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Chapter 3 : Early Events in Infection: Receptor Binding and Cell Entry

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Abstract:

As knowledge of the early events in infection with enteroviruses is limited, this chapter focuses on studies with poliovirus but examines the emerging data on several other enteroviruses. The early events in virus infection, from virus binding to uncoating of the viral genome, are well characterized for a number of enveloped viruses. The poliovirus-receptor interaction is a particularly good model for studying virus entry because of the experimental manipulations that are possible given the known structure of the virus and our ability to mutagenize both the virus and its cellular receptor. Despite our increasing genetic and structural understanding of early events in poliovirus infection, many problems, such as the location of the uncoating event, remain unsolved. Perhaps imminent studies on the entry of echoviruses (ECVs) and coxsackieviruses, stimulated by the identification of their receptors, will provide clues. The roles of receptors in host range and pathogenesis have been extensively studied for poliovirus, but many questions, such as the basis of tissue tropism, remain. A study of the cell functions of virus receptors may provide information on their role in virus replication. It has been suggested that virus binding to cell receptors may lead to activation of cell events that lead to disease, and there is evidence that receptors may regulate virus-induced cytopathic effects. Studies of the interactions of cell receptors with their natural cell ligands may therefore provide clues about cell processes that are activated upon virus binding and govern the outcome of virus infections.

Citation: Racaniello V. 1995. Early Events in Infection: Receptor Binding and Cell Entry, p 73-93. In Rotbart H (ed), Human Enterovirus Infections. ASM Press, Washington, DC. doi: 10.1128/9781555818326.ch3

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Figures

Image of FIGURE 1
FIGURE 1

Locations of the VP 1 BC loop and mutations in the poliovirus capsid. The virion is shown schematically at left, with one protomer shaded gray. At right is an α-carbon tracing of VP1 and VP2 only. The BC loop is highlighted at the fivefold axis of symmetry. Sites of amino acid changes that confer the phenotype are shown as dots, and the amino acid residues are indicated. Sphingosine in the hydrocarbon-binding pocket is shown in dark gray.

Citation: Racaniello V. 1995. Early Events in Infection: Receptor Binding and Cell Entry, p 73-93. In Rotbart H (ed), Human Enterovirus Infections. ASM Press, Washington, DC. doi: 10.1128/9781555818326.ch3
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Image of FIGURE 2
FIGURE 2

Structural model of the first Ig-like domain of PVR. The structure was predicted as described in reference . The β strands are lettered, and locations of mutations that affect virus binding are given as amino acid numbers, which begin with the first methionine of PVR ( ). This predicted structure differs slightly from two other published versions ( ).

Citation: Racaniello V. 1995. Early Events in Infection: Receptor Binding and Cell Entry, p 73-93. In Rotbart H (ed), Human Enterovirus Infections. ASM Press, Washington, DC. doi: 10.1128/9781555818326.ch3
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Image of FIGURE 3
FIGURE 3

Model for poliovirus entry into cells. Binding of virus to cells is reversible when carried out at temperatures below 33°C; at higher temperatures, bound viruses are converted to A particles. These particles are found both outside and inside the cell and may be intermediates in the uncoating process. Uncoating may occur at the cell surface or from within endosomes.

Citation: Racaniello V. 1995. Early Events in Infection: Receptor Binding and Cell Entry, p 73-93. In Rotbart H (ed), Human Enterovirus Infections. ASM Press, Washington, DC. doi: 10.1128/9781555818326.ch3
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References

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1. Agol, V. I.,, S. G. Drozdov,, T. A. Ivannicova,, M. S. Kolesnikova,, M. B. Korolev,, and E. A. Tolskaya. 1989. Restricted growth of attenuated poliovirus strains in cultured cells of a human neuroblastoma. J. Virol. 63: 4035 4038.
2. Aoki, J.,, S. Koike,, I. Ise,, Y. Sato-Yoshida,, and A. Nomoto. 1994. Amino acid residues on human poliovirus receptor involved in interaction with poliovirus. J. Biol. Chem. 269: 8431 8438.
3. Armstrong, C. 1939. Successful transfer of the Lansing strain of poliomyelitis virus from the cotton rat to the white mouse. Public Health Rep. 54: 2302 2305.
4. Badger, J.,, I. Minor,, M. J. Kremer,, M. A. Oliveira,, T. J. Smith,, J. P. Griffith,, D. M. A. Guerin,, S. Krishnaswamy,, M. Luo,, M. G. Rossmann,, M. A. McKinlay,, G. D. Diana,, F. J. Dutko,, M. Fancher,, R. R. Rueckert,, and B. A. Heinz. 1988. Structural analysis of a series of antiviral agents complexed with human rhinovirus 14. Proc. Natl. Acad. Sci. USA 85: 3304 3308.
5. Bergelson, J. M.,, B. Chan,, R. W. Finberg,, and M. E. Hemler. 1993. The integrin VLA-2 binds echovirus 1 and extracellular matrix ligands by different mechanisms. J. Clin. Invest. 92: 232 239.
6. Bergelson, J. M.,, M. Chan,, K. R. Solomon,, N. F. St. John,, H. Lin,, and R. W. Finberg. 1994. Decay-accelerating factor (CD55), a glycosylphosphatidylinositol-anchored complement regulatory protein, is a receptor for several echoviruses. Proc. Natl. Acad. Sci. USA 91: 6245 6248.
7. Bergelson, J. M.,, M. P. Shepley,, B. M. C. Chan,, M. E. Hemler,, and R. W. Finberg. 1992. Identification of the integrin VLA-2 as a receptor for echovirus 1. Science 255: 1718 1720.
8. Bergelson, J. M.,, N. St. John,, S. Kawaguchi,, M. Chan,, H. Stubdal,, J. Modlin,, and R. W. Finberg. 1993. Infection by echoviruses 1 and 8 depends on the alpha2 subunit of human VLA-2. J. Virol. 67: 6847 6852.
9. Bernhardt, G.,, J. A. Bibb,, J. Bradley,, and E. Wimmer. 1994. Molecular characterization of the cellular receptor for poliovirus. Virology 199: 105 113.
10. Bernhardt, G.,, J. Harber,, A. Zibert,, M. deCrombrugghe,, and E. Wimmer. 1994. The poliovirus receptor: identification of domains and amino acid residues critical for virus binding. Virology 203: 344 356.
11. Bibb, J. A.,, G. Bernhardt,, and E. Wimmer. 1994. The human poliovirus receptor alpha is a serine phosphoprotein. J. Virol. 68: 6111 6115.
12. Bodian, D., 1959. Poliomyelitis: pathogenesis and histopathology, p. 479 498. In T. M. Rivers, and F. L. Horsfall (ed.), Viral and Rickettsial Infections of Man. J. B. Lippincott, Philadelphia.
13. Brown, R. H.,, D. Johnson,, M. Ogonowski,, and H. L. Weiner. 1987. Type 1 human poliovirus binds to human synaptosomes. Ann. Neurol. 21: 64 70.
14. Campbell, B. A.,, and C. E. Cords. 1983. Monoclonal antibodies that inhibit attachment of group B coxsackieviruses. J. Virol. 48: 561 564.
15. Chang, K. H.,, C. Day,, J. Walker,, T. Hyypiä,, and G. Stanway. 1992. The nucleotide sequences of wild-type coxsackievirus A9 strains imply that an RGD motif in VP1 is functionally significant. J. Gen. Virol. 73: 621 626.
16. Chow, M.,, J. F. E. Newman,, D. Filman,, J. M. Hogle,, D. J. Rowlands,, and F. Brown. 1987. Myristylation of picornavirus capsid protein VP4 and its structural significance. Nature (London) 327: 482 486.
17. Colonno, R. J.,, P. L. Callahan,, and W. L. Long. 1986. Isolation of a monoclonal antibody that blocks attachment of the major group of human rhinoviruses. J. Virol. 57: 7 12.
18. Colston, E.,, and V. R. Racaniello. Poliovirus variants selected on mutant receptor-expressing cells identify capsid residues that expand receptor recognition. Submitted for publication.
19. Colston, E.,, and V. R. Racaniello. Soluble receptor-resistant poliovirus mutants identify surface and internal capsid residues that control interaction with the cell receptor. EMBO J., in press.
20. Couderc, T.,, J. Hogle,, H. Le Blay,, F. Horaud,, and B. Blondel. 1993. Molecular characterization of mouse-virulent poliovirus type 1 Mahoney mutants: involvement of residues of polypeptides VP1 and VP2 located on the inner surface of the capsid protein shell. J. Virol. 67: 3808 3817.
21. Couderc, T.,, A. Martin,, C. Wychowski,, M. Girard,, F. Horaud,, and R. Crainic. 1991. Analysis of neutralization-escape mutants selected from a mouse virulent type 1/type 2 chimeric poliovirus: identification of a type 1 poliovirus with antigenic site 1 deleted. J. Gen. Virol. 72: 973 977.
22. Crowell, R. L. 1963. Specific viral interference in HeLa cell cultures chronically infected with coxsackie B5 virus. J. Bacteriol. 86: 517 526.
23. Crowell, R. L.,, A. K. Field,, W. A. Schleif,, W. L. Long,, R. J. Colonno,, J. E. Mapoles,, and E. A. Emini. 1986. Monoclonal antibody that inhibits infection of HeLa and rhabdomyosarcoma cells by selected enteroviruses through receptor blockade. J. Virol. 57: 438 445.
24. Crowell, R. L.,, and B. J. Landau,. 1983. Receptors in the initiation of picornavirus infections, p. 1 42. In H. Fraenkel-Conrat, and R. R. Wagner (ed.), Comprehensive Virology. Academic Press, Inc., New York.
25. de Verdugo, U. R.,, H.-C. Selinka,, M. Huber,, P. H. Hofschneider,, and R. Kandolf. 1994. Purification and characterization of a specific attachment protein for coxsackie B viruses, abstr. 5, p. 5. Abstr. Europic ‘94.
26. Evans, C. A.,, P. H. Byatt,, V. C. Chambers,, and W. M. Smith. 1954. Growth of neurotropic viruses in extraneural tissues.VI. Absence of in vivo multiplication of poliomyelitis virus, types I and II, after intratesticular inoculation of monkeys and other animals. J. Immunol. 72: 348 352.
27. Filman, D. J.,, R. Syed,, M. Chow,, A. J. Macadam,, P. D. Minor,, and J. M. Hogle. 1989. Structural factors that control conformational transitions and serotype specificity in type 3 poliovirus. EMBO J. 8: 1567 1579.
28. Fox, M. P.,, M. J. Otto,, and M. A. McKinlay. 1986. Prevention of rhinovirus and poliovirus uncoating by WIN 51711, a new antiviral drug. Antimicrob. Agents Chemother. 30: 110 116.
29. Freistadt, M. F.,, G. Kaplan,, and V. R. Racaniello. 1990. Heterogeneous expression of poliovirus receptor-related proteins in human cells and tissues. Mol. Cell. Biol. 10: 5700 5706.
30. Freistadt, M. S.,, H. B. Fleit,, and E. Wimmer. 1993. Poliovirus receptor on human blood cells: a possible extraneural site of poliovirus replication. Virology 195: 798 803.
31. Fricks, C. E.,, and J. M. Hogle. 1990. The cell-induced conformational change of poliovirus: externalization of the amino terminus of VP1 is responsible for liposome binding. J. Virol. 64: 1934 1945.
32. Gromeier, M.,, and K. Wetz. 1990. Kinetics of poliovirus uncoating in HeLa cells in a nonacidic environment. Virology 64: 3590 3597.
33. Hogle, J. M.,, M. Chow,, and D. J. Filman. 1985. Three-dimensional structure of poliovirus at 2.9 Å resolution. Science 229: 1358 1365.
34. Holland, J. J. 1961. Receptor affinities as major determinants of enterovirus tissue tropisms in humans. Virology 15: 312 326.
35. Holland, J. J.,, and B. H. Hoyer. 1962. Early stages of enterovirus infection. Cold Spring Harbor Symp. Quant. Biol. 27: 101 111.
36. Holland, J. J.,, J. C. McLaren,, and J. T. Syverton. 1959. The mammalian cell virus relationship. III. Production of infectious poliovirus by non-primate cells exposed to poliovirus ribonucleic acid. Proc. Soc. Exp. Biol. Med. 100: 843 845.
37. Holland, J. J.,, J. C. McLaren,, and J. T. Syverton. 1959. The mammalian cell virus relationship. IV Infection of naturally insusceptible cells with enterovirus ribonucleic acid. J. Exp. Med. 110: 65 80.
38. Hynes, R. O. 1992. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69: 11 22.
39. Hyypia, T.,, C. Horsnell,, M. Maaronen,, M. Khan,, N. Kalkkinen,, P. Auvinen,, L. Kinnunen,, and G. Stanway. 1992. A distinct picornavirus group identified by sequence analysis. Proc. Natl. Acad. Sci. USA 89: 8847 8851.
40. Incardona, N. L.,, and P. Kaesberg. 1974. A pH-induced structural change in bromegrass mosaic virus. Biophys. J. 4: 11 21.
41. Joklik, W. K.,, and J. E. Darnell. 1961. The absorption and early fate of purified poliovirus in HeLa cells. Virology 13: 439 447.
42. Jubelt, B.,, B. Gallez-Hawkins,, O. Narayan,, and R. T. Johnson. 1980. Pathogenesis of human poliovirus infection in mice. I. Clinical and pathological studies. J. Neuropathol. Exp. Neurol. 39: 138 148.
43. Jubelt, B.,, O. Narayan,, and R. T. Johnson. 1980. Pathogenesis of human poliovirus infection in mice. II. Age-dependency of paralysis. J. Neuropathol. Exp. Neurol. 39: 149 158.
44. Kaplan, A. S. 1955. Comparison of susceptible and resistant cells to infection with poliomyelitis virus. Ann. N.Y. Acad. Sci. 61: 830 839.
45. Kaplan, G.,, M. S. Freistadt,, and V. R. Racaniello. 1990. Neutralization of poliovirus by cell receptors expressed in insect cells. J. Virol. 64: 4697 4702.
46. Kaplan, G.,, D. Peters,, and V. R. Racaniello. 1990. Poliovirus mutants resistant to neutralization with soluble cell receptors. Science 250: 1596 1599.
47. Kirkegaard, K. 1990. Mutations in VP1 of poliovirus specifically affect both encapsidation and release of viral RNA. J. Virol. 64: 195 206.
48. Koike, S.,, H. Horie,, I. Dise,, H. Okitsu,, M. Yoshida,, N. Iizuka,, K. Takeuthi,, T. Takegami,, and A. Nomoto. 1990. The poliovirus receptor protein is produced both as membrane-bound and secreted forms. EMBO J. 9: 3217 3224.
49. Koike, S.,, I. Ise,, and A. Nomoto. 1991. Functional domains of the poliovirus receptor. Proc. Natl. Acad. Sci. USA 88: 4104 4108.
50. Koike, S.,, I. Ise,, Y. Sato,, H. Yonekawa,, O. Gotoh,, and A. Nomoto. 1992. A second gene for the African green monkey poliovirus receptor that has no putative N-glycosylation site in the functional N-terminal immunoglobulin-like domain. J. Virol. 66: 7059 7066.
51. Koike, S.,, C. Taya,, T. Kurata,, S. Abe,, I. Ise,, H. Yonekawa,, and A. Nomoto. 1991. Transgenic mice susceptible to poliovirus. Proc. Natl. Acad. Sci. USA. 88: 951 955.
52. Krah, D. L.,, and R. L. Crowell. 1982. A solid-phase assay of solubilized HeLa cell membrane receptors for binding group B coxsackieviruses and polioviruses. Virology 118: 148 156.
53. Krah, D. L.,, and R. L. Crowell. 1985. Properties of the deoxycholate-solubilized HeLa cell plasma membrane receptor for binding group B coxsackieviruses. J. Virol. 53: 867 870.
54. Kunin, C. M. 1962. Virus-tissue union and the pathogenesis of enterovirus infections. J. Immunol. 8: 556 559.
55. Kunin, C. M.,, and W. S. Jordan. 1961. In vitro adsorption of poliovirus by noncultured tissues. Effect of species, age and malignancy. Am. J. Hyg. 73: 245 257.
56. Ledinko, N.,, J. T. Riordan,, and J. L. Melnick. 1951. Differences in cellular pathogenicity of two immunologically related poliomyelitis viruses as revealed in tissue culture. Proc. Soc. Exp. Biol. Med. 78: 83 88.
57. Li, Q.,, A. G. Yafal,, Y. H. Lee,, J. Hogle,, and M. Chow. 1994. Poliovirus neutralization by antibodies to internal epitopes of VP4 and VP1 results from reversible exposure of these sequences at physiological temperature. J. Virol. 68: 3965 3970.
58. Lindberg, A. M.,, R. L. Crowell,, R. Zell,, R. Kandolf,, and U. Pettersson. 1992. Mapping of the RD phenotype of the Nancy strain of coxsackievirus B3. Virus Res. 24: 187 196.
59. Lloyd, R. E.,, and M. Bovee. 1993. Persistent infection of human erythroblastoid cells by poliovirus. Virology 194: 200 209.
60. Lonberg-Holm, K.,, R. L. Crowell,, and L. Philipson. 1976. Unrelated animal viruses share receptors. Nature (London) 259: 679 681.
61. Lonberg-Holm, K.,, and L. Philipson. 1974. Early interaction between animal viruses and cells. Monogr. Virol. 9: 1 148.
62. Lublin, D.,, and J. Atkinson. 1989. Decay-accelerating factor: biochemistry, molecular biology, and function. Annu. Rev. Immunol. 7: 35 57.
63. Macadam, A. J.,, G. Ferguson,, A. Nomoto,, and P. D. Minor. 1994. Sequences of the cellular receptor and viral capsid proteins influence the cytopathic effect of poliovirus, abstr. A2, p. 2. Abstr. Europic ‘94.
64. Madshus, I. H.,, S. Olsnes,, and K. Sandvig. 1984. Mechanism of entry into the cytosol of poliovirus type 1: requirement for low pH. J. Cell Biol. 98: 1194 1200.
65. Madshus, I. H.,, S. Olsnes,, and K. Sandvig. 1984. Requirements for entry of poliovirus RNA into cells at low pH. EMBO J. 3: 1945 1950.
66. Marsh, M.,, and A. Helenius. 1989. Virus entry into animal cells. Adv. Virus Res. 36: 107 151.
67. Martin, A.,, C. Wychowski,, T. Couderc,, R. Crainic,, J. Hogle,, and M. Girard. 1988. Engineering a poliovirus type 2 antigenic site on a type 1 capsid results in a chimaeric virus which is neurovirulent for mice. EMBO J. 7: 2839 2847.
68. Mason, P. W.,, B. Baxt,, F. Brown,, J. Harber,, A. Murdin,, and E. Wimmer. 1993. Antibody-complexed foot-and-mouth disease virus, but not poliovirus, can infect normally insusceptible cells via the Fc receptor. Virology 192: 568 577.
69. Mbida, A. D.,, O. G. Gaudin,, O. Sabido,, B. Pozzetto,, and J.-C. Le Bihan. 1992. Monoclonal antibody specific for the cellular receptor of echoviruses. Intervirology 33: 17 22.
70. Mbida, A. D.,, B. Pozzetto,, O. G. Gaudin,, F. Grattard,, J.-C. Le Bihan,, Y. Akono,, and A. Ros. 1992. A 44,000 glycoprotein is involved in the attachment of echovirus-11 onto susceptible cells. Virology 189: 350 353.
71. Mbida, A. D.,, B. Pozzetto,, O. Sabido,, Y. Akono,, F. Grattard,, M. Habib,, and O. G. Gaudin. 1991. Competition binding studies with biotinylated echovirus 11 in cytofluorimetry analysis. J. Virol. Methods 35: 169 176.
72. McLaren, L. C.,, J. J. Holland,, and J. T. Syverton. 1959. The mammalian cell-virus relationship. I. Attachment of poliovirus to cultivated cells of primate and non-primate origin. J. Exp. Med. 109: 475 485.
73. McLaren, L. C.,, J. J. Holland,, and J. T. Syverton. 1960. The mammalian cell-virus relationship. V. Susceptibility and resistance of cells in vitro to infection by coxsackie A9 virus. J. Exp. Med. 112: 581 594.
74. Melnick, J. L., 1990. Enteroviruses: polioviruses, coxsackieviruses, echoviruses and newer enteroviruses, p. 549 605. In B. N. Fields,, D. M. Knipe,, R. M. Chanock,, M. S. Hirsch,, J. L. Melnick,, T. P. Monath,, and B. Roizman (ed.), Virology. Raven Press, New York.
75. Mendelsohn, C.,, B. Johnson,, K. A. Lionetti,, P. Nobis,, E. Wimmer,, and V. R. Racaniello. 1986. Transformation of a human poliovirus receptor gene into mouse cells. Proc. Natl. Acad. Sci. USA 83: 7845 7849.
76. Mendelsohn, C.,, E. Wimmer,, and V. R. Racaniello. 1989. Cellular receptor for poliovirus: molecular cloning, nucleotide sequence and expression of a new member of the immunoglobulin superfamily. Cell 56: 855 865.
77. Miller, D. A.,, O. J. Miller,, V. G. Dev,, S. Hashmi,, R. Tantravahi,, L. Medrano,, and H. Green. 1974. Human chromosome 19 carries a poliovirus receptor gene. Cell 1: 167 173.
78. Minor, P. D.,, P. A. Pipkin,, D. Hockley,, G. C. Schild,, and J. W. Almond. 1984. Monoclonal antibodies which block cellular receptors of poliovirus. Virus Res. 1: 203 212.
79. Morrison, M. E.,, and V. R. Racaniello. 1992. Molecular cloning and expression of a murine homolog of the human poliovirus receptor gene. J. Virol. 66: 2807 2813.
80. Morrison, M. E.,, H. Yuan-Jing,, M. W. Wien,, J. W. Hogle,, and V. R. Racaniello. 1994. Homolog scanning mutagenesis reveals poliovirus receptor residues important for virus binding and replication. J. Virol. 68: 2578 2588.
81. Moscufo, N.,, A. G. Yafal,, A. Rogove,, J. Hogle,, and M. Chow. 1993. A mutation in VP4 defines a new step in the late stages of cell entry by poliovirus. J. Virol. 67: 5075 5078.
82. Moss, E. G.,, R. E. O’Neill,, and V. R. Racaniello. 1989. Mapping of attenuating sequences of an avirulent poliovirus type 2 strain. J. Virol. 63: 1884 1890.
83. Moss, E. G.,, and V. R. Racaniello. 1991. Host range determinants located on the interior of the poliovirus capsid. EMBO J. 5: 1067 1074.
84. Mosser, A. G.,, and R. R. Rueckert. 1993. WIN 51711-dependent mutants of poliovirus type 3: evidence that virions decay after release from cells unless drug is present. J. Virol. 67: 1246 1254.
85. Moyer, A. Q.,, C. Accorti,, and H. R. Cox. 1952. Poliomyelitis I. Propagation of the MEF1 strain of poliomyelitis virus in the suckling hamster. Proc. Soc. Exp. Biol. Med. 81: 513 518.
86. Murray, M. G.,, J. Bradley,, X. F. Yang,, E. Wimmer,, E. G. Moss,, and V. R. Racaniello. 1988. Poliovirus host range is determined by a short amino acid sequence in neutralization antigenic site I. Science 241: 213 215.
87. Nobis, P.,, R. Zibirre,, G. Meyer,, J. Kuhne,, G. Warnecke,, and G. Koch. 1985. Production of a monoclonal antibody against an epitope on HeLa cells that is the functional poliovirus binding site. J. Gen. Virol. 6: 2563 2569.
88. Olson, N. H.,, P. R. Kolatkar,, M. A. Oliveira,, R. H. Cheng,, J. M. Greve,, A. McClelland,, T. S. Baker,, and M. G. Rossmann. 1993. Structure of a human rhi-novirus complexed with its receptor molecule. Proc. Natl. Acad. Sci. USA 90: 507 511.
89. Pérez, L.,, and L. Carrasco. 1993. Entry of poliovirus into cells does not require a low-pH step. J. Virol. 67: 4543 4548.
90. Racaniello, V. R.,, and D. Baltimore. 1981. Cloned poliovirus complementary DNA is infectious in mammalian cells. Science 214: 916 919.
91. Reagan, K. J.,, B. Goldberg,, and R. L. Crowell. 1984. Altered receptor specificity of coxsackievirus B3 after growth in rhabdomyosarcoma cells. J. Virol. 49: 635 640.
92. Ren, R.,, F. C. Costantini,, E. J. Gorgacz,, J. J. Lee,, and V. R. Racaniello. 1990. Transgenic mice expressing a human poliovirus receptor: a new model for poliomyelitis. Cell 63: 353 362.
93. Ren, R.,, and V. Racaniello. 1992. Human poliovirus receptor gene expression and poliovirus tissue tropism in transgenic mice. J Virol. 66: 296 304.
94. Roca-Garcia, M.,, A. W. Moyer,, and H. R. Cox. 1952. Poliomyelitis. II. Propagation of MEF1 strain of poliomyelitis virus in developing chick embryo by yolk sac inoculation. Proc. Soc. Exp. Biol. Med. 81: 519 525.
95. Roivainen, M.,, T. Hyypiä,, L. Piirainen,, N. Kalkkinen,, G. Stanway,, and T. Hovi. 1991. RGD-dependent entry of coxsackievirus A9 into host cells and its bypass after cleavage of VP1 protein by intestinal proteases. J. Virol. 65: 4735 4740.
96. Roivainen, M.,, L. Piirainen,, T. Hyypiä,, I. Virtanen,, and T. Hovi. 1994. Receptors for coxsackievirus A9, abstr. A7, p. 7. Abstr. Europic ‘94.
97. Rombaut, B.,, P. Brioen,, and A. Boeyé. 1990. Disoxaril stabilization and immunogenic-ity of poliovirus procapsids. J. Gen. Virol. 71: 1081 1086.
98. Rossmann, M. G.,, E. Arnold,, J. W. Erickson,, E. A. Frankenberger,, J. P. Griffith,, H.-J. Hecht,, J. E. Johnson,, and G. Kamer. 1985. Structure of a human common cold virus and functional relationship to other picornaviruses. Nature (London) 317: 145 153.
99. Ryu, S.,, P. D. Kwong,, A. Truneh,, T. G. Porter,, J. Arthos,, M. Rosenberg,, X. Dai,, N. Xuong,, R. Axel,, R. W. Sweet,, and W. A. Hendrickson. 1990. Crystal structure of an HIV-binding recombinant fragment of human CD4. Nature (London) 348: 419 426.
100. Selinka, H.-C.,, A. Zibert,, and E. Wimmer. 1991. Poliovirus can enter and infect mammalian cells by way of an intercellular adhesion molecule 1 pathway. Proc. Natl. Acad. Sci. USA 88: 3598 3602.
101. Selinka, H.-C.,, A. Zibert,, and E. Wimmer. 1992. A chimeric poliovirus/CD4 receptor confers susceptibility to poliovirus on mouse cells. J. Virol. 66: 2523 2526.
102. Shepard, D. A.,, B. A. Heinz,, and R. R. Rueckert. 1993. WIN 52035-2 inhibits both attachment and eclipse of human rhinovirus 14. J. Virol. 67: 2245 2254.
103. Shepley, M. P.,, and V. R. Racaniello. 1994. A monoclonal antibody that blocks poliovirus attachment recognizes the lymphocyte homing receptor CD44. J. Virol. 68: 1301 1308.
104. Shepley, M. P.,, B. Sherry,, and H. L. Weiner. 1988. Monoclonal antibody identification of a 100-kDa membrane protein in HeLa cells and human spinal cord involved in poliovirus attachment. Proc. Natl. Acad. Sci. USA 85: 7743 7747.
105. Smith, T. J.,, M. J. Kremer,, M. Luo,, G. Vriend,, E. Arnold,, G. Kamer,, M. G. Rossmann,, M. A. McKinlay,, G. D. Diana,, and M.J. Otto. 1986. The site of attachment in human rhinovirus 14 for antiviral agents that inhibit uncoating. Science 233: 1286 1293.
106. Stamenkovic, I.,, M. Amiot,, M. Pesando,, and B. Seed. 1989. A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family. Cell 56: 1057 1062.
107. Vile, R. G.,, and R.A. Weiss. 1991. Virus receptors as permeases. Nature (London) 352: 666 667.
108. Wetz, K.,, and T. Kucinski. 1991. Influence of different ionic and pH environments on structural alteration of poliovirus and their possible relation to virus uncoating. J. Gen. Virol. 72: 2541 2544.
109. Willems, F. T. C.,, J. L. Melnick,, and W. E. Rawls. 1969. Replication of poliovirus in phytohemagglutinin-stimulated human lymphocytes. J. Virol. 3: 451 457.
110. Williams, A. F.,, and A. N. Barclay. 1988. The immunoglobulin superfamily—domains for cell surface recognition. Annu. Rev. Immunol. 6: 381 405.
111. Willingmann, P.,, H. Barnert,, H. Zeichhardt,, and K. O. Habermehl. 1989. Recovery of structurally intact and infectious poliovirus type 1 from HeLa cells during receptor-mediated endocytosis. Virology 168: 417 420.
112. Yeates, T. O.,, D. H. Jacobson,, A. Martin,, C. Wychowski,, M. Girard,, D. J. Filman,, and J. M. Hogle. 1991. Three-dimensional structure of a mouse-adapted type 2/type 1 poliovirus chimera. EMBO J. 10: 2331 2341.
113. Zajac, I.,, and R. Crowell. 1965. Location and regeneration of enterovirus receptors of HeLa cells. J. Bacteriol. 89: 1097 1100.
114. Zajac, I.,, and R. L. Crowell. 1965. Effect of enzymes on the interaction of enteroviruses with living HeLa cells. J. Bacteriol. 89: 574 582.
115. Zeichhardt, H.,, K. Wetz,, P. Willingmann,, and K.-O. Habermehl. 1985. Entry of poliovirus type 1 and mouse Elberfeld (ME) virus into Hep2 cells: receptor-mediated endocytosis and endosomal or lysosomal uncoating. J. Gen. Virol. 66: 483 492.
116. Zhou, D. F. H.,, J. F. Ding,, L. J. Picker,, R. F. Bargatze,, E. C. Butcher,, and D. F. Goeddel. 1989. Molecular cloning and expression of Pgp-1. The mouse homologue of the human H-CAM (Hermes) lymphocyte homing receptor. J. Immunol. 143: 3390 3395.
117. Zibert, A.,, H.-C. Selinka,, O. Elroy-Stern,, B. Moss,, and E. Wimmer. 1991. Vaccinia virus-mediated expression and identification of the human poliovirus receptor. Virology 182: 250 259.
118. Zibert, A.,, and E. Wimmer. 1992. N glycosylation of the virus binding domain is not essential for function of the human poliovirus receptor. J. Virol. 66: 7368 7373.

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