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Chapter 9 : Guinea Pig Model of Tuberculosis

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Abstract:

Recent studies of the comparative biology of the guinea pig have revealed a number of remarkable similarities between and humans. Guinea pigs have been employed in the testing of both biological reagents and drugs for use in human beings with tuberculosis. Guinea pigs respond quite well to many of the antibiotics currently used to treat tuberculosis patients. The chapter presents guinea pig model of pulmonary tuberculosis, and discusses application of modern immunological techniques in the guinea pig. A model of endogenous reactivation disease would contribute to ones understanding of the factors associated with persistence of in the tissues as well as of the events that allow the dormant mycobacteria to reappear in large numbers. The advantages of the guinea pig model of tuberculosis are as follows: (i) animals can be infected reproducibly by the pulmonary route with very small numbers of virulent human tubercle bacilli; (ii) the course of disease following pulmonary infection, which includes bacillemia and hematogenous reseeding of the lung, is similar to that in humans; (iii) the similarities between the granulomatous and hypersensitivity responses of guinea pigs and humans to are remarkable; (iv) the degree of protection induced by vaccination with BCG is excellent, and one can discriminate between various degrees of protection; and (v) there is the potential for modeling other clinical forms of tuberculosis in the guinea pig.

Citation: McMurray D. 1994. Guinea Pig Model of Tuberculosis, p 135-147. In Bloom B (ed), Tuberculosis. ASM Press, Washington, DC. doi: 10.1128/9781555818357.ch9
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Figure 1

Primary tubercle in the lung of a guinea pig 4 weeks following inhalation of a few virulent H37Rv bacilli (Mainali and McMurray, submitted).

Citation: McMurray D. 1994. Guinea Pig Model of Tuberculosis, p 135-147. In Bloom B (ed), Tuberculosis. ASM Press, Washington, DC. doi: 10.1128/9781555818357.ch9
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Figure 2

Survival curves for groups of guinea pigs vaccinated with either BCG (•), nonviable defatted bacilli (O), or placebo (Δ) and infected with a few virulent H37Rv bacilli (from , with permission).

Citation: McMurray D. 1994. Guinea Pig Model of Tuberculosis, p 135-147. In Bloom B (ed), Tuberculosis. ASM Press, Washington, DC. doi: 10.1128/9781555818357.ch9
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Figure 3

Influence of BCG vaccination on the early course of pulmonary infection with virulent H37Rv in the lungs of vaccinated and nonvaccinated guinea pigs (from , with permission).

Citation: McMurray D. 1994. Guinea Pig Model of Tuberculosis, p 135-147. In Bloom B (ed), Tuberculosis. ASM Press, Washington, DC. doi: 10.1128/9781555818357.ch9
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Figure 4

Primary and secondary tubercles in the lung of a protein-malnourished guinea pig 4 weeks following inhalation of a few virulent H37Rv bacilli (Mainali and McMurray, submitted).

Citation: McMurray D. 1994. Guinea Pig Model of Tuberculosis, p 135-147. In Bloom B (ed), Tuberculosis. ASM Press, Washington, DC. doi: 10.1128/9781555818357.ch9
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Tables

Generic image for table
Table 1

Impact of chronic, moderate protein deficiency on immunity to experimental pulmonary tuberculosis in the guinea pig model

Citation: McMurray D. 1994. Guinea Pig Model of Tuberculosis, p 135-147. In Bloom B (ed), Tuberculosis. ASM Press, Washington, DC. doi: 10.1128/9781555818357.ch9
Generic image for table
Table 2

Diet-induced immunological spectrum of experimental pulmonary tuberculosis in the guinea pig

Citation: McMurray D. 1994. Guinea Pig Model of Tuberculosis, p 135-147. In Bloom B (ed), Tuberculosis. ASM Press, Washington, DC. doi: 10.1128/9781555818357.ch9

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