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Chapter 10 : The Skin Microbiome: Insights into Potential Impact on Diagnostic Practice

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Abstract:

No type of culture medium can exactly replicate the complex environment of the skin surface. Slightly cooler than body temperature, exposed to the external environment, and generally arid compared to other body habitats, the skin presents a formidable challenge for the colonization and growth of most microorganisms. To fully appreciate the microbial complexity of the skin, one must first be familiar with the unique features of the skin as a habitat. The outer layer of the skin, the epidermis, is composed of keratinocytes in various stages of differentiation. The most superficial layer of the epidermis, the stratum corneum, forms a semi-impenetrable barrier consisting of several layers of dead, flattened, enucleated, polyhedral, keratin-filled cells, termed corneocytes. Through the process of desquamation, corneocytes are continuously shed from the skin surface through terminal differentiation, providing a continuous supply of nutrients (i.e., keratins) to support the growth of microorganisms. Beneath the epidermis lies the dermis, a connective tissue layer rich in blood and lymphatic vessels. Subcutaneous connective tissue and fat separate the skin from the muscles and organs of the body.

Citation: Grice E. 2016. The Skin Microbiome: Insights into Potential Impact on Diagnostic Practice, p 117-125. In Persing D, Tenover F, Hayden R, Ieven M, Miller M, Nolte F, Tang Y, van Belkum A (ed), Molecular Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555819071.ch10
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Tables

Generic image for table
TABLE 1

Skin disorders caused by or associated with bacterial colonization and/or infection

Citation: Grice E. 2016. The Skin Microbiome: Insights into Potential Impact on Diagnostic Practice, p 117-125. In Persing D, Tenover F, Hayden R, Ieven M, Miller M, Nolte F, Tang Y, van Belkum A (ed), Molecular Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555819071.ch10
Generic image for table
TABLE 2

Skin disorders caused by or associated with fungal agents

Citation: Grice E. 2016. The Skin Microbiome: Insights into Potential Impact on Diagnostic Practice, p 117-125. In Persing D, Tenover F, Hayden R, Ieven M, Miller M, Nolte F, Tang Y, van Belkum A (ed), Molecular Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555819071.ch10
Generic image for table
TABLE 3

Skin disorders caused by or associated with viruses

Citation: Grice E. 2016. The Skin Microbiome: Insights into Potential Impact on Diagnostic Practice, p 117-125. In Persing D, Tenover F, Hayden R, Ieven M, Miller M, Nolte F, Tang Y, van Belkum A (ed), Molecular Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555819071.ch10

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