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Chapter 115 : Non-Human Leukocyte Antigen Antibodies in Organ Transplantation

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Non-Human Leukocyte Antigen Antibodies in Organ Transplantation, Page 1 of 2

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Abstract:

Transplantation can significantly extend the life of patients with end-stage renal disease and provide a lifesaving treatment for patients with failure of other major organs. Extending the long-term survival of these transplanted organs requires a better understanding of the mechanisms of immune injury, including humoral immunity. Alloantibodies were determined early on to be a contraindication to transplantation, but until recently the primary focus has been on HLA-specific antibodies (1). Historically, the lymphocyte crossmatch was the primary tool used to detect HLA antibodies in the sera of transplant recipients and to assess the risk of antibody-mediated rejection posttransplantation. Now, with the advent of solid-phase immunoassays, we can detect HLA antibodies at very low levels and provide a more accurate characterization of their antigen specificities (2).

Citation: Jackson A, Dale B. 2016. Non-Human Leukocyte Antigen Antibodies in Organ Transplantation, p 1103-1107. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch115
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References

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1. McKenna RM, Takemoto SK, Terasaki PI. 2000. Anti-HLA antibodies after solid organ transplantation. Transplantation 69:319326.[PubMed].[CrossRef]
2. Leffell MS, Zachary AA. 2010. Anti-allograft antibodies: some are harmful, some can be overcome, and some may be beneficial. Discov Med 9:478484.[PubMed]
3. Kalil J, Guilherme L, Neumann J, Rosales C, Marin M, Saldanha L, Chocair PR, Ianhez LE, Sabbaga E. 1989. Humoral rejection in two HLA identical living related donor kidney transplants. Transplant Proc 21:711713.[PubMed]
4. Grafft CA, Cornell LD, Gloor JM, Cosio FG, Gandhi MJ, Dean PG, Stegall MD, Amer H. 2010. Antibody-mediated rejection following transplantation from an HLA-identical sibling. Nephrol Dial Transplant 25:307310.[CrossRef].[PubMed]
5. Opelz G Collaborative Transplant Study. 2005. Non-HLA transplantation immunity revealed by lymphocytotoxic antibodies. Lancet 365:15701576.[CrossRef].[PubMed]
6. Sigdel TK, Sarwal MM. 2013. Moving beyond HLA: a review of nHLA antibodies in organ transplantation. Hum Immunol 74:14861490.[CrossRef].[PubMed]
7. Zhang Q, Reed EF. 2010. Non-MHC antigenic targets of the humoral immune response in transplantation. Curr Opin Immunol 22:682688.[CrossRef].[PubMed]
8. Fukami N, Ramachandran S, Saini D, Walter M, Chapman W, Patterson GA, Mohanakumar T. 2009. Antibodies to MHC class I induce autoimmunity: role in the pathogenesis of chronic rejection. J Immunol 182:309318.[PubMed].[CrossRef]
9. Thaunat O, Graff-Dubois S, Fabien N, Duthey A, Attuil-Audenis V, Nicoletti A, Patey N, Morelon E. 2012. A stepwise breakdown of B-cell tolerance occurs within renal allografts during chronic rejection. Kidney Int 81:207219.[CrossRef].[PubMed]
10. Chong AS, Alegre ML. 2012. The impact of infection and tissue damage in solid-organ transplantation. Nat Rev Immunol 12:459471.[CrossRef].[PubMed]
11. Li L, Sigdel T, Vitalone M, Lee SH, Sarwal M. 2010. Differential immunogenicity and clinical relevance of kidney compartment specific antigens after renal transplantation. J Proteome Res 9:67156721.[CrossRef].[PubMed]
12. Dinavahi R, George A, Tretin A, Akalin E, Ames S, Bromberg JS, Deboccardo G, Dipaola N, Lerner SM, Mehrotra A, Murphy BT, Nadasdy T, Paz-Artal E, Salomon DR, Schröppel B, Sehgal V, Sachidanandam R, Heeger PS. 2011. Antibodies reactive to non-HLA antigens in transplant glomerulopathy. J Am Soc Nephrol 22:11681178.[CrossRef].[PubMed]
13. Otten HG, van den Bosch JM, van Ginkel WG, van Loon M, van de Graaf EA. 2006. Identification of non-HLA target antigens recognized after lung transplantation. J Heart Lung Transplant 25:14251430.[CrossRef].[PubMed]
14. Lucchiari N, Panajotopoulos N, Xu C, Rodrigues H, Ianhez LE, Kalil J, Glotz D. 2000. Antibodies eluted from acutely rejected renal allografts bind to and activate human endothelial cells. Hum Immunol 61:518527.[PubMed].[CrossRef]
15. Breimer ME, Rydberg L, Jackson AM, Lucas DP, Zachary AA, Melancon JK, Von Visger J, Pelletier R, Saidman SL, Williams WW Jr, Holgersson J, Tydén G, Klintmalm GK, Coultrup S, Sumitran-Holgersson S, Grufman P. 2009. Multicenter evaluation of a novel endothelial cell crossmatch test in kidney transplantation. Transplantation 87:549556.[CrossRef].[PubMed]
16. Qin Z, Zou Y, Lavingia B, Stastny P. 2013. Identification of endothelial cell surface antigens encoded by genes other than HLA. A combined immunoprecipitation and proteomic approach for the identification of antigens recognized by antibodies against endothelial cells in transplant recipients. Hum Immunol 74:14451452.[CrossRef].[PubMed]
17. Sumitran-Karuppan S, Tyden G, Reinholt F, Berg U, Moller E. 1997. Hyperacute rejections of two consecutive renal allografts and early loss of the third transplant caused by non-HLA antibodies specific for endothelial cells. Transpl Immunol 5:321327.[PubMed].[CrossRef]
18. Jackson AM, Kuperman MB, Montgomery RA. 2012. Multiple hyperacute rejections in the absence of detectable complement activation in a patient with endothelial cell reactive antibody. Am J Transplant 12:16431649.[CrossRef].[PubMed]
19. Cornell LD, Smith RN, Colvin RB. 2008. Kidney transplantation: mechanisms of rejection and acceptance. Annu Rev Pathol 3:189220.[CrossRef].[PubMed]
20. Valenzuela NM, Reed EF. 2013. Antibodies in transplantation: the effects of HLA and non-HLA antibody binding and mechanisms of injury. Methods Mol Biol 1034:4170.[CrossRef].[PubMed]
21. Taniguchi M, Rebellato LM, Cai J, Hopfield J, Briley KP, Haisch CE, Catrou PG, Bolin P, Parker K, Kendrick WT, Kendrick SA, Harland RC, Terasaki PI. 2013. Higher risk of kidney graft failure in the presence of anti-angiotensin II type-1 receptor antibodies. Am J Transplant 13:25772589.[CrossRef].[PubMed]
22. Le Bas-Bernardet S, Hourmant M, Coupel S, Bignon JD, Soulillou JP, Charreau B. 2003. Non-HLA-type endothelial cell reactive alloantibodies in pre-transplant sera of kidney recipients trigger apoptosis. Am J Transplant 3:167177.[PubMed].[CrossRef]
23. Cardinal H, Dieudé M, Brassard N, Qi S, Patey N, Soulez M, Beillevaire D, Echeverry F, Daniel C, Durocher Y, Madore F, Hébert MJ. 2013. Antiperlecan antibodies are novel accelerators of immune-mediated vascular injury. Am J Transplant 13:861874.[CrossRef].[PubMed]
24. Florey OJ, Johns M, Esho OO, Mason JC, Haskard DO. 2007. Antiendothelial cell antibodies mediate enhanced leukocyte adhesion to cytokine-activated endothelial cells through a novel mechanism requiring cooperation between FcγRIIa and CXCR1/2. Blood 109:38813889.[CrossRef].[PubMed]
25. Leong HS, Mahesh BM, Day JR, Smith JD, McCormack AD, Ghimire G, Podor TJ, Rose ML. 2008. Vimentin autoantibodies induce platelet activation and formation of platelet-leukocyte conjugates via platelet-activating factor. J Leukoc Biol 83:263271.[CrossRef].[PubMed]
26. Dragun D, Müller DN, Bräsen JH, Fritsche L, Nieminen-Kelhä M, Dechend R, Kintscher U, Rudolph B, Hoebeke J, Eckert D, Mazak I, Plehm R, Schönemann C, Unger T, Budde K, Neumayer HH, Luft FC, Wallukat G. 2005. Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection. N Engl J Med 352:558569.[CrossRef].[PubMed]
27. Vermehren D, Sumitran-Holgersson S. 2002. Isolation of precursor endothelial cells from peripheral blood for donor-specific crossmatching before organ transplantation. Transplantation 74:14791486.[CrossRef].[PubMed]
28. Harrison RL, Jarvis DL. 2006. Protein N-glycosylation in the baculovirus–insect cell expression system and engineering of insect cells to produce “mammalianized” recombinant glycoproteins. Adv Virus Res 68:159191.[CrossRef].[PubMed]
29. Bilalic S, Veitinger M, Ahrer KH, Gruber V, Zellner M, Brostjan C, Bartel G, Cejka D, Reichel C, Jordan V, Burghuber C, Mühlbacher F, Böhmig GA, Oehler R. 2010. Identification of non-HLA antigens targeted by alloreactive antibodies in patients undergoing chronic hemodialysis. J Proteome Res 9:10411049.[CrossRef].[PubMed]
30. Drouet C, Nissou MF, Ponard D, Arvieux J, Dumestre-Pérard C, Gaudin P, Imbert B, Massot C, Sarrot-Reynauld F. 2003. Detection of antiendothelial cell antibodies by an enzyme-linked immunosorbent assay using antigens from cell lysate: minimal interference with antinuclear antibodies and rheumatoid factors. Clin Diagn Lab Immunol 10:934939.[PubMed]
31. Zachary AA, Lucas DP, Detrick B, Leffell MS. 2009. Naturally occurring interference in Luminex assays for HLA-specific antibodies: characteristics and resolution. Hum Immunol 70:496501.[CrossRef].[PubMed]
32. Schnaidt M, Weinstock C, Jurisic M, Schmid-Horch B, Ender A, Wernet D. 2011. HLA antibody specification using single-antigen beads—a technical solution for the prozone effect. Transplantation 92:510515.[CrossRef].[PubMed]
33. Gibbs J. 2001. Effective blocking procedures. ELISA technical bulletin no. 3. Corning Inc Life Sciences, Acton, MA. http://www.labcluster.com/news4_3/Corning_elisa3_4.pdf.
34. Baumgarth N, Roederer M. 2000. A practical approach to multicolor flow cytometry for immunophenotyping. J Immunol Methods 243:7797.[PubMed].[CrossRef]

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