic sampling techniques for cryptococcal disease in AIDS. Chest 99: 370 373.
220. Manfredi, R.,, O. V. Coronado,, A. Mastroianni,, and F. Chiodo. 1997. Liposomal amphotericin B and recombinant human granulocyte-macrophage colony stimulating factor in the treatment of paediatric AIDS-related cryptococcosis. Int. J. STD AIDS 8: 406 408.
221. Manfredi, R.,, G. Rezza,, and V. G. Coronado. 1995. Is AIDS-related cryptococcosis more frequent among men? AIDS 9: 397 398.
222. Mansoor, G.A.,, and D. B. Omt1994. Cryptococcal peritonitis in peritoneal dialysispatients: a case report. Clin. Nephrol. 41: 230 232.
223. Martinelli, C.,, C. E. Comin,, S. Ambu,, D. Bartolozzi,, and F. Leoncini. 1997. Solitary cutaneous cryptococcosis resembling chickenpox: a case report. AIDS 11: 260 261.
224. Massa, M. C.,, and J. A. Doyle. 1981. Cutaneous cryptococcosis simulating pyoderma gangrenosum. J. Am. Acad. Dermatol. 5: 32 36.
225. Matsushita, T.,, and K. Suzuki. 1985. Spastic paraparesis due to cryptococcal osteomyelitis. A case report. Clin. Orthopaed. Rel. Res. 196: 279 284.
226. McAllister, C. K.,, C. E. Davis, Jr.,, A. J. Ognibene,, and J. L. Carpenter. 1984. Cryptococcal pleuro-pulmonary disease: infection of the pleural fluid in the absence of disseminated cryptococcosis. Case report. Milit. Med. 149: 684 686.
227. McClusky, P. J.,, and D. Wakefield. 1985. Ocular involvement in the acquired immune deficiency syndrome. Aust. N.Z. J. Ophthalmol. 13: 293 298.
228. Menon, A.,, and R. Rajamani. 1976. Giant "cryptococcoma" of the lung. Br. J. Dis. Chest 70: 269 272.
229. Metroka, C. E.,, S. Cunningham-Rundles,, M. S. Pollack,, J. A. Sonnabend,, J. M. Davis,, B. Gordon,, R. D. Fernandez,, and J. Mouradian. 1983. Generalized lymphade-nopathy in homosexual men Ann. Intern. Med. 99: 585 591.
230. Meyohas, M.C.,, P. Roux,, D. Bollens,, C. Chouaid,, W. Rozenbaum,, J. L. Meynard,, J. L. Poirot,, J. Frottier,, and C. Mayaud. 1995. Pulmonary cryptococcosis: localized and disseminated infections in 27 patients with AIDS. Clin. Infect. Dis. 21: 628 633.
231. Middleton, F. G.,, and W. H. Prioleau. 1982. Pulmonary cryptococcosis: review of eleven cases. J. S.C Med. Assoc. 78: 419 423.
232. Miller, K. D.,, J. A. M. Mican,, and R. T. Davey. 1996. Asymptomatic solitary pulmonary modules due to Cryptococcus neoformans in patients infected with human immunodeficiency virus. Clin. Infect. Dis. 23: 810 812.
233. Miller, M.J., 1995. Fungal infections,p. 709 713. In J. S. Remington, and J. O. Klein (ed.), Infectious Diseases of the Fetus and Newborn Infant. W.B. Saunders, Philadelphia.
234. Miller, W. T.,, and J. M. Edelman. 1990. Cryptococcal pulmonary infection in patients with AIDS: radiographic appearance. Radiology 175: 725 728.
235. Mitchell, D. H.,, and T. C. Sorrell. 1992. Pancoast's syndrome due to pulmonary infection with Cryptococcus neoformans variety gattii. Clin. Infect. Dis. 14: 1142 1144.
236. Mitchell, D. H.,, T. C. Sorrell,, A. M. Allworth,, C. H. Heath,, A. R. McGregor,, K. Papahaoum,, M. J. Richards,, and T. Gottlieb. 1995. Cryptococcal disease of the CNS in immunocompetent hosts: influence of cryptococcal variety on clinical manifestations and outcome. Clin. Infect. Dis. 20: 611 616.
237. Mitchell, T. G.,, and J. R. Perfect. 1995. Cryptococcosis in the era of AIDS—100 years after the discovery of Cryptococcus neoformans. Clin. Microbiol. Rev. 8: 515 548.
238. Mohr, J. A.,, H. Long,, B. A. McKown,, and H. G. Muchmore. 1972. In vitro susceptibility of Cryptococcus neoformans to steroids. Sabouraudia 10: 171 172.
239. Molina, J. M.,, E. Oksenhendler,, M. T. Daniel,, and J. P. Clauvel. 1988. Fine needle aspiration and cryptococcosis in the acquired immunodeficiency syndrome. Ann. Intern. Med. 108: 772.
240. Molnar-Nadasdy, G.,, I. Haesly,, J. Reed,, and G. Altshuler. 1994. Placental cryptococcosis in a mother with systemic lupus erythematosus. Arch. Pathol. Lab. Med. 118: 757 759.
241. Moncino, M. D.,, and L. T. Gutman. 1990. Severe systemic cryptococcal disease in a child: review of prognostic indicators predicting treatment failure and an approach to maintenance therapy with oral fluconazole. Pediatr. Infect. Dis. J. 9: 363 368.
242. Monteil, R. A.,, P. Hofman,, J. E. Michiels,, and R. Loubiere. 1997. Oral cryptococcosis: a case report of salivary gland involvement in an AIDS patient. J. Oral Pathol Med. 26: 53 56.
243. Moosa, M. Y. S.,, and V. M. Coovadia. 1997. Cryptococcal meningitis in Durban, South Africa: a comparison of clinical features, laboratory findings, and outcome for human immunodeficiency virus (HlV)-positive and HIV-negative patients. Clin. Infect. Dis. 24: 131 134.
244. Morris, E.,, and E. Wolinsky. 1965. Localized osseous cryptococcosis. A case report. J. Bone Joint Surg. 47: 1027.
245. Moser, S. A.,, L. Friedman,, and A. R. Varraux. 1978. Atypical isolate of Cryptococcus neoformans cultured from sputum of a patient with pulmonary cancer and blastomycosis. J. Clin. Microbiol 7: 316 318.
246. Muccioli, C.,, J. R. Belfort,, R. Neves,, and N. Rao. 1995. Limbal and choroidal cryptococcus infection in the acquired immunodeficiency syndrome. Am. J. Ophthalmol 120: 539 540.
247. Mulanovich, V. E.,, W. E. Dismukes,, and N. Markowitz. 1995. Cryptococcal empyema: case report and review. Clin. Infect. Dis. 20: 1396 1398.
248. Mundy, L. M.,, and W. G. Powderly. 1997. Invasive fungal infections: cryptococcosis. Semin. Respir. Crit. Care Med. 18: 249 257.
249. Munoz-Perez, M. A.,, M. A. Colmenero,, A. Rodriquez-Pichardo,, F. J. Rodriquez-Pin-ero,, J. J. Ris,, and F. Comacho. 1996. Disseminated cryptococcosis presenting as molluscum-like lesions as the first manifestation of AIDS. Int. J. Dermatol 35: 646 648.
250. Murakawa, G. J.,, R. Kerschmann,, and T. Berger. 1996. Cutaneous Cryptococcus infection and AIDS—report of 12 cases and review of the literature. Arch. Dermatol 132: 545 548.
251. Murakawa, G. J.,, T. M. Mauro,, and B. Egbert. 1995. Disseminated cutaneous cryptococcus clinically mimicking basal cell carcinoma. Dermatol Surg. 21: 992 993.
252. Murata, K.,, A. Khan,, and P. G. Herman. 1989. Pulmonary parenchymal disease: evaluation with high-resolution CT. Radiology 170: 629 635.
253. Murray, R. J.,, P. Becker,, P. Furth,, and G. J. Criner. 1988. Recovery from cryptococcemia and the adult respiratory distress syndrome in the acquired immunodeficiency syndrome. Chest 93: 1304 1307.
254. Myers, S. A.,, and O. H. Kamin. 1996. Cutaneous cryptococcosis and histoplasmosis coinfection in a patient with AIDS. J. Am. Acad. Dermatol 34: 898 900.
255. Naka, W.,, M. Masuda,, A. Konohana,, T. Shinoda,, and T. Nishikawa. 1995. Primary cutaneous cryptococcosis and Cryptococcus neoformans serotype D. Clin. Exp. Dermatol. 20: 221 225.
256. Nampoory, M. R.,, Z. V. Khan,, K. V. Johny,, J. N. Constandi,, R. K. Gupta,, I. Al-Muzqiri,, M. Samhan,, M. Mozavi,, and T. D. Chugh. 1996. Invasive fungal infections in renal transplant recipients. J. Infect. 33: 95 101.
257. Neuhauser, E. B.,, and A. Tucker. 1948. The roentgen changes produced by diffuse torulosis in the newborn. Am. J. Roentgenol. 59: 805 815.
258. Newberry, W. M., Jr.,, J. E. Walter,, J. W. Chandler, Jr.,, and F. E. Tosh. 1967. Epidemiologic study of Cryptococcus neoformans. Ann. Intern. Med. 67: 724 732.
259. Noble, R. C.,, and L. P. Fajardo. 1972. Primary cutaneous cryptococcosis: a review and morphologic study. Am. J. Clin. Pathol. 57: 13 17.
260. Ofori-Kwakye, S. K.,, A. M. Wang,, J. H. Morris,, G. V. O'Reilly,, E. G. Fischer,, and C. L. Rumbaugh. 1986. Septation and focal dilatation of ventricles associated with cryptococcal meningoencephalitis. Surg. Neurol. 25: 253 260.
261. Okun, E.,, and W. T. Butler. 1964. Ophthalmologic complications of cryptococcal meningitis. Arch. Ophthalmol. 71: 52 57.
262. Page, B.,, E. Thervet,, C. Legendre,, and H. Kreis. 1995. Cryptococcosis after renal transplantation. Transplant. Proc. 27: 1732.
263. Paillas, J.,, M. Sinico,, A. Vieillefond,, and N. Blaye. 1982. Un cas de cryptococcose pulmonaire pseudo-tumorale. Sew. Hop. Paris 58: 2402 2404.
264. Pankey, G. A.,, J. D. Key,, and T. K. Setze,. 1976. Osseous cryptococcosis syndrome distinct from other forms of disseminated cryptococcosis, p. 84. In W. H. Holloway (ed.), Infectious Disease Reviews TV. W. H. Futura, New York.
265. Pappas, P.,, J. Perfect,, H. Henderson,, C. Kauffman,, M. Saccente,, D. Haas,, G. Pankey,, D. Lancaster,, M. Holloway,, G. Cloud,, and W. Dismukes. 1997. Cryptococcosis in non-HIV infected patients: a multicenter survey, abstr. 128. 35th Annu. Meet. Infectious Disease Society of America.
266. Patronas, N. J.,, and E. V. Makariou. 1993. MRI of choroidal plexus involvement in intracranial cryptococcosis. J. Comput. Assist. Tomogr. 17: 547 550.
267. Paya, C. V. 1993. Fungal infections in solid-organ transplantation. Clin. Infect. Dis. 16: 677 688.
268. Paya, C. V.,, P. E. Hermans,, and J. A. Washington. 1989. Incidence, distribution, and outcome of episodes of infection in 100 orthotopic liver transplantations. Mayo Clin. Proc. 64: 555 564.
269. Pema, K.,, J. Diaz,, L. G. Guerra,, D. Nabhan,, and A. Verghese. 1994. Disseminated cutaneous cryptococcosis. Comparison of clinical manifestations in the pre-AIDS and AIDS eras. Arch. Intern. Med. 154: 1032 1034.
270. Penar, P. L.,, J. Kim,, and D. Chylatte. 1988. Intraventricular cryptococcal granuloma. Report of two cases. J. Neurosurg. 68: 145 148.
271. Pereira, C. A.,, O. Fischman,, A. L. Colombo,, A. L. Moron,, and A. C. Pignatari. 1993. Cryptococcal meningitis in pregnancy. Review of the literature. Report of two cases. Rev. Inst. Med. Trop. Sao Paulo 35: 367 371.
272. Perfect, J.R. 1989. Cryptococcosis. Infect. Dis. Clin. North Am. 3: 77 102.
272a. Perfect, J. R. Unpublished observation.
273. Perfect, J.R.,, and M. L. Cameron,. 1994. Pulmonarycryptococcosis: pathophysiological and clinical characteristics, p. 249 279. In H. Friedman,, M. Berdinelli,, and H. Chmel (ed.), Infectious Agents and Pathogenesis. Plenum Press, New York.
274. Perfect, J. R.,, D. T. Durack,, and H. A. Gallis. 1983. Cryptococcemia. Medicine 62: 98 109.
275. Perfect, J. R.,, S. D. R. Lang,, and D. T. Durack. 1980. Chronic cryptococcal meningitis: a new experimental model in rabbits. Am. J. Pathol. 101: 177 194.
276. Perfect, J. R.,, and B. Seaworth. 1985. Penile cryptococcosis with a review of mycotic infections of the penis. Urology 25: 528 531.
277. Perry, H. D.,, and E. D. Donnenfeld. 1990. Cryptococcal keratitis after keratoplasty. Am. J. Ophthalmol. 110: 320 321.
278. Petrites-Murphy, M. B.,, L. A. Robbins,, J. M. Donahue,, and B. Smith. 1996. Equine cryptococcal endometritis and placentitis with neonatal cryptococcal pneumonia. J. Vet. Diagn. Invest. 8: 383 386.
279. Petrucco, O. M.,, R. F. Seamark,, K. Holmes,, I. J. Forbes,, and R. G. Symons. 1976. Changes in lymphocyte function during pregnancy. Br. J. Obstet. Gynaecol. 83: 245 250.
280. Philpot, C. R.,, and D. Lo. 1972. Cryptococcal meningitis in pregnancy. Med. J. Aust. 28: 1005 1007.
281. Pierard, G. E.,, C. Pierard-Franchimont,, J. A. Estrada,, A. Rurangirwa,, and F. L. Dosai. 1990. Cutaneous mixed infections in AIDS. Am. J. Dermatopathol. 12: 63 66.
282. Pincus, M. R.,, M. Silva-Hutner,, G. Rebotta,, and A. W. Branwood. 1981. Disseminated cryptococcosis in an asymptomatic alcoholic man. Arch. Intern. Med. 141: 796 798.
283. Pippard, M. J.,, A. Dagleish,, P. Gibson,, M. Malkovsky,, and A. D. B. Webster. 1986. Acquired immunodeficiency with disseminated cryptococcosis. Arch. Dis. Child. 61: 289 302.
284. Plunkett, J. M.,, B. I. Turner,, and M. B. Tallent. 1981. Cryptococcal septicemia associated with urologie instrumentation in a renal allograft recipient. J. Urol. 125: 241 242.
285. Poprich, M. J.,, R. H. Arthur, and E. Helmer. 1990. CT of intracranial cryptococcosis. Am. J. Roentgenol. 154: 603 606.
286. Pounden, W. D.,, J. M. Amberson,, and R. F. Jaeger. 1952. A severe mastitis problem associated with Cryptococcus neoformans in a large dairy herd. Am. J. Vet. Res. 13: 121 128.
287. Powderly, W. G. 1993. Cryptococcal meningitis and AIDS. Clin. Infect. Dis. 17: 837 842.
288. Powers, C. N.,, G. M. Rupp,, S. J. Maygarden,, and W. J. Frable. 1991. Fine-needle aspiration cytology of adrenal cryptococcosis: a case report. Diagn. Cytopathol. 7: 88 91.
289. Proknow, J.J.,, J. R. Benfield,, and J. W. Rippon. 1965. Cryptococcal hepatitispresenting as a surgical emergency.
290. Pursley, T. J.,, I. K. Blomquist,, J. Abraham,, H. F. Andersen,, and J. A. Bartley. 1996. Fluconazole-induced congenital anomalies in three infants. Clin. Infect. Dis. 22: 336 340.
291. Ramirez-Ortiz, R.,, J. Rodriquez,, Z. Soto,, M. Rivas,, and W. Rodriquez-Clintron. 1997. Synchronous pulmonary cryptococcosis and histoplasmosis. South. Med. J.<