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Chapter 106 : Monitoring Autoimmune Reactivity within the Retina

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Abstract:

The identification of immune reactivity against self components is a key element in the characterization of autoimmunity and autoimmune diseases. This autoimmune reactivity is most frequently monitored by the detection of specific autoantibodies or the presence of T-cell reactivity to self peptides. Numerous studies have now demonstrated that distinct profiles of autoantibodies are seen in clinically distinct autoimmune syndromes, such as systemic lupus erythematosus, myositis, and insulin-dependent diabetes mellitus. Moreover, the autoantigens are targets of an adaptive immune response.

Citation: Hooks J, Chan C, Sen H, Nussenblatt R, Detrick B. 2016. Monitoring Autoimmune Reactivity within the Retina, p 998-1003. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch106
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Figures

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FIGURE 1

Immunofluorescence staining for antiretinal antibodies. Frozen sections of normal mouse retina were incubated with “normal” nonreactive human sera (A) or with sera from a patient with AIR (B). Both sera were tested at a 1:160 dilution. Note reactivity with several marked areas of the retina: retinal ganglia cell layer (RGC), INL, ONL, and RPE.

Citation: Hooks J, Chan C, Sen H, Nussenblatt R, Detrick B. 2016. Monitoring Autoimmune Reactivity within the Retina, p 998-1003. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch106
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References

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Tables

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TABLE 1

Antibody responses directed against retinal antigens in sera from patients with retinal diseases

Citation: Hooks J, Chan C, Sen H, Nussenblatt R, Detrick B. 2016. Monitoring Autoimmune Reactivity within the Retina, p 998-1003. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch106

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