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Chapter 7.1 : Introduction
Tuberculosis (TB) remains a major global public health problem. The disease is the second biggest killer of adults due to an infectious disease after HIV. The World Health Organization (WHO) estimated 9 million new cases, 1.5 million deaths, and 3 million missed cases in 2013. In the United States, a total of 9,582 TB cases (a rate of 3 cases per 100,000 persons) were reported in 2013. Early and accurate diagnosis of TB and the detection of multidrug-resistant cases is critical to preventing disease transmission and expediting appropriate treatment and patient management.