1887

Chapter 11.5 : Detection of Antibodies

MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.

Ebook: Choose a downloadable PDF or ePub file. Chapter is a downloadable PDF file. File must be downloaded within 48 hours of purchase

Buy this Chapter
Digital (?) $30.00

Preview this chapter:
Zoom in
Zoomout

Detection of Antibodies, Page 1 of 2

| /docserver/preview/fulltext/10.1128/9781555818814/9781555818814_Chap11.5-1.gif /docserver/preview/fulltext/10.1128/9781555818814/9781555818814_Chap11.5-2.gif

Abstract:

Lyme disease, or Lyme borreliosis (LB), is a multisystem disease caused by and transmitted through the bite of infected ticks ( ). It is currently the most frequent vector-borne infectious disease in the United States, with the highest incidence in the northeastern and midwestern states ( ). LB is also prevalent in Europe, where evidence of the disease existed in the early 1900s and where it is transmitted by complex ticks.

Citation: Leber A. 2016. Detection of Antibodies, p 11.5.1-11.5.10. In Clinical Microbiology Procedures Handbook, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818814.ch11.5
Highlighted Text: Show | Hide
Loading full text...

Full text loading...

References

/content/book/10.1128/9781555818814.chap11.5
1. Steere AC. 2001. Lyme disease. N Engl J Med 345:115125.
2. Centers for Disease Control and Prevention. 2014. Summary of notifiable diseases, United States, 2012. MMWR Morb Mortal Wkly Rep 61:1121.
3. Richter D, Postic D, Sertour N, Livey L, Matuschka FR, Baranton G. 2006. Delineation of Borrelia burgdorferi sensu lato species by multilocus sequence analysis and confirmation of the delineation of Borrelia spielmanii sp. nov. Int J Syst Evol Microbiol 56:873881.
4. Wilske B, Fingerle V, Schultze-Spechtel U. 2007. Microbiological and serological diagnosis of Lyme borreliosis. FEMS Immunol Med Microbiol 49:1321.
5. Van Dam AP, Kuiper H, Vos A, Widjojokusumo K, De Jongh BM, Spanjaard I, Ramselaar ACP, Kramer MD, Dankert J. 1993. Different genospecies of Borrelia burgdorferi are associated with distinct clinical manifestations of Lyme borreliosis. Clin Infect Dis 17:709717.
6. Wormser GP, Liveris D, Nowakowski J, Nadelman RB, Cavaliere FL, McKenna D, Holmgren D, Schwartz I. 1999. Association of specific subtypes of Borrelia burgdorferi with hematogenous dissemination in early Lyme disease. J Infect Dis 180:720725.
7. Barbour AG, Hayes SF. 1986. Biology of Borrelia species. Microbiol Rev 50:381400.
8. Casjens S, Palmer N, van Vugt R, Mun HW, Stevenson B, Rosa P, Lathigra R, Sutton G, Peterson J, Dodson RJ, Haft D, Hickey E, Gwinn M, White O, Fraser M. 2000. A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi. Mol Microbiol 35:490516.
9. Schwan TG, Piesman J, Golde WT, Dolan MC, Rosa PA. 1995. Induction of an outer surface protein on Borrelia burgdorferi during tick feeding. Proc Natl Acad Sci USA 92:29092913.
10. Schwan TG, Piesman J. 2000. Temporal changes in outer surface proteins A and C of the Lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and mice. J Clin Microbiol 38:382388.
11. Crother TR, Champion CI, Wu X-Y, Blanco DR, Miller JN, Lovett MA. 2003. Antigenic composition of Borrelia burgdorferi during infection of SCID mice. Infect Immun 71:34193428.
12. Fikrig E, Feng W, Barthold SW, Telford SRIII, Flavell RA. 2000. Arthropod- and host-specific Borrelia burgdorferi bbk32 expression and the inhibition of spirochete transmission. J Immunol 164:53445351.
13. Miller JC, von Lackum K, Babb K, McAlister JD, Stevenson B. 2003. Temporal analysis of Borrelia burgdorferi Erp protein expression throughout the mammal-tick infectious cycle. Infect Immun 71:69436952.
14. Yang X, Popova TG, Hagman KE, Wikel SK, Schoeler GB, Caimano MJ, Radolf JD, Norgard MV. 1999. Identification, characterization, and expression of three new members of the Borrelia burgdorferi Mlp (2.9) lipoprotein gene family. Infect Immun 67:60086018.
15. Aguero-Rosenfeld ME, Wang G, Schwartz I, Wormser GP. 2005. Diagnosis of Lyme borreliosis. Clin Microbiol Rev 18:484509.
16. Schwartz I, Wormser GP, Schwartz JJ, Cooper D, Weissensee P, Gazumyan A, Zimmermann E, Goldberg NS, Bittker S, Campbell GL, Pavia CS. 1992. Diagnosis of early Lyme disease by polymerase chain reaction amplification and culture of skin biopsies from erythema migrans lesions. J Clin Microbiol 30:30823088.
17. Liveris D, Schwartz I, McKenna D, Nowakowski J, Nadelman RB, DeMarco J, Iyer R, Bittker S, Cooper D, Holmgren D, Wormser GP. 2012. Comparison of five diagnostic modalities for direct detection of Borrelia burgdorferi in patients with early Lyme disease. Diagn Microbiol Infect Dis 73:243245.
18. Barbour AG. 1984. Isolation and cultivation of Lyme disease spirochetes. Yale J Biol Med 57:521524.
19. Wormser GP, Bittker S, Cooper D, Nowakowski J, Nadelman RB, Pavia C. 2001. Yield of large-volume blood cultures in patients with early Lyme disease. J Infect Dis 184:10701072.
20. Nocton JJ, Dressler F, Rutledge BJ, Rys PN, Persing DH, Steere AC. 1994. Detection of Borrelia burgdorferi DNA by polymerase chain reaction in synovial fluid from patients with Lyme arthritis. N Engl J Med 330:229234.
21. Klempner MS, Schmid CH, Hu L, Steere AC, Johnson G, McCloud B, Noring R, Weinstein A. 2001. Intralaboratory reliability of serologic and urine testing for Lyme disease. Am J Med 110:217219.
22. Centers for Disease Control and Prevention. 2005. Notice to readers: caution regarding testing for Lyme disease. MMWR Morb Mortal Wkly Rep 54:125.
23. Aguero-Rosenfeld ME, Nowakowski J, Bittker S, Cooper D., Nadelman RB, Wormser GP. 1996. Evolution of the serologic response to Borrelia burgdorferi in treated patients with culture-confirmed erythema migrans. J Clin Microbiol 34:19.
24. Wormser GP, Liveris D, Hanincova K, Brisson D, Ludin S, Stracuzzi VJ, Embers ME, Philipp MT, Levin A, Aguero-Rosenfeld M, Schwartz I. 2008. Effect of B. burgdorferi genotype on the sensitivity of C6 and 2-tier testing in North American patients with culture-confirmed Lyme disease. Clin Infect Dis 47:910914.
25. Wormser GP, Nowakowski J, Nadelman R, Visintainer P, Levin A, Aguero-Rosenfeld ME. 2008. Impact of clinical variables on Borrelia burgdorferi-specific antibody seropositivity in acute-phase sera from patients in North America with culture-confirmed early Lyme disease. Clin Vaccine Immunol 15:15191522.
26. Aguero-Rosenfeld ME, Nowakowski J, McKenna DF, Carbonaro CA, Wormser GP. 1993. Serodiagnosis in early Lyme disease. J Clin Microbiol 31:30903095.
27. Dressler F, Whalen JA, Reinhardt BN, Steere AC. 1993. Western blotting in the serodiagnosis of Lyme disease. J Infect Dis 167:392400.
28. Engstrom SM, Shoop E, Johnson RC. 1995. Immunoblot interpretation criteria for serodiagnosis of early Lyme disease. J Clin Microbiol 33:419427.
29. Gilmore RDJr, Murphree RL, James AM, Sullivan SA, Johnson BJB. 1999. The Borrelia burgdorferi 37-kilodalton immunoblot band (P37) used in serodiagnosis of early Lyme disease is the flaA gene product. J Clin Microbiol 37:548552.
30. Coleman JL, Benach JL. 1987. Isolation of antigenic components from the Lyme disease spirochete: their role in early diagnosis. J Infect Dis 155:756765.
31. Craft JE, Fischer K, Shimamoto GT, Steere AC. 1986. Antigens of Borrelia burgdorferi recognized during early Lyme disease. J Clin Invest 78:934939.
32. Feder HMJr, Gerber MA, Luger SW, Ryan RW. 1992. Persistence of serum antibodies to Borrelia burgdorferi in patients treated for Lyme disease. Clin Infect Dis 15:788793.
33. Fawcett PT, Gibney KM, Rose CD, Dubb SB, Doughty RA. 1992. Frequency and specificity of antibodies that cross-react with Borrelia burgdorferi antigens. J Rheumatol 19:582587.
34. Brown SL, Hansen SL, Langone JJ. 1999. Role of serology in the diagnosis of Lyme disease. JAMA 282:6266.
35. Nachamkin I, Riddle DL, Feldman M, Edelstein PH. 1996. Utilization of tests for Lyme disease antibody at a university hospital. Clin Diagn Lab Immunol 3:287289.
36. Centers for Disease Control and Prevention. 1995. Recommendations for test performance and interpretation from the second national conference on serologic diagnosis of Lyme disease. MMWR Morb Mortal Wkly Rep 44:590591.
37. Bacon RM, Biggerstaff BJ, Schriefer ME Gilmore RDJr, Philipp MT, Steere AC, Wormser GP, Marques AR, Johnson BJ. 2003. Serodiagnosis of Lyme disease by kinetic enzyme-linked immunosorbent assay using recombinant VlsE1 or peptide antigens of Borrelia burgdorferi compared with 2-tiered testing using whole-cell lysates. J Infect Dis 187:11871199.
38. Lawrenz MB, Hardham JM, Owens RT, Nowakowski J, Steere AC, Wormser GP, Norris SJ. 1999. Human antibody responses to VlsE antigenic variation protein of Borrelia burgdorferi. J Clin Microbiol 37:39974004.
39. Liang FT, Steere AC, Marques AR, Johnson BJB, Miller JN, Philipp MT. 1999. Sensitive and specific serodiagnosis of Lyme disease by enzyme-linked immunosorbent assay with a peptide based on an immunodominant conserved region of Borrelia burgdorferi VlsE. J Clin Microbiol 37:39903996.
40. Nyman D, Willen L, Jansson C, Carlsson SA, Granlund H, Wahlberg P. 2006. VlsE C6 peptide and IgG ELISA antibody analysis for clinical diagnosis of Lyme borreliosis in an endemic area. Clin Microbiol Infect 12:496497.
41. Branda JA, Linskey K, Kim YA, Steere AC, Ferraro MJ. 2011. Two-tiered antibody testing for Lyme disease with use of 2 enzyme immunoassays, a whole-cell sonicate enzyme immunoassay followed by a VlsE C6 peptide immunoassay. Clin Infect Dis 53:541547.
42. Mogilyansky E, Loa CC, Adelson ME, Mordechai E, Tilton RC. 2004. Comparison of Western immunoblotting and the C6 Lyme antibody test for laboratory detection of Lyme disease. Clin Diagn Lab Immunol 11:924929.
43. Wormser GP, Schriefer M, Aguero-Rosenfeld ME, Levin A, Steere AC, Nadelman RB, Nowakowski J, Marques A, Johnson BJB, Dumler JS. 2013. Single-tier testing with the C6 peptide ELISA kit compared to two-tier testing for Lyme disease. Diagn Microbiol Infect Dis 75:915.
44. Branda JA, Strle F, Strle K, Sikand N, Ferraro MJ, Steere AC. 2013. Performance of United States serologic assays in the diagnosis of Lyme borreliosis in Europe. Clin Infect Dis 57:333340.
45. Porwancher RB, Hagerty CG, Fan J, Landsberg L, Johnson BJB, Kopnitsky M, Steere AC, Kulas K, Wong SJ. 2011. Multiplex immunoassay for Lyme disease using VlsE1-IgG and pepC10-IgM antibodies: improving test performance through bioinformatics. Clin Vaccine Immunol 18:851859.
46. Ledue TB, Collins MF, Young J, Schriefer ME. 2008. Evaluation of the recombinant VlsE-based Liaison chemiluminescence immunoassay for detection of Borrelia burgdorferi and diagnosis of Lyme disease. Clin Vaccine Immunol 15:17961804.
47. Agger WA, Case KL. 1997. Clinical comparison of borreliacidal-antibody test with indirect immunofluorescence and enzyme-linked immunosorbent assays for diagnosis of Lyme disease. Mayo Clin Proc 72:510514.
48. Callister SM, Schell RF, Lim LCL, Jobe DA, Case KL, Bryant GL, Molling PE. 1994. Detection of borreliacidal antibodies by flow cytometry. Arch Intern Med 154:16251632.
49. Callister SM, Jobe DA, Agger WA, Schell RF, Kowalski TJ, Lovrich SD, Marks JA. 2002. Ability of the borreliacidal antibody test to confirm Lyme disease in clinical practice. Clin Diagn Lab Immunol 9:908912.
50. Steere AC, Sikand V, Meurice F, Parenti DL, Fikrig E, Schoen RT, Nowakowski J, Schmid CH, Laukamp S, Buscarino C, Krause DS, the Lyme Disease Vaccine Study. 1998. Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer surface lipoprotein A with adjuvant. N Engl J Med 339:209215.
51. Aguero-Rosenfeld ME, Roberge J, Carbonaro CA, Nowakowski J, Nadelman RB, Wormser GP. 1999. Effects of OspA vacci-nation on Lyme disease serologic testing. J Clin Microbiol 37:37183721.
52. Robertson J, Guy E, Andrews N, Wilske B, Anda P, Granstrom M, Hauser U, Moosmann Y, Sambri V, Schellekens J, Stanek G, Gray J. 2000. A European multicenter study of immunoblotting in serodiagnosis of Lyme borreliosis. J Clin Microbiol 38:20972102.
53. Branda JA, Aguero-Rosenfeld ME, Ferraro MJ, Johnson BJB, Wormser GP, Steere AC. 2010. Two-tiered antibody testing for early and late Lyme disease using only an immunoglobulin G blot with the addition of VlsE band as the second-tier test. Clin Infect Dis 50:2026.
54. Gomes-Solecki MJC, Dunn JJ, Luft BJ, Castillo J, Dykhuizen DE, Yang X, Glass JD, Dattwyler RJ. 2000. Recombinant chimeric borrelia proteins for diagnosis of Lyme disease. J Clin Microbiol 38:25302535.
55. Magnarelli LA, IJdo JW, Padula SJ, Flavell RA, Fikrig E. 2000. Serologic diagnosis of Lyme borreliosis by using enzyme-linked immunosorbent assays with recombinant antigens. J Clin Microbiol 38:17351739.
56. Padula SJ, Dias F, Sampieri A, Craven RB, Ryan RW. 1994. Use of recombinant OspC from Borrelia burgdorferi for serodiagnosis of early Lyme disease. J Clin Microbiol 32:17331738.
57. NCCLS. 2000. Western Blot Assay for Antibodies to Borrelia burgdorferi. Approved guideline M34-A, vol 20, no 20. NCCLS, Wayne, PA.
58. Molloy PJ, Verardi VP, Persing DH, Sigal LH. 1999. Detection of multiple reactive protein species by immunoblotting after recombinant outer surface protein A Lyme disease vaccination. Clin Infect Dis 31:4247.
59. Seriburi V, Ndukwe N, Chang Z, Cox ME, Wormser GP. 2011. High frequency of false positive IgM immunoblots for Borrelia burgdorferi in clinical practice. Clin Microbiol Infect 18:12361240.
60. Bakken LL, Callister SM, Wand PJ, Schell RF. 1997. Interlaboratory comparison of test results for detection of Lyme disease by 516 participants in the Wisconsin State Laboratory of Hygiene/College of American Pathologists proficiency testing program. J Clin Microbiol. 35:537543.
61. Trevejo RT, Krause PJ, Sikand VK, Schriefer ME, Ryan R, Lepore T, Dennis DT. 1999. Evaluation of two-test serodiagnostic method for early Lyme disease in clinical practice. J Infect Dis 179:931938.
62. Johnson BJ, Biggerstaff BJ, Bacon RM, Schriefer ME. 2004. Cost-effectiveness of peptide-antigen immunoassays for Lyme disease. J Infect Dis 189:19621964.
63. Seder RH, Verardi VP. 1996. Proficiency testing program for Lyme disease. Arch Pathol Lab Med 120:323325. (Letter.)
64. DeBiasi RL. 2014. A concise critical analysis of serologic testing for the diagnosis of Lyme disease. Curr Infect Dis Rep 16:450454.
65. American College of Physicians. 1997. Guidelines for laboratory evaluation in the diagnosis of Lyme disease. Clinical guideline part 1. Ann Intern Med 127:11061108.
66. Tugwell P, Dennis DT, Weinstein A, Wells G, Shea B, Nichol G, Hayward R, Lightfoot R, Baker P, Steere AC. 1997. Laboratory evaluation in the diagnosis of Lyme disease. Ann Intern Med 127:11091123.
67. Nichol G, Dennis DT, Steere AC, Lightfoot R, Wells G, Shea B, Tugwell P. 1998. Test-treatment strategies for patients suspected of having Lyme disease: a cost-effectiveness analysis. Ann Intern Med 128:3748.
68. Massarotti EM, Luger SW, Rahn DW, Messner RP, Wong JB, Johnson RC, Steere AC. 1992. Treatment of early Lyme disease. Am J Med 92:396403.

Tables

Generic image for table
Table 11.5–1

Lyme disease stages

Citation: Leber A. 2016. Detection of Antibodies, p 11.5.1-11.5.10. In Clinical Microbiology Procedures Handbook, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818814.ch11.5

This is a required field
Please enter a valid email address
Please check the format of the address you have entered.
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error