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The group presently consists of seven , i.e., , , , , , , and the most recently recognized member of the group, , which is thermotolerant. There are two types of foodborne illness. The first type, which is caused by an emetic toxin, results in vomiting, whereas the second type, which is caused by enterotoxin(s), results in diarrhea. The most recently discovered enterotoxin, cytotoxin K (CytK), is similar to the β-toxin of (and other related toxins) and was the causative agent in a severe outbreak of foodborne illness in France in 1998. The two types of foodborne illness are caused by very different types of toxins including emetic toxin and enterotoxins. Expression of the toxins Hb1, Nhe, and CytK is regulated by the PlcR quorum-sensing system. The spore of is an important factor in contributing to foodborne illness. The spore is more hydrophobic than spores from any other spp., which enables it to adhere to several types of surfaces. foodborne illness is likely to be highly underreported because of its relatively mild symptoms with short duration. However, increased consumer interest for precooked, chilled food products with extended shelf lives may be well suited for survival and growth. Such foods could increase the prominence of as a foodborne pathogen.

Citation: Granum P, Lindbäck T. 2013. , p 491-502. In Doyle M, Buchanan R (ed), Food Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555818463.ch19
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Figure 19.1

The operon with promoter and regulatory sites. The indicated regulatory sequences are from type strain (ATCC 14579). The consensus PlcR box ( ) and the putative PlcR box with one mismatch in strain ATCC 14579 (underlined) and six bases between the palindromic flanks of the recognition sequence instead of four as in the established consensus ( ) and the two predicted sites (with mismatches towards the consensus underlined) are shown as boxes. The inverted repeat between and ( ) is indicated as a stem-loop structure. The bent arrows indicate the positions of transcriptional start sites, preceded by putative −10 and −35 regions. The transcriptional start site closest to the gene was identified using RNA isolated from strains NVH 0075/95 and NVH 1230/88 ( ), whereas the one further upstream was identified using a plasmid carrying the promoter from strain 407 ( ). The scale (in bp) is shown in the lower part of the figure. doi:10.1128/9781555818463.ch19f1

Citation: Granum P, Lindbäck T. 2013. , p 491-502. In Doyle M, Buchanan R (ed), Food Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555818463.ch19
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1. Agaisse, H.,, M. Gominet,, O. A. Okstad,, A. B. Kolsto,, and D. Lereclus. 1999. PlcR is a pleiotropic regulator of extracellular virulence factor gene expression in Bacillus thuringiensis. Mol. Microbiol. 32:10431053.
2. Agata, N.,, M. Mori,, M. Ohta,, S. Suwan,, I. Ohtani,, and M. Isobe. 1994. A novel dodecadepsipeptide, cereulide, isolated from Bacillus cereus causes vacuole formation in HEp-2 cells. FEMS Microbiol. Lett. 121:3134.
3. Agata, N.,, M. Ohta,, M. Mori,, and M. Isobe. 1995. A novel dodecadepsipeptide, cereulide, is an emetic toxin of Bacillus cereus. FEMS Microbiol. Lett. 129:1720.
4. Andersson, A.,, P. E Granum,, and U. Rönner. 1998. The adhesion of Bacillus cereus spores to epithelial cells might be an additional virulence mechanism. Int. J. Food Microbiol. 39:9399.
5. Andersson, A.,, U. Rönner,, and P. E. Granum. 1995. What problems does the food industry have with the sporeforming pathogens Bacillus cereus and Clostridium perfringens? Int. J. Food Microbiol. 28:145156.
6. Ash, C.,, and M. D. Collins. 1992. Comparative analysis of 23S ribosomal RNA gene sequence of Bacillus anthracis and emetic Bacillus cereus determined by PCR-direct sequencing. FEMS Microbiol. Lett. 73:7580.
7. Ash, C.,, J. A. Farrow,, M. Dorsch,, E. Steckebrandt,, and M. D. Collins. 1991. Comparative analysis of Bacillus anthracis, Bacillus cereus, and related species on the basis of reverse transcriptase sequencing of 16S rRNA. Int. J. Syst. Bacteriol. 41:343346.
8. Beecher, D. J.,, and J. D. Macmillan. 1991. Characterization of the components of hemolysin BL from Bacillus cereus. Infect. Immun. 59:17781784.
9. Beecher, D. J.,, J. L. Schoeni,, and A. C. L. Wong. 1995. Enterotoxin activity of hemolysin BL from Bacillus cereus. Infect. Immun. 63:44234428.
10. Beecher, D. J.,, and A. C. L Wong. 1997. Tripartite hemolysin BL from Bacillus cereus. Hemolytic analysis of component interaction and model for its characteristic paradoxical zone phenomenon. J. Biol. Chem. 272:233239.
11. Beecher, D. J.,, and A. C. L. Wong. 1994. Identification and analysis of the antigens detected by two commercial Bacillus cereus diarrheal enterotoxin immunoassay kits. Appl. Environ. Microbiol. 60:46144616.
12. Beecher, D. J.,, and A. C. L. Wong. 1994. Improved purification and characterization of hemolysin BL, a hemolytic dermonecrotic vascular permeability factor from Bacillus cereus. Infect. Immun. 62:980986.
13. Blatch, G. L.,, and M. Lassle. 1999. The tetratricopeptide repeat: a structural motif mediating protein-protein interactions. Bioessays 21:932939.
14. Borge, G. A.,, M. Skeie,, T. Langsrud,, and P. E. Granum. 2001. Growth and toxin profiles of Bacillus cereus isolated from different food sources. Int. J. Food Microbiol 69:237246.
15. Bouillaut, L.,, S. Perchat,, S. Arold,, S. Zorrilla,, L. Slamti,, C. Henry,, M. Gohar,, N. Declerck,, and D. Lereclus. 2008. Molecular basis for group-specific activation of the virulence regulator PlcR by PapR heptapeptides. Nucleic Acids Res. 36:37913801.
16. Brynestad, S.,, and P. E. Granum. 2002. Clostridium perfringens and foodborne infections. Int. J. Food Microbiol. 74:195202.
17. Carlson, C. R.,, D. A. Caugant,, and A.-B. Kolstø. 1994. Genotypic diversity among Bacillus cereus and Bacillus thuringiensis strains. Appl. Environ. Microbiol. 60:17191725.
18. Christiansson, A.,, A. S. Naidu,, I. Nilsson,, T. Wadström,, and H.-E. Pettersson. 1989. Toxin production by Bacillus cereus dairy isolates in milk at low temperatures. Appl. Environ. Microbiol. 55:25952600.
19. Claus, D.,, and R. C. W. Berkeley,. 1986. Genus Bacillus, p. 11051139, vol . 2. In P. H. A. Seneath (ed.), Bergey’s Manual of Systematic Bacteriology. The Williams and Wilkins Co., Baltimore, MD.
20. Damgaaerd, P. H.,, H. D. Larsen,, B. M. Hansen,, J. Bresciani,, and K. Jørgensen. 1996. Enterotoxin-producing strains of Bacillus thuringiensis isolated from food. Lett. Appl. Microbiol. 23:146150.
21. Declerck, N.,, L. Bouillaut,, D. Chaix,, N. Rugani,, L. Slamti,, F. Hoh,, D. Lereclus,, and S. T. Arold. 2007. Structure of PlcR: insights into virulence regulation and evolution of quorum sensing in Gram-positive bacteria. Proc. Natl. Acad. Sci. USA 104:1849018495.
22. Dierick, K.,, E. Van Coillie,, I. Swiecicka,, G. Meyfroidt,, H. Devlieger,, A. Meulemans,, G. Hoedemaekers,, L. Fourie,, M. Heyndrickx,, and J. Mahillon. 2005. Fatal family outbreak of Bacillus cereus-associated food poisoning. J. Clin. Microbiol. 43:42774279.
23. Dietrich, R.,, M. Moravek,, C. Bürk,, P. E. Granum,, and E. Märtlbauer. 2005. Production and characterization of antibodies against each of the three subunits of the Bacillus cereus non-hemolytic enterotoxin complex. Appl. Environ. Microbiol. 257:293298.
24. Duport, C.,, S. Thomassin,, G. Bourel,, and P. Schmitt. 2004. Anaerobiosis and low specific growth rates enhance hemolysin BL production by Bacillus cereus F4430/73. Arch. Microbiol. 182:9095.
25. Ehling-Schulz, M.,, M. Fricker,, H. Grallert,, P. Rieck,, M. Wagner,, and S. Scherer. 2006. Cereulide synthetase gene cluster from emetic Bacillus cereus: structure and location on a mega virulence plasmid related to Bacillus anthracis toxin plasmid pXO1. BMC Microbiol. 6:20.
26. Ehling-Schulz, M.,, B. Svensson,, M.-H. Guinebritiere,, T. Lindbäck,, M. Andersson,, A. Schulz,, A. Christiansson,, P. E. Granum,, E. Märtelbauer,, C. Nyguyen-The,, M. Salkinoja-Salonen,, and S. Scherer. 2005. Emetic toxin formation of Bacillus cereus is restricted to a single evolutionary lineage of closely related strains. Microbiology 151:183197.
27. Ehling-Schulz, M.,, N. Vukov,, A. Schulz,, R. Shaheen,, M. Andersson,, E. Martlbauer,, and S. Scherer. 2005. Identification and partial characterization of the nonribosomal peptide synthetase gene responsible for cereulide production in emetic Bacillus cereus. Appl. Environ. Microbiol. 71:105113.
28. Fagerlund, A.,, J. Brillard,, R. Furst,, M. H. Guinebretiere,, and P. E. Granum. 2007. Toxin production in a rare and genetically remote cluster of strains of the Bacillus cereus group. BMC Microbiol. 7:43.
29. Fagerlund, A.,, T. Lindbäck,, and P. E. Granum. 2010. Bacillus cereus cytotoxins Hbl, Nhe and CytK are secreted via the Sec translocation pathway. BMC Microbiol. 10:304.
30. Fagerlund, A.,, T. Lindbäck,, A. K. Storset,, P. E. Granum,, and S. P. Hardy. 2008. Bacillus cereus Nhe is a pore-forming toxin with structural and functional properties similar to the ClyA (HlyE, SheA) family of haemolysins, able to induce osmotic lysis in epithelia. Microbiology 154:693704.
31. Fagerlund, A.,, O. Ween,, T. Lund,, S. P. Hardy,, and P. E. Granum. 2004. Different cyto-toxicity of CytK and CytK-like proteins from Bacillus cereus. Microbiology 150:26892697.
32. Gohar, M.,, K. Faegri,, S. Perchat,, S. Ravnum,, O. A. Okstad,, M. Gominet,, A. B. Kolsto,, and D. Lereclus. 2008. The PlcR virulence regulon of Bacillus cereus. PLoS ONE 3:e2793.
33. Gohar, M.,, O. A. Okstad,, N. Gilois,, V. Sanchis,, A. B. Kolsto,, and D. Lereclus. 2002. Two-dimensional electrophoresis analysis of the extracellular proteome of Bacillus cereus reveals the importance of the PlcR regulon. Proteomics 2:784791.
34. Gominet, M.,, L. Slamti,, N. Gilois,, M. Rose,, and D. Lereclus. 2001. Oligopeptide permease is required for expression of the Bacillus thuringiensis plcR regulon and for virulence. Mol. Microbiol. 40:963975.
35. Granum, P. E. 1994. Bacillus cereus and its toxins. J. Appl. Bacteriol. 76:61S66S.
36. Granum, P. E.,, A. Andersson,, C. Gayther,, M. C. te Giffel,, H. D. Larsen,, T. Lund,, and K. O’Sullivan. 1996. Evidence for a further enterotoxin complex produced by Bacillus cereus. FEMS Microbiol. Lett. 141:145149.
37. Granum, P. E.,, and T. C. Baird-Parker,. 2000. Bacillus spp., p. 10291039. In B. Lund,, T. Baird-Parker,, and G. Gould (ed.), The Microbiological Safety and Quality of Food. Aspen Publishers, Aspen Hill, MD.
38. Granum, P. E.,, S. Brynestad,, and J. M. Kramer. 1993. Analysis of enterotoxin production by Bacillus cereus from dairy products, food poisoning incidents and non-gastrointestinal infections. Int. J. Food Microbiol. 17:269279.
39. Granum, P. E.,, and T. Lund. 1997. Bacillus cereus enterotoxins. FEMS Microbiol. Lett. 157:223228.
40. Granum, P. E.,, K. O’Sullivan,, and T. Lund. 1999. The sequence of the non-haemolytic enterotoxin operon from Bacillus cereus. FEMS Microbiol. Lett. 177:225229.
41. Griffiths, M. W. 1990. Toxin production by psychrotrophic Bacillus spp. present in milk. J. Food Prot. 53:790792.
42. Haggblom, M. M.,, C. Apetroaie,, M. A. Andersson,, and M. S. Salkinoja-Salonen. 2002. Quantitative analysis of cereulide, the emetic toxin of Bacillus cereus, produced under various conditions. Appl. Environ. Microbiol. 68:24792483.
43. Hardy, S. P.,, T. Lund, and P. E. Granum. 2001. CytK toxin of Bacillus cereus forms pores in planar lipid bilayers and is cytotoxic to intestinal epithelia. FEMS Microbiol. Lett. 197:4751.
44. Hauge, S. 1955. Food poisoning caused by aerobic spore forming bacilli. J. Appl. Bacteriol. 18:591595.
45. Heinrichs, J. H.,, D. J. Beecher,, J. M. MacMillan,, and B. A. Zilinskas. 1993. Molecular cloning and characterization of the hblA gene encoding the B component of hemolysin BL from Bacillus cereus. J. Bacteriol. 175:67606766.
46. Hoffmaster, A. R.,, J. Ravel,, D. A. Rasko,, G. D. Chapman,, M. D. Chute,, C. K. Marston,, B. K. De,, C. T. Sacchi,, C. Fitzgerald,, L. W. Mayer,, M. C. Maiden,, F. G. Priest,, M. Barker,, L. Jiang,, R. Z. Cer,, J. Rilstone,, S. N. Peterson,, R. S. Weyant,, D. R. Galloway,, T. D. Read,, T. Popovic,, and C. M. Fraser. 2004. Identification of anthrax toxin genes in a Bacillus cereus associated with an illness resembling inhalation anthrax. Proc. Natl. Acad. Sci. USA 101:84498454.
47. Hoton, F. M.,, L. Andrup,, I. Swiecicka,, and J. Mahillon. 2005. The cereulide genetic determinants of emetic Bacillus cereus are plasmid-borne. Microbiology 151:21212124.
48. Hueck, C. J.,, and W. Hillen. 1995. Catabolite repression in Bacillus subtilis: a global regulatory mechanism for the gram-positive bacteria? Mol. Microbiol. 15:395401.
49. Hughes, S.,, B. Bartholomew,, J. C. Hardy,, and J. M. Kramer. 1988. Potential application of a HEp-2 cell assay in the investigation of Bacillus cereus emetic-syndrome food poisoning. FEMS Microbiol. Lett. 52:712.
50. Husmark, U. 1993. Adhesion mechanisms of bacterial spores to solid surfaces. Ph.D. thesis. Department of Food Science, Chalmers University of Technology and SIK, The Swedish Institute for Food Research, Göteborg, Sweden.
51. Jackson, S. G.,, R. B. Goodbrand,, R. Ahmed,, and S. Kasatiya. 1995. Bacillus cereus and Bacillus thuringiensis isolated in a gastroenteritis outbreak investigation. Lett. Appl. Microbiol. 21:103105.
52. Klimowicz, A. K.,, T. A. Benson,, and J. Handelsman. 2010. A quadruple enterotoxin-deficient mutant of Bacillus thuringiensis remains insecticidal. Microbiology 156:35753583.
53. Kramer, J.M.,, and R. J. Gilbert,. 1989. Bacillus cereus and other Bacillus species, p. 2170. In M. P. Doyle (ed.), Foodborne Bacterial Pathogens. Marcel Dekker, New York, NY.
54. Lechner, S.,, R. Mayr,, K. P. Francic,, B. M. Prub,, T. Kaplan,, E. Wieber-Gunkel,, G. A. S. B. Stewart,, and S. Scherer. 1998. Bacillus weihenstephanensis sp. nov. is a new psychrotolerant species of the Bacillus cereus group. Int. J. Syst. Bacteriol. 48:13731382.
55. Lereclus, D.,, H. Agaisse,, M. Gominet,, S. Salamitou,, and V. Sanchis. 1996. Identification of a Bacillus thuringiensis gene that positively regulates transcription of the phosphatidylinositol-specific phospholipase C gene at the onset of the stationary phase. J. Bacteriol. 178:27492756.
56. Lindbäck, T.,, A. Fagerlund,, M. S. Rødland,, and P. E. Granum. 2004. Characterization of the Bacillus cereus Nhe enterotoxin. Microbiology 150:39593967.
57. Lindbäck, T.,, S. P. Hardy,, R. Dietrich,, M. Sodring,, A. Didier,, M. Moravek,, A. Fagerlund,, S. Bock,, C. Nielsen,, M. Casteel,, P. E. Granum,, and E. Martlbauer. 2010. Cytotoxicity of the Bacillus cereus Nhe enterotoxin requires specific binding order of its three exoprotein components. Infect. Immun. 78:38133821.
58. Lund, T.,, M. L. De Buyser,,and P. E. Granum. 2000. A new cytotoxin from Bacillus cereus that may cause necrotic enteritis. Mol. Microbiol. 38:254261.
59. Lund, T.,, and P. E. Granum. 1996. Characterisation of a non-haemolytic enterotoxin complex from Bacillus cereus isolated after a foodborne outbreak. FEMS Microbiol. Lett. 141:151156.
60. Lund, T.,, and P. E. Granum. 1997. Comparison of biological effect of the two different enterotoxin complexes isolated from three different strains of Bacillus cereus. Microbiology 143:33293336.
61. Mahler, H.,, A. Pasi,, J. M. Kramer,, P. Schulte,, A. C. Scoging,, W. Bar,, and S. Krahenbuhl. 1997. Fulminant liver failure in association with the emetic toxin of Bacillus cereus. N. Engl. J. Med. 336:11421148.
62. Mignot, T.,, M. Mock,, D. Robichon,, A. Landier,, D. Lereclus,, and A. Fouet. 2001. The incompatibility between the PlcR- and AtxA-controlled regulons may have selected a nonsense mutation in Bacillus anthracis. Mol. Microbiol. 42:11891198.
63. Miwa, Y.,, A. Nakata,, A. Ogiwara,, M. Yamamoto,, and Y. Fujita. 2000. Evaluation and characterization of catabolite-responsive elements (cre) of Bacillus subtilis. Nucleic Acids Res. 28:12061210.
64. Moravek, M.,, R. Dietrich,, C. Buerk,, V. Broussolle,, M. H. Guinebretiere,, P. E. Granum,, C. Nguyen-The,, and E. Martlbauer. 2006. Determination of the toxic potential of Bacillus cereus isolates by quantitative enterotoxin analyses. FEMS Microbiol. Lett. 257:293298.
65. Mortimer, P.R.,, and G. McCann. 1974. Food poisoning episodes associated with Bacillus cereus in fried rice. Lancet i:10431045.
66. Nakamura, L. K. 1998. Bacillus pseudomycoides sp. nov. Int. J. Syst. Bacteriol. 48:10311035.
67. Ouhib, O.,, T. Clavel,, and P. Schmitt. 2006. The production of Bacillus cereus enterotoxins is influenced by carbohydrate and growth rate. Curr. Microbiol. 53:222226.
68. Ray, D.E., 1991. Pesticides derived from plants andother organisms, p. 585636. In W. J. Hayes, and E. R. Laws, Jr. (ed.), Handbook of Pesticide Toxicology. Academic Press, Inc., New York, NY.
69. Rivera, A. M. G.,, P. E. Granum,, and F. G Priest. 2000. Common occurrence of enterotoxin genes and enterotoxicity in Bacillus thuringiensis. FEMS Microbiol. Lett. 190:151155.
70. Rosenquist, H.,, L. Smidt,, S. R. Andersen,, G. B. Jensen,, and A. Wilcks. 2005. Occurrence and significance of Bacillus cereus and Bacillus thuringiensis in ready-to-eat food. FEMS Microbiol Lett. 250:129136.
71. Ryan, P. A.,, J. M. Macmillan,, and B. A. Zilinskas. 1997. Molecular cloning and characterization of the genes encoding the L1 and L2 components of hemolysin BL from Bacillus cereus. J. Bacteriol. 179:25512556.
72.Schmidt, K. (ed). 2001. WHO Surveillance Programme for Control of Foodborne Infections and Intoxications in Europe. Seventh Report. FAO/WHO Collaborating Centre for Research and Training in Food Hygiene and Zoonoses, Berlin, Germany.
73. Schoeni, J. L.,, and A. C. L Wong. 1999. Heterogeneity observed in the components of hemolysin BL, an enterotoxin produced by Bacillus cereus. Int. J. Food Microbiol. 53:159167.
74. Shinagawa, K. 1993. Serology and characterization of Bacillus cereus in relation to toxin production. Bull. Int. Dairy Fed. 287:4249.
75. Shinagawa, K.,, H. Konuma,, H. Sekita,, and S. Sugii. 1995. Emesis of rhesus monkeysinduced by intragastric administration with the HEp-2 vacuolation factor (cereulide) produced by Bacillus cereus. FEMS Microbiol. Lett. 130:8790.
76. Shinagawa, K.,, S. Otake,, N. Matsusaka,, and S. Sugii. 1992. Production of the vacuolation factor of Bacillus cereus isolated from vomiting-type food poisoning. J. Vet. Med. Sci. 54:443446.
77. Shiota, M.,, K. Saitou,, H. Mizumoto,, M. Matsusaka,, N. Agata,, M. Nakayama,, M. Kage,, S. Tatsumi,, A. Okamoto,, S. Yamaguchi,, M. Ohta,, and D. Hata. 2010. Rapid detoxification of cereulide in Bacillus cereus food poisoning. Pediatrics 125:e951e955.
78. Slamti, L.,, and D. Lereclus. 2002. A cell-cell signaling peptide activates the PlcR virulence regulon in bacteria of the Bacillus cereus group. EMBO J. 21:45504559.
79. Slamti, L.,, and D. Lereclus. 2005. Specificity and polymorphism of the PlcR-PapR quorum-sensing system in the Bacillus cereus group. J. Bacteriol. 187:11821187.
80. Guinebretiere, M. H.,, S. Auger,, N. Galleron,, M. Contzen,, B. De Sarrau,, M. L. De Buyser,, G. Lamberet,, A. Fagerlund,, P. E. Granum,, D. Lereclus,, P. De Vos,, C. Nguyen-The,, and A. Sorokin. 2012. Bacillus cytotoxicus sp. nov. is a new thermotolerant species of the Bacillus cereus group occasionally associated with food poisoning. Int. J. Syst. Evol. Microbiol. 17 Feb 2012. [Epub ahead of print] PubMed PMID: 22328607.
81. Stenfors Arnesen, L. P.,, A. Fagerlund,, and P. E. Granum. 2008. From soil to gut: Bacillus cereus and its food poisoning toxins. FEMS Microbiol. Rev. 32:579606.
82. Stenfors Arnesen, L. P.,, K. O’Sullivan,, and P. E. Granum. 2007. Food poisoning potential of Bacillus cereus strains from Norwegian dairies. Int. J. Food Microbiol. 116:292296.
83. Thorsen, L.,, B. B. Budde,, L. Henrichsen,, T. Martinussen,, and M. Jakobsen. 2009. Cereulide formation by Bacillus weihenstephanensis and mesophilic emetic Bacillus cereus at temperature abuse depends on pre-incubation conditions. Int. J. Food Microbiol. 134:133139.
84. Thorsen, L.,, B. M. Hansen,, K. F. Nielsen,, N. B. Hendriksen,, R. K. Phipps,, and B. B. Budde. 2006. Characterization of emetic Bacillus weihenstephanensis, a new cereulide-producing bacterium. Appl. Environ. Microbiol. 72:51185121.
85. van Netten, P.,, A. van de Moosdijk,, P. van Hoensel,, D. A. A. Mossel,, and I. Perales. 1990. Psychrotrophic strains of Bacillus cereus producing enterotoxin. J. Appl. Bacteriol. 69:7379.
86. Yokoyama, K.,, M. Ito,, N. Agata,, M. Isobe,, K. Shibayama,, T. Horii,, and M. Ohta. 1999. Pathological effect of synthetic cereulide, an emetic toxin of Bacillus cereus, is reversible in mice. FEMS Immunol. Med. Microbiol. 24:115120.


Generic image for table
Table 19.1

Criteria to differentiate members of the group

Citation: Granum P, Lindbäck T. 2013. , p 491-502. In Doyle M, Buchanan R (ed), Food Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555818463.ch19
Generic image for table
Table 19.2

Examples of foods involved in food poisoning events

Citation: Granum P, Lindbäck T. 2013. , p 491-502. In Doyle M, Buchanan R (ed), Food Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555818463.ch19
Generic image for table
Table 19.3

Characteristics of the two types of illness caused by

Citation: Granum P, Lindbäck T. 2013. , p 491-502. In Doyle M, Buchanan R (ed), Food Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555818463.ch19
Generic image for table
Table 19.4

Properties of the emetic toxin cereulide

Citation: Granum P, Lindbäck T. 2013. , p 491-502. In Doyle M, Buchanan R (ed), Food Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555818463.ch19
Generic image for table
Table 19.5

Toxins produced by

Citation: Granum P, Lindbäck T. 2013. , p 491-502. In Doyle M, Buchanan R (ed), Food Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555818463.ch19
Generic image for table
Table 19.6

Properties of the Nhe proteins

Citation: Granum P, Lindbäck T. 2013. , p 491-502. In Doyle M, Buchanan R (ed), Food Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555818463.ch19

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