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Chapter 33 : Using Plasmids as DNA Vaccines for Infectious Diseases
Category: Clinical Microbiology
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The observation that antigens encoded by DNA could induce an immune response when injected in vivo was first made in the 1960s using DNA from mouse tumors ( 1 ). Humoral (antibody) responses were subsequently observed following injection of DNA from polyoma ( 2 ) and hepatitis B viruses ( 3 ). The first study to specifically look at DNA as an immunogen was performed in the early 1990s using human growth hormone as a model antigen, delivered by a biolistic transfer device (gene gun) ( 4 ). This was quickly followed by studies showing that not only antibody, but also cytotoxic T cells could be induced by DNA delivery ( 5 – 7 ).
Key Concept Ranking
- Major Histocompatibility Complex Class I