Chapter 17 : Host Susceptibility

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In this chapter, the term cholera gravis will denote the most severe life-threatening form of the disease, which can be rapidly fatal without treatment. One of the clear messages about cholera is that if the environment is made safer by sound sanitary practices and if good personal hygiene is put in place, the disease largely goes away. Anti-cholera toxin binding (CTB) antibody titers in contact with children's saliva were used to correlate their immune responses to CTB vaccination with nutritional status as part of the intervention arm of the family study mentioned in the chapter. The cholera attack rates were 88% in the heavy users of cannabis and 37% in light users. Because of the extensive use of cannabis-containing products in many areas where cholera is endemic, habitual usage may be a factor in host susceptibility where the risk of intake of contaminated food and water is high. The molecular genetic basis for the group ABO system was elucidated by Yamamoto, who suggested that the ABO markers be designated a histo-blood system, since the genes and their products are also found in many other cell types, e.g., epithelial cells. At present, two major attachment systems are known to be involved in adherence and colonization of animals and humans. The toxin-coregulated pilis (TCPs) share 80% amino acid homology at the amino acid level.

Citation: Richardson S. 1994. Host Susceptibility, p 273-289. In Wachsmuth I, Blake P, Olsvik Ø (ed), and Cholera. ASM Press, Washington, DC. doi: 10.1128/9781555818364.ch17

Key Concept Ranking

Outer Membrane Proteins
Small Intestine
DNA Restriction Enzymes
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Table 1

Evidence linking cholera severity to ABO blood type

Citation: Richardson S. 1994. Host Susceptibility, p 273-289. In Wachsmuth I, Blake P, Olsvik Ø (ed), and Cholera. ASM Press, Washington, DC. doi: 10.1128/9781555818364.ch17
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Table 2

CT binding and cAMP accumulation in ETS and ETS cell lines

Citation: Richardson S. 1994. Host Susceptibility, p 273-289. In Wachsmuth I, Blake P, Olsvik Ø (ed), and Cholera. ASM Press, Washington, DC. doi: 10.1128/9781555818364.ch17
Generic image for table
Table 3

Effects of preincubation with neuraminidase, LT Da, and LT lib on CT-induced cAMP accumulation in ETS and ETS transformed cells

Citation: Richardson S. 1994. Host Susceptibility, p 273-289. In Wachsmuth I, Blake P, Olsvik Ø (ed), and Cholera. ASM Press, Washington, DC. doi: 10.1128/9781555818364.ch17

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