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Chapter 8 : Human Papillomavirus

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Human Papillomavirus, Page 1 of 2

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Abstract:

Human papillomavirus (HPV), a member of the family, is a small (8kb), nonenveloped, double-stranded DNA virus. HPV has a predilection for infecting cutaneous and mucosal epithelial cells ( ). Infection with HPV is associated with a wide range of pathology. HPV is the etiological factor in benign cutaneous warts and juvenile respiratory papillomatosis, as well as low-grade squamous intraepithelial lesions (LSIL), high-grade squamous intraepithelial lesions (HSIL), a precursor to cancer, and invasive carcinoma ( ). Harald zur Hausen, a German virologist, was the first to describe the association of HPV and cervical cancer in the 1970s ( ). It is now understood that HPV is necessary in the development of cervical cancer and is also associated with carcinoma of the vulva, vagina, penis, anus, and oropharynx ( ).

Citation: Burd E, Dean C. 2016. Human Papillomavirus, p 177-195. In Hayden R, Wolk D, Carroll K, Tang Y (ed),

Diagnostic Microbiology of the Immunocompromised Host, Second Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0001-2015
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Figure 1

Algorithm for diagnosis of oropharyngeal squamous cell carcinoma.

Citation: Burd E, Dean C. 2016. Human Papillomavirus, p 177-195. In Hayden R, Wolk D, Carroll K, Tang Y (ed),

Diagnostic Microbiology of the Immunocompromised Host, Second Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0001-2015
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Image of Figure 2
Figure 2

Algorithm for screening and diagnosis of anal cancer in high-risk groups. There are currently no formal recommendations for routine anal cancer screening in the United States.

Citation: Burd E, Dean C. 2016. Human Papillomavirus, p 177-195. In Hayden R, Wolk D, Carroll K, Tang Y (ed),

Diagnostic Microbiology of the Immunocompromised Host, Second Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0001-2015
Permissions and Reprints Request Permissions
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Image of Figure 3
Figure 3

Algorithm for screening and diagnosis of cervical cancer in immunosuppressed women. For HIV-infected women ( ), screen at 6 months, 12 months, then annually; consider screening within 1 year of onset of sexual activity ( ); some experts would recommend continued cytology screening every 6 months in women with CD4 counts less than 200/mm or a history of HPV infection. For immunosuppressed women without HIV, annual cervical cytology screening is recommended ( ).

Citation: Burd E, Dean C. 2016. Human Papillomavirus, p 177-195. In Hayden R, Wolk D, Carroll K, Tang Y (ed),

Diagnostic Microbiology of the Immunocompromised Host, Second Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0001-2015
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Tables

Generic image for table
Table 1

Cytological and histological classification of anal dysplasia and cervical dysplasia

Citation: Burd E, Dean C. 2016. Human Papillomavirus, p 177-195. In Hayden R, Wolk D, Carroll K, Tang Y (ed),

Diagnostic Microbiology of the Immunocompromised Host, Second Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0001-2015
Generic image for table
Table 2

Cervical cancer screening guidelines

Citation: Burd E, Dean C. 2016. Human Papillomavirus, p 177-195. In Hayden R, Wolk D, Carroll K, Tang Y (ed),

Diagnostic Microbiology of the Immunocompromised Host, Second Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0001-2015
Generic image for table
Table 3

Role for HPV testing in HIV-infected women ( )

Citation: Burd E, Dean C. 2016. Human Papillomavirus, p 177-195. In Hayden R, Wolk D, Carroll K, Tang Y (ed),

Diagnostic Microbiology of the Immunocompromised Host, Second Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0001-2015

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