Chapter 5 : Biosecurity: Food Protection and Defense

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This chapter examines the risk of intentional food contamination, primarily with microbiological agents. It provides an overview of current methods for evaluating risk and defining appropriate interventions. It lists a sampling of microbial pathogens and toxins of concern, along with some of the potential chemical agents of concern provided for comparison; several references that go into significant detail on the agents of concern and illness progression and food protection more broadly are available. The basic scales used in operational risk management (ORM) as they could be applied to the food system are noted in a table. Importantly, successful utilization of ORM does not require sensitive details on potential agents. As applied to the food and agriculture critical infrastructure, detection and diagnostic tools have the potential to prevent or contain intentional contamination events. Approaches to harden the food system against intentional contamination and enhance its inherent biosecurity are being adapted from ORM, CARVER, CARVER+Shock, and other systems from military and law enforcement experience and new concepts in intelligent adversary modeling, among others. While similar to the continual improvement approach dictated by food safety systems to prevent unintentional microbiological contamination of food products, food system defense represents an additional set of challenges.

Citation: Kennedy S, Busta F. 2013. Biosecurity: Food Protection and Defense, p 91-108. In Doyle M, Buchanan R (ed), Food Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555818463.ch5
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Figure 5.1

General ice cream production process flow diagram. doi:10.1128/9781555818463.ch5f1

Citation: Kennedy S, Busta F. 2013. Biosecurity: Food Protection and Defense, p 91-108. In Doyle M, Buchanan R (ed), Food Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555818463.ch5
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Figure 5.2

Generic egg processing model. doi:10.1128/9781555818463.ch5f2

Citation: Kennedy S, Busta F. 2013. Biosecurity: Food Protection and Defense, p 91-108. In Doyle M, Buchanan R (ed), Food Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555818463.ch5
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1.AIB International. https://www.aibonline.org/auditservices/index.html. Accessed 21 October 2011.
2. Akbulut, D.,, K. A. Grant,, and J. McLauchlin. 2004. Development and application of Real-Time PCR assays to detect fragments of the Clostridium botulinum types A, B, and E neurotoxin genes for investigation of human foodborne and infant botulism. Foodborne Pathog. Dis. 1:247257.
3. Arnon, S.,, R. Schechter,, T. V. Inglesby,, D. A. Henderson,, J. G. Bartlett,, M. S. Ascher,, E. Eitzen,, A. D. Fine,, J. Hauer,, M. Layton,, S. Lillibridge,, M. T. Osterholm,, T. O’Toole,, G. Parker,, T. M. Perl,, P. K. Russell,, D. L. Swerdlow,, and K. Tonat. 2001. Botulinum toxin as a biological weapon. Medical and public health management. JAMA 285:10591070.
4. Arranz, I.,, W. R. G. Baeyens,, G. Van Der Weken,, S. De Saeger,, and C. Van Peteghem. 2004. HPLC determination of fumonisin mycotoxins. Crit. Rev. Food Sci. Nutr. 44:195203.
5. Ashford, D. A.,, R. M. Kaiser,, M. E. Bales,, K. Shutt,, A. Patrawalla,, A. McShan,, J. W. Tappero,, B. A. Perkins,, and A. L. Dannenberg. 2003. Planning against biological terrorism: lessons from outbreak investigations. Emerg. Infect. Dis. 9:515519.
6.Associated Press. 2006. Insurgent suspected of mass poisoning of Iraq police, The Australian, 11 October 2006. www.theaustralian.news.com.au/story/0,20867,20560653-2703,00.html. Accessed 19 October 2011.
7. Atkins, H. S.,, M. Morton,, K. F. Griffin,, M. G. M. Stokes,, J. P. Nataro,, and R. W. Titball. 2006. Recombinant Salmonella vaccines for biodefence. Vaccine 24:27102717.
8. Ayyadurai, S.,, C. Flaudrops,, D. Raoult,, and M. Drancourt. 2010. Rapid identification and typing of Yersinia pestis and other Yersinia species by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. BMC Microbiol. 10:285. doi:10.1186/1471-2180-10-285.
9. Banerjee, P.,, and A. K. Bhunia. 2010. Cell-based biosensor for rapid screening of pathogens and toxins. Biosens. Bioelectron. 26:99106.
10. Bazerman, M. H.,, and M. D. Watkins. 2004. Predictable Surprises: The Disasters You Should Have Seen Coming and How To Prevent Them. Harvard Business School Press, Cambridge, MA.
11. Bennett, R. W. 2005. Staphylococcal enterotoxin and its rapid identification in foods by enzyme-linked immunosorbent assay-based methodology. J. Food Prot. 68:12641270.
12. Blyn, L. B. 2006. Biosensors and food protection. Food Technol. 60:3641.
13. Boulton, M.,, M. Stanbury,, D. Wade,, J. Tilden,, D. Bryan,, J. Payne,, and B. Eisenga. 2003. Nicotine poisoning after ingestion of contaminated ground beef. MMWR Morb. Mortal. Wkly. Rep. 52:413416.
14. Brooks, L. F. 2004. Testimony, Committee on Government Reform, Subcommittee on National Security, Emerging Threats, and International Relations. Washington, DC. http://www.gpo.gov/fdsys/pkg/CHRG-108hhrg/html/CHRG-108hhrg96313.htm. Accessed 8 August 2012.
15. Brown, G. G.,, and L. A. Cox, Jr. 2011. How probabilistic risk assessment can mislead risk analysts. Risk Anal. 31:196204.
16. Burows, W. D.,, and S. E. Renner. 1999. Biological warfare agents as threats to potable water. Environ. Health Perspect. 107:975984.
17. Bush, G. W. 2004. Homeland Security Presidential Direc-tive/HSPD-9: Defense of United States Agriculture and Food. http://www.dhs.gov/xabout/laws/gc_1217449547663.shtm. Department of Homeland Security, Washington, DC. Accessed 21 October 2011.
18. Carus, W. S. 2001. Bioterrorism and Biocrimes: The Illicit Use of Biological Agents Since 1900. Center for Counterproliferation Research, National Defense University. Washington, DC.
19. Cavallaro, E.,, K. Date,, C. Medus,, S. Meyer,, B. Miller,, C. Kim,, S. Nowicki,, S. Cosgrove,, D. Sweat,, Q. Phan,, J. Flint,, E. R. Daly,, J. Adams,, E. Hyytia-Trees,, P. Gerner-Smidt,, R. M. Hoekstra,, C. Schwensohn,, A. Langer,, S. V. Sodha,, M. C. Rogers,, F. J. Angulo,, R. V. Tauxe,, I. T. Williams,, and C. Barton Behravesh. 2011. Salmonella Typhimurium infections associated with peanut products. N. Engl. J. Med. 364:601610.
20.CBWInfo. 2006. Factsheets on chemical and biological warfare agents. http://www.cbwinfo.com/intro.html. Accessed October 2011.
21. Cebula, T.,, E. W. Brown,, S. A. Jackson,, M. K. Mammel,, A. Mukherjee,, and J. E. LeClerc. 2005. Molecular applications for identifying microbial pathogens in the post-9/11 era. Expert Rev. Mol. Diagn. 5:432445.
22. Cebula, T. A.,, S. A. Jackson,, E. W. Brown,, B. Goswami,, and J. E. LeClerc. Chips and SNPs, bugs and thugs: a molecular sleuthing perspective. J. Food Prot. 68:12711284.
23.Center for Food Safety and Applied Nutrition. 2005. USDA, FDA and DHS sign agreement with NASDA to make nation’s agriculture and food supply more secure. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2004/ucm108357.htm. Accessed 21 October 2011.
24.Center for Food Safety and Applied Nutrition. Guidance documents. http://www.fda.gov/Food/GuidanceComplianceRegulatoryInformation/GuidanceDocuments/default.htm. Accessed 21 October 2011.
25.Centers for Disease Control andP revention. Bioterrorism agents/diseases. http://www.bt.cdc.gov/agent/agentlist.asp. Accessed 21 October 2011.
26.Centers for Disease Control and Prevention. 2006. HHS and USDA Select Agents and Toxins: 7 CFR Part 331, 9 CFR Part 121, and 42 CFR Part 73. http://www.selectagents.gov/Select%20Agents%20and%20Toxins%20List.html. Accessed 21 October 2011.
27.Centers for Disease Control and Prevention, Agency for Toxic Substances and Disease Registry. 2006. http://www.atsdr.cdc.gov/. Accessed 21 October 2011.
28. Christopher, G. W.,, T. J. Cieslak,, J. A. Pavlin,, and E. M. Eitzen. 1997. Biological warfare: a historical perspective. JAMA 278:412417.
29.Committee on Methodological Improvements to the Department of Homeland Security’s Biological Agent Risk Analysi,National Research Council. 2008. Department of Homeland Security Bioterrorism Risk Assessment: A Call for Change. The National Academies Press, Washington, DC.
30. Conner, C. F. 2006. Testimony of the Honorable Charles F. Conner, Deputy Secretary, United States Department of Agriculture Before the U.S. Senate Committee on Agriculture, Nutrition, and Forestry Subcommittee on Research, Nutrition and General Legislation. http://www.usda.gov/documents/DepSecTest_jan09.pdf. Accessed October 21, 2011.
31. Cosgrove, S. E.,, T. M. Perl,, X. Song,, and S. D. Sisson. 2005. Ability of physicians to diagnose and manage illness due to category A bioterrorism agents. Arch. Intern. Med. 165:18.
32. Dalziel, G. R. 2009. Food defence incidents 1950-2008: a chronology and analysis of incidents involving the malicious contamination of the food supply chain. http://www.rsis.edu.sg/cens/publications/reports/RSIS_Food%20Defence_170209.pdf. Accessed 21 October 2011.
33. Danzig, R. 2003. Catastrophic Bioterrorism—What Is To Be Done? Center for Technology and National Security Policy, National Defense University, Washington, DC.
34. Darling, R. G.,, and J. B. Woods. 2004. Medical Management of Biological Casualties Handbook, 5th ed. USAMRID, Fort Detrick, MD.
35. Dembek, Z. F.,, R. L Buckman,, S. K. Fowler,, and J. L. Hadler. 2003. Missed sentinel case of naturally occurring pneumonic tularemia outbreak: lessons for detection of bioterrorism. J. Am. Board Fam. Pract. 16:339342.
36. Dennis, D. T.,, T. V. Inglesby,, D. A. Henderson,, J. G. Bartlett,, M. S. Ascher,, E. Eitzen,, A. D. Fine,, A. M. Friedlander,, J. Hauer,, M. Layton,, S. R. Lillibridge,, J. E. McDade,, M. T. Osterholm,, T. O’Toole,, G. Parker,, T. M. Perl,, P. K. Russell,, and K. Tonat. 2001. Tularemia as a biological weapon: medical and public health management. JAMA 285:27632773.
37. Detlefsen, C. 2005. Dairy industry vigilant in addressing food security. Cheese Market News 25:1.
38. Dyckman, L. J. 2003. Food-Processing Security: Voluntary Efforts Are Under Way, but Federal Agencies Cannot Fully Assess Their Implementation. GAO (03-342). U.S. General Accounting Office, Washington, DC.
39. Dyckman, L. J. 2003. Bioterrorism: A Threat to Agriculture and the Food Supply. GAO (04-259T). U.S. General Accounting Office, Washington, DC.
40.European Food Safety Authority. 2011. Shiga toxin-producing E. coli (STEC) O104:H4 2011 outbreaks in Europe: taking stock. EFSA J. 9(10):2390.
41. Ezell, B. A.,, S. P. Bennett,, D. von Winterfeldt,, J. Sokolowski,, and A. J. Collins. 2010. Probabilistic risk analysis and terrorism risk. Risk Anal. 30:575589.
42.Food and Agriculture Organization of the United Nations. 2011. Food security statistics. http://www.fao.org/economic/ess/ess-fs/en/. Accessed 21 October 2011.
43.Food and Agriculture Organization of the United Nations. 2011. World Health Day. http://www.fao.org/getinvolved/worldfoodday/en/. Accessed 21 October 2011.
44.Reference deleted.
45.Food Safety and Inspection Services. 2005. Food Security and Emergency Preparedness Security Guidelines. http://www.fsis.usda.gov/food_defense_&_emergency_response/index.asp. Accessed 21 October 2011.
46. Franz, D. R.,, P. B. Jahrling,, A. M. Friedlander,, D. J. McClain,, D. L. Hoover,, R. W. Bryne,, J. A. Pavlin,, G. W. Christopher,, and E. M. Eitzen. 1997. Clinical recognition and management of patients exposed to biological warfare agents. JAMA 278:399411.
47. Garber, E. A.,, R. M. Eppley,, M. E. Stack,, M. A. McLaughlin,, and D. L. Park. 2005. Feasibility of immunodiagnostic devices for the detection of ricin, amanitin, and T-2 toxin in food. J. Food Prot. 68:12941301.
48.Reference deleted.
49. Harper, G. J. 1961. Airborne microorganisms: survival test with four viruses. J. Hyg. 59:479486.
50. Harris, S. H., 2003. Japanese biomedical experimentation during the World-War-II era, p. 463506. In D. E. Lounsbury, and R. F. Bellamy (ed.), Military Medical Ethics, vol. II. Office of the Surgeon General, Department of the Army, United States of America, Washington, DC.
51. Hauschild, A. H. W.,, and K. L. Dodds. 1993. Clostridium botulinum. Ecology and Control in Foods. Marcel Dekker, Inc., New York, NY.
52. He, L. B. Deen,, T. Rodda,, I. Ronningen,, T. Blasius,, C. Haynes,, F. Diez-Gonzalez,, and T. P. Labuza. 2011. Rapid detection of ricin in milk using immunomagnetic separation combined with surface-enhanced Raman spectroscopy. J. Food Sci. 76(5):N49N53.
53. He, X.,, S. McMahon,, T. A. McKeon,, and D. L. Brandon. 2010. Development of a novel immuno-PCR assay for detection of ricin in ground beef, liquid chicken egg, and milk. J. Food Prot. 73:695700.
54. Hennessy, T. W.,, C. W. Hedberg,, L. Slutsker,, K. E. White,, J. M. Besser-Wiek,, M. E. Moen,, J. Feldman,, W. W. Coleman,, L. M. Edmonson,, K. L. MacDonald,, and M. T. Osterholm. 1996. A national outbreak of Salmonella Enteritidis infections from ice cream. N. Engl. J. Med. 334:12811286.
55. Hilgren, J.,, K. M. J. Swanson,, F. Diez-Gonzalez,, and B. Cords. 2009. Inactivation of Yersinia pseudotuberculosis, as a surrogate for Yersinia pestis, by liquid biocides in the presence of food residue. J. Food Prot. 72:392398.
56. Hilgren, J.,, K. M. J. Swanson,, F. Diez-Gonzalez,, and B. Cords. 2009. Susceptibilities of Bacillus subtilis, Bacillus cereus, and avirulent Bacillus anthracis spores to liquid biocides. J. Food Prot. 72:360364.
57.IPCS Inchem. Chemical Safety Information from Intergovernmental Organizations. http://www.inchem.org. Accessed 21 October 2011.
58. Jones, T. S. 2005. NAVMC Directive 3500.86. http://ebookbrowse.com/navmc-dir-3500-86-pdf-d102394294. Accessed 8 August 2012.
59. Jotcham, R. 2005. Authentication, antitamper, and track-and-trace technology options to protect foods. J. Food Prot. 68:13141317.
60. Kahn, A. S.,, D. L. Swerdlow,, and D. D. Juranek. 2001. Precautions against biological and chemical terrorism directed at food and water supplies. Public Health Rep. 116(1):314.
61. Kahn, S. A.,, K. Sung,, M. S. Nawaz,, C. E. Cerniglia,, M. L. Tamplin,, R. W. Phillips,, and L. C. Kelley. 2009. The survivability of Bacillus anthracis (Sterne strain) in processed liquid eggs. Food Microbiol. 26:123127.
62. Kavanaugh, J. J. 1996. Air Force Handbook 31-302. U.S. Air Force. U.S. Department of Commerce, National Technical Information Service, Springfield, VA.
63. Klietmann, W. F.,, and K. L. Ruoff. 2001. Bioterrorism: implications for the clinical microbiologist. Clin. Microbiol. Rev. 14:364381.
64. Koenig, M. G.,, A. Spickard,, M. A. Cardella,, and D. E. Rogers. 1964. Clinical and laboratory observations on Type E botulism in man. Medicine 43:517545.
65. Lado, B. H.,, and A. E. Yousef. 2002. Alternative food-preservation technologies: efficacy and mechanisms. Microbes Infect. 4:433440.
66. Lamont, E. A.,, L. He,, K. Warriner,, T. P. Labuza,, and S. Sreevatsan. 2011. A single DNA aptamer functions as a biosensor for ricin. Analyst 136:38843895.
67. Lee, T. 2005. Dioxin in local cows’ milk meets with EU standard, EQPF says. The China Post http://www.chinapost.com.tw/news/2005/09/28/69302/Dioxin-in.htm
68. Lincoln, R. E.,, J. S. Walker,, F. Klein,, A. J. Rosenwald,, and W. I. Jong. 1967. Value of field data for the extrapolation in anthrax. Food. Proc. 26:15581562.
69. Locasto, D.,, M. Allswede,, and T. M. Stein. 2005. CBRNE - T-2 Mycotoxins. http://www.emedicine.com. Accessed 21 October 2011.
70. MacNeil, A.,, T. G. Ksiazek,, and P. E. Rollin. 2011. Hantavirus pulmonary syndrome, United States, 1993-2009. Emerg. Infect. Dis. 17:1198.
71. Matero, P.,, T. Pasanen,, R. Laukkanen,, P. Tissari,, E. Tarkka,, M. Vaara,, and M. Skurnik. 2009. Real-time multiplex PCR assay for detection of Yersinia pestis and Yersinia pseudotuberculosis. APMIS 117:3444.
72. Mayor, A. 2004. Greek Fire, Poison Arrows & Scorpion Bombs: Biological and Chemical Warfare in the Ancient World, p. 99118, 145169. The Overlook Press, Peter Mayer Publishers, Inc., Woodstock, NY.
73. Miller, A. J.,, C. L. Hielman,, S. Droby,, and N. Paster. 2005. Science and technology based countermeasures to foodborne terrorism: introduction. J. Food Prot. 68:12531255.
74. Mohtadi, H.,, and A. Murshid. 2006. A global chronology of incidents of chemical, biological, radioactive and nuclear attacks: 1950-2005. http://www.ncfpd.umn.edu/Ncfpd/assets/File/pdf/GlobalChron.pdf. Accessed 21 October 2011.
75. Montville, T. J.,, T. De Siano,, A. Nock,, S. Padhi,, and D. Wade. 2006. Inhibition of Bacillus anthracis and potential surrogate bacilli growth from spore inocula by nisin and other antimicrobial peptides. J. Food Prot. 69:25292533.
76.National Center for Food Protection and Defense. 2011. Food Ag Sector Criticality Assessment Tool. http://www.ncfpd.umn.edu/index.cfm/research/fascat/. Accessed 21 October 2011.
77.National Consortium for the Study of Terrorism and Responses to Terrorism. 2011. Global Terrorism Database. http://www.start.umd.edu/gtd/. Accessed 21 October 2011.
78.National Infrastructure Institute: Center for Infrastructure Expertise. http://www.ni2cie.org/CARVER2.asp. Accessed 21 October 2011.
79. Newkirk, R. 2010. A risk and vulnerability assessment methodology for food systems. DHS Science Conference—Fifth Annual University Network Summit, 30 March to 1 April 2011. http://www.orau.gov/dhssummit/2010/presentations/March10/Panel06/newkirk_ryan.pdf. Accessed 21 October 2011.
80. Novak, J. S.,, J. Call,, P. Tomasula,, and J. B. Luchansky. 2005. An assessment of pasteurization treatment of water, media, and milk with respect to Bacillus spores. J. Food Prot. 68:751757.
81. Oltmanns, R. 2004. Puts & calls: A Tale of Two Vegetables (OK, a Veggie and a Fruit). Corporate communications key in times of crisis. Crisis Manager, 1 September 2004. http://www.bernsteincrisismanagement.com/nl/crisismgr040901.html
82. Pal, S.,, and E.C. Alocilja. 2009. Electrically active polyaniline coated magnetic (EAPM) nanoparticle as novel transducer in biosensor for detection of Bacillus anthracis spores in food samples. Biosens. Bioelectron. 24:14371444.
83. Pal, S.,, E. Setterington,, and E. C. Alocilja. 2008. Electrically-active magnetic nanoparticles for concentrating and detecting Bacillus anthracis spores in a direct-charge transfer biosensor. IEEE Sensors J. 8:647654.
84. Parnell, G. S.,, C. M. Smith,, and F. I. Moxley. 2010. Intelligent adversary risk analysis: a bioterrorism risk management model. Risk Anal. 30:3248.
85. Pauly, D.,, S. Kirchner,, B. Stoermann,, T. Schreiber,, S. Kaulfuss,, R. Schade,, R. Zbinden,, M.-A. Avondet,, M. B. Dorner,, and B. G. Dorner. 2009. Simultaneous quantification of five bacterial and plant toxins from complex matrices using a multiplexed fluorescent magnetic suspension assay. Analyst 134:20282039.
86. Principato, M.,, T. Boyle,, J. Njoroge,, R. L. Jones, Jr.,, and M. O’Donnell. 2009. Effect of thermal processing during yogurt production upon the detection of staphylococcal enterotoxin B. J. Food Prot. 72:22122216.
87. Rasco, B. A.,, and G. E. Bledsoe. 2005. Bioterrorism and Food Safety. CRC Press, Boca Raton, FL.
88. Rasooly, R.,, and P. M. Do. 2010. Clostridium botulinum neurotoxin type b is heat-stable in milk and not inactivated by pasteurization. J. Agric. Food Chem. 58:1255712561.
89.Robert Koch Institute. 2011. Report: Final Presentation and Evaluation of Epidemiological Findings in the EHEC O104:H4 Outbreak, Germany 2011. Robert Koch Institute, Berlin, Germany.
90. Robertson, R. E. 1999. Food Safety: Agencies Should Further Test Plans for Responding to Deliberate Contamination. GAO(RCED-00-3). U.S. General Accounting Office, Washington, DC.
91. Rong-Hwa, S.,, T. Shiao-Shek,, C. Der-Jiang,, and H. Yao-Wen. 2010. Gold nanoparticle-based lateral flow assay for detection of staphylococcal enterotoxin B. Food Chem. 118:462466.
92. Ryan, C. A.,, M. K. Nickels,, N. T. Hargrett-Bean,, M. E. Potter,, T. Endo,, L. Mayer,, C. W. Langkop,, C. Gibson,, R. C. McDonald,, R. T. Kenney,, N. D. Puhr,, P. J. McDonnell,, R. J. Martin,, M. L. Cohen,, and P. A. Blake. 1987. Massive outbreak of antimicrobial-resistant salmonellosis traced to pasteurized milk. JAMA 258:32693274.
93. Salerno, R. M.,, and J. G. Koelm. 2002. Biological Laboratory and Transportation Security and the Biological Weapons Convention. SAN No:2002-1067P. Sandia National Laboratories, Albuquerque, NM.
94. Sanvicens, N.,, C. Pastells,, N. Pascual,, and M.-P. Marco. 2009. Nanoparticle-based biosensors for detection of pathogenic bacteria. Trends Anal. Chem. 28:12431252.
95. Sapsford, K. E.,, C. R. Taitt,, N. Loo,, and F. S. Ligler. 2005. Biosensor detection of botulinum toxoid A and staphylococcal enterotoxin B in food. Appl. Environ. Microbiol. 71:55905592.
96. Schlesser, J. E. 2009. Inactivation of Yersinia pseudotuberculosis 197 and Francisella tularensis LVS in beverages by high pressure processing. J. Food Prot. 72:165168.
97. Sharma, S. K.,, B. S. Eblen,, R. L. Bull,, D. H. Burr,, and R. C. Whiting. 2005. Evaluation of lateral-flow Clostridium botulinum neurotoxin detection kits for food analysis. Appl. Environ. Microbiol. 71:39353941.
98. Sharma, S. K.,, and R. C. Whiting. 2005. Methods for detection of Clostridium botulinum toxin in foods. J. Food Prot. 68:12561263.
99. Sidell, F. R.,, E. T. Takafuji,, and D. R. Franz. 1997. Medical Aspects of Chemical and Biological Warfare. Office of the Surgeon General, Department of the Army, United States of America, Washington, DC.
100. Slovic, P. 1987. Perception of risk. Science 236:280285.
101. Stark, A.-A. 2005. Threat assessment of mycotoxins as weapons: molecular mechanisms of acute toxicity. J. Food Prot. 68:12851293.
102. Stier, R. 2003. The dirty dozen: ways to reduce the 12 biggest foreign materials problems. Food Safety Magazine 03:67.
103. Stinson, T., 2007. The national economic impacts of a food terrorism event: initial estimates of indirect costs, p. 145158. In H. W. Richardson,, P. Gordon,, and J. E. Moore II (ed.), The Economic Costs and Consequences of Terrorism. Edward Elgar, Cheltenham, United Kingdom.
104. Taitt, C. R.,, A. P. Malanoski,, B. Lin,, D. A. Stenger,, F. S. Ligler,, A. W. Kusterbeck,, G. P. Anderson,, S. E. Harmon,, L. C. Shriver-Lake,, S. K. Pollack,, D. M. Lennon,, F. Lobo-Menendez,, Z. Wang,, and J. M. Schnur. 2008. Discrimination between biothreat agents and ‘near neighbor’ species using a resequencing array. FEMS Immunol. Med. Microbiol. 54:356364.
105. Tamplin, M. L.,, R. Phillips,, T. A. Stewart,, J. B. Luchansky,, and L. C. Kelley. 2008. Behavior of Bacillus anthracis strains Sterne and Ames K0610 in sterile raw ground beef. Appl. Environ. Microbiol. 74:11111116.
106.Therapeutic Intranasal Drug Delivery. http://intranasal.net/overview/default.htm. Accessed 19 October 2011.
107. Tomasula, P. M.,, S. Mukhopadhyay,, N. Datta,, A. Porto-Fett,, J. E. Call,, J. B. Luchansky,, J. Renye,, and M. Tunick. 2011. Pilot-scale crossflow-microfiltration and pasteurization to remove spores of Bacillus anthracis (Sterne) from milk. J. Dairy Sci. 94:42774291.
108. Torok, T. J.,, R. V. Tauxe,, R. P. Wise,, J. R. Livengood,, R. Sokolow,, S. Mauvais,, K. A. Birkness,, M. Skeels,, J. Horan,, and L. R. Foster. 1997. A large community outbreak of salmonellosis caused by intentional contamination of restaurant salad bars. JAMA 278:389395.
109.TOXNET. 2005. Toxicology Data Network. http://www.toxnet.nlm.nih.gov. National Library of Medicine, National Institutes of Health, Bethesda, MD. Accessed 21 October 2011.
110. Treadwell, T. A.,, D. Koo,, K. Kuker,, and A. S. Kahn. 2003. Epidemiologic clues to bioterrorism. MMWR Morb. Mortal. Wkly. Rep. 118:9298.
111. Tucker, J. B. 2003. Biosecurity: Limiting Terrorist Access to Deadly Pathogens. Peaceworks 52. U.S. Institute of Peace, Washington, DC.
112. Tumin, T. 2009. Visualizing food safety: seeing the linkages in a networked world. A Fire Under Embers. http://blogs.law.harvard.edu/fireunderembers/. Accessed 21 October 2011.
113.U.S. Department of Agriculture—Food Safety and Inspection Service. 2005. Model Food Security Plan for Egg Processing Facilities. http://www.fsis.usda.gov/PDF/Model_FoodSec_Plan_Eggs.pdf. Accessed 21 October 2011.
113.a.U.S. Food and Drug Administration. 2005. Food security awareness training course. http://www.fda.gov/Training/ForStateLocalTribalRegulators/ucm120929.htm. Accessed 21 October 2011.
114.U.S. Food and Drug Administration. 2011. CARVER+ Shock http://www.fda.gov/Food/FoodDefense/CARVER/default.htm. Accessed 19 October 2011.
115.U.S. Food and Drug Administration. 2011. Food Defense Mitigation Strategies Database. http://www.fda.gov/Food/FoodDefense/ucm245544.htm. Accessed 21 October 2011.
116.U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition. 2009. Summaries of Competitive Food Defense Research Reports, 2007. http://www.fda.gov/Food/FoodDefense/FoodDefense Programs/FoodDefenseResearchReports/ucm175833.htm. Accessed 21 October 2011.
117.U.S. Food and Drug Administration, Department of Homeland Security, U.S. Department of Agriculture, and Federal Bureau of Investigation. 2008. Strategic Partnership Program Agroterrorism (SPPA) Initiative Final Summary Report September 2005-September 2008. http://www.fda.gov/Food/FoodDefense/FoodDefense Programs/ucm170509.htm. Accessed 21 October 2011.
118.U. S. Navy. Naval Safety Center. http://www.safetycenter.navy.mil/. Accessed 21 October 2011.
119.U.S. Senate Subcommittee on Oversight of Government Management, the Federal Workforce, and the District of Columbia. 2011. Agro-Defense: Responding to Threats Against America’s Agriculture and Food System. Hearing, 13 September 2011. (Testimony provided by Colonel John T. Hoffman [Ret.]) Government Printing Office, Washington, DC.
120. Whitaker, T. B.,, and A. S. Johansson. 2005. Sampling uncertainties for the detection of chemical agents in complex food matrices. J. Food Prot. 68:13061313.
121. Woodbury, G. 2005. Measuring prevention. Homeland Security Affairs 1:19.
122.World Health Organization. 2002. Terrorist Threats to Food: Guidance for Establishing and Strengthening Prevention and Response Systems. World Health Organization, Geneva, Switzerland. http://www.who.int/foodsafety/publications/general/en/terrorist.pdf. Accessed 21 October 2011.
123. Xu, S.,, T. P. Labuza,, and F. Diez-Gonzalez. 2008. Inactivation kinetics of avirulent Bacillus anthracis spores in milk with a combination of heat and hydrogen peroxide. J. Food Prot. 71:333338.
124. Xu, S.,, T. P. Labuza,, and F. Diez-Gonzalez. 2006. Thermal inactivation of Bacillus anthracis spores in cow’s milk. Appl. Environ. Microbiol. 72:44794483.
125. Zhang, X.,, F. Liu,, R. Yan,, P. Xue,, Y. Li,, L. Chen,, C. Song,, C. Liu,, B. Jin,, Z. Zhang,, and K. Yang. 2011. An ultrasensitive immunosensor array for determination of staphylococcal enterotoxin B. Talanta 85:10701074.


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Table 5.1

Potential food contamination agents

Citation: Kennedy S, Busta F. 2013. Biosecurity: Food Protection and Defense, p 91-108. In Doyle M, Buchanan R (ed), Food Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555818463.ch5
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Table 5.2

Operational risk management semantic scales

Citation: Kennedy S, Busta F. 2013. Biosecurity: Food Protection and Defense, p 91-108. In Doyle M, Buchanan R (ed), Food Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555818463.ch5
Generic image for table
Table 5.3

Operational risk management: grid for categorizing

Citation: Kennedy S, Busta F. 2013. Biosecurity: Food Protection and Defense, p 91-108. In Doyle M, Buchanan R (ed), Food Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555818463.ch5

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