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Chapter 93 : Antiphospholipid Antibody Syndrome: Clinical Manifestations and Laboratory Diagnosis

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Antiphospholipid Antibody Syndrome: Clinical Manifestations and Laboratory Diagnosis, Page 1 of 2

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Abstract:

Antiphospholipid antibody syndrome (APS) is an acquired thrombotic disorder caused by a heterogenous group of antibodies directed against plasma proteins that bind phospholipids. These are termed “antiphospholipid antibodies” (aPLs), and while they are required for the diagnosis for APS, they can also be detected in otherwise healthy individuals. The clinical manifestations of APS can be divided into thrombotic and obstetrical. Thrombotic complications include both venous and arterial thrombosis. Obstetrical complications include recurrent first trimester miscarriage and second trimester fetal demise, as well as other pregnancy complications like preeclampsia and placental insufficiency (1). APS is classified as “primary” when not associated with an underlying disease and accounts for over 50% of cases (2). Secondary APS is the distinction given to APS associated with an underlying autoimmune connective tissue disorder such as SLE.

Citation: Murphy M, Harris N. 2016. Antiphospholipid Antibody Syndrome: Clinical Manifestations and Laboratory Diagnosis, p 905-908. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch93
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References

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13. Lakos G, Favaloro EJ, Harris EN, Meroni PL, Tincani A, Wong RC, Pierangeli SS. 2012. International consensus guidelines on anticardiolipin and anti-β2-glycoprotein I testing: report from the 13th International Congress on Antiphospholipid Antibodies. Arthritis Rheum 64:110.[CrossRef].[PubMed]
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Tables

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TABLE 1

Criteria for the diagnosis of antiphospholipid syndrome

Citation: Murphy M, Harris N. 2016. Antiphospholipid Antibody Syndrome: Clinical Manifestations and Laboratory Diagnosis, p 905-908. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch93
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Untitled

Citation: Murphy M, Harris N. 2016. Antiphospholipid Antibody Syndrome: Clinical Manifestations and Laboratory Diagnosis, p 905-908. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch93

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