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Chapter 18 : Cherish An Idea That Does Not Attach Itself to Anything

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Abstract:

Pre-T cells migrate from the bone marrow into the thymus, where they mature. The most primitive T cells begin as double-negative thymocytes with no CD4 or CD8 on the cell surface. While characterization of the receptor genes is clearly important to understanding the selection process and other T-cell functions, the genes coding for the T-cell receptor (TcR) had eluded isolation. A technique of differential screening and molecular subtraction, favoring a subtraction approach partly because of previous use of the protocol to isolate virus-specific sequences is used. T-cell-specific genes involved in differentiation and function were simply set out to isolate. Encouraged by the results with the CD4 and CD8 knockout mice, researchers proceeded to generate mice lacking genes engaged in TcR-mediated signal transduction. From Howard Temin, the author learned that science has its own integrity and that one must work tirelessly, be innovative, and, above all, occasionally cherish an idea that does not attach itself to anything.

Citation: Wah Mak T. 1995. Cherish An Idea That Does Not Attach Itself to Anything, p 271-286. In Cooper G, Temin R, Sugden B (ed), The DNA Provirus. ASM Press, Washington, DC. doi: 10.1128/9781555818302.ch18

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Figures

Image of Figure 1
Figure 1

Schematic map of restriction sites for REV-A and REV-T unintegrated linear cDNAs. Numbers show distances in kilobases from the 5' end of the viral DNA. Shaded areas denote sequences.

Citation: Wah Mak T. 1995. Cherish An Idea That Does Not Attach Itself to Anything, p 271-286. In Cooper G, Temin R, Sugden B (ed), The DNA Provirus. ASM Press, Washington, DC. doi: 10.1128/9781555818302.ch18
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Image of Figure 2
Figure 2

Mechanism proposed in 1983 for the production of SFFV from murine leukemia virus. F-MuLV, Friend murine leukemia virus; Xeno, xenotropic virus; MCF, mink cell focus virus.

Citation: Wah Mak T. 1995. Cherish An Idea That Does Not Attach Itself to Anything, p 271-286. In Cooper G, Temin R, Sugden B (ed), The DNA Provirus. ASM Press, Washington, DC. doi: 10.1128/9781555818302.ch18
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Image of Figure 3
Figure 3

Cartoon depicting steps in T-cell development in the murine thymus. Positive selection is by stromal epithelial (EPITH) cells. Negative selection occurs on bone marrow (BM)-derived elements.

Citation: Wah Mak T. 1995. Cherish An Idea That Does Not Attach Itself to Anything, p 271-286. In Cooper G, Temin R, Sugden B (ed), The DNA Provirus. ASM Press, Washington, DC. doi: 10.1128/9781555818302.ch18
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Image of Figure 4
Figure 4

Genomic arrangement of alpha-beta and gamma-delta TcR genes.

Citation: Wah Mak T. 1995. Cherish An Idea That Does Not Attach Itself to Anything, p 271-286. In Cooper G, Temin R, Sugden B (ed), The DNA Provirus. ASM Press, Washington, DC. doi: 10.1128/9781555818302.ch18
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Image of Figure 5
Figure 5

Locations of blocks in T-cell development in gene-targeted mutant mice. For example, alpha-beta T cells in the CD3 knockout mice are blocked at the double-positive 48 stage, while ontogeny of the gamma-delta lineage is unimpeded. TGF-β, TGF-α, transforming growth factors β and α, respectively; TAP-1, transporter associated with antigen processing; Inv ch, invariant chain.

Citation: Wah Mak T. 1995. Cherish An Idea That Does Not Attach Itself to Anything, p 271-286. In Cooper G, Temin R, Sugden B (ed), The DNA Provirus. ASM Press, Washington, DC. doi: 10.1128/9781555818302.ch18
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