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Chapter 5 : Introduction

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Introduction, Page 1 of 2

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Abstract:

The section on immunoglobulin methods covers the basic genetic background for immunoglobulin production, measurement of immunoglobulins, identification of monoclonal protein products by serum protein electrophoresis and immunofixation, and detection of oligoclonal bands in cerebrospinal fluid. In addition, this section covers the characterization of cryoglobulins and cryofibrinogens and an overall strategy for using all the techniques in this section to detect, stratify risks of progression of, and monitor patients with monoclonal gammopathies.

Citation: Keren D. 2016. Introduction, p 47-50. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch5
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References

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1. Tate JR, Mollee P, Dimeski G, Carter AC, Gill D. 2007. Analytical performance of serum free light-chain assay during monitoring of patients with monoclonal light-chain diseases. Clin Chim Acta 376:3036.[CrossRef].[PubMed]
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3. Bradwell AR, Harding SJ, Fourier NJ, Wallis GL, Drayson MT, Carr-Smith HD, Mead GP. 2009. Assessment of monoclonal gammopathies by nephelometric measurement of individual immunoglobulin kappa/lambda ratios. Clin Chem55:16461655.[CrossRef].[PubMed]
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5. Keren DF. 2012. Protein Electrophoresis in Clinical Diagnosis. American Society for Clinical Pathology Press, Chicago, IL.[CrossRef]
6. Jacobs JFM, van der Molen RG, Keren DF. 2014. Relatively restricted migration of polyclonal IgG4 may mimic a monoclonal gammopathy in IgG4-related disease. Am J Clin Pathol 142:7681.[CrossRef].[PubMed]
7. Russi S, Sansonno D, Mariggio MA, Vinella A, Pavone F, Lauletta G, Sansonno S, Dammacco F. 2014. Assessment of hepatitis core protein in HCV-related mixed cryoglobulinemia. Arthritis Res Ther 18:16.
8. Warren JS. 2013. Clinically unsuspected cryoglobulinemia. Am J Clin Pathol 139:352359.[CrossRef].[PubMed]

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