Chapter 19 : Enterohemorrhagic Pathogenesis and the Host Response

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Bacterial exotoxins may cause damage to host cells by defined mechanisms. Depending on the presence of the globotriaosylceramide (Gb3) receptor, Shiga toxin may bind to cells and induce the ribotoxic stress response and apoptosis ( ). The toxin can also induce a proinflammatory response in cells, an effect that may be dissociated from ribosome inactivation and can even occur in cells lacking protein synthesis machinery. Bacterial lipopolysaccharide (LPS) induces a host response by binding to Toll-like receptor 4 (TLR4) and activating specific intracellular pathways. The activation of proinflammatory pathways, if excessive, promotes damage to the host. This article addresses enterohemorrhagic (EHEC) pathogenesis and the host response, examining the innate and adaptive immune responses to the bacteria and virulence factors and how they affect the process of colonization, transfer and transport of virulence factors in the circulation, activation of thrombosis and inflammation, and specific end-organ damage to the kidney and the brain.

Citation: Karpman D, Ståhl A. 2015. Enterohemorrhagic Pathogenesis and the Host Response, p 403-417. In Sperandio V, Hovde C (ed), Enterohemorrhagic and Other Shiga Toxin-Producing . ASM Press, Washington, DC. doi: 10.1128/microbiolspec.EHEC-0009-2013
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