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Chapter 102 : Cardiovascular Diseases

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Cardiovascular Diseases, Page 1 of 2

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Abstract:

Acute myocardial injury (AMI) most often results from a lack of sufficient blood supply to the myocardium. When patients present with symptoms of chest pain, rapid diagnosis of potential AMI and characterization of the extent of cardiac injury are essential for delivering appropriate treatment, e.g., intervention with thrombolytic therapy or angioplasty. Such interventions are aimed at minimizing the risk of (further) cardiac injury and death. Distinguishing patients with unstable angina from those with AMI is necessary to triage whether patients may be managed in the outpatient setting versus inpatient admission and immediate intervention. Serologic measurements of soluble biomarkers released during myocyte necrosis are used in conjunction with electrocardiograms and with more sophisticated imaging techniques like echocardiography and perfusion scintigraphy. Serum biomarkers have the greater advantage of detecting recent myocardial injury, which is not easily distinguishable by cardiac imaging techniques in patients with clinical evidence of preexisting heart disease (Table 1).

Citation: Maier C, Burek C, Rose N, Ansari A. 2016. Cardiovascular Diseases, p 975-982. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch102
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References

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1. Gotlieb AI, Freeman MR, Salerno TA, Lichtenstein SV, Armstrong PW . 1991. Ultrastructural studies of unstable angina in living man. Mod Pathol 4 : 75 80.[PubMed]
2. Levin ER, Gardner DG, Samson WK . 1998. Natriuretic peptides. N Engl J Med 339 : 321 328.[CrossRef].[PubMed]
3. Apple FS, Quist HE, Doyle PJ, Otto AP, Murakami MM . 2003. Plasma 99th percentile reference limits for cardiac troponin and creatine kinase MB mass for use with European Society of Cardiology/American College of Cardiology consensus recommendations. Clin Chem 49 : 1331 1336.[PubMed].[CrossRef]
4. McCord J, Nowak RM, McCullough PA, Foreback C, Borzak S, Tokarski G, Tomlanovich MC, Jacobsen G, Weaver WD . 2001. Ninety-minute exclusion of acute myocardial infarction by use of quantitative point-of-care testing of myoglobin and troponin I. Circulation 104 : 1483 1488.[PubMed].[CrossRef]
5. Khan SQ, Dhillon OS, O'Brien RJ, Struck J, Quinn PA, Morgenthaler NG, Squire IB, Davies JE, Bergmann A, Ng LL . 2007. C-terminal provasopressin (copeptin) as a novel and prognostic marker in acute myocardial infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) study. Circulation 115 : 2103 2110.[CrossRef].[PubMed]
6. Nickel CH, Bingisser R, Morgenthaler NG . 2012. The role of copeptin as a diagnostic and prognostic biomarker for risk stratification in the emergency department. BMC Med 10 : 7. doi:10.1186/1741-7015-10-7.[CrossRef].[PubMed] http://dx.doi.org/doi:10.1186/1741-7015-10-7
7. Seino Y, Ogata K, Takano T, Ishii J, Hishida H, Morita H, Takeshita H, Takagi Y, Sugiyama H, Tanaka T, Kitaura Y . 2003. Use of a whole blood rapid panel test for heart-type fatty acid-binding protein in patients with acute chest pain: comparison with rapid troponin T and myoglobin tests. Am J Med 115 : 185 190.[PubMed].[CrossRef]
8. de Lemos JA, Morrow DA, Gibson CM, Murphy SA, Sabatine MS, Rifai N, McCabe CH, Antman EM, Cannon CP, Braunwald E . 2002. The prognostic value of serum myoglobin in patients with non-ST-segment elevation acute coronary syndromes. Results from the TIMI 11B and TACTICS-TIMI 18 studies. J Am Coll Cardiol 40 : 238 244.[PubMed].[CrossRef]
9. Kilcullen N, Viswanathan K, Das R, Morrell C, Farrin A, Barth JH, Hall AS EMMACE-2 Investigators . 2007. Heart-type fatty acid-binding protein predicts long-term mortality after acute coronary syndrome and identifies high-risk patients across the range of troponin values. J Am Coll Cardiol 50 : 2061 2067.[CrossRef].[PubMed]
10. Altieri P, Brunelli C, Garibaldi S, Nicolino A, Ubaldi S, Spallarossa P, Olivotti L, Rossettin P, Barsotti A, Ghigliotti G . 2003. Metalloproteinases 2 and 9 are increased in plasma of patients with heart failure. Eur J Clin Invest 33 : 648 656.[PubMed].[CrossRef]
11. Mann DL . 2003. Stress-activated cytokines and the heart: from adaptation to maladaptation. Annu Rev Physiol 65 : 81 101.[CrossRef].[PubMed]
12. Schwartzkopff B, Fassbach M, Pelzer B, Brehm M, Strauer BE . 2002. Elevated serum markers of collagen degradation in patients with mild to moderate dilated cardiomyopathy. Eur J Heart Fail 4 : 439 444.[PubMed].[CrossRef]
13. Yamazaki T, Lee JD, Shimizu H, Uzui H, Ueda T . 2004. Circulating matrix metalloproteinase-2 is elevated in patients with congestive heart failure. Eur J Heart Fail 6 : 41 45.[CrossRef].[PubMed]
14. Feuerstein GZ, Rozanski D . 2000. G proteins and heart failure: is Gαq a novel target for heart failure? Circ Res 87 : 1085 1086.[PubMed].[CrossRef]
15. Wettschureck N, Rütten H, Zywietz A, Gehring D, Wilkie TM, Chen J, Chien KR, Offermanns S . 2001. Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Gα q/Gα 11 in cardiomyocytes. Nat Med 7 : 1236 1240.[CrossRef].[PubMed]
16. Suzuki T, Yamazaki T, Yazaki Y . 2001. The role of the natriuretic peptides in the cardiovascular system. Cardiovasc Res 51 : 489 494.[PubMed].[CrossRef]
17. Prontera C, Emdin M, Zucchelli GC, Ripoli A, Passino C, Clerico A . 2003. Natriuretic peptides (NPs): automated electrochemiluminescent immunoassay for N-terminal pro-BNP compared with IRMAs for ANP and BNP in heart failure patients and healthy individuals. Clin Chem 49 : 1552 1554.[PubMed].[CrossRef]
18. Li YY, McTiernan CF, Feldman AM . 2000. Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodeling. Cardiovasc Res 46 : 214 224.[PubMed].[CrossRef]
19. Upadhya B, Kontos JL, Ardeshirpour F, Pye J, Boucher WS, Theoharides TC, Dehmer GJ, Deliargyris EN . 2004. Relation of serum levels of mast cell tryptase of left ventricular systolic function, left ventricular volume or congestive heart failure. J Card Fail 10 : 31 35.[PubMed].[CrossRef]
20. Aukrust P, Ueland T, Lien E, Bendtzen K, Müller F, Andreassen AK, Nordøy I, Aass H, Espevik T, Simonsen S, Frøland SS, Gullestad L . 1999. Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 83 : 376 382.[PubMed].[CrossRef]
21. Tsutamoto T, Hisanaga T, Wada A, Maeda K, Ohnishi M, Fukai D, Mabuchi N, Sawaki M, Kinoshita M . 1998. Interleukin-6 spillover in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure. J Am Coll Cardiol 31 : 391 398.[PubMed].[CrossRef]
22. Gullestad L, Aukrust P, Ueland T, Espevik T, Yee G, Vagelos R, Frøland SS, Fowler M . 1999. Effect of high- versus low-dose angiotensin converting enzyme inhibition on cytokine levels in chronic heart failure. J Am Coll Cardiol 34 : 2061 2067.[PubMed].[CrossRef]
23. Wollert KC, Drexler H . 2001. The role of interleukin-6 in the failing heart. Heart Fail Rev 6 : 95 103.[PubMed].[CrossRef]
24. Noutsias M, Hohmann C, Pauschinger M, Schwimmbeck PL, Ostermann K, Rode U, Yacoub MH, Kühl U, Schultheiss HP . 2003. sICAM-1 correlates with myocardial ICAM-1 expression in dilated cardiomyopathy. Int J Cardiol 91 : 153 161.[PubMed].[CrossRef]
25. Alcalai R, Seidman JG, Seidman CE . 2008. Genetic basis of hypertrophic cardiomyopathy: from bench to the clinics. J Cardiovasc Electrophysiol 19 : 104 110.[CrossRef].[PubMed]
26. Keren A, Syrris P, McKenna WJ . 2008. Hypertrophic cardiomyopathy: the genetic determinants of clinical disease expression. Nat Clin Pract Cardiovasc Med 5 : 158 168.[CrossRef].[PubMed]
27. Watkins H, Ashrafian H, McKenna WJ . 2008. The genetics of hypertrophic cardiomyopathy: teare redux. Heart 94 : 1264 1268.[CrossRef].[PubMed]
28. Olivotto I, Girolami F, Ackerman MJ, Nistri S, Bos JM, Zachara E, Ommen SR, Theis JL, Vaubel RA, Re F, Armentano C, Poggesi C, Torricelli F, Cecchi F . 2008. Myofilament protein gene mutation screening and outcome of patients with hypertrophic cardiomyopathy. Mayo Clin Proc 83 : 630 638.[CrossRef].[PubMed]
29. Wang L, Seidman JG, Seidman CE . 2010. Narrative review: harnessing molecular genetics for the diagnosis and management of hypertrophic cardiomyopathy. Ann Intern Med 152 : 513 520, W181.[CrossRef].[PubMed]
30. Petretta M, Pirozzi F, Sasso L, Paglia A, Bonaduce D . 2011. Review and metaanalysis of the frequency of familial dilated cardiomyopathy. Am J Cardiol 108 : 1171 1176.[CrossRef].[PubMed]
31. McNally EM, Golbus JR, Puckelwartz MJ . 2013. Genetic mutations and mechanisms in dilated cardiomyopathy. J Clin Invest 123 : 19 26.[CrossRef].[PubMed]
32. Gahl WA, Markello TC, Toro C, Fajardo KF, Sincan M, Gill F, Carlson-Donohoe H, Gropman A, Pierson TM, Golas G, Wolfe L, Groden C, Godfrey R, Nehrebecky M, Wahl C, Landis DM, Yang S, Madeo A, Mullikin JC, Boerkoel CF, Tifft CJ, Adams D . 2012. The National Institutes of Health Undiagnosed Diseases Program: insights into rare diseases. Genet Med 14 : 51 59.[CrossRef].[PubMed]
33. LeWinter MM, Wu Y, Labeit S, Granzier H . 2007. Cardiac titin: structure, functions and role in disease. Clin Chim Acta 375 : 1 9.[CrossRef].[PubMed]
34. Herman DS, Lam L, Taylor MR, Wang L, Teekakirikul P, Christodoulou D, Conner L, DePalma SR, McDonough B, Sparks E, Teodorescu DL, Cirino AL, Banner NR, Pennell DJ, Graw S, Merlo M, Di Lenarda A, Sinagra G, Bos JM, Ackerman MJ, Mitchell RN, Murry CE, Lakdawala NK, Ho CY, Barton PJ, Cook SA, Mestroni L, Seidman JG, Seidman CE . 2012. Truncations of titin causing dilated cardiomyopathy. N Engl J Med 366 : 619 628.[CrossRef].[PubMed]
35. Norton N, Robertson PD, Rieder MJ, Züchner S, Rampersaud E, Martin E, Li D, Nickerson DA, Hershberger RE National Heart, Lung and Blood Institute GO Exome Sequencing Project . 2012. Evaluating pathogenicity of rare variants from dilated cardiomyopathy in the exome era. Circ Cardiovasc Genet 5 : 167 174.[CrossRef].[PubMed]
36. Mason JW . 2003. Myocarditis and dilated cardiomyopathy: an inflammatory link. Cardiovasc Res 60 : 5 10.[PubMed].[CrossRef]
37. Aretz HT . 1987. Myocarditis: the Dallas criteria. Hum Pathol 18 : 619 624.[PubMed].[CrossRef]
38. Aretz HT, Billingham ME, Edwards WD, Factor SM, Fallon JT, Fenoglio JJ Jr, Olsen EG, Schoen FJ . 1987. Myocarditis. A histopathologic definition and classification. Am J Cardiovasc Pathol 1 : 3 14.[PubMed]
39. Mason JW . 1996. Immunopathogenesis and treatment of myocarditis: the United States Myocarditis Treatment Trial. J Card Fail 2( Suppl) : S173 S177.[PubMed].[CrossRef]
40. Fett JD, McTiernan CF . 2011. Towards a unifying hypothesis for the pathogenesis of peripartum cardiomyopathy. Int J Cardiol 153 : 1 3.[CrossRef].[PubMed]
41. Harper MA, Meyer RE, Berg CJ . 2012. Peripartum cardiomyopathy: population-based birth prevalence and 7-year mortality. Obstet Gynecol 120 : 1013 1019.[CrossRef].[PubMed]
42. Fett JD, Ansari AA . 2010. Inflammatory markers and cytokines in peripartum cardiomyopathy: a delicate balance. Expert Opin Ther Targets 14 : 895 898.[CrossRef].[PubMed]
43. McTiernan C, Hanley-Yanez K, Pisarcik JE, Morel PA, Cooper LT, Elkayam E, Fett JD, McNamara DM . 2011. Activation of cellular immunity in peripartum cardiomyopathy: results of the multicenter IPAC Registry. Circulation 124 : A14173. https://circ.ahajournals.org/cgi/content/meeting_abstract/124/21_MeetingAbstracts/A14173.
44. Fett JD . 2013. Earlier detection can help avoid many serious complications of peripartum cardiomyopathy. Future Cardiol 9 : 809 816.[CrossRef].[PubMed]
45. Hilfiker-Kleiner D, Kaminski K, Podewski E, Bonda T, Schaefer A, Sliwa K, Forster O, Quint A, Landmesser U, Doerries C, Luchtefeld M, Poli V, Schneider MD, Balligand JL, Desjardins F, Ansari A, Struman I, Nguyen NQ, Zschemisch NH, Klein G, Heusch G, Schulz R, Hilfiker A, Drexler H . 2007. A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy. Cell 128 : 589 600.[CrossRef].[PubMed]
46. Sliwa K, Blauwet L, Tibazarwa K, Libhaber E, Smedema JP, Becker A, McMurray J, Yamac H, Labidi S, Struman I, Hilfiker-Kleiner D . 2010. Evaluation of bromocriptine in the treatment of acute severe peripartum cardiomyopathy: a proof-of-concept pilot study. Circulation 121 : 1465 1473.[CrossRef].[PubMed]
47. Patten IS, Rana S, Shahul S, Rowe GC, Jang C, Liu L, Hacker MR, Rhee JS, Mitchell J, Mahmood F, Hess P, Farrell C, Koulisis N, Khankin EV, Burke SD, Tudorache I, Bauersachs J, del Monte F, Hilfiker-Kleiner D, Karumanchi SA, Arany Z . 2012. Cardiac angiogenic imbalance leads to peripartum cardiomyopathy. Nature 485 : 333 338.[CrossRef].[PubMed]
48. Rana S, Powe CE, Salahuddin S, Verlohren S, Perschel FH, Levine RJ, Lim KH, Wenger JB, Thadhani R, Karumanchi SA . 2012. Angiogenic factors and the risk of adverse outcomes in women with suspected preeclampsia. Circulation 125 : 911 919.[CrossRef].[PubMed]
49. Fett JD, Sannon H, Thélisma E, Sprunger T, Suresh V . 2009. Recovery from severe heart failure following peripartum cardiomyopathy. Int J Gynaecol Obstet 104 : 125 127.[CrossRef].[PubMed]
50. Huang GY, Zhang LY, Long-Le MA, Wang LX . 2012. Clinical characteristics and risk factors for peripartum cardiomyopathy. Afr Health Sci 12 : 26 31.[PubMed]
51. Sliwa K, Förster O, Libhaber E, Fett JD, Sundstrom JB, Hilfiker-Kleiner D, Ansari AA . 2006. Peripartum cardiomyopathy: inflammatory markers as predictors of outcome in 100 prospectively studied patients. Eur Heart J 27 : 441 446.[CrossRef].[PubMed]
52. Warraich RS, Sliwa K, Damasceno A, Carraway R, Sundrom B, Arif G, Essop R, Ansari A, Fett J, Yacoub M . 2005. Impact of pregnancy-related heart failure on humoral immunity: clinical relevance of G3-subclass immunoglobulins in peripartum cardiomyopathy. Am Heart J 150 : 263 269.[CrossRef].[PubMed]
53. Mascaro-Blanco A, Alvarez K, Yu X, Lindenfeld J, Olansky L, Lyons T, Duvall D, Heuser JS, Gosmanova A, Rubenstein CJ, Cooper LT, Kem DC, Cunningham MW . 2008. Consequences of unlocking the cardiac myosin molecule in human myocarditis and cardiomyopathies. Autoimmunity 41 : 442 453.[CrossRef].[PubMed]

Tables

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TABLE 1

Serum biomarkers used for diagnosis of AMI

Citation: Maier C, Burek C, Rose N, Ansari A. 2016. Cardiovascular Diseases, p 975-982. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch102
Generic image for table
TABLE 2

Serum biomarkers for CMI

Citation: Maier C, Burek C, Rose N, Ansari A. 2016. Cardiovascular Diseases, p 975-982. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch102
Generic image for table
TABLE 3

Infectious and noninfectious etiologies of inflammatory cardiomyopathy

Citation: Maier C, Burek C, Rose N, Ansari A. 2016. Cardiovascular Diseases, p 975-982. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch102
Generic image for table
TABLE 4

Autoantibodies detected in inflammatory cardiomyopathies

Citation: Maier C, Burek C, Rose N, Ansari A. 2016. Cardiovascular Diseases, p 975-982. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch102
Generic image for table
TABLE 5

Clinical immunological assays for detection and characterization of inflammatory heart disease

Citation: Maier C, Burek C, Rose N, Ansari A. 2016. Cardiovascular Diseases, p 975-982. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch102

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