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Chapter 47 : Lyme Disease, Relapsing Fever, and Leptospirosis

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Lyme Disease, Relapsing Fever, and Leptospirosis, Page 1 of 2

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Abstract:

Lyme disease, relapsing fever, and leptospirosis are infections caused by spirochetes, a phylogenetically ancient and distinct group of microorganisms among the prokaryotes.

Citation: Wang G, Aguero-Rosenfeld M. 2016. Lyme Disease, Relapsing Fever, and Leptospirosis, p 419-432. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch47
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Figures

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FIGURE 1

(A) Examples of positive Lyme IgM (lane 1) and IgG (lane 2) Western blots (MarDx Inc). The IgM and IgG bands in the CDC interpretive criteria are indicated. (B) VlsE–IgG Western blots (Viralab Inc, not currently FDA-approved in the U.S.) ( ). Sequential sera from a culture-confirmed EM patient are shown in lanes 1 to 4. Serum samples were collected at Baseline (BL, lane 4), 8 days (d8, lane 3), 20 days (d20, lane 2) and 3 months (3m, lane 1) post onset of illness.

Citation: Wang G, Aguero-Rosenfeld M. 2016. Lyme Disease, Relapsing Fever, and Leptospirosis, p 419-432. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch47
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References

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Tables

Generic image for table
TABLE 1

Characteristics of selected species associated with Lyme disease and relapsing fever

Citation: Wang G, Aguero-Rosenfeld M. 2016. Lyme Disease, Relapsing Fever, and Leptospirosis, p 419-432. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch47
Generic image for table
TABLE 2

Clinical manifestations of Lyme disease and specimen types for laboratory diagnosis

Citation: Wang G, Aguero-Rosenfeld M. 2016. Lyme Disease, Relapsing Fever, and Leptospirosis, p 419-432. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch47
Generic image for table
TABLE 3

Comparative sensitivity of different immunologic methods to detect antibodies to in Lyme disease patients from the United States

Citation: Wang G, Aguero-Rosenfeld M. 2016. Lyme Disease, Relapsing Fever, and Leptospirosis, p 419-432. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch47
Generic image for table
TABLE 4

Comparison of different modalities for laboratory diagnosis of Lyme disease

Citation: Wang G, Aguero-Rosenfeld M. 2016. Lyme Disease, Relapsing Fever, and Leptospirosis, p 419-432. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch47
Generic image for table
TABLE 5

species and selected pathogenic serovars

Citation: Wang G, Aguero-Rosenfeld M. 2016. Lyme Disease, Relapsing Fever, and Leptospirosis, p 419-432. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch47

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