Chapter 1 : Transfer RNA in Its Fourth Decade

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Transfer RNA in Its Fourth Decade, Page 1 of 2

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Nearly four decades have passed since the discovery of tRNA. Much progress was made in the first two decades: elucidation of the role of tRNA as an adaptor in protein biosynthesis, determination of the primary sequences of several tRNAs, and solution of the three-dimensional structure of a tRNA. In addition, genes for tRNA were synthesized and the synthetic gene for an amber suppressor tRNA was shown to be functional in vivo. Progress has been made on a broad front in the last two decades also, and tRNA has remained an attractive and active area of research. In summarizing the four decades of tRNA research, it is appropriate to note that tRNA has been the source of many firsts in nucleic acid research.

Citation: Raj Bhandary U, Söll D. 1995. Transfer RNA in Its Fourth Decade, p 1-4. In tRNA. ASM Press, Washington, DC. doi: 10.1128/9781555818333.ch1

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Gene Expression and Regulation
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