Chapter 2 : Taxonomy

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Taxonomy, Page 1 of 2

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Members of the genus generally are considered to be yeasts that are nonfermentative, assimilate inositol, and produce urease. Besides the pathogenic , at least 38 other species have been found in a wide variety of environmental locations. Humans are frequently exposed to these species, which can be found in aqueous environments, soil, human skin such as toe webs, and bird guano, but for all practical purposes should be considered the only species to consistently cause cryptococcosis. Despite the differences in morphology, biochemistry, ecology, and pathogenicity, and are phylogenetically related and belong in the same genus based upon DNA homology. Although taxonomic relationships between and have been based on fatty acid compositions and other phenotypic characteristics, molecular phylogeny studies provide the most objective evidence for genus and species relationships. The molecular phylogeny of in relationship to other closely related fungi has continued to be elucidated. As more genetic loci, such as the conserved actin gene, are sequenced and compared, the phylogenetic relationships on a molecular level can be interpreted further with regard to classical methods of taxonomy.

Citation: Casadevall A, Perfect J. 1998. Taxonomy, p 29-40. In . ASM Press, Washington, DC. doi: 10.1128/9781555818241.ch2

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Cryptococcus gattii
Pneumocystis carinii
Schizosaccharomyces pombe
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Figure 1

Phylogenetic relations within Amastigomycota as derived from parsimony analysis of 1,927 nucleotides of small subunit rDNA sequences. (From reference with permission.)

Citation: Casadevall A, Perfect J. 1998. Taxonomy, p 29-40. In . ASM Press, Washington, DC. doi: 10.1128/9781555818241.ch2
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Image of Figure 2
Figure 2

General phylogeny of and related species from partial sequence rDNA large subunit. (From reference with permission.)

Citation: Casadevall A, Perfect J. 1998. Taxonomy, p 29-40. In . ASM Press, Washington, DC. doi: 10.1128/9781555818241.ch2
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1. Aulakh, H. J.,, S. E. Straus,, and K. J. Kwon-Chung. 1981. Genetic relatedness of Filobasidiella neoformans (Cryptococcus neoformans) and Filobasidiella bacillispora (Cryptococcus bacillisporus) as determined by deoxyribonucleic acid base composition and sequence homology studies. Int. J. Syst. Bacteriol. 31:97103.
2. Bangert, R. L.,, B. R. Cho,, R R. Widders,, E. H. Stauber,, and A. C. Ward. 1988. A survey of aerobic bacteria and fungi in the feces of healthy psittacine birds. Avian Dis. 32:4652.
3. Barnett, J.A.,, R. W. Payne,, and D. Yarrow (ed.). 1990. Yeasts: Characteristics and Identification, 2nd ed., p. 282320. Cambridge University Press, Cambridge.
4. Benham, R. W. 1935. Cryptococci, their identification by morphology and serology. J. Infect. Dis. 57:255274.
5. Boekhout, T.,, A. Van Belkum,, A. C. Leenders,, H. A. Verbrugh,, P. Mukamurangwa,, D. Swinne,, and W. A. Scheffers. 1997. Molecular typing of Cryptococcus neoformans: taxonomic and epidemiological aspects. Int. J. Syst. Bacteriol. 47:432442.
6. Buschke, A. 1895. Ueber eine durch Coccidien hemorgerufene Krankheit des Menschen. Dtsch. Med. Wochenschr. 21:14.
7. Busse, O. 1894. Ueber parasitaere Zelleinschlusse and ihre Zuchtung. Int. J. Med. Microbiol. 16:175180.
8. Cox, G. M.,, T. H. Rude,, C. C. Dykstra,, and J. R. Perfect 1995. The actin gene from Cryptococcus neoformans: structure and phylogenetic analysis. J. Med. Vet. Mycol. 33:261266.
9. Cuna, T.,, and J. Lusins. 1973. Cryptococcus albidus meningitis. South. Med. J. 66:1230.
10. Curtis, F. 1895. Note sur un nouveau parasite humain, megalococcus myxoides, trouve dans im neoplasme de la region inguino-crurole. C.R. Soc. Biol. (Paris) 1895:715718.
11. Curtis, P. H.,, J. A. Haller,, and E. de Juan. 1995. An unusual case of cryptococcal endophthalmitis. Retina 15:300304.
12. Dromer, F.,, A. Moulignier,, B. Dupont,, E. Gueho,, M. Baudrimont,, L. Improvisi,, F. Provost,, and G. Gonzalez-Cavali. 1995. Myeloradiculitis due to Cryptococcus curvatus in AIDS. AIDS 9:395396.
13. Drouhet, E. 1997. Milestones in the history of cryptococcus and cryptococcosis. J. Mycol. Med. 7:1027.
14. Ellis, D. H.,, and T. J. Pfeiffer. 1990. Ecology, life cycle, and infectious propagule of Cryptococcus neoformans. Lancet 336:923925.
15. Erke, K. H.,, and J. D. Schneidau. 1973. Relationship of some Cryptococcus neoformans hypha-fonning strains to standard strains and to other species of yeasts as determined by deoxyribonucleic acid base ratios and homologies. Infect. Immun. 7:941948.
16. Esser, K.,, and F. Meinhardt. 1977. A common genetic control of dikaryotic and monokaryotic fruiting in the basidiomycete Agrocybe acgerita. Mol. Gen. Genet. 155:113115.
17. Fan, M.,, and A. Casadevall. 1992. URA5 gene of Cryptococcus neoformans var. gattii and C. neoformans var. neoformans. J. Gen. Appl. Microbiol. 38:491495.
18. Fan, M.,, L. C. Chen,, M. A. Ragan,, R. R. Gutell,, J. R. Warner,, B. P. Currie,, and A. Casadevall. 1995. The 5S rRNA and rRNA intergenic spacer of the two varieties of Cryptococcus neoformans. J. Med. Vet. Mycol. 33:215221.
19. Fan, M.,, B. P. Currie,, R. R. Gutell,, M. A. Ragen,, and A. Casadevall. 1994. The 16s-like, 5.8s and 23s-like rRNA of the two varieties of Cryptococcus neoformans: sequence secondary structure, phylogenetic analysis, and restriction fragment polymorphisms. J. Med. Vet. Mycol. 32:163180.
20. Fell, J. W.,, C. P. Kurtzman,, and K. J. Kwon-Chung. 1989. Proposal to conserve cryptococcus. Taxon 38:151152.
21. Gargas, A.,, P. T. DePriest,, M. Grube,, and A. Tehler. 1995. Multiple origins of lichen symbioses in fungi: suggested by SSU rDNA phylogeny. Science 268:14921495.
22. Gatti, E.,, and H. Eeckels. 1970. An atypical strain of Cryptococcus neoformans (Sanfelice) Vullemin. Part I. Description of the disease and of the strain. Ann. Soc. Belg. Med. Trap. 50:689694.
23. Gluck, J. L.,, J. P. Myers,, and L. M. Pass. 1987. Cryptococcemia due to Cryptococcus albidus. South. Med. J. 80:511513.
24. Gordon, M. A. 1972. Pulmonary cryptococcosis. A case due to Cryptococcus albidus. Am. Rev. Respir. Dis. 106:786787.
25. Gueho, E.,, L. Improvisi,, R. Christen,, and G. S. de Hoog. 1993. Phylogenetic relationships of Cryptococcus neoformans and some related basidiomycetous yeasts determined from partial large subunit rRNA sequences. Antonie van Leeuwenhoek 63:175189.
26. Horowitz, I. D.,, E. A. Blumberg,, and L. Krevolin. 1993. Cryptococcus albidus and mucormycosis empyema in a patient receiving hemodialysis. South. Med. J. 86:10701072. (Abstract)
27. Kamalam, A.,, and A. S. Thambiah. 1976. A study of 3891 cases of mycoses in the tropics. Sabouraudia 14:129148.
28. Kamalam, A.,, P. Yesudian,, and A. S. Thambiah. 1977. Cutaneous infection by Cryptococcus laurentii. Br. J. Dermatol 97:221223.
29. Kromery, V.,, A. Kunova,, and J. Mardiak. 1997. Nosocomial Cryptococcus laurentii fungemia in a bone marrow transplant patient after prophylaxis with ketoconazole successfully treated with oral fluconazole. Infection 25:130.
30. Krumholz, R. A. 1972. Pulmonary cryptococcosis. A case due to Cryptococcus albidus. Am. Rev. Respir. Dis. 105:421424.
31. Kützing, F. 1833. Systematische Zusammenstellung der niedern Algen-Gattungen und Arten. Linneae 8:365.
32. Kwon-Chung, K. J. 1975. A new genus, Filobasidiella, the perfect state of Cryptococcus neoformans. Mycologia 67:11971200.
33. Kwon-Chung, K. J. 1976. A new species of Filobasidiella, the sexual state of Cryptococcus neoformans B and C serotypes. Mycologia 68:942946.
34. Kwon-Chung, K. J. 1976. Morphogenesis of Filobasidiella neoformans, the sexual state of Cryptococcus neoformans. Mycologia 68:821833.
35. Kwon-Chung, K. J.,, and J. E. Bennett. 1978. Distribution of "alpha" and "a" mating types of Cryptococcus neoformans among natural and clinical isolates. Am. J. Epidemiol. 108:337.
36. Kwon-Chung, K.J.,, and J. E. Bennett,. 1992. Cryptococcosis, p. 426429. In K. J. Kwon-Chung, and \ Bennett (ed.), Medical Mycolology. Lea & Febiger, Philadelphia.
37. Kwon-Chung, K.J.,, Y. C. Chang,, R. Bauer,, E. C. Swann,, J. W. Taylor,, and R. Goel,. 1995. The characteristics that differentiate Filobasidiella depauperato from Filobasidiella neoformans, p. 6779. In T. Boekhout, and A. Samson (ed.), Heterobasidiomycetes: Systematic and Applied. Studies in Mycology. CBS, Baarn, Switzerland.
38. Lin, S. R.,, C. F. Peng,, S. A. Yang,, and H. S. Yu. 1989. Isolation of Cryptococcus albidus var. albidus in patient with pemphigus foliaceous. Kaohsiung J. Med. Sci. 5:126128.
39. Litherland, D. K. 1972. Pulmonary cryptococcosis. A case due to Cryptococcus albidus. Am. Rev. Respir. Dis. 106:786.
40. Loison, J.,, J. P. Bouchara,, E. Gueho,, L. de Gentile,, B. Cimon,, J. M. Chennebault,, and D. Chabasse. 1996. First report of Cryptococcus albidus septicemia in an HTV patient. J. Infect. 33:139140.
41. Lynch, J.P.III,, D. R. Schaberg,, D. G. Kissner,, and C. A. Kauffman. 1981. Cryptococcus laurentii lung abscess. Am. Rev. Respir. Dis. 123:135138.
42. Madrenys, N.,, C. de Vroey,, C. Raes-Wuytack,, and J. M. Torres-Rodriquez. 1993. Identification of the perfect state of Cryptococcus neoformans from 195 clinical isolates including 84 from AIDS patients. Mycopathologia 123:6568.
43. McGinnis, M. R.,, M. G. Rinaldi,, C. Halde,, and A. E. Hilger. 1975. Mycotic flora of the interdigital spaces of the human foot: a preliminary investigation. Mycopathologia 55:4752.
44. Melo, J. C.,, S. Srinivason,, M. L. Scott,, and M. J. Raff. 1980. Cryptococcus albidus meningitis. J. Infect. 2:7982.
45. Mitchell, T. G.,, T. J. White,, and J. W. Taylor. 1992. Comparison of 5.8S ribosomal DNA sequences among the basidiomycetous yeast genera Cytofilobasidium, Filobasidium, Filobasidiella. J. Med. Vet. Mycol. 30:207218.
46. Mocan, H.,, A. V. Murphy,, T. J. Beattie,, and T. A. McAllister. 1989. Fungal peritonitis in children on continuous ambulatory peritoneal dialysis. Scott. Med. J. 34:494496.
47. Petter, R.,, A. Varma,, T. Boekhout,, S. Salas,, B. Davis,, and K. J. Kwon-Chung. 1996. Molecular divergence of the virulence factors of Filobasidiella neoformans found in other heterobasidiomycetous species, abstr. 2.2:3638. 3rd International Conference on Cryptococcus and Cryptococcosis, Paris.
48. Phaff, H.J.,, and J. F. T. Spencer. 1966. Improved parameters inthe separation of species in the genera Rhodotorula and Cryptococcus, p. 5967. Proceedings of the Second International Symposium on Yeasts, Bratislava.
49. 48a. Rippon, J. W. 1988. Medical Mycology. The Pathogenic Fungi and the Pathogenic Acti-nomycetes, 3rd edv p. 582609. W. B. Saunders, Philadelphia.
49. Saldanha-da-Gama, A.,, M. Malfeito-Ferreira,, and V. Loureiro. 1997. Characterization of yeasts associated with Portuguese pork-based products. Int. J. Food Microbiol 37:201207.
50. Sanfelice, F. 1894. Contributo alia morfologia e biolgia dei blastomiceti che si sviluppano nei succhi di alcuni frutti. Ann. Ig. 4:463495.
51. Shadomy, H. J. 1970. Clamp connections in two strains of Cryptococcus neoformans. Spectrum monograph series. Arts and Sciences, Georgia State University 1:6772.
52. Shadomy, H. J.,, and J. P. Utz. 1966. Preliminary studies on a hypha-fonning mutant of Cryptococcus neoformans. Mycologia 58:383390.
53. Sinnott, J. T.,, J. Rodnite,, P. J. Emmanuel,, and A. Campos. 1989. Cryptococcus laurentii infection complicating peritoneal dialysis. Pediatr. Infect. Dis. J. 8:803805.
54. Smit, E. J.,, J. L. F. Kock,, J. P. J. Van der Westhuizen,, and T. J. Britz. 1988. Taxonomic relationships of Cryptococcus and Tremella based on fatty acid composition and other phenotypic characters. J. Gen. Microbiol. 134:28492855.
55. Stahl, U.,, and K. Essex. 1976. Genetics of fruit body production in higher basidiomycetes. Mol Gen. Genet. 148:183197.
56. Stoddard, J. L.,, and E. C. Cutler. 1916. Torula Infection in Man, p. 198. Monograph no. 6. Rockefeller Institute for Medical Research, New York.
57. Taylor, G.D.,, M. Buchanan-Chell,, T. Kirkland,, M. McKenzie,, and R. Wiens. 1994. Trends and sources of nosocomial fungaemia. Mycoses 37:187190.
58. Vadkertiova, R.,, and E. Slavikova. 1995. Killer activity of yeasts isolated from the water environment. Can.J. Microbiol 41:759766.
59. Vanbreuseghem, R.,, and M. Takashio. 1970. An atypical strain of Cryptococcus neoformans (Sanfelice) Vuillemin. Part II. Cryptococcus neoformans var. gattii. Nov. Ann. Soc. Belg. Med. Trop. 50:695702.
60. Vuillemin, P. 1901. Les blastomycetes pathogenes. Rev. Gen. Sci. Pures Appl 12:732751.
61. Wickes, B. L.,, M. E. Mayorga,, J. Edman,, and J. C. Edman. 1996. Dimorphism and haploid fruiting in Cryptococcus neoformans: association with the alpha-mating type. Proc. Natl Acad. Sci. USA 93:73277331.


Generic image for table
Table 1

species (other than ) and where they are found

Table compiled from data in reference .

Citation: Casadevall A, Perfect J. 1998. Taxonomy, p 29-40. In . ASM Press, Washington, DC. doi: 10.1128/9781555818241.ch2
Generic image for table

Citation: Casadevall A, Perfect J. 1998. Taxonomy, p 29-40. In . ASM Press, Washington, DC. doi: 10.1128/9781555818241.ch2

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