1887

Chapter 10 : The Global Network for Neglected Tropical Diseases

MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.

Ebook: Choose a downloadable PDF or ePub file. Chapter is a downloadable PDF file. File must be downloaded within 48 hours of purchase

Buy this Chapter
Digital (?) $7.00

Preview this chapter:
Zoom in
Zoomout

The Global Network for Neglected Tropical Diseases, Page 1 of 2

| /docserver/preview/fulltext/10.1128/9781555818753/9781555818746_Chap10-1.gif /docserver/preview/fulltext/10.1128/9781555818753/9781555818746_Chap10-2.gif

Abstract:

The neglected tropical diseases (NTDs) are among the leading disabling conditions of humankind. According to one estimate the NTDs result in 56.6 million disability-adjusted life years (DALYs ), i.e., the number of healthy life years lost from disability or premature death) lost annually. Mass drug administration (MDA) has been effective against NTDs. The World Health Assembly (WHA) has adopted a number of ambitious resolutions over the years to promote the use of MDA for NTDs. In order to raise awareness about the NTDs and the promise of integrated NTD control, the Global Network for Neglected Tropical Diseases was established by the Sabin Vaccine Institute in 2006 to work with the health ministries in countries where the diseases are endemic. It focuses its activities primarily on advocacy, resource mobilization, bilateral engagement (parliaments and ministries of health), and international development banks in order to achieve the overall goal of increasing access to essential medicines for the estimated 1.4 billion people affected by the major NTDs targeted through preventive chemotherapy. Doing so would improve childhood development, school attendance and performance, pregnancy outcomes, and worker productivity among the world’s poorest populations. Integrated control of the NTDs is under way in at least seven sub-Saharan African countries.

Citation: Hotez P. 2013. The Global Network for Neglected Tropical Diseases, p 189-211. In Forgotten People Forgotten Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555818753.ch10

Key Concept Ranking

Human African Trypanosomiasis
0.78481096
Lymphatic Filariasis
0.5289886
Immune Systems
0.42860743
0.78481096
Highlighted Text: Show | Hide
Loading full text...

Full text loading...

Figures

Image of Figure 10.1
Figure 10.1

The 10 leading causes of DALYs. (Modified from .)

Citation: Hotez P. 2013. The Global Network for Neglected Tropical Diseases, p 189-211. In Forgotten People Forgotten Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555818753.ch10
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of Figure 10.2
Figure 10.2

Global distribution of the NTDs. Countries with five, six, and seven NTDs are shown in yellow, orange, and red, respectively. (Map prepared by Sophia Raff based on information summarized in .)

Citation: Hotez P. 2013. The Global Network for Neglected Tropical Diseases, p 189-211. In Forgotten People Forgotten Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555818753.ch10
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of Figure 10.3
Figure 10.3

Range of treatment costs per person per year for HIV/AIDS, tuberculosis (TB), malaria, and the rapid-impact package for integrated NTD control. The rapid-impact package costs as little as US$0.50 per person for packaged intervention ( ). (Figure modified from .)

Citation: Hotez P. 2013. The Global Network for Neglected Tropical Diseases, p 189-211. In Forgotten People Forgotten Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555818753.ch10
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of Figure 10.4
Figure 10.4

Logos of the founding partners of the Global Network for Neglected Tropical Diseases.

Citation: Hotez P. 2013. The Global Network for Neglected Tropical Diseases, p 189-211. In Forgotten People Forgotten Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555818753.ch10
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of Figure 10.5
Figure 10.5

Geographic overlap of moderate to high hookworm infection prevalence (>20% prevalence of infection among school-age children) and transmission of falciparum malaria (based on a map of climatic suitability for malaria transmission adjusted for urbanization). (Modified by Simon Brooker from .)

Citation: Hotez P. 2013. The Global Network for Neglected Tropical Diseases, p 189-211. In Forgotten People Forgotten Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555818753.ch10
Permissions and Reprints Request Permissions
Download as Powerpoint

References

/content/book/10.1128/9781555818753.chap10
1. Adelman C ,, Norris J ,, Spantchak Y ,, Marano K . 2012. Social and Economic Impact Review on Neglected Tropical Diseases. Hudson Institute, Washington, DC.
2. Baird S ,, Hicks JH ,, Kremer M ,, Miguel E . 2012. Worms at Work: Long-Run Impacts of Child Health Gains. www.economics.harvard.edu/faculty/kremer/files/KLPS-Labor_2012-03-23_clean.pdf.
3. Blackburn BG ,, Eigege A ,, Gotau H ,, Gerlong G ,, Miri E ,, Hawley WA ,, Mathieu E ,, Richards F . 2006. Successful integration of insecticide-treated bed net distribution with mass drug administration in Central Nigeria. Am J Trop Med Hyg 75: 650655.
4. Bleakley H . 2007. Disease and development: evidence from hookworm eradication in the American South. Q J Econ 122: 73112.
5. Borkow G ,, Bentwich Z . 2006. HIV and helminth co-infection. Parasite Immunol 28: 605612.
6. Brady MA ,, Hooper PJ ,, Ottesen EA . 2006. Projected benefits from integrating NTD programs in sub-Saharan Africa. Trends Parasitol 22: 285291.
7. Brooker S ,, Akhwale W ,, Pullan R ,, Estambale B ,, Clarke SE ,, Snow RW ,, Hotez PJ . 2007. Epidemiology of plasmodium-helminth co-infection in Africa: populations at risk, potential impact on anemia, and prospects for combining control. Am J Trop Med Hyg 77(6 Suppl): 8898.
8. Brooker S ,, Clements AC ,, Hotez PJ ,, Hay SI ,, Tatem AJ ,, Bundy DA ,, Snow RW . 2006. The co-distribution of Plasmodium falciparum and hookworm among African schoolchildren. Malar J 5: 99.
9. Brooker S ,, Hotez PJ ,, Bundy DA . 2008. Hookworm-related anaemia among pregnant women: a systematic review. PLoS Negl Trop Dis 2: e291.
10. Brooker S ,, Utzinger J . 2007. Integrated disease mapping in a polyparasitic world. Geospat Health 1: 141146.
11. Canning D . 2006. Priority setting and the ‘neglected' tropical diseases. Trans R Soc Trop Med Hyg 100: 499504.
12. Christian P ,, Khatry SK, West KP Jr. 2004. Antenatal anthelmintic treatment, birth-weight, and infant survival in rural Nepal. Lancet 364: 981983.
13. Crompton DW . 2000. The public health importance of hookworm disease. Parasitology 121 (Suppl): S39S50.
14. Druilhe P ,, Tall A ,, Sokhna C . 2005. Worms can worsen malaria: towards a new means to roll back malaria? Trends Parasitol 21: 359362.
15. Evans D ,, McFarland D ,, Adamani W ,, Eigege A ,, Miri E ,, Schulz J ,, Pede E ,, Umbugadu C ,, Ogbu-Pearse P ,, Richards FO . 2011. Cost-effectiveness of triple drug administration (TDA) with praziquantel, ivermectin and albendazole for the prevention of neglected tropical diseases in Nigeria. Ann Trop Med Parasitol 105: 537547.
16. Fenwick A ,, Molyneux D ,, Nantulya V . 2005. Achieving the Millennium Development Goals. Lancet 365: 10291030.
17. Fleming AF . 1994. Agriculture-related anemias. Br J Biomed Sci 31: 345357.
18. Fleming FM ,, Brooker S ,, Geiger SM ,, Caldas IR ,, Correa-Oliveira R ,, Hotez PJ ,, Bethony JM . 2006. Synergistic associations between hookworm and other helminth species in a rural community in Brazil. Trop Med Int Health 11: 5664.
19. Gallagher M ,, Malhotra I ,, Mungai PL ,, Wamachi AN ,, Kioko JM ,, Ouma JH ,, Muchiri E ,, King CL . 2005. The effects of maternal helminth and malaria infections on mother-to-child HIV transmission. AIDS 19: 18491855.
20. Gerns HL ,, Sangaré LR ,, Walson JL . 2012. Integration of deworming into HIV care and treatment: a neglected opportunity. PLOS Negl Trop Dis 6: e1738.
21. Greenwood B . 2006. Review: intermittent preventive treatment—a new approach to the prevention of malaria in children in areas with seasonal malaria transmission. Trop Med Int Health 11: 983991.
22. Guyatt HL ,, Snow RW . 2004. Impact of malaria during pregnancy on low birth weight in sub-Saharan Africa. Clin Microbiol Rev 17: 760769.
23. Hotez PJ . 2009. Mass drug administration and integrated control for the world's high-prevalence neglected tropical diseases. Clin Pharmacol Ther 85: 659664.
24. Hotez PJ . 2010. Neglected tropical disease control in the “post-American World.” PLoS Negl Trop Dis 4: e812.
25. Hotez PJ ,, Fenwick A ,, Kjetland EF . 2009a. Africa's 32 cents solution for HIV/AIDS. PLoS Negl Trop Dis 3: e430.
26. Hotez PJ ,, Fenwick A ,, Savioli L ,, Molyneux DH . 2009b. Rescuing the bottom billion through control of neglected tropical diseases. Lancet 373: 15701575.
27. Hotez PJ ,, Ferris MT . 2006. The antipoverty vaccines. Vaccine 24: 57875799.
28. Hotez PJ ,, Mistry N ,, Rubinstein J ,, Sachs JD . 2011. Integrating neglected tropical diseases into AIDS, tuberculosis, and malaria control. N Engl J Med 364: 20862089.
29. Hotez PJ ,, Molyneux DH ,, Fenwick A ,, Kumaresan J ,, Ehrlich Sachs S ,, Sachs JD ,, Savioli L . 2007a. Control of neglected tropical diseases. N Engl J Med 357: 10181027.
30. Hotez PJ ,, Molyneux DH ,, Fenwick A ,, Ottesen E ,, Ehrlich Sachs S ,, Sachs JD . 2006. Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malaria. PLoS Med 3: e102.
31. Hotez P ,, Raff S ,, Fenwick A ,, Richards F Jr, Molyneux DH. 2007b. Recent progress in integrated neglected tropical disease control. Trends Parasitol 23: 511514.
32. King CH . 2007. Lifting the burden of schistosomiasis—defining elements of infection-associated disease and the benefits of antiparasite treatment. J Infect Dis 196: 653655.
33. King CH ,, Dickman K ,, Tisch DJ . 2005. Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis. Lancet 365: 15611569.
34. Kjetland EF ,, Ndhlovu PD ,, Gomo E ,, Mduluza T ,, Midzi N ,, Gwanzura L ,, Mason PR ,, Sandvik L ,, Friis H ,, Gudnersen SG . 2006. Association between genital schistosomiasis and HIV in rural Zimbabwean women. AIDS 20: 593600.
35. Kristof N s. 2007. Attack of the worms. The New York Times 2007(July 2).
36. Lammie PJ ,, Fenwick A ,, Utzinger J . 2006. A blueprint for success: integration of neglected tropical disease control programmes. Trends Parasitol 22: 313321.
37. Magalhaes RJ ,, Clements AC ,, Patil AP ,, Gething PW ,, Brooker S . 2011. The applications of model-based geostatistics in helminth epidemiology and control. Adv Parasitol 74: 267296.
38. McKenzie FE . 2005. Polyparasitism. Int J Parasitol 34: 221222.
39. Miguel E ,, Kremer M . 2004. Worms: identifying impacts on education and health in the presence of treatment externalities. Econometrica 72: 159217.
40. Molyneux DH ,, Hotez PJ ,, Fenwick A . 2005. “Rapid-impact interventions”: how a policy of integrated control for Africa's neglected tropical diseases could benefit the poor. PLoS Med 2: e336.
41. Murray CJ ,, Vos T ,, Lozano R ,, Naghavi M ,, Flaxman AD ,, Michaud C ,, Ezzati M ,, Shibuya K ,, Salomon JA , et al. 2012. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380:21972223.
42. Ntab B ,, Cisse B ,, Boulanger D ,, Sokhna C ,, Targett G ,, Lines J ,, Alexander N ,, Trape JF ,, Simondon F ,, Greenwood BM ,, Simondon KB . 2007. Impact of intermittent preventive anti-malarial treatment on the growth and nutritional status of preschool children in rural Senegal (West Africa). Am J Trop Med Hyg 77: 411417.
43. Porco TC ,, Gebre T ,, Ayele B ,, House J ,, Keenan J ,, Zhou Z ,, Hong KC ,, Stoller N ,, Ray KJ ,, Emerson P ,, Gaynor BD ,, Lietman TM . 2009. Effect of mass distribution of azithromycin for trachoma control on overall mortality in Ethiopian children: a randomized trial. JAMA 302: 962968.
44. Raso G ,, Luginbühl A ,, Adjoua C ,, Tian-Bi NT ,, Silué KD ,, Matthys B ,, Vounatsou P ,, Wang Y ,, Dumas ME ,, Homes E ,, Singer BH ,, Tanner M ,, N'Goran EK ,, Utzinger J . 2004. Multiple parasite infections and their relationship to self-reported morbidity in a community of rural Côte d'Ivoire. Int J Epidemiol 33: 10921102.
45. Raso G ,, Vounatsou P ,, Singer BH ,, N'Goran EK ,, Tanner M ,, Utzinger J . 2006. An integrated approach for risk profiling and spatial prediction of Schistosoma mansoni-hookworm coinfection. Proc Natl Acad Sci USA 103: 69346939.
46. Sachs JD ,, Hotez PJ . 2006. Fighting tropical diseases. Science 311: 1521.
47. Secor WE . 2006. Interactions between schistosomiasis and infection with HIV-1. Parasite Immunol 28: 597603.
48. Smith JL ,, Brooker S . 2010. Impact of hookworm infection and deworming on anaemia in non-pregnant populations: a systematic review. Trop Med Int Health 15: 776795.
49. Teklehaimanot A ,, Sachs JD ,, Curtis C . 2007. Malaria control needs mass distribution of insecticidal bednets. Lancet 369: 21432146.
50. Torlesse H ,, Hodges M . 2000. Anthelminthic treatment and haemoglobin concentrations during pregnancy. Lancet 356: 1083.
51. Walson JL ,, Herrin BR ,, John-Stewart G . 2009. Deworming helminth co-infected individuals for delaying HIV disease progression. Cochrane Database Syst Rev 8: CD006419.
52. World Bank. 2003. School deworming at a glance. World Bank, Washington, DC. http://siteresources.worldbank.org/INTPHAAG/Resources/AAGDewormingEng110603.pdf.
53. World Health Organization. 2006. Preventive Chemotherapy in Human Helminthiasis. World Health Organization, Geneva, Switzerland.
54. World Health Organization. 2012a. Integrated preventive chemotherapy for neglected tropical diseases: estimation of the number of interventions required and delivered, 20092010. Wkly Epidemiol Rec 87: 1728.
55. World Health Organization. 2012b. Global WHO Alliance for the Elimination of Blinding Trachoma by 2020. Wkly Epidemiol Rec 87: 161168.
56. Wright JW (ed). 2006. The 2006 New York Times Almanac. Penguin, New York, NY.
57. Zimmermann MB ,, Hurrell R . 2007. Nutritional iron deficiency. Lancet 370: 511520.

Tables

Generic image for table
Table 10.1

Ranking of the seven most prevalent NTDs by DALYs

Modified from , and also .

Prevalence total includes individuals with multiple infections (polyparasitism).

Citation: Hotez P. 2013. The Global Network for Neglected Tropical Diseases, p 189-211. In Forgotten People Forgotten Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555818753.ch10
Generic image for table
Table 10.2

Summary of MDA programs for the most prevalent NTDs

See notes and .

Citation: Hotez P. 2013. The Global Network for Neglected Tropical Diseases, p 189-211. In Forgotten People Forgotten Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555818753.ch10

This is a required field
Please enter a valid email address
Please check the format of the address you have entered.
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error