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Chapter 95 : IgG4-Related Disease: Diagnostic Testing by Serology, Flow Cytometry, and Immunohistopathology

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IgG4-Related Disease: Diagnostic Testing by Serology, Flow Cytometry, and Immunohistopathology, Page 1 of 2

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Abstract:

IgG4-related disease (IgG4-RD) is a multiorgan immune-mediated condition that mimics many malignant, infectious, and inflammatory disorders (1–3). The diagnosis links numerous conditions once regarded as isolated, single-organ diseases that existed outside of any known underlying systemic condition (Table 1). The histopathological findings in IgG4-RD are consistent across the wide range of organ systems that can be involved. IgG4-RD is often confused with a malignancy upon presentation because it has a tendency to form mass lesions. In addition, IgG4-RD can mimic a host of immune-mediated conditions, e.g., primary sclerosing cholangitis, idiopathic interstitial lung disease, Sjögren's syndrome, granulomatosis with polyangiitis, and idiopathic membranous nephropathy.

Citation: Stone J. 2016. IgG4-Related Disease: Diagnostic Testing by Serology, Flow Cytometry, and Immunohistopathology, p 917-921. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch95
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References

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Tables

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TABLE 1

Names of previously recognized conditions that comprise parts of the IgG4-related disease spectrum

Citation: Stone J. 2016. IgG4-Related Disease: Diagnostic Testing by Serology, Flow Cytometry, and Immunohistopathology, p 917-921. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch95

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