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Chapter 14 : Filamentous Fungi

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Abstract:

Fungi are ubiquitous, eukaryotic organisms found throughout the environment. These microorganisms exist as either saprophytes or parasites, with the former obtaining nutrients from decaying organic matter and the latter sequestering nutrients from a living host. As such, fungi can be both plant and animal pathogens with significant agricultural and medical impact. A limited number of fungi are primary pathogens. These organisms have the ability to cause disease in both immunocompetent and immunosuppressed individuals. In contrast, the majority of filamentous fungi causing disease in humans are opportunistic and require specific host conditions be met before infection can occur. Immunocompromised patients are at highest risk for the development of invasive infection with opportunistic organisms. The focus of this chapter is on the medically important filamentous (i.e., molds) and dimorphic fungi known to cause disease in immunocompromised hosts.

Citation: Powers-Fletcher M, Kendall B, Griffin A, Hanson K. 2016. Filamentous Fungi, p 311-341. In Hayden R, Wolk D, Carroll K, Tang Y (ed),

Diagnostic Microbiology of the Immunocompromised Host, Second Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0002-2015
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References

/content/book/10.1128/9781555819040.chap14
1. Douglas LJ . 2003. Candida biofilms and their role in infection. Trends Microbiol 11 : 3036.[PubMed] [CrossRef]
2. Warenda AJ,, Kauffman S,, Sherrill TP,, Becker JM,, Konopka JB . 2003. Candida albicans septin mutants are defective for invasive growth and virulence. Infect Immun 71 : 40454051.[PubMed] [CrossRef]
3. Cole GT, . 1996. Basic Biology of Fungi. In Baron S (ed), Medical Microbiology, 4th ed. University of Texas Medical Branch at Galveston, Galveston, TX.
4. Hawksworth DL . 2011. A new dawn for the naming of fungi: impacts of decisions made in Melbourne in July 2011 on the future publication and regulation of fungal names. IMA Fungus 2 : 155162.[PubMed] [CrossRef]
5. O’Brien HE,, Parrent JL,, Jackson JA,, Moncalvo JM,, Vilgalys R . 2005. Fungal community analysis by large-scale sequencing of environmental samples. Appl Environ Microbiol 71 : 55445550.[PubMed] [CrossRef]
6. Köhler JR,, Casadevall A,, Perfect J . 2014. The spectrum of fungi that infects humans. Cold Spring Harb Perspect Med 5 : a019273. [PubMed] [CrossRef]
7. Sutton DA,, Fothergill AW,, Rinaldi MG . 1998. Guide to Clinically Significant Fungi. Williams and Wilkins, MD.
8. Larone DH . 2011. Medically Important Fungi: A Guide to Identification, 5th ed. ASM Press, Washington, DC.
9. Brandt ME,, Gomez BL,, Warnock DW, . 2011. Histoplasma, Blastomyces, Coccidioides, and Other Dimorphic Fungi Causing Systemic Mycoses. In Versalovic J,, Carroll KC,, Funke G,, Jorgensen JH,, Landry ML,, Warnock DW (ed), Manual of Clinical Microbiology, 10th ed, vol 2. ASM Press, Washington, DC. [CrossRef]
10. LaRocco M, . 2007. Mycology and Antifungal Susceptibility Testing. In Garcia LS (ed), Clinical Microbiology Procedures Handbook, 3rd ed, vol 2. ASM Press, Washington, DC.
11. US Department of Health and Human Services . 2009. Biosafety in Microbiological and Biomedical Laboratories, 5th ed. Centers for Disease Control and Prevention/National Institutes of Health, Washington, DC.
12. Emmons CW . 1949. Isolation of Histoplasma capsulatum from soil. Public Health Rep 64 : 892896.[PubMed] [CrossRef]
13. Garcia-Guiñon A,, Torres-Rodríguez JM,, Ndidongarte DT,, Cortadellas F,, Labrín L . 2009. Disseminated histoplasmosis by Histoplasma capsulatum var. duboisii in a paediatric patient from the Chad Republic, Africa. Eur J Clin Microbiol Infect Dis 28 : 697699.[PubMed] [CrossRef]
14. Baddley JW,, Winthrop KL,, Patkar NM,, Delzell E,, Beukelman T,, Xie F,, Chen L,, Curtis JR . 2011. Geographic distribution of endemic fungal infections among older persons, United States. Emerg Infect Dis 17 : 16641669.[PubMed] [CrossRef]
15. Guarner J,, Brandt ME . 2011. Histopathologic diagnosis of fungal infections in the 21st century. Clin Microbiol Rev 24 : 247280.[PubMed] [CrossRef]
16. Newman SL,, Smulian AG . 2013. Iron uptake and virulence in Histoplasma capsulatum . Curr Opin Microbiol 16 : 700707.[PubMed] [CrossRef]
17. Moore M . 1955. Morphologic variation in tissue of the organisms of the blastomycoses and of histoplasmosis. Am J Pathol 31 : 10491063.[PubMed]
18. Saccente M,, Woods GL . 2010. Clinical and laboratory update on blastomycosis. Clin Microbiol Rev 23 : 367381.[PubMed] [CrossRef]
19. Chapman SW,, Dismukes WE,, Proia LA,, Bradsher RW,, Pappas PG,, Threlkeld MG,, Kauffman CA . 2008. Clinical practice guidelines for the management of blastomycosis: 2008 update by the Infectious Diseases Society of America. Clin Infect Dis 46 : 18011812.[PubMed] [CrossRef]
20. Taxy JB . 2007. Blastomycosis: contributions of morphology to diagnosis: a surgical pathology, cytopathology, and autopsy pathology study. Am J Surg Pathol 31 : 615623.[PubMed] [CrossRef]
21. Pfaller MA,, Diekema DJ . 2010. Epidemiology of invasive mycoses in North America. Crit Rev Microbiol 36 : 153.[PubMed] [CrossRef]
22. Fisher FS,, Bultman MW,, Johnson SM,, Pappagianis D,, Zaborsky E . 2007. Coccidioides niches and habitat parameters in the southwestern United States: A matter of scale. Ann N Y Acad Sci 1111 : 4772.[PubMed] [CrossRef]
23. Adam RD,, Elliott SP,, Taljanovic MS . 2009. The spectrum and presentation of disseminated coccidioidomycosis. Am J Med 122 : 770777.[PubMed] [CrossRef]
24. Huppert M,, Sun SH,, Harrison JL . 1982. Morphogenesis throughout saprobic and parasitic cycles of Coccidioides immitis . Mycopathologia 78 : 107122.[PubMed] [CrossRef]
25. Converse JL . 1955. Growth of spherules of Coccidioides immitis in a chemically defined liquid medium. Proc Soc Exp Biol Med 90 : 709711.[PubMed] [CrossRef]
26. Nicas M,, Hubbard A . 2002. A risk analysis for airborne pathogens with low infectious doses: application to respirator selection against Coccidioides immitis spores. Risk Anal 22 : 11531163.[PubMed] [CrossRef]
27. Yilmaz N,, Visagie CM,, Houbraken J,, Frisvad JC,, Samson RA . 2014. Polyphasic taxonomy of the genus Talaromyces . Stud Mycol 78 : 175341.[PubMed] [CrossRef]
28. Barros MB,, de Almeida Paes R,, Schubach AO . 2011. Sporothrix schenckii and sporotrichosis. Clin Microbiol Rev 24 : 633654.[PubMed] [CrossRef]
29. Aung AK,, Teh BM,, McGrath C,, Thompson PJ . 2013. Pulmonary sporotrichosis: case series and systematic analysis of literature on clinico-radiological patterns and management outcomes. Med Mycol 51 : 534544.[PubMed] [CrossRef]
30. Satterwhite TK,, Kageler WV,, Conklin RH,, Portnoy BL,, DuPont HL . 1978. Disseminated sporotrichosis. JAMA 240 : 771772.[PubMed] [CrossRef]
31. Cooper CR Jr,, Haycocks NG . 2000. Penicillium marneffei: An insurgent species among the penicillia. J Eukaryot Microbiol 47 : 2428.[PubMed] [CrossRef]
32. Duong TA . 1996. Infection due to Penicillium marneffei, an emerging pathogen: review of 155 reported cases. Clin Infect Dis 23 : 125130.[PubMed] [CrossRef]
33. Lyratzopoulos G,, Ellis M,, Nerringer R,, Denning DW . 2002. Invasive infection due to Penicillium species other than P. marneffei . J Infect 45 : 184195.[PubMed] [CrossRef]
34. Cao C,, Liang L,, Wang W,, Luo H,, Huang S,, Liu D,, Xu J,, Henk DA,, Fisher MC . 2011. Common reservoirs for Penicillium marneffei infection in humans and rodents, China. Emerg Infect Dis 17 : 209214.[PubMed] [CrossRef]
35. Anstead GM,, Sutton DA,, Graybill JR . 2012. Adiaspiromycosis causing respiratory failure and a review of human infections due to Emmonsia and Chrysosporium spp. J Clin Microbiol 50 : 13461354.[PubMed] [CrossRef]
36. Emmons CW,, Jellison WL . 1960. Emmonsia crescens sp. n. and adiaspiromycosis (haplomycosis) in mammals. Ann N Y Acad Sci 89 : 91101.[PubMed] [CrossRef]
37. Hubálek Z,, Nesvadbová J,, Halouzka J . 1998. Emmonsiosis of rodents in an agroecosystem. Med Mycol 36 : 387390.[PubMed] [CrossRef]
38. Pelegrín I,, Ayats J,, Xiol X,, Cuenca-Estrella M,, Jucglà A,, Boluda S,, Fernàndez-Sabé N,, Rafecas A,, Gudiol F,, Cabellos C . 2011. Disseminated adiaspiromycosis: case report of a liver transplant patient with human immunodeficiency infection, and literature review. Transpl Infect Dis 13 : 507514.[PubMed] [CrossRef]
39. Latgé JP . 1999. Aspergillus fumigatus and aspergillosis. Clin Microbiol Rev 12 : 310350.[PubMed]
40. Malik KA,, Sandhu GR . 1973. Decomposition of organic matter by fungi in saline soils. Mycopathol Mycol Appl 50 : 339347.[PubMed] [CrossRef]
41. Lewis RE,, Cahyame-Zuniga L,, Leventakos K,, Chamilos G,, Ben-Ami R,, Tamboli P,, Tarrand J,, Bodey GP,, Luna M,, Kontoyiannis DP . 2013. Epidemiology and sites of involvement of invasive fungal infections in patients with haematological malignancies: A 20-year autopsy study. Mycoses 56 : 638645.[PubMed] [CrossRef]
42. Brakhage AA,, Langfelder K . 2002. Menacing mold: The molecular biology of Aspergillus fumigatus . Annu Rev Microbiol 56 : 433455.[PubMed] [CrossRef]
43. Beffa T,, Staib F,, Lott Fischer J,, Lyon PF,, Gumowski P,, Marfenina OE,, Dunoyer-Geindre S,, Georgen F,, Roch-Susuki R,, Gallaz L,, Latgé JP . 1998. Mycological control and surveillance of biological waste and compost. Med Mycol 36(Suppl 1): 137145.[PubMed]
44. Araujo R,, Rodrigues AG . 2004. Variability of germinative potential among pathogenic species of Aspergillus . J Clin Microbiol 42 : 43354337.[PubMed] [CrossRef]
45. Bhabhra R,, Askew DS . 2005. Thermotolerance and virulence of Aspergillus fumigatus: role of the fungal nucleolus. Med Mycol 43(Suppl 1): S87S93.[PubMed] [CrossRef]
46. Bhabhra R,, Miley MD,, Mylonakis E,, Boettner D,, Fortwendel J,, Panepinto JC,, Postow M,, Rhodes JC,, Askew DS . 2004. Disruption of the Aspergillus fumigatus gene encoding nucleolar protein CgrA impairs thermotolerant growth and reduces virulence. Infect Immun 72 : 47314740.[PubMed] [CrossRef]
47. Abad A,, Fernández-Molina JV,, Bikandi J,, Ramírez A,, Margareto J,, Sendino J,, Hernando FL,, Pontón J,, Garaizar J,, Rementeria A . 2010. What makes Aspergillus fumigatus a successful pathogen? Genes and molecules involved in invasive aspergillosis. Rev Iberoam Micol 27 : 155182.[PubMed] [CrossRef]
48. Askew DS . 2008. Aspergillus fumigatus: virulence genes in a street-smart mold. Curr Opin Microbiol 11 : 331337.[PubMed] [CrossRef]
49. Krishnan S,, Manavathu EK,, Chandrasekar PH . 2009. Aspergillus flavus: An emerging non-fumigatus Aspergillus species of significance. Mycoses 52 : 206222.[PubMed] [CrossRef]
50. García-Agudo L,, Aznar-Marán P,, Galán-Sánchez F,, García-Martos P,, Marín-Casanova P,, Rodríguez-Iglesias M . 2011. Otomycosis due to filamentous fungi. Mycopathologia 172 : 307310.[PubMed] [CrossRef]
51. Vennewald I,, Schönlebe J,, Klemm E . 2003. Mycological and histological investigations in humans with middle ear infections. Mycoses 46 : 1218.[PubMed] [CrossRef]
52. Punia RS,, Kundu R,, Chander J,, Arya SK,, Handa U,, Mohan H . 2014. Spectrum of fungal keratitis: clinicopathologic study of 44 cases. Int J Ophthalmol 7 : 114117.[PubMed]
53. Osborne LE,, Stein JM . 2007. Epidemiology of Fusarium head blight on small-grain cereals. Int J Food Microbiol 119 : 103108.[PubMed] [CrossRef]
54. Smiley RW,, Gourlie JA,, Easley SA,, Patterson L-M,, Whittake RG . 2005. Crop damage estimates for crown rot of wheat and barley in the Pacific Northwest. Plant Dis 89 : 595604.[CrossRef]
55. Wu F,, Groopman JD,, Pestka JJ . 2014. Public health impacts of foodborne mycotoxins. Annu Rev Food Sci Technol 5 : 351372.[PubMed] [CrossRef]
56. Balajee SA,, Borman AM,, Brandt ME,, Cano J,, Cuenca-Estrella M,, Dannaoui E,, Guarro J,, Haase G,, Kibbler CC,, Meyer W,, O’Donnell K,, Petti CA,, Rodriguez-Tudela JL,, Sutton D,, Velegraki A,, Wickes BL . 2009. Sequence-based identification of Aspergillus, Fusarium, and Mucorales species in the clinical mycology laboratory: where are we and where should we go from here? J Clin Microbiol 47 : 877884.[PubMed] [CrossRef]
57. Triest D,, Stubbe D,, De Cremer K,, Piérard D,, Normand AC,, Piarroux R,, Detandt M,, Hendrickx M . 2015. Use of matrix-assisted laser desorption ionization-time of flight mass spectrometry for identification of molds of the Fusarium genus. J Clin Microbiol 53 : 465476.[PubMed] [CrossRef]
58. Cuvelier I,, Vogelaers D,, Peleman R,, Benoit D,, Van Marck V,, Offner F,, Vandewoude K,, Colardyn F . 1998. Two cases of disseminated mucormycosis in patients with hematological malignancies and literature review. Eur J Clin Microbiol Infect Dis 17 : 859863.[PubMed] [CrossRef]
59. Roden MM,, Zaoutis TE,, Buchanan WL,, Knudsen TA,, Sarkisova TA,, Schaufele RL,, Sein M,, Sein T,, Chiou CC,, Chu JH,, Kontoyiannis DP,, Walsh TJ . 2005. Epidemiology and outcome of zygomycosis: A review of 929 reported cases. Clin Infect Dis 41 : 634653.[PubMed] [CrossRef]
60. Spellberg B,, Edwards J Jr,, Ibrahim A . 2005. Novel perspectives on mucormycosis: pathophysiology, presentation, and management. Clin Microbiol Rev 18 : 556569.[PubMed] [CrossRef]
61. Pritchard RC,, Muir DB . 1987. Black fungi: a survey of dematiaceous hyphomycetes from clinical specimens identified over a five year period in a reference laboratory. Pathology 19 : 281284.[PubMed] [CrossRef]
62. Revankar SG,, Sutton DA . 2010. Melanized fungi in human disease. Clin Microbiol Rev 23 : 884928.[PubMed] [CrossRef]
63. Park BJ,, Pappas PG,, Wannemuehler KA,, Alexander BD,, Anaissie EJ,, Andes DR,, Baddley JW,, Brown JM,, Brumble LM,, Freifeld AG,, Hadley S,, Herwaldt L,, Ito JI,, Kauffman CA,, Lyon GM,, Marr KA,, Morrison VA,, Papanicolaou G,, Patterson TF,, Perl TM,, Schuster MG,, Walker R,, Wingard JR,, Walsh TJ,, Kontoyiannis DP . 2011. Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001–2006. Emerg Infect Dis 17 : 18551864.[PubMed] [CrossRef]
64. Bonifaz A,, Tirado-Sánchez A,, Calderón L,, Saúl A,, Araiza J,, Hernández M,, González GM,, Ponce RM . 2014. Mycetoma: experience of 482 cases in a single center in Mexico. PLoS Negl Trop Dis 8 : e3102. doi:10.1371/journal.pntd.0003102 [PubMed] [CrossRef]
65. Estrada R,, Chavez-Lopez G,, Estrada-Chavez G,, Lopez-Martinez R,, Welsh O . 2012. Eumycetoma. Clin Dermatol 30 : 389396.[PubMed] [CrossRef]
66. Revankar SG . 2007. Dematiaceous fungi. Mycoses 50 : 91101.[PubMed] [CrossRef]
67. Gade L,, Grgurich DE,, Kerkering TM,, Brandt ME,, Litvintseva AP . 2015. Utility of real-time PCR for detection of Exserohilum rostratum in body and tissue fluids during the multistate outbreak of fungal meningitis and other infections. J Clin Microbiol 53 : 618625.[PubMed] [CrossRef]
68. Brandt ME,, Warnock DW . 2003. Epidemiology, clinical manifestations, and therapy of infections caused by dematiaceous fungi. J Chemother 15(Suppl 2): 3647.[PubMed] [CrossRef]
69. Roche M,, Redmond RM,, O’Neill S,, Smyth E . 2005. A case of multiple cerebral abscesses due to infection with Cladophialophora bantiana . J Infect 51 : e285e288.[PubMed] [CrossRef]
70. Shoham S,, Pic-Aluas L,, Taylor J,, Cortez K,, Rinaldi MG,, Shea Y,, Walsh TJ . 2008. Transplant-associated Ochroconis gallopava infections. Transpl Infect Dis 10 : 442448.[PubMed] [CrossRef]
71. Sutton DA,, Slifkin M,, Yakulis R,, Rinaldi MG . 1998. U.S. case report of cerebral phaeohyphomycosis caused by Ramichloridium obovoideum (R. mackenziei): criteria for identification, therapy, and review of other known dematiaceous neurotropic taxa. J Clin Microbiol 36 : 708715.[PubMed]
72. Chang CL,, Kim DS,, Park DJ,, Kim HJ,, Lee CH,, Shin JH . 2000. Acute cerebral phaeohyphomycosis due to Wangiella dermatitidis accompanied by cerebrospinal fluid eosinophilia. J Clin Microbiol 38 : 19651966.[PubMed]
73. Matsumoto T,, Matsuda T,, McGinnis MR,, Ajello L . 1993. Clinical and mycological spectra of Wangiella dermatitidis infections. Mycoses 36 : 145155.[PubMed] [CrossRef]
74. Brown GD . 2011. Innate antifungal immunity: The key role of phagocytes. Annu Rev Immunol 29 : 121.[PubMed] [CrossRef]
75. Schaffner A,, Douglas H,, Braude A . 1982. Selective protection against conidia by mononuclear and against mycelia by polymorphonuclear phagocytes in resistance to Aspergillus. Observations on these two lines of defense in vivo and in vitro with human and mouse phagocytes. J Clin Invest 69 : 617631.[CrossRef]
76. Boyle KB,, Stephens LR,, Hawkins PT . 2012. Activation of the neutrophil NADPH oxidase by Aspergillus fumigatus . Ann N Y Acad Sci 1273 : 6873.[PubMed] [CrossRef]
77. Duong M,, Ouellet N,, Simard M,, Bergeron Y,, Olivier M,, Bergeron MG . 1998. Kinetic study of host defense and inflammatory response to Aspergillus fumigatus in steroid-induced immunosuppressed mice. J Infect Dis 178 : 14721482.[PubMed] [CrossRef]
78. Ng TT,, Robson GD,, Denning DW . 1994. Hydrocortisone-enhanced growth of Aspergillus spp.: implications for pathogenesis. Microbiology 140 : 24752479.[PubMed] [CrossRef]
79. Romani L . 2011. Immunity to fungal infections. Nat Rev Immunol 11 : 275288.[PubMed] [CrossRef]
80. Braedel S,, Radsak M,, Einsele H,, Latgé JP,, Michan A,, Loeffler J,, Haddad Z,, Grigoleit U,, Schild H,, Hebart H . 2004. Aspergillus fumigatus antigens activate innate immune cells via toll-like receptors 2 and 4. Br J Haematol 125 : 392399.[PubMed] [CrossRef]
81. Netea MG,, Warris A,, Van der Meer JW,, Fenton MJ,, Verver-Janssen TJ,, Jacobs LE,, Andresen T,, Verweij PE,, Kullberg BJ . 2003. Aspergillus fumigatus evades immune recognition during germination through loss of toll-like receptor-4-mediated signal transduction. J Infect Dis 188 : 320326.[PubMed] [CrossRef]
82. Osorio F,, Reis e Sousa C . 2011. Myeloid C-type lectin receptors in pathogen recognition and host defense. Immunity 34 : 651664.[PubMed] [CrossRef]
83. Ramirez-Ortiz ZG,, Means TK . 2012. The role of dendritic cells in the innate recognition of pathogenic fungi (A. fumigatus, C. neoformans and C. albicans). Virulence 3 : 635646.[PubMed] [CrossRef]
84. Roy RM,, Klein BS . 2012. Dendritic cells in antifungal immunity and vaccine design. Cell Host Microbe 11 : 436446.[PubMed] [CrossRef]
85. Espinosa V,, Rivera A . 2012. Cytokines and the regulation of fungus-specific CD4 T cell differentiation. Cytokine 58 : 100106.[PubMed] [CrossRef]
86. Wüthrich M,, Deepe GS Jr,, Klein B . 2012. Adaptive immunity to fungi. Annu Rev Immunol 30 : 115148.[PubMed] [CrossRef]
87. Rivera A,, Ro G,, Van Epps HL,, Simpson T,, Leiner I,, Sant’Angelo DB,, Pamer EG . 2006. Innate immune activation and CD4+ T cell priming during respiratory fungal infection. Immunity 25 : 665675.[PubMed] [CrossRef]
88. Rivera A,, Hohl TM,, Collins N,, Leiner I,, Gallegos A,, Saijo S,, Coward JW,, Iwakura Y,, Pamer EG . 2011. Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation. J Exp Med 208 : 369381.[PubMed] [CrossRef]
89. Wüthrich M,, Gern B,, Hung CY,, Ersland K,, Rocco N,, Pick-Jacobs J,, Galles K,, Filutowicz H,, Warner T,, Evans M,, Cole G,, Klein B . 2011. Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice. J Clin Invest 121 : 554568.[PubMed] [CrossRef]
90. Wüthrich M,, Hung CY,, Gern BH,, Pick-Jacobs JC,, Galles KJ,, Filutowicz HI,, Cole GT,, Klein BS . 2011. A TCR transgenic mouse reactive with multiple systemic dimorphic fungi. J Immunol 187 : 14211431.[PubMed] [CrossRef]
91. Cheson BD . 1995. Infectious and immunosuppressive complications of purine analog therapy. J Clin Oncol 13 : 24312448.[PubMed]
92. Tsiodras S,, Samonis G,, Boumpas DT,, Kontoyiannis DP . 2008. Fungal infections complicating tumor necrosis factor alpha blockade therapy. Mayo Clin Proc 83 : 181194.[PubMed] [CrossRef]
93. Hernández-Santos N,, Gaffen SL . 2012. Th17 cells in immunity to Candida albicans . Cell Host Microbe 11 : 425435.[PubMed] [CrossRef]
94. Edwards JE Jr . 2012. Fungal cell wall vaccines: An update. J Med Microbiol 61 : 895903.[PubMed] [CrossRef]
95. Torosantucci A,, Chiani P,, Bromuro C,, De Bernardis F,, Palma AS,, Liu Y,, Mignogna G,, Maras B,, Colone M,, Stringaro A,, Zamboni S,, Feizi T,, Cassone A . 2009. Protection by anti-beta-glucan antibodies is associated with restricted beta-1,3 glucan binding specificity and inhibition of fungal growth and adherence. PLoS One 4 : e5392. doi:10.1371/journalpone.0005392
96. Guimarães AJ,, Frases S,, Gomez FJ,, Zancopé-Oliveira RM,, Nosanchuk JD . 2009. Monoclonal antibodies to heat shock protein 60 alter the pathogenesis of Histoplasma capsulatum . Infect Immun 77 : 13571367.[PubMed] [CrossRef]
97. Buissa-Filho R,, Puccia R,, Marques AF,, Pinto FA,, Munoz JE,, Nosanchuk JD,, Travassos LR,, Taborda CP . 2008. The monoclonal antibody against the major diagnostic antigen of Paracoccidioides brasiliensis mediates immune protection in infected BALB/c mice challenged intratracheally with the fungus. Infect Immun 76 : 33213328.[PubMed] [CrossRef]
98. Bochud PY,, Chien JW,, Marr KA,, Leisenring WM,, Upton A,, Janer M,, Rodrigues SD,, Li S,, Hansen JA,, Zhao LP,, Aderem A,, Boeckh M . 2008. Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation. N Engl J Med 359 : 17661777.[PubMed] [CrossRef]
99. Kesh S,, Mensah NY,, Peterlongo P,, Jaffe D,, Hsu K,, Van Den Brink M,, O’Reilly R,, Pamer E,, Satagopan J,, Papanicolaou GA . 2005. TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation. Ann N Y Acad Sci 1062 : 95103.[PubMed] [CrossRef]
100. Seo KW,, Kim DH,, Sohn SK,, Lee NY,, Chang HH,, Kim SW,, Jeon SB,, Baek JH,, Kim JG,, Suh JS,, Lee KB . 2005. Protective role of interleukin-10 promoter gene polymorphism in the pathogenesis of invasive pulmonary aspergillosis after allogeneic stem cell transplantation. Bone Marrow Transplant 36 : 10891095.[PubMed] [CrossRef]
101. Sainz J,, Hassan L,, Perez E,, Romero A,, Moratalla A,, López-Fernández E,, Oyonarte S,, Jurado M . 2007. Interleukin-10 promoter polymorphism as risk factor to develop invasive pulmonary aspergillosis. Immunol Lett 109 : 7682.[PubMed] [CrossRef]
102. Sainz J,, Pérez E,, Hassan L,, Moratalla A,, Romero A,, Collado MD,, Jurado M . 2007. Variable number of tandem repeats of TNF receptor type 2 promoter as genetic biomarker of susceptibility to develop invasive pulmonary aspergillosis. Hum Immunol 68 : 4150.[PubMed] [CrossRef]
103. Cordonnier C,, Pautas C,, Maury S,, Vekhoff A,, Farhat H,, Suarez F,, Dhédin N,, Isnard F,, Ades L,, Kuhnowski F,, Foulet F,, Kuentz M,, Maison P,, Bretagne S,, Schwarzinger M . 2009. Empirical versus preemptive antifungal therapy for high-risk, febrile, neutropenic patients: A randomized, controlled trial. Clin Infect Dis 48 : 10421051.[PubMed] [CrossRef]
104. Pagano L,, Akova M,, Dimopoulos G,, Herbrecht R,, Drgona L,, Blijlevens N . 2011. Risk assessment and prognostic factors for mould-related diseases in immunocompromised patients. J Antimicrob Chemother 66(Suppl 1): i5i14.[PubMed] [CrossRef]
105. Bodey GP . 1966. Infectious complications of acute leukemia. Med Times 94 : 10761085.[PubMed]
106. Portugal RD,, Garnica M,, Nucci M . 2009. Index to predict invasive mold infection in high-risk neutropenic patients based on the area over the neutrophil curve. J Clin Oncol 27 : 38493854.[PubMed] [CrossRef]
107. Garcia-Vidal C,, Upton A,, Kirby KA,, Marr KA . 2008. Epidemiology of invasive mold infections in allogeneic stem cell transplant recipients: biological risk factors for infection according to time after transplantation. Clin Infect Dis 47 : 10411050.[PubMed] [CrossRef]
108. Azie N,, Neofytos D,, Pfaller M,, Meier-Kriesche HU,, Quan SP,, Horn D . 2012. The PATH (Prospective Antifungal Therapy) Alliance® registry and invasive fungal infections: update 2012. Diagn Microbiol Infect Dis 73 : 293300.[PubMed] [CrossRef]
109. Neofytos D,, Horn D,, Anaissie E,, Steinbach W,, Olyaei A,, Fishman J,, Pfaller M,, Chang C,, Webster K,, Marr K . 2009. Epidemiology and outcome of invasive fungal infection in adult hematopoietic stem cell transplant recipients: analysis of Multicenter Prospective Antifungal Therapy (PATH) Alliance registry. Clin Infect Dis 48 : 265273.[PubMed] [CrossRef]
110. Kontoyiannis DP,, Marr KA,, Park BJ,, Alexander BD,, Anaissie EJ,, Walsh TJ,, Ito J,, Andes DR,, Baddley JW,, Brown JM,, Brumble LM,, Freifeld AG,, Hadley S,, Herwaldt LA,, Kauffman CA,, Knapp K,, Lyon GM,, Morrison VA,, Papanicolaou G,, Patterson TF,, Perl TM,, Schuster MG,, Walker R,, Wannemuehler KA,, Wingard JR,, Chiller TM,, Pappas PG . 2010. Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001-2006: overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) Database. Clin Infect Dis 50 : 10911100.[PubMed] [CrossRef]
111. Balajee SA,, Kano R,, Baddley JW,, Moser SA,, Marr KA,, Alexander BD,, Andes D,, Kontoyiannis DP,, Perrone G,, Peterson S,, Brandt ME,, Pappas PG,, Chiller T . 2009. Molecular identification of Aspergillus species collected for the Transplant-Associated Infection Surveillance Network. J Clin Microbiol 47 : 31383141.[PubMed] [CrossRef]
112. Steinbach WJ,, Marr KA,, Anaissie EJ,, Azie N,, Quan SP,, Meier-Kriesche HU,, Apewokin S,, Horn DL . 2012. Clinical epidemiology of 960 patients with invasive aspergillosis from the PATH Alliance registry. J Infect 65 : 453464.[PubMed] [CrossRef]
113. Marty FM,, Cosimi LA,, Baden LR . 2004. Breakthrough zygomycosis after voriconazole treatment in recipients of hematopoietic stem-cell transplants. N Engl J Med 350 : 950952.[PubMed] [CrossRef]
114. Kontoyiannis DP,, Lionakis MS,, Lewis RE,, Chamilos G,, Healy M,, Perego C,, Safdar A,, Kantarjian H,, Champlin R,, Walsh TJ,, Raad II . 2005. Zygomycosis in a tertiary-care cancer center in the era of Aspergillus-active antifungal therapy: A case-control observational study of 27 recent cases. J Infect Dis 191 : 13501360.[PubMed] [CrossRef]
115. Pappas PG,, Alexander BD,, Andes DR,, Hadley S,, Kauffman CA,, Freifeld A,, Anaissie EJ,, Brumble LM,, Herwaldt L,, Ito J,, Kontoyiannis DP,, Lyon GM,, Marr KA,, Morrison VA,, Park BJ,, Patterson TF,, Perl TM,, Oster RA,, Schuster MG,, Walker R,, Walsh TJ,, Wannemuehler KA,, Chiller TM . 2010. Invasive fungal infections among organ transplant recipients: results of the Transplant-Associated Infection Surveillance Network (TRANSNET). Clin Infect Dis 50 : 11011111.[PubMed] [CrossRef]
116. Neofytos D,, Fishman JA,, Horn D,, Anaissie E,, Chang CH,, Olyaei A,, Pfaller M,, Steinbach WJ,, Webster KM,, Marr KA . 2010. Epidemiology and outcome of invasive fungal infections in solid organ transplant recipients. Transpl Infect Dis 12 : 220229.[PubMed] [CrossRef]
117. Kauffman CA,, Freifeld AG,, Andes DR,, Baddley JW,, Herwaldt L,, Walker RC,, Alexander BD,, Anaissie EJ,, Benedict K,, Ito JI,, Knapp KM,, Lyon GM,, Marr KA,, Morrison VA,, Park BJ,, Patterson TF,, Schuster MG,, Chiller TM,, Pappas PG . 2014. Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant-Associated Infection Surveillance Network (TRANSNET). Transpl Infect Dis 16 : 213224.[PubMed] [CrossRef]
118. Gomez CA,, Singh N . 2013. Donor-derived filamentous fungal infections in solid organ transplant recipients. Curr Opin Infect Dis 26 : 309316.[PubMed] [CrossRef]
119. Altfeld M,, Fadda L,, Frleta D,, Bhardwaj N . 2011. DCs and NK cells: critical effectors in the immune response to HIV-1. Nat Rev Immunol 11 : 176186.[PubMed] [CrossRef]
120. Armstrong-James D,, Meintjes G,, Brown GD . 2014. A neglected epidemic: fungal infections in HIV/AIDS. Trends Microbiol 22 : 120127.[PubMed] [CrossRef]
121. Holding KJ,, Dworkin MS,, Wan PC,, Hanson DL,, Klevens RM,, Jones JL,, Sullivan PS . 2000. Aspergillosis among people infected with human immunodeficiency virus: incidence and survival. Adult and Adolescent Spectrum of HIV Disease Project. Clin Infect Dis 31 : 12531257.[PubMed] [CrossRef]
122. Lortholary O,, Meyohas MC,, Dupont B,, Cadranel J,, Salmon-Ceron D,, Peyramond D,, Simonin D . 1993. Invasive aspergillosis in patients with acquired immunodeficiency syndrome: report of 33 cases. French Cooperative Study Group on Aspergillosis in AIDS. Am J Med 95 : 177187.[CrossRef]
123. Denning DW,, Follansbee SE,, Scolaro M,, Norris S,, Edelstein H,, Stevens DA . 1991. Pulmonary aspergillosis in the acquired immunodeficiency syndrome. N Engl J Med 324 : 654662.[PubMed] [CrossRef]
124. Schneider E,, Whitmore S,, Glynn KM,, Dominguez K,, Mitsch A,, McKenna MT ; Centers fo Disease Control and Prevention (CDC) . 2008. Revised surveillance case definitions for HIV infection among adults, adolescents, and children aged <18 months and for HIV infection and AIDS among children aged 18 months to <13 years—United States, 2008. MMWR Recomm Rep 57 : 112.[PubMed]
125. Vanittanakom N,, Cooper CR Jr,, Fisher MC,, Sirisanthana T . 2006. Penicillium marneffei infection and recent advances in the epidemiology and molecular biology aspects. Clin Microbiol Rev 19 : 95110.[PubMed] [CrossRef]
126. Kaplan JE,, Masur H,, Holmes KK ; USPHS; Infectious Diseases Society of America . 2002. Guidelines for preventing opportunistic infections among HIV-infected persons--2002. Recommendations of the U.S. Public Health Service and the Infectious Diseases Society of America. MMWR Recomm Rep 51 : 152.[PubMed]
127. Panel on Opportunistic Infections in HIV-Infected Adults and Adolescents . Guidelines for the prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from the Centers for Disease Control and Prevention, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. http://aidsinfo.nih.gov/contentfiles/lvguidelines/adult_oi.pdf. Accessed March 1, 2015.
128. Jones JL,, Fleming PL,, Ciesielski CA,, Hu DJ,, Kaplan JE,, Ward JW . 1995. Coccidioidomycosis among persons with AIDS in the United States. J Infect Dis 171 : 961966.[PubMed] [CrossRef]
129. Supparatpinyo K,, Sirisanthana T . 1994. Disseminated Penicillium marneffei infection diagnosed on examination of a peripheral blood smear of a patient with human immunodeficiency virus infection. Clin Infect Dis 18 : 246247.[PubMed] [CrossRef]
130. Supparatpinyo K,, Khamwan C,, Baosoung V,, Nelson KE,, Sirisanthana T . 1994. Disseminated Penicillium marneffei infection in southeast Asia. Lancet 344 : 110113.[PubMed] [CrossRef]
131. Alba-Loureiro TC,, Munhoz CD,, Martins JO,, Cerchiaro GA,, Scavone C,, Curi R,, Sannomiya P . 2007. Neutrophil function and metabolism in individuals with diabetes mellitus. Braz J Med Biol Res 40 : 10371044.[PubMed] [CrossRef]
132. Foss NT,, Foss-Freitas MC,, Ferreira MA,, Cardili RN,, Barbosa CM,, Foss MC . 2007. Impaired cytokine production by peripheral blood mononuclear cells in type 1 diabetic patients. Diabetes Metab 33 : 439443.[PubMed] [CrossRef]
133. Petrikkos G,, Skiada A,, Lortholary O,, Roilides E,, Walsh TJ,, Kontoyiannis DP . 2012. Epidemiology and clinical manifestations of mucormycosis. Clin Infect Dis 54(Suppl 1): S23S34.[PubMed] [CrossRef]
134. Artis WM,, Fountain JA,, Delcher HK,, Jones HE . 1982. A mechanism of susceptibility to mucormycosis in diabetic ketoacidosis: transferrin and iron availability. Diabetes 31 : 11091114.[PubMed] [CrossRef]
135. Lanternier F,, Cypowyj S,, Picard C,, Bustamante J,, Lortholary O,, Casanova JL,, Puel A . 2013. Primary immunodeficiencies underlying fungal infections. Curr Opin Pediatr 25 : 736747.[PubMed] [CrossRef]
136. Blumental S,, Mouy R,, Mahlaoui N,, Bougnoux ME,, Debré M,, Beauté J,, Lortholary O,, Blanche S,, Fischer A . 2011. Invasive mold infections in chronic granulomatous disease: A 25-year retrospective survey. Clin Infect Dis 53 : e159e169.[PubMed] [CrossRef]
137. Vinh DC,, Sugui JA,, Hsu AP,, Freeman AF,, Holland SM . 2010. Invasive fungal disease in autosomal-dominant hyper-IgE syndrome. J Allergy Clin Immunol 125 : 13891390.[PubMed] [CrossRef]
138. Bellanné-Chantelot C,, Clauin S,, Leblanc T,, Cassinat B,, Rodrigues-Lima F,, Beaufils S,, Vaury C,, Barkaoui M,, Fenneteau O,, Maier-Redelsperger M,, Chomienne C,, Donadieu J . 2004. Mutations in the ELA2 gene correlate with more severe expression of neutropenia: A study of 81 patients from the French Neutropenia Register. Blood 103 : 41194125.[PubMed] [CrossRef]
139. Fischer A,, Lisowska-Grospierre B,, Anderson DC,, Springer TA . 1988. Leukocyte adhesion deficiency: molecular basis and functional consequences. Immunodefic Rev 1 : 3954.[PubMed]
140. Kortsik C,, Elmer A,, Tamm I . 2003. Pleural effusion due to Histoplasma capsulatum and idiopathic CD4 lymphocytopenia. Respiration 70 : 118122.[PubMed] [CrossRef]
141. Vinh DC,, Schwartz B,, Hsu AP,, Miranda DJ,, Valdez PA,, Fink D,, Lau KP,, Long-Priel D,, Kuhns DB,, Uzel G,, Pittaluga S,, Hoover S,, Galgiani JN,, Holland SM . 2011. Interleukin-12 receptor β1 deficiency predisposing to disseminated coccidioidomycosis. Clin Infect Dis 52 : e99e102.[PubMed] [CrossRef]
142. Vinh DC,, Masannat F,, Dzioba RB,, Galgiani JN,, Holland SM . 2009. Refractory disseminated coccidioidomycosis and mycobacteriosis in interferon-gamma receptor 1 deficiency. Clin Infect Dis 49 : e62e65.[PubMed] [CrossRef]
143. Zerbe CS,, Holland SM . 2005. Disseminated histoplasmosis in persons with interferon-gamma receptor 1 deficiency. Clin Infect Dis 41 : e38e41.[PubMed] [CrossRef]
144. Paramythiotou E,, Frantzeskaki F,, Flevari A,, Armaganidis A,, Dimopoulos G . 2014. Invasive fungal infections in the ICU: how to approach, how to treat. Molecules 19 : 10851119.[PubMed] [CrossRef]
145. Garnacho-Montero J,, Olaechea P,, Alvarez-Lerma F,, Alvarez-Rocha L,, Blanquer J,, Galván B,, Rodriguez A,, Zaragoza R,, Aguado JM,, Mensa J,, Solé A,, Barberán J . 2013. Epidemiology, diagnosis and treatment of fungal respiratory infections in the critically ill patient. Rev Esp Quimioter 26 : 173188.[PubMed]
146. He H,, Jiang S,, Zhang L,, Sun B,, Li F,, Zhan Q,, Wang C . 2014. Aspergillus tracheobronchitis in critically ill patients with chronic obstructive pulmonary diseases. Mycoses 57 : 473482.[PubMed] [CrossRef]
147. Mandell LA,, Wunderink RG,, Anzueto A,, Bartlett JG,, Campbell GD,, Dean NC,, Dowell SF,, File TM Jr,, Musher DM,, Niederman MS,, Torres A,, Whitney CG , Infectious Diseases Society of America, American Thoracic Society . 2007. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 44(Suppl 2): S27S72.[PubMed] [CrossRef]
148. Hummel M,, Rudert S,, Hof H,, Hehlmann R,, Buchheidt D . 2008. Diagnostic yield of bronchoscopy with bronchoalveolar lavage in febrile patients with hematologic malignancies and pulmonary infiltrates. Ann Hematol 87 : 291297.[PubMed] [CrossRef]
149. Maeda H,, Ishida N . 1967. Specificity of binding of hexopyranosyl polysaccharides with fluorescent brightener. J Biochem 62 : 276278.[PubMed]
150. Sangoi AR,, Rogers WM,, Longacre TA,, Montoya JG,, Baron EJ,, Banaei N . 2009. Challenges and pitfalls of morphologic identification of fungal infections in histologic and cytologic specimens: A ten-year retrospective review at a single institution. Am J Clin Pathol 131 : 364375.[PubMed] [CrossRef]
151. McGowan KL, . 2011. Specimen Collection, Transport, and Processing: Mycology. In Versalovic J,, Carroll KC,, Funke G,, Jorgensen JH,, Landry ML,, Warnock DW (ed), Manual of Clinical Microbiology, 10th ed, vol 2. ASM Press, Washington, DC. [CrossRef]
152. Levine SJ . 1992. An approach to the diagnosis of pulmonary infections in immunosuppressed patients. Semin Respir Infect 7 : 8195.[PubMed]
153. Guimãraes AJ,, Nosanchuk JD,, Zancopé-Oliveira RM . 2006. Diagnosis of histoplasmosis. Braz J Microbiol 37 : 113.[PubMed] [CrossRef]
154. Pappagianis D,, Zimmer BL . 1990. Serology of coccidioidomycosis. Clin Microbiol Rev 3 : 247268.[PubMed]
155. Marr KA,, Balajee SA,, McLaughlin L,, Tabouret M,, Bentsen C,, Walsh TJ . 2004. Detection of galactomannan antigenemia by enzyme immunoassay for the diagnosis of invasive aspergillosis: variables that affect performance. J Infect Dis 190 : 641649.[PubMed] [CrossRef]
156. Machetti M,, Zotti M,, Veroni L,, Mordini N,, Van Lint MT,, Bacigalupo A,, Paola D,, Viscoli C . 2000. Antigen detection in the diagnosis and management of a patient with probable cerebral aspergillosis treated with voriconazole. Transpl Infect Dis 2 : 140144.[PubMed] [CrossRef]
157. Kono Y,, Tsushima K,, Yamaguchi K,, Kurita N,, Soeda S,, Fujiwara A,, Sugiyama S,, Togashi Y,, Kasagi S,, To M,, To Y,, Setoguchi Y . 2013. The utility of galactomannan antigen in the bronchial washing and serum for diagnosing pulmonary aspergillosis. Respir Med 107 : 10941100.[PubMed] [CrossRef]
158. Bio-Rad . 2009. Platelia™ Aspergillus. EIA Package Insert, Marnes La Coquette, France.
159. Maertens J,, Maertens V,, Theunissen K,, Meersseman W,, Meersseman P,, Meers S,, Verbeken E,, Verhoef G,, Van Eldere J,, Lagrou K . 2009. Bronchoalveolar lavage fluid galactomannan for the diagnosis of invasive pulmonary aspergillosis in patients with hematologic diseases. Clin Infect Dis 49 : 16881693.[PubMed] [CrossRef]
160. Pasqualotto AC,, Xavier MO,, Sánchez LB,, de Oliveira Costa CD,, Schio SM,, Camargo SM,, Camargo JJ,, Sukiennik TC,, Severo LC . 2010. Diagnosis of invasive aspergillosis in lung transplant recipients by detection of galactomannan in the bronchoalveolar lavage fluid. Transplantation 90 : 306311.[PubMed] [CrossRef]
161. Maertens J,, Theunissen K,, Verhoef G,, Verschakelen J,, Lagrou K,, Verbeken E,, Wilmer A,, Verhaegen J,, Boogaerts M,, Van Eldere J . 2005. Galactomannan and computed tomography-based preemptive antifungal therapy in neutropenic patients at high risk for invasive fungal infection: A prospective feasibility study. Clin Infect Dis 41 : 12421250.[PubMed] [CrossRef]
162. Husain S,, Kwak EJ,, Obman A,, Wagener MM,, Kusne S,, Stout JE,, McCurry KR,, Singh N . 2004. Prospective assessment of Platelia Aspergillus galactomannan antigen for the diagnosis of invasive aspergillosis in lung transplant recipients. Am J Transplant 4 : 796802.[PubMed] [CrossRef]
163. Schelenz S,, Barnes RA,, Barton RC,, Cleverley JR,, Lucas SB,, Kibbler CC,, Denning DW ; British Society for Medical Mycology . 2015. British Society for Medical Mycology best practice recommendations for the diagnosis of serious fungal diseases. Lancet Infect Dis 15 : 461474.[PubMed] [CrossRef]
164. Pfeiffer CD,, Fine JP,, Safdar N . 2006. Diagnosis of invasive aspergillosis using a galactomannan assay: A meta-analysis. Clin Infect Dis 42 : 14171427.[PubMed] [CrossRef]
165. Lamoth F,, Cruciani M,, Mengoli C,, Castagnola E,, Lortholary O,, Richardson M,, Marchetti O . 2012. β-Glucan antigenemia assay for the diagnosis of invasive fungal infections in patients with hematological malignancies: A systematic review and meta-analysis of cohort studies from the Third European Conference on Infections in Leukemia (ECIL-3). Clin Infect Dis 54 : 633643.[PubMed] [CrossRef]
166. Mennink-Kersten MA,, Donnelly JP,, Verweij PE . 2004. Detection of circulating galactomannan for the diagnosis and management of invasive aspergillosis. Lancet Infect Dis 4 : 349357.[PubMed] [CrossRef]
167. Guigue N,, Menotti J,, Ribaud P . 2013. False positive galactomannan test after ice-pop ingestion. N Engl J Med 369 : 9798.[PubMed] [CrossRef]
168. Fisher CE,, Stevens AM,, Leisenring W,, Pergam SA,, Boeckh M,, Hohl TM . 2014. Independent contribution of bronchoalveolar lavage and serum galactomannan in the diagnosis of invasive pulmonary aspergillosis. Transpl Infect Dis 16 : 505510.[PubMed] [CrossRef]
169. Avni T,, Levy I,, Sprecher H,, Yahav D,, Leibovici L,, Paul M . 2012. Diagnostic accuracy of PCR alone compared to galactomannan in bronchoalveolar lavage fluid for diagnosis of invasive pulmonary aspergillosis: A systematic review. J Clin Microbiol 50 : 36523658.[PubMed] [CrossRef]
170. Zou M,, Tang L,, Zhao S,, Zhao Z,, Chen L,, Chen P,, Huang Z,, Li J,, Chen L,, Fan X . 2012. Systematic review and meta-analysis of detecting galactomannan in bronchoalveolar lavage fluid for diagnosing invasive aspergillosis. PLoS One 7 : e43347. doi:10.1371/journal.pone.0043347 [CrossRef]
171. Heng SC,, Morrissey O,, Chen SC,, Thursky K,, Manser RL,, Nation RL,, Kong DC,, Slavin M . 2013. Utility of bronchoalveolar lavage fluid galactomannan alone or in combination with PCR for the diagnosis of invasive aspergillosis in adult hematology patients: A systematic review and meta-analysis. Crit Rev Microbiol 41 : 124134.[PubMed] [CrossRef]
172. Aguado JM,, Vázquez L