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Chapter 105 : Immune Thrombocytopenia
Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by a platelet count of <100,000/μl in the absence of any underlying cause. The incidence of newly diagnosed ITP in adults ranges from 1.6 to 3.9 per 100,000 person-years. The female-to-male ratio ranges from 1.2 to 1.9. The general consensus is that the diagnosis is one of exclusion based on patient clinical history, physical examination, review of medication history, and performance of a complete blood count with review of the peripheral blood smear. One can classify the illness based on duration: (i) newly diagnosed with a duration of up to 3 months, (ii) persistent ITP of 3 months to 1 year, or (iii) chronic ITP of >1 year (1).