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Chapter 9 : Guinea Pig Model of Tuberculosis

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Abstract:

Recent studies of the comparative biology of the guinea pig have revealed a number of remarkable similarities between and humans. Guinea pigs have been employed in the testing of both biological reagents and drugs for use in human beings with tuberculosis. Guinea pigs respond quite well to many of the antibiotics currently used to treat tuberculosis patients. The chapter presents guinea pig model of pulmonary tuberculosis, and discusses application of modern immunological techniques in the guinea pig. A model of endogenous reactivation disease would contribute to ones understanding of the factors associated with persistence of in the tissues as well as of the events that allow the dormant mycobacteria to reappear in large numbers. The advantages of the guinea pig model of tuberculosis are as follows: (i) animals can be infected reproducibly by the pulmonary route with very small numbers of virulent human tubercle bacilli; (ii) the course of disease following pulmonary infection, which includes bacillemia and hematogenous reseeding of the lung, is similar to that in humans; (iii) the similarities between the granulomatous and hypersensitivity responses of guinea pigs and humans to are remarkable; (iv) the degree of protection induced by vaccination with BCG is excellent, and one can discriminate between various degrees of protection; and (v) there is the potential for modeling other clinical forms of tuberculosis in the guinea pig.

Citation: McMurray D. 1994. Guinea Pig Model of Tuberculosis, p 135-147. In Bloom B (ed), Tuberculosis. ASM Press, Washington, DC. doi: 10.1128/9781555818357.ch9
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Figure 1

Primary tubercle in the lung of a guinea pig 4 weeks following inhalation of a few virulent H37Rv bacilli (Mainali and McMurray, submitted).

Citation: McMurray D. 1994. Guinea Pig Model of Tuberculosis, p 135-147. In Bloom B (ed), Tuberculosis. ASM Press, Washington, DC. doi: 10.1128/9781555818357.ch9
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Figure 2

Survival curves for groups of guinea pigs vaccinated with either BCG (•), nonviable defatted bacilli (O), or placebo (Δ) and infected with a few virulent H37Rv bacilli (from , with permission).

Citation: McMurray D. 1994. Guinea Pig Model of Tuberculosis, p 135-147. In Bloom B (ed), Tuberculosis. ASM Press, Washington, DC. doi: 10.1128/9781555818357.ch9
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Figure 3

Influence of BCG vaccination on the early course of pulmonary infection with virulent H37Rv in the lungs of vaccinated and nonvaccinated guinea pigs (from , with permission).

Citation: McMurray D. 1994. Guinea Pig Model of Tuberculosis, p 135-147. In Bloom B (ed), Tuberculosis. ASM Press, Washington, DC. doi: 10.1128/9781555818357.ch9
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Figure 4

Primary and secondary tubercles in the lung of a protein-malnourished guinea pig 4 weeks following inhalation of a few virulent H37Rv bacilli (Mainali and McMurray, submitted).

Citation: McMurray D. 1994. Guinea Pig Model of Tuberculosis, p 135-147. In Bloom B (ed), Tuberculosis. ASM Press, Washington, DC. doi: 10.1128/9781555818357.ch9
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References

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1. Barnes, P. F.,, S.-J. Fong,, P. J. Brennan,, P. E. Twomey,, A. Mazumder,, and P. L. Modlin. 1990. Local production of tumor necrosis factor and IFN-? in tuberculous pleuritis. J. Immunol. 145: 149 154.
2. Bartow, R. A.,, and D. N. McMurray. 1989. Vaccination with Mycobacterium bovis BCG affects the distribution of Fc receptor-bearing T lymphocytes in experimental pulmonary tuberculosis. Infect. Immun. 57: 1374 1379.
3. Bartow, R. A.,, and D. N. McMurray. 1990. Erythrocyte receptor (CD2)-bearing T lymphocytes are affected by diet in experimental pulmonary tuberculosis. Infect. Immun. 58: 1843 1847.
4. Berthrong, M.,, and M. A. Hamilton. 1959. Tissue culture studies on resistance in tuberculosis. II. Monocytes from normal and immunized guinea pigs infected with virulent human tubercle bacilli. Am. Rev. Tuberc. 79: 221 231.
5. Bloch, H.,, and H. Noll. 1953. Studies on the virulence of tubercle bacilli. Variations in the virulence effect elicited by Tween 80 and thiosemicarbazone. Br. J. Exp. Pathol. 97: 1 16.
6. Caiman, H. N. 1972. Corticosteroids and lymphoid cells. N. Engl. J. Med. 287: 388 397.
7. Calmette, A.,, A. Boquet,, and L. Negre. 1924. Essais de vaccination contre l'infection tuberculeuse par voie buccale chez les petits animaux de laboratorie. Ann. Inst. Pasteur 38: 399 404.
8. Carlomagno, M. A.,, C. L. Mintzer,, C. L. McFarland,, and D. N. McMurray. 1985. Differential effect of protein and zinc deficiencies on delayed hypersensitivity and lymphokine activity in BCG-vaccinated guinea pigs. Nutr. Res. 5: 959 968.
9. Chaisson, R.,, and G. Slutkin. 1989. Tuberculosis and human immunodeficiency virus infection. J. Infect. Dis. 159: 96 100.
10. Cohen, M. K.,, R. A. Bartow,, C. L. Mintzer,, and D. N. McMurray. 1987. Effects of diet and genetics on Mycobacterium bovis BCG vaccine efficacy in inbred guinea pigs. Infect. Immun. 55: 314 319.
11. Cohn, M. L.,, C. L. Davis,, and G. Middlebrook. 1962. Chemoprophylaxis with isoniazid against aerogenic tuberculosis infection with the guinea pig. Am. Rev. Respir. Dis. 86: 95 97.
12. Collins, F. M. 1993. Tuberculosis: the return of an old enemy. Crit. Rev. Microbiol. 19: 1 16.
13. Collins, M.,, and C. A. Elvehjem. 1958. Ascorbic acid requirement of the guinea pig using growth and tissue ascorbic acid concentrations as criteria. J. Nutr. 64: 503 511.
14. Collins, P. D.,, V. B. Weg,, L. H. Faccioli,, M. L. Watson,, R. Moqbel,, and T. J. Williams. 1993. Eosinophil accumulation induced by human interleu-kin-8 in the guinea pig in vivo. Immunology 79: 312 318.
15. Dannenberg, A. M. Jr.,. 1984. Pathogenesis of tuberculosis: native and acquired resistance in animals and humans, p. 344 354. In L. Leive, and D. Schlessinger (ed.), Microbiology— 1984. American Society for Microbiology, Washington, D.C.
16. Ediger, R. D., 1976. Care and management, p. 5 12. In J. E. Wagner, and P. J. Manning (ed.), The Biology of the Guinea Pig. Academic Press, Inc., New York.
17. Edwards, M. L.,, J. M. Goodrich,, D. Muller,, A. Pollack,, J. E. Ziegler,, and D. W. Smith. 1982. Infection with Mycobacterium avium-intracellulare and the protective effects of bacille-Calmette-Guérin. J. Infect. Dis. 145: 733 741.
18. Elias, J. M.,, J. Chiba,, E. M. Shevach,, and H. P. Godfrey. 1985. Guinea pig T lymphocyte development analyzed by enzyme histocytochemistry, monoclonal antibodies and flow cytometry. Lab. Invest. 52: 270 277.
19. Ernstrom, U. 1970. Hormonal influences on thymic release of lymphocytes into the blood. CIBA Found. Study Group 36: 53 65.
20. Fok, J. S.,, R. S. Ho,, P. K. Arora,, G. E. Harding,, and D. W. Smith. 1976. Host-parasite relationships in experimental airborne tuberculosis. V. Lack of hematogenous dissemination of Mycobacterium tuberculosis to the lungs of animals vaccinated with bacille-Calmette-Guérin. J. Infect. Dis. 133: 137 144.
21. Fregnan, G. B.,, and D. W. Smith. 1963. Immunogenicity and allergenicity in guinea pigs of a defatted mycobacterial vaccine and its fractions. Am. Rev. Respir. Dis. 87: 877 888.
22. Graur, D.,, W. A. Hide,, and L. Wen-Hsiung. 1991. Is the guinea pig a rodent? Nature 351: 649 652.
23. Grover, A. A.,, H. K. Kim,, E. H. Wiegeshaus,, and D. W. Smith. 1967. Host-parasite relationships in experimental airborne tuberculosis. II. Reproducible infection by means of an inoculum preserved at -70°C. J. Bacterial. 94: 832 835.
24. Harding, G. E.,, and D. W. Smith. 1977. Host-parasite relationships in experimental airborne tuberculosis. VI. Influence of vaccination with bacille-Calmette-Guérin on the onset and/or extent of hematogenous dissemination of virulent Mycobacterium tuberculosis to the lungs . J. Infect. Dis. 136: 439 443.
25. Hart, I. J.,, H. Schafer,, R. J. Scheper,, and G. T. Stevenson. 1992. Subpopulations of guinea pig T lymphocytes defined by isoforms of the leukocyte common antigen. Immunology 77: 377 384.
26. Haslov, K.,, and I. Heron. 1989. The generation of guinea pig T-cell lines reactive to antigens from Mycobacterium tuberculosis. Selected lines induce erythematous skin reactions. Scand. J. Immunol. 29: 281 288.
27. Ho, R. S.,, J. S. Fok,, G. E. Harding,, and D. W. Smith. 1978. Host-parasite relationships in experimental airborne tuberculosis. VII. Fate of Mycobacterium tuberculosis in primary lung lesions and in primary lesion-free lung tissue infected as a result of bacillemia. J. Infect. Dis. 138: 237 241.
28. Jensen, K. A.,, G. Bindslev,, and J. Holm. 1935. Experimental studies on the development of tuberculosis infection in allergic and nonallergic animals. I. Development of tuberculous infection in the lungs after inhalation of virulent tubercle bacilli. Acta Tuberc. Scand. 9: 27 46.
29. Jespersen, A. 1956. Studies on tuberculin sensitivity and immunity in guinea pigs induced by vaccination with varying doses of BCG vaccine. Acta Pathol. Microbiol. Scand. 38: 203 209.
30. Koch, R. 1882. Aetiologie der Tuberculose. Berlin Klin. Wochenschr. 19: 221 230.
31. Kramer, T. R.,, and R. A. Good. 1978. Increased in vitro cell-mediated immunity in protein-malnourished guinea pigs. Clin. Immunol. Immunopathol. 11: 212 228.
32. Ladefoged, A.,, K. Bunch-Christensen,, and J. Guld. 1976. Tuberculin sensitivity in guinea pigs after vaccination with varying doses of BCG of 12 different strains. Bull. W.H.O. 53: 435 443.
33. Lechner, A. J.,, and N. Banchero. 1982. Advanced pulmonary development in newborn guinea pigs (Cavia porcellus). Am. J. Anat. 163: 235 246.
34. Legranderie, M.,, P. Ravisse,, G. Marchal,, M. Gheorghiu,, V. Balasubramanian,, E. H. Wiegeshaus,, and D. W. Smith. 1993. BCG-induced protection in guinea pigs vaccinated and challenged via the respiratory route. Tuberc. Lung Dis. 74: 38 46.
35. Leichentritt, B. 1924. Tuberkulose und Ernahrung. I. Mitteilung. Z. Hyg. Infektionskr. 102: 388 407.
36. Lenzini, L.,, P. Rottoli,, and L. Rottoli. 1977. The spectrum of human tuberculosis. Clin. Exp. Immunol. 27: 230 237.
37. Liebow, A. A.,, C. G. Burn,, and W. B. Soper. 1940. BCG immunization. A comparison of the effects of BCG and of heat-killed organisms on the course of a subsequent infection with virulent tubercle bacilli in the guinea pig. Am. Rev. Tuberc. 41: 592 604.
38. Long, E. R.,, A. J. Vorwald,, and L. Donaldson. 1931. Early cellular reaction to tubercle bacilli: a comparison of this reaction in normal and tuberculous guinea pigs and in guinea pigs immunized with dead bacilli. Arch. Pathol. 12: 956 969.
39. Mainali, E. S.,, and D. N. McMurray. Unpublished data.
40. Mainali, E. S.,, and D. N. McMurray. 1992. Influence of infection route in the generation of immune lymphocytes by guinea pigs infected with virulent Mycobacterium tuberculosis. FASEB J. 6: A1335.
41. Mainali, E. S.,, and D. N. McMurray. Adoptive transfer of resistance to pulmonary tuberculosis in guinea pigs is altered by protein deficiency. Submitted for publication.
42. Malek, T. R.,, R. B. Clark,, and E. M. Shevach. 1981. Alloreactive T cells from individual soft agar colonies specific for guinea pig Ia antigens. J. Immunol. 127: 616 621.
43. McConkey, M.,, and D. T. Smith. 1933. The relation of vitamin C deficiency to intestinal tuberculosis in the guinea pig. J. Exp. Med. 58: 503 512.
44. McMurray, D. N. 1980. Mechanisms of anergy in tuberculosis. Chest 77: 4 5.
45. McMurray, D. N. 1984. Cell-mediated immunity in nutritional deficiency. Prog. Food Nutr. Sci. 8: 193 228.
46. McMurray, D. N.,, and R. A. Bartow. 1992. Immunosuppression and alteration of resistance to pulmonary tuberculosis in guinea pigs by protein undernutrition. J. Nutr. 122: 738 743.
47. McMurray, D. N.,, R. A. Bartow,, and C. L. Mintzer. 1989a. Impact of protein malnutrition on exogenous reinfection with Mycobacterium tuberculosis. Infect. Immun. 57: 1746 1749.
48. McMurray, D. N.,, R. A. Bartow,, and C. L. Mintzer. 1990. Protein malnutrition alters the distribution of Fc ?R + (T?) and Fc?R + (T?) T lymphocytes in experimental pulmonary tuberculosis. Infect. Immun. 58: 563 565.
49. McMurray, D. N.,, M. A. Carlomagno,, C. L. Mintzer,, and C. L. Tetzlaff. 1985. Mycobacterium bovis BCG vaccine fails to protect protein-deficient guinea pigs against respiratory challenge with virulent Mycobacterium tuberculosis. Infect. Immun. 50: 555 559.
50. McMurray, D. N.,, and A. Echeverry. 1978. Cell-mediated immunity in anergic patients with pulmonary tuberculosis. Am. Rev. Respir. Dis. 118: 827 834.
51. McMurray, D. N.,, M. S. Kimball,, C. L. Tetzlaff,, and C. L. Mintzer. 1986a. Effects of protein deprivation and BCG vaccination on alveolar macrophage function in pulmonary tuberculosis. Am. Rev. Respir. Dis. 133: 1081 1085.
52. McMurray, D. N.,, E. S. Mainali,, and S. Phalen. 1993. Malnutrition, immunoregulatory defects and the white plague. Adv. Biosci. 86: 19 28.
53. McMurray, D. N.,, C. L. Mintzer,, R. A. Bartow,, and R. L. Parr. 1989b. Dietary protein deficiency and Mycobacterium bovis BCG affect interleukin 2 activity in experimental pulmonary tuberculosis. Infect. Immun. 57: 2606 2611.
54. McMurray, D. N.,, C. L. Mintzer,, C. L. Tetzlaff,, and M. A. Carlomagno. 1986b. Influence of dietary protein on the protective effect of BCG in guinea pigs. Tubercle 67: 31 39.
55. McMurray, D. N.,, and E. A. Yetley. 1983. Response to Mycobacterium bovis BCG vaccination in protein-and zinc-deficient guinea pigs. Infect. Immun. 39: 755 761.
56. McPhee, C. A.,, J. I. Milton,, and A. W. Thomson. 1988. Flow cytometric analysis of lymphocyte populations in guinea pig blood and spleen. Int. Arch. Allergy Appl. Immunol. 87: 275 280.
57. Middlebrook, G.,, R. J. Dubos,, and C. H. Pierce. 1947. Virulence and morphological characteristics of mammalian tubercle bacilli. J. Exp. Med. 86: 175 184.
58. Middlebrook, G. M. 1952. An apparatus for airborne infection of mice. Proc. Soc. Exp. Biol. Med. 80: 105 110.
59. Nardell, E.,, B. McInnis,, B. Thomas,, and S. Weidhaas. 1986. Exogenous reinfection with tuberculosis in a shelter for the homeless. N. Engl. J. Med. 315: 1570 1575.
60. Oosterhaut, A. J. M. V.,, A. R. C. Ladenius,, H. F. J. Savelkoul,, I. V. Ark,, K. C. Delsman,, and F. P. Nijkamp. 1993. Effect of anti-IL-5 and IL-5 on airway hyperreactivity and eosinophils in guinea pigs. Am. Rev. Respir. Dis. 147: 548 552.
61. Palmer, C. E.,, and L. Hopwood. 1962. Effect of previous infection with unclassified mycobacteria on survival of guinea pigs challenged with virulent tubercle bacilli. Bull. Int. Union Tuberc. 32: 389 398.
62. Pavia, C. S.,, and C. J. Niederbuhl. 1985. Experimental infections of inbred guinea pigs with Treponema pallidum: development of lesions and formation of antibodies. Genitourin. Med. 61: 75 81.
63. Payne, S. N. L.,, and A. W. Thomson. 1989. Immuno-histochemical analysis of contact sensitivity reactions in the guinea pig using novel monoclonal antibodies: the influence of topical cyclosporin A. Clin. Exp. Immunol. 75: 444 450.
64. Phalen, S. W.,, and D. N. McMurray. 1993a. T lymphocyte response in a guinea pig model of tuberculous pleuritis. Infect. Immun. 61: 142 145.
65. Phalen, S. W.,, and D. N. McMurray. 1993b. Production of tumor necrosis factor (TNFa) in experimental tuberculous pleuritis. J. Immunol. 150: 66A.
66. Polak, L.,, and R. J. Scheper. 1983. Antigen-specific T cell lines in DNCB-contact sensitivity in guinea pigs. J. Invest. Dermatol. 80: 398 402.
67. Prabhakar, R.,, R. Ventkataraman,, R. S. Vallishayee,, P. Reeser,, S. Musa,, R. Hashim,, Y. Kim,, C. Dimmer,, E. Wiegeshaus,, M. Edwards,, and D. W. Smith. 1987. Virulence for guinea pigs of tubercle bacilli isolated from the sputum of participants in the BCG trial, Chingleput district, south India. Tubercle 68: 3 17.
68. Rao, B. S. N.,, and C. Gopalan. 1958. Nutrition and tuberculosis. II. Studies on nitrogen, calcium and phosphorus metabolism in tuberculosis. Indian J. Med. Res. 46: 93 112.
69. Ratcliffe, H. L.,, and V. S. Palladino. 1953. Tuberculosis induced by droplet nuclei infection: initial homogeneous response of small mammals (rats, mice, guinea pigs and hamsters) to human and to bovine bacilli and the rate and pattern of tubercle development. J. Exp. Med. 97: 61 68.
70. Riley, R. L.,, C. C. Mills,, W. Nyka,, N. Weinstock,, P. B. Storey,, L. U. Sultan,, M. C. Riley,, and W. F. Wells. 1959. Aerial dissemination of pulmonary tuberculosis. A two year study of contagion in a tuberculosis ward. Am. J. Hyg. 70: 185 196.
71. Schafer, H.,, and R. Burger. 1992. Analysis of mature guinea pig T cells with a monoclonal antibody directed against a framework determinant of the T-cell receptor for antigen. Scand. J. Immunol. 36: 587 595.
72. Schafer, H.,, B. Muller,, A. Bader,, J. Schenke,, and R. Burger. 1989. Analysis of guinea pig leukocyte antigens using interspecies T cell hybrids. J. Immunol. Methods 118: 169 177.
73. Schenkel, J.,, H. Schafer,, U. Baron,, B. Muller,, and R. Burger. 1992. cDNA cloning of the constant region genes of the guinea pig ?/? T-cell receptor. Dev. Comp. Immunol. 16: 221 227.
74. Schwabacher, H.,, and G. S. Wilson. 1938. The vaccination of guinea pigs with living BCG, together with observations on tuberculous superinfection in rabbits. J. Pathol. Bacterial. 46: 535 547.
75. Shewell, J.,, and D. A. Long. 1956. A species difference with regard to the effect of cortisone acetate on body weight, ?-globulin and circulating antitoxin levels . J. Hyg. 54: 452 460.
76. Shigeki, K.,, K. Itoh,, I. Kurane,, and K. Kumagai. 1982. Detection of guinea pig T? and T?, cells by a double rosette assay. J. Immunol. Methods 51: 89 100.
77. Sisk, D. B., 1976. Physiology, p. 63 98. In J. E. Wagner, and P. J. Manning (ed.), The Biology of the Guinea Pig. Academic Press, Inc., New York.
78. Smith, D. W. 1985. Protective effect of BCG in experimental tuberculosis. Adv. Tuberc. Res. 22: 1 93.
79. Smith, D. W.,, V. Balasubramanian,, and E. H. Wiegeshaus. 1991. A guinea pig model of experimental airborne tuberculosis for the evaluation of the response to chemotherapy: the effect on bacilli in the initial phase of treatment. Tubercle 72: 223 321.
80. Smith, D. W.,, and G. E. Harding. 1977. Animal model: experimental airborne tuberculosis in the guinea pig. Am. J. Pathol. 89: 273 276.
81. Smith, D. W.,, and G. E. Harding,. 1978. Influence of BCG vaccination on the bacillemic phase of experimental airborne tuberculosis in guinea pigs, p. 85 90. In R. J. Montali (ed.), Mycobacterial Infections of Zoo Animals. Smithsonian Institution Press, Washington, D.C.
82. Smith, D. W.,, G. E. Harding,, and J. K. Chan. 1979. Potency of 10 BCG vaccines as evaluated by their influence on the bacillemic phase of experimental airborne tuberculosis in guinea pigs. J. Biol. Stand. 7: 179 197.
83. Smith, D. W.,, D. N. McMurray,, E. H. Wiegeshaus,, A. A. Grover,, and G. E. Harding. 1970. Host-parasite relationships in experimental airborne tuberculosis. IV. Early events in the course of infection in vaccinated and nonvaccinated guinea pigs. Am. Rev. Respir. Dis. 102: 937 949.
84. Smith, D. W.,, and E. H. Wiegeshaus. 1989. What animal models can teach us about the pathogenesis of tuberculosis in humans. Rev. Infect. Dis. 11: S385 S393.
85. Smith, D. W.,, E. H. Wiegeshaus,, R. Navalkar,, and A. A. Grover. 1966. Host-parasite relationships in experimental airborne tuberculosis. I. Preliminary studies in BCG-vaccinated and nonvaccinated animals. J. Bacterial. 91: 718 724.
86. Smith, D. W.,, E. H. Wiegeshaus,, R. H. Stark,, and G. E. Harding. 1972. Models for potency assays of tuberculosis vaccines. Fogarty Int. Cent. Proc. 14: 205 218.
87. Stadecker, M.,, G. Bishop,, and H. Wartis. 1973. Rosette formation by guinea pig thymocytes and thy-mus-derived lymphocytes with rabbit red blood cells. J. Immunol. 111: 1834 1837.
88. Stead, W. W. 1989. Pathogenesis of tuberculosis: clinical and epidemiological perspective. Rev. Infect. Dis. 11: 366 368.
89. Tan, B. T. G.,, F. Ekelaar,, J. Luirink,, G. Rimmelzwaan,, A. J. R. Dejonge,, and R. J. Scheper. 1985. Production of monoclonal antibodies defining guinea pig T cell surface markers and a strain 13 la-like antigen: the value of immunohistological screening. Hybridoma 4: 115 124.
90. Tolderland, K.,, K. Bunch-Christensen,, and J. Guld. 1967. Duration of allergy and immunity in BCG-vaccinated guinea pigs. A five-year study. Bull. W.H.O. 36: 759 769.
91. Wicher, V.,, K. Wiener,, A. Jakubowski,, and S. M. Nakeeb. 1987. Adoptive transfer of immunity to Treponema pallidum Nichols infection in inbred strain 2 and C4D guinea pigs. Infect. Immun. 55: 2502 2508.
92. Wiegeshaus, E. H.,, D. N. McMurray,, A. A. Grover,, G. E. Harding,, and D. W. Smith. 1970. Host-parasite relationships in experimental airborne tuberculosis. III. Relevance of microbial enumeration to acquired resistance in guinea pigs. Am. Rev. Respir. Dis. 102: 422 429.
93. Wiegeshaus, E. H.,, and D. W. Smith. 1989. Evaluation of the protective potency of new tuberculosis vaccines. Rev. Infect. Dis. 11: S484 S490.
94. Windstrom, O.,, and B. S. Nilsson. 1982. Pleurisy induced by intrapleural BCG in immunized guinea pigs. Eur. J. Respir. Dis. 63: 425 434.
95. Yamashita, T.,, K. Shinohara,, and Y. Yamashita. 1993. Expression cloning of complementary DNA encoding three distinct isoforms of guinea pig Fc receptor for IgG1 and IgG2. J. Immunol. 151: 2014 2023.
96. Yoshimura, T. 1993. cDNA cloning of guinea pig monocyte chemoattractant protein-1 and expression of the recombinant protein. J. Immunol. 150: 5025 5032.
97. Zeitz, S. J.,, J. H. Ostrow,, and P. P. Van Arsdel. 1974. Humoral and cellular immunity in the anergic tuberculosis patient. J. Allergy Clin. Immunol. 53: 20 26.
98. Zhao, J.,, V. Wicher,, R. Burger,, H. Schafer,, and K. Wicher. 1992. Strain- and age-associated differences in lymphocyte phenotypes and immune responsiveness in C4-deficient and Albany strains of guinea pigs. Immunology 77: 165 170.
99. Ziegler, J. E.,, M. L. Edwards,, and D. W. Smith. 1985. Exogenous reinfection in experimental airborne tuberculosis. Tubercle 66: 121 128.

Tables

Generic image for table
Table 1

Impact of chronic, moderate protein deficiency on immunity to experimental pulmonary tuberculosis in the guinea pig model

Citation: McMurray D. 1994. Guinea Pig Model of Tuberculosis, p 135-147. In Bloom B (ed), Tuberculosis. ASM Press, Washington, DC. doi: 10.1128/9781555818357.ch9
Generic image for table
Table 2

Diet-induced immunological spectrum of experimental pulmonary tuberculosis in the guinea pig

Citation: McMurray D. 1994. Guinea Pig Model of Tuberculosis, p 135-147. In Bloom B (ed), Tuberculosis. ASM Press, Washington, DC. doi: 10.1128/9781555818357.ch9

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