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Chapter 82 : Immunological Methods in the Diagnostic Allergy Clinical and Research Laboratory

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Immunological Methods in the Diagnostic Allergy Clinical and Research Laboratory, Page 1 of 2

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Abstract:

Nearly 50 years have passed since IgE was identified as the reagin or serum antibody that sensitizes skin mast cells and circulating basophils and mediates immediate-type hypersensitivity reactions in humans (1, 2). Since IgE's identification, the clinical immunology laboratory has provided the clinician with analytical measurements that aid in the diagnosis, management, and research of the natural history and epidemiology of IgE-mediated diseases. Total and allergen-specific IgE antibody are the primary analytes measured clinically to support the diagnosis of human allergic disease. Antigen-specific IgG antibodies are measured as a research analyte to identify chronic allergen exposure and to monitor potential blocking antibody activity following immunotherapy.

Citation: Hamilton R. 2016. Immunological Methods in the Diagnostic Allergy Clinical and Research Laboratory, p 795-800. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch82
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References

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1. Bennich HH, Ishizaka K, Johansson SGO, Rowe DS, Stanworth DR, Terry WD. 1968. Immunoglobulin E: a new class of human immunoglobulin. Immunology 15:323324.[PubMed]
2. Saini SS, MacGlashan DW Jr, Sterbinsky SA, Togias A, Adelman DC, Lichtenstein LM, Bochner BS. 1999. Down-regulation of human basophil IgE and FC epsilon RI alpha surface densities and mediator release by anti-IgE-infusions is reversible in vitro and in vivo. J Immunol 162:56245630.[PubMed]
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6. Hamilton RG,. 2006. Immunological methods in the diagnostic allergy clinical and research laboratory, p 955963. In Detrick B, Hamilton RG, Folds JD (ed), Manual of Molecular and Clinical Laboratory Immunology, 7th ed. ASM Press, Washington, D.C.
7. Hamilton RG. 2010. Proficiency survey-based evaluation of clinical total and allergen-specific IgE assay performance. Arch Pathol Lab Med 134:975982.[CrossRef].[PubMed]
8. Valenta R, Lidholm J, Niederberger V, Hayek B, Kraft D, Grönlund H. 1999. The recombinant allergen-based concept of component-resolved diagnostics and immunotherapy (CRD and CRIT). Clin Exp Allergy 29:896904.[PubMed].[CrossRef]
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16. Matsson P, Hamilton RG. 2009. Evaluation methods and analytical performance characteristics of immunological assays for human IgE antibody of defined allergen specificities: Guideline, National Committee on Clinical Laboratory Standards 1/LA20-A.
17. Thorpe SJ, Heath A, Fox B, Patel D, Egner W. 2014. The 3rd International Standard for serum IgE: international collaborative study to evaluate a candidate preparation. Clin Chem Lab Med 52:12831289.[CrossRef].[PubMed]
18. Hiller R, Laffer S, Harwanegg C, Huber M, Schmidt WM, Twardosz A, Barletta B, Becker WM, Blaser K, Breiteneder H, Chapman M, Crameri R, Duchêne M, Ferreira F, Fiebig H, Hoffmann-Sommergruber K, King TP, Kleber-Janke T, Kurup VP, Lehrer SB, Lidholm J, Müller U, Pini C, Reese G, Scheiner O, Scheynius A, Shen HD, Spitzauer S, Suck R, Swoboda I, Thomas W, Tinghino R, Van Hage-Hamsten M, Virtanen T, Kraft D, Müller MW, Valenta R. 2002. Microarrayed allergen molecules: diagnostic gatekeepers for allergy treatment. FASEB J 16:414416.[CrossRef].[PubMed]
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20. Butler JE, Hamilton RG,. 1981. Quantitation of specific antibodies: methods of expression, standards, solid phase considerations and specific applications, chapter 9. In Butler JE (ed), Immunochemistry of Solid Phase Immunoassays. CRC Press, Boca Raton, FL.

Tables

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TABLE 1

Clinical conditions in which serological determination of IgE and IgG antibodies may be useful in the differential diagnosis

Citation: Hamilton R. 2016. Immunological Methods in the Diagnostic Allergy Clinical and Research Laboratory, p 795-800. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch82

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