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Chapter 103 : Celiac Disease and Inflammatory Bowel Disease

Author: Melissa R. Snyder1
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Affiliations: 1: Mayo Clinic, Hilton 2-10D, 200 First St. SW, Rochester, MN 55905
Content Type: Reference
Publication Year: 2016

Category: Immunology

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Abstract:

Celiac disease (CeD) and inflammatory bowel disease (IBD) are chronic inflammatory diseases affecting the gastrointestinal tract. They share certain characteristics, including autoimmune features, the presence of both gastrointestinal and systemic clinical symptoms, and pathogenic contributions by genetic and environmental factors. However, there are several stark differences that must be appreciated. The immunogenic mechanisms of the two diseases are unique, with differing contributions by the innate and adaptive immune responses. Histologically, CeD is distinct from IBD, which is useful diagnostically as well as for gaining insight into disease mechanisms. Lastly, the role of diagnostic laboratory testing, both serologic and genetic, differs greatly between CeD and IBD. The purpose of this chapter is to provide a summary of what is currently known about the pathogenesis, epidemiology, clinical presentation, and diagnostic testing for CeD and IBD.

Citation: Snyder M. 2016. Celiac Disease and Inflammatory Bowel Disease, p 983-989. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch103
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Celiac Disease and Inflammatory Bowel Disease
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Citation: Snyder M. 2016. Celiac Disease and Inflammatory Bowel Disease, p 983-989. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch103
/content/10.1128/9781555818722.ch103.ch103fig1
FIGURE 1

EMA by indirect immunofluorescence. The presence of an EMA is identified based on the appearance of latticework staining of the endomysium surrounding the smooth muscle fiber. This photo is a 10× magnification of an indirect immunofluorescence method using monkey esophagus. (Photo courtesy of the Immunodermatology Laboratory, Mayo Clinic, Rochester, MN.)

10.1128/9781555818722/8722ch103fig1_thmb.gif
10.1128/9781555818722/8722ch103fig1.gif
Image of FIGURE 1
FIGURE 1

EMA by indirect immunofluorescence. The presence of an EMA is identified based on the appearance of latticework staining of the endomysium surrounding the smooth muscle fiber. This photo is a 10× magnification of an indirect immunofluorescence method using monkey esophagus. (Photo courtesy of the Immunodermatology Laboratory, Mayo Clinic, Rochester, MN.)

Citation: Snyder M. 2016. Celiac Disease and Inflammatory Bowel Disease, p 983-989. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch103
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Tables

Celiac Disease and Inflammatory Bowel Disease
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Citation: Snyder M. 2016. Celiac Disease and Inflammatory Bowel Disease, p 983-989. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch103
/content/10.1128/9781555818722.ch103.ch103tab1
TABLE 1

Summary of serologic tests available for evaluation of suspected CeD and IBD

Generic image for table
TABLE 1

Summary of serologic tests available for evaluation of suspected CeD and IBD

Citation: Snyder M. 2016. Celiac Disease and Inflammatory Bowel Disease, p 983-989. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch103

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