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Chapter 21 : Reprint of Temin's 1993 Paper Proposing a New Approach to Developing a Human Immunodeficiency Virus Vaccine

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Reprint of Temin's 1993 Paper Proposing a New Approach to Developing a Human Immunodeficiency Virus Vaccine, Page 1 of 2

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Abstract:

From the mid-1980s, Howard Temin not only was keenly aware of the threat to public health posed by the expanding AIDS epidemic but also acted to limit that threat. He tried to minimize the personal and scientific conflicts among early workers on human immunodeficiency virus (HIV) so as not to obscure the national and international problem this virus presents. He also sought to contribute scientifically to the resolution of this problem, as evidenced by his "Proposal for a New Approach to a Preventive Vaccine against Human Immunodeficiency Virus Type 1" and his experimental pursuit of that proposal. In this article, Howard Temin built on his appreciation of simple and complex retroviruses to formulate a hypothesis, to develop a test of that hypothesis, and to propose an application of the hypothesis, if it were proven correct, in developing a vaccine against HIV. Howard's proposal is not conventional. It does not build on forced passage of HIV in cells in culture, an approach that seems unwise in view of this virus's capacity to generate variants in vivo. It is based on his novel biological insight. More important, it provides an approach that can be tested in animal models and thereby yields one rational approach to the development of a vaccine for HIV and eventual prevention of AIDS.

Citation: Cooper G, Temin R, Sugden B. 1995. Reprint of Temin's 1993 Paper Proposing a New Approach to Developing a Human Immunodeficiency Virus Vaccine, p 313-316. In The DNA Provirus. ASM Press, Washington, DC. doi: 10.1128/9781555818302.ch21

Key Concept Ranking

Human immunodeficiency virus 1
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Simian immunodeficiency virus
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Citation: Cooper G, Temin R, Sugden B. 1995. Reprint of Temin's 1993 Paper Proposing a New Approach to Developing a Human Immunodeficiency Virus Vaccine, p 313-316. In The DNA Provirus. ASM Press, Washington, DC. doi: 10.1128/9781555818302.ch21
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Image of Figure 1b
Figure 1b

Citation: Cooper G, Temin R, Sugden B. 1995. Reprint of Temin's 1993 Paper Proposing a New Approach to Developing a Human Immunodeficiency Virus Vaccine, p 313-316. In The DNA Provirus. ASM Press, Washington, DC. doi: 10.1128/9781555818302.ch21
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Download as Powerpoint

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