Chapter 32 : Parvoviruses

MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.

Preview this chapter:
Zoom in

Parvoviruses, Page 1 of 2

| /docserver/preview/fulltext/10.1128/9781555819156/9781555819149.ch32-1.gif /docserver/preview/fulltext/10.1128/9781555819156/9781555819149.ch32-2.gif


The parvoviruses are a large group of DNA viruses capable of infecting a wide variety of both invertebrate and vertebrate hosts, including humans and their companion animals. Depending on the virus and the immune status of the host, human infection can range from overt disease to persistent asymptomatic infection. Current parvovirus taxonomy dates from 2004; however, in the intervening 10 years, as new viruses have been identified and more taxonomic data have become available, the current taxonomy is now considered outdated. A new taxonomic classification of the family has therefore been proposed and is currently under review and likely to be instituted in the near future (1). The proposed taxonomy, based on the amino acid sequence of the NS1 and viral capsid proteins, maintains the family and subfamily for the vertebrate parvoviruses, but adds three new genera and a nomenclature change that impact the taxonomy of the human parvoviruses. A member of a proposed genus must now have >30% amino acid sequence identity to other members of the same genus but <30% identity to members of other genera (1). Criteria for inclusion in a viral species have also changed under the proposed taxonomy, with members of the same species having >85% amino acid sequence identity to other members of the same species and >15% amino acid diversity from members of other species (1). The proposed genera and the human viruses they contain are : human bocaviruses 1–4 (HBoV1-4); : human adeno-associated viruses (AAVs); : human parvovirus B19-related viruses; : human bufaviruses; and : human parvovirus 4–related viruses (Par4) (1).

Citation: Buller R. 2016. Parvoviruses, p 443-455. In Loeffelholz M, Hodinka R, Young S, Pinsky B (ed), Clinical Virology Manual, Fifth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819156.ch32
Highlighted Text: Show | Hide
Loading full text...

Full text loading...


1. Cotmore SF, Agbandje-McKenna M, Chiorini JA, Mukha DV, Pintel DJ, Qiu J, Soderlund-Venermo M, Tattersall P, Tijssen P, Gatherer D, Davison AJ. 2014. The family Parvoviridae. Arch Virol 159:12391247[CrossRef].[PubMed]
2. Flotte TR, Berns KI. 2005. Adeno-associated virus: a ubiquitous commensal of mammals. Hum Gene Ther 16:401407[CrossRef].[PubMed]
3. Berns KI, Parrish CR,. 2013. Parvoviridae, p 17681791. In Knipe DM, Howley PM (eds.), Fields Virology, 6th ed, vol 2. Lippincott Williams & Wilkins, Philadelphia, PA.
4. Truyen U. 1999. Emergence and recent evolution of canine parvovirus. Vet Microbiol 69:4750[CrossRef].[PubMed]
5. Servant A, Laperche S, Lallemand F, Marinho V, De Saint Maur G, Meritet JF, Garbarg-Chenon A. 2002. Genetic diversity within human erythroviruses: identification of three genotypes. J Virol 76:91249134[CrossRef].[PubMed]
6. Kapoor A, Simmonds P, Slikas E, Li L, Bodhidatta L, Sethabutr O, Triki H, Bahri O, Oderinde BS, Baba MM, Bukbuk DN, Besser J, Bartkus J, Delwart E. 2010. Human bocaviruses are highly diverse, dispersed, recombination prone, and prevalent in enteric infections. J Infect Dis 201:16331643[CrossRef].[PubMed]
7. Cheng W, Chen J, Xu Z, Yu J, Huang C, Jin M, Li H, Zhang M, Jin Y, Duan ZJ. 2011. Phylogenetic and recombination analysis of human bocavirus 2. BMC Infect Dis 11:50[CrossRef].[PubMed]
8. Matthews PC, Malik A, Simmons R, Sharp C, Simmonds P, Klenerman P. 2014. PARV4: an emerging tetraparvovirus. PLoS Pathog 10:e1004036[CrossRef].[PubMed]
9. Fryer JF, Kapoor A, Minor PD, Delwart E, Baylis SA. 2006. Novel parvovirus and related variant in human plasma. Emerg Infect Dis 12:151154[CrossRef].[PubMed]
10. Phan TG, Vo NP, Bonkoungou IJ, Kapoor A, Barro N, O'Ryan M, Kapusinszky B, Wang C, Delwart E. 2012. Acute diarrhea in West African children: diverse enteric viruses and a novel parvovirus genus. J Virol 86:1102411030[CrossRef].[PubMed]
11. Yahiro T, Wangchuk S, Tshering K, Bandhari P, Zangmo S, Dorji T, Tshering K, Matsumoto T, Nishizono A, Söderlund-Venermo M, Ahmed K. 2014. Novel human bufavirus genotype 3 in children with severe diarrhea, Bhutan. Emerg Infect Dis 20:10371039[CrossRef].[PubMed]
12. Anderson MJ, Higgins PG, Davis LR, Willman JS, Jones SE, Kidd IM, Pattison JR, Tyrrell DA. 1985. Experimental parvoviral infection in humans. J Infect Dis 152:257265[CrossRef].[PubMed]
13. Brown KE, Anderson SM, Young NS. 1993. Erythrocyte P antigen: cellular receptor for B19 parvovirus. Science 262:114117[CrossRef].[PubMed]
14. Brown KE, Hibbs JR, Gallinella G, Anderson SM, Lehman ED, McCarthy P, Young NS. 1994. Resistance to parvovirus B19 infection due to lack of virus receptor (erythrocyte P antigen). N Engl J Med 330:11921196[CrossRef].[PubMed]
15. Brown KE. 2010. The expanding range of parvoviruses which infect humans. Rev Med Virol 20:231244[CrossRef].[PubMed]
16. Röhrer C, Gärtner B, Sauerbrei A, Böhm S, Hottenträger B, Raab U, Thierfelder W, Wutzler P, Modrow S. 2008. Seroprevalence of parvovirus B19 in the German population. Epidemiol Infect 136:15641575[CrossRef].[PubMed]
17. Miron D, Luder A, Horovitz Y, Izkovitz A, Shizgreen I, Ben David E, Ohnona FS, Schlesinger Y. 2006. Acute human parvovirus B-19 infection in hospitalized children: A serologic and molecular survey. Pediatr Infect Dis J 25:898901[CrossRef].[PubMed]
18. Smith-Whitley K, Zhao H, Hodinka RL, Kwiatkowski J, Cecil R, Cecil T, Cnaan A, Ohene-Frempong K. 2004. Epidemiology of human parvovirus B19 in children with sickle cell disease. Blood 103:422427[CrossRef].[PubMed]
19. Parsyan A, Candotti D. 2007. Human erythrovirus B19 and blood transfusion–an update. Transfus Med 17:263278[CrossRef].[PubMed]
20. Musiani M, Zerbini M, Gentilomi G, Plazzi M, Gallinella G, Venturoli S. 1995. Parvovirus B19 clearance from peripheral blood after acute infection. J Infect Dis 172:13601363[CrossRef].[PubMed]
21. Kooistra K, Mesman HJ, de Waal M, Koppelman MH, Zaaijer HL. 2011. Epidemiology of high-level parvovirus B19 viraemia among Dutch blood donors, 2003–2009. Vox Sang 100:261266[CrossRef].[PubMed]
22. Soucie JM, De Staercke C, Monahan PE, Recht M, Chitlur MB, Gruppo R, Hooper WC, Kessler C, Kulkarni R, Manco-Johnson MJ, Powell J, Pyle M, Riske B, Sabio H, Trimble S Network USHTC, US Hemophilia Treatment Center Network. 2013. Evidence for the transmission of parvovirus B19 in patients with bleeding disorders treated with plasma-derived factor concentrates in the era of nucleic acid test screening. Transfusion 53:12171225[CrossRef].[PubMed]
23. 2009, Guidance for Industry: Nucleic Acid Testing (NAT) to Reduce the Possible Risk of Parvovirus B19 Transmission by Plasma-Derived Products. U.S. Department of Health and Human Services Food and Drug Administration Center for Biologics Evaluation and Research. [Online.]
24. Eid AJ, Brown RA, Patel R, Razonable RR. 2006. Parvovirus B19 infection after transplantation: a review of 98 cases. Clin Infect Dis 43:4048[CrossRef].[PubMed]
25. Söderlund-Venermo M, Hokynar K, Nieminen J, Rautakorpi H, Hedman K. 2002. Persistence of human parvovirus B19 in human tissues. Pathol Biol (Paris) 50:307316[CrossRef].[PubMed]
26. de Jong EP, Walther FJ, Kroes AC, Oepkes D. 2011. Parvovirus B19 infection in pregnancy: new insights and management. Prenat Diagn 31:419425[CrossRef].[PubMed]
27. Candotti D, Etiz N, Parsyan A, Allain JP. 2004. Identification and characterization of persistent human erythrovirus infection in blood donor samples. J Virol 78:1216912178[CrossRef].[PubMed]
28. Sanabani S, Neto WK, Pereira J, Sabino EC. 2006. Sequence variability of human erythroviruses present in bone marrow of Brazilian patients with various parvovirus B19-related hematological symptoms. J Clin Microbiol 44:604606[CrossRef].[PubMed]
29. Rinckel LA, Buno BR, Gierman TM, Lee DC. 2009. Discovery and analysis of a novel parvovirus B19 Genotype 3 isolate in the United States. Transfusion 49:14881492[CrossRef].[PubMed]
30. Norja P, Hokynar K, Aaltonen LM, Chen R, Ranki A, Partio EK, Kiviluoto O, Davidkin I, Leivo T, Eis-Hübinger AM, Schneider B, Fischer HP, Tolba R, Vapalahti O, Vaheri A, Söderlund-Venermo M, Hedman K. 2006. Bioportfolio: lifelong persistence of variant and prototypic erythrovirus DNA genomes in human tissue. Proc Natl Acad Sci USA 103:74507453[CrossRef].[PubMed]
31. Manning A, Willey SJ, Bell JE, Simmonds P. 2007. Comparison of tissue distribution, persistence, and molecular epidemiology of parvovirus B19 and novel human parvoviruses PARV4 and human bocavirus. J Infect Dis 195:13451352[CrossRef].[PubMed]
32. Hübschen JM, Mihneva Z, Mentis AF, Schneider F, Aboudy Y, Grossman Z, Rudich H, Kasymbekova K, Sarv I, Nedeljkovic J, Tahita MC, Tarnagda Z, Ouedraogo JB, Gerasimova AG, Moskaleva TN, Tikhonova NT, Chitadze N, Forbi JC, Faneye AO, Otegbayo JA, Charpentier E, Muller CP. 2009. Phylogenetic analysis of human parvovirus b19 sequences from eleven different countries confirms the predominance of genotype 1 and suggests the spread of genotype 3b. J Clin Microbiol 47:37353738[CrossRef].[PubMed]
33. Allander T, Tammi MT, Eriksson M, Bjerkner A, Tiveljung-Lindell A, Andersson B. 2005. Cloning of a human parvovirus by molecular screening of respiratory tract samples. Proc Natl Acad Sci USA 102:1289112896[CrossRef].[PubMed]
34. Jartti T, Hedman K, Jartti L, Ruuskanen O, Allander T, Söderlund-Venermo M. 2012. Human bocavirus–the first 5 years. Rev Med Virol 22:4664[CrossRef].[PubMed]
35. Costa C, Bergallo M, Cavallo R. 2009. Detection of Human Bocavirus in bronchoalveolar lavage from Italian adult patients. J Clin Virol 45:8182[CrossRef].[PubMed]
36. Peltola V, Söderlund-Venermo M, Jartti T. 2013. Human bocavirus infections. Pediatr Infect Dis J 32:178179[CrossRef].[PubMed]
37. Allander T, Jartti T, Gupta S, Niesters HG, Lehtinen P, Osterback R, Vuorinen T, Waris M, Bjerkner A, Tiveljung-Lindell A, van den Hoogen BG, Hyypiä T, Ruuskanen O. 2007. Human bocavirus and acute wheezing in children. Clin Infect Dis 44:904910[CrossRef].[PubMed]
38. Bonvicini F, Manaresi E, Gentilomi GA, Di Furio F, Zerbini M, Musiani M, Gallinella G. 2011. Evidence of human bocavirus viremia in healthy blood donors. Diagn Microbiol Infect Dis 71:460462[CrossRef].[PubMed]
39. Karalar L, Lindner J, Schimanski S, Kertai M, Segerer H, Modrow S. 2010. Prevalence and clinical aspects of human bocavirus infection in children. Clin Microbiol Infect 16:633639[CrossRef].[PubMed]
40. Risku M, Kätkä M, Lappalainen S, Räsänen S, Vesikari T. 2012. Human bocavirus types 1, 2 and 3 in acute gastroenteritis of childhood. Acta Paediatr 101:e405e410[CrossRef].[PubMed]
41. Vicente D, Cilla G, Montes M, Pérez-Yarza EG, Pérez-Trallero E. 2007. Human bocavirus, a respiratory and enteric virus. Emerg Infect Dis 13:636637[CrossRef].[PubMed]
42. Chow BD, Esper FP. 2009. The human bocaviruses: a review and discussion of their role in infection. Clin Lab Med 29:695713[CrossRef].[PubMed]
43. Kapoor A, Slikas E, Simmonds P, Chieochansin T, Naeem A, Shaukat S, Alam MM, Sharif S, Angez M, Zaidi S, Delwart E. 2009. A newly identified bocavirus species in human stool. J Infect Dis 199:196200[CrossRef].[PubMed]
44. Arthur JL, Higgins GD, Davidson GP, Givney RC, Ratcliff RM. 2009. A novel bocavirus associated with acute gastroenteritis in Australian children. PLoS Pathog 5:e1000391[CrossRef].[PubMed]
45. Han TH, Chung JY, Hwang ES. 2009. Human bocavirus 2 in children, South Korea. Emerg Infect Dis 15:16981700[CrossRef].[PubMed]
46. Song JR, Jin Y, Xie ZP, Gao HC, Xiao NG, Chen WX, Xu ZQ, Yan KL, Zhao Y, Hou YD, Duan ZJ. 2010. Novel human bocavirus in children with acute respiratory tract infection. Emerg Infect Dis 16:324327[CrossRef].[PubMed]
47. Kantola K, Hedman L, Arthur J, Alibeto A, Delwart E, Jartti T, Ruuskanen O, Hedman K, Söderlund-Venermo M. 2011. Seroepidemiology of human bocaviruses 1–4. J Infect Dis 204:14031412[CrossRef].[PubMed]
48. Blacklow NR, Hoggan MD, Rowe WP. 1968. Serologic evidence for human infection with adenovirus-associated viruses. J Natl Cancer Inst 40:319327.[PubMed]
49. Chirmule N, Propert K, Magosin S, Qian Y, Qian R, Wilson J. 1999. Immune responses to adenovirus and adeno-associated virus in humans. Gene Ther 6:15741583[CrossRef].[PubMed]
50. Calcedo R, Vandenberghe LH, Gao G, Lin J, Wilson JM. 2009. Worldwide epidemiology of neutralizing antibodies to adeno-associated viruses. J Infect Dis 199:381390[CrossRef].[PubMed]
51. Jones MS, Kapoor A, Lukashov VV, Simmonds P, Hecht F, Delwart E. 2005. New DNA viruses identified in patients with acute viral infection syndrome. J Virol 79:82308236[CrossRef].[PubMed]
52. Drexler JF, Reber U, Muth D, Herzog P, Annan A, Ebach F, Sarpong N, Acquah S, Adlkofer J, Adu-Sarkodie Y, Panning M, Tannich E, May J, Drosten C, Eis-Hübinger AM. 2012. Human parvovirus 4 in nasal and fecal specimens from children, Ghana. Emerg Infect Dis 18:16501653[CrossRef].[PubMed]
53. Fryer JF, Delwart E, Hecht FM, Bernardin F, Jones MS, Shah N, Baylis SA. 2007. Frequent detection of the parvoviruses, PARV4 and PARV5, in plasma from blood donors and symptomatic individuals. Transfusion 47:10541061[CrossRef].[PubMed]
54. Fryer JF, Delwart E, Bernardin F, Tuke PW, Lukashov VV, Baylis SA. 2007. Analysis of two human parvovirus PARV4 genotypes identified in human plasma for fractionation. J Gen Virol 88:21622167[CrossRef].[PubMed]
55. Chen MY, Yang SJ, Hung CC. 2011. Placental transmission of human parvovirus 4 in newborns with hydrops, Taiwan. Emerg Infect Dis 17:19541956[CrossRef].[PubMed]
56. Corcioli F, Zakrzewska K, Fanci R, De Giorgi V, Innocenti M, Rotellini M, Di Lollo S, Azzi A. 2010. Human parvovirus PARV4 DNA in tissues from adult individuals: a comparison with human parvovirus B19 (B19V). Virol J 7:272[CrossRef].[PubMed]
57. Schneider B, Fryer JF, Reber U, Fischer HP, Tolba RH, Baylis SA, Eis-Hübinger AM. 2008. Persistence of novel human parvovirus PARV4 in liver tissue of adults. J Med Virol 80:345351[CrossRef].[PubMed]
58. Väisänen E, Kuisma I, Phan TG, Delwart E, Lappalainen M, Tarkka E, Hedman K, Söderlund-Venermo M. 2014. Bufavirus in feces of patients with gastroenteritis, Finland. Emerg Infect Dis 20:10771079[CrossRef].[PubMed]
59. Smits SL, Schapendonk CM, van Beek J, Vennema H, Schürch AC, Schipper D, Bodewes R, Haagmans BL, Osterhaus AD, Koopmans MP. 2014. New viruses in idiopathic human diarrhea cases, the Netherlands. Emerg Infect Dis 20:12181222[CrossRef].[PubMed]
60. Cossart YE, Field AM, Cant B, Widdows D. 1975. Parvovirus-like particles in human sera. Lancet 305:7273[CrossRef].[PubMed]
61. Broliden K, Tolfvenstam T, Norbeck O. 2006. Clinical aspects of parvovirus B19 infection. J Intern Med 260:285304[CrossRef].[PubMed]
62. Woolf AD, Campion GV, Chishick A, Wise S, Cohen BJ, Klouda PT, Caul O, Dieppe PA. 1989. Clinical manifestations of human parvovirus B19 in adults. Arch Intern Med 149:11531156[CrossRef].[PubMed]
63. Edmonson MB, Riedesel EL, Williams GP, Demuri GP. 2010. Generalized petechial rashes in children during a parvovirus B19 outbreak. Pediatrics 125:e787e792[CrossRef].[PubMed]
64. Fuller A, Moaven L, Spelman D, Spicer WJ, Wraight H, Curtis D, Leydon J, Doultree J, Locarnini S. 1996. Parvovirus B19 in HIV infection: a treatable cause of anemia. Pathology 28:277280[CrossRef].[PubMed]
65. Graeve JL, de Alarcon PA, Naides SJ. 1989. Parvovirus B19 infection in patients receiving cancer chemotherapy: the expanding spectrum of disease. Am J Pediatr Hematol Oncol 11:441444[CrossRef].[PubMed]
66. Blaeser F, Kelly M, Siegrist K, Storch GA, Buller RS, Whitlock J, Truong N, Chatila TA. 2005. Critical function of the CD40 pathway in parvovirus B19 infection revealed by a hypomorphic CD40 ligand mutation. Clin Immunol 117:231237[CrossRef].[PubMed]
67. Florea AV, Ionescu DN, Melhem MF. 2007. Parvovirus B19 infection in the immunocompromised host. Arch Pathol Lab Med 131:799804.[PubMed]
68. Morelli P, Bestetti G, Longhi E, Parravicini C, Corbellino M, Meroni L. 2007. Persistent parvovirus B19-induced anemia in an HIV-infected patient under HAART. Case report and review of literature. Eur J Clin Microbiol Infect Dis 26:833837[CrossRef].[PubMed]
69. Slavov SN, Kashima S, Pinto AC, Covas DT. 2011. Human parvovirus B19: general considerations and impact on patients with sickle-cell disease and thalassemia and on blood transfusions. FEMS Immunol Med Microbiol 62:247262[CrossRef].[PubMed]
70. Barah F, Vallely PJ, Chiswick ML, Cleator GM, Kerr JR. 2001. Association of human parvovirus B19 infection with acute meningoencephalitis. Lancet 358:729730[CrossRef].[PubMed]
71. Bonvicini F, Marinacci G, Pajno MC, Gallinella G, Musiani M, Zerbini M. 2008. Meningoencephalitis with persistent parvovirus B19 infection in an apparently healthy woman. Clin Infect Dis 47:385387[CrossRef].[PubMed]
72. Bültmann BD, Klingel K, Sotlar K, Bock CT, Baba HA, Sauter M, Kandolf R. 2003. Fatal parvovirus B19-associated myocarditis clinically mimicking ischemic heart disease: an endothelial cell-mediated disease. Hum Pathol 34:9295[CrossRef].[PubMed]
73. Enders G, Dötsch J, Bauer J, Nützenadel W, Hengel H, Haffner D, Schalasta G, Searle K, Brown KE. 1998. Life-threatening parvovirus B19-associated myocarditis and cardiac transplantation as possible therapy: two case reports. Clin Infect Dis 26:355358[CrossRef].[PubMed]
74. Pankuweit S, Moll R, Baandrup U, Portig I, Hufnagel G, Maisch B. 2003. Prevalence of the parvovirus B19 genome in endomyocardial biopsy specimens. Hum Pathol 34:497503[CrossRef].[PubMed]
75. Schildgen O, Müller A, Allander T, Mackay IM, Völz S, Kupfer B, Simon A. 2008. Human bocavirus: passenger or pathogen in acute respiratory tract infections? Clin Microbiol Rev 21:291304. Table of contents[CrossRef].[PubMed]
76. Söderlund-Venermo M, Lahtinen A, Jartti T, Hedman L, Kemppainen K, Lehtinen P, Allander T, Ruuskanen O, Hedman K. 2009. Clinical assessment and improved diagnosis of bocavirus-induced wheezing in children, Finland. Emerg Infect Dis 15:14231430[CrossRef].[PubMed]
77. 2008. Control of Cummunicable Diseases Manual, 19th ed. Amerian Public Health Association, Washington, DC, USA.
78. Bell LM, Naides SJ, Stoffman P, Hodinka RL, Plotkin SA. 1989. Human parvovirus B19 infection among hospital staff members after contact with infected patients. N Engl J Med 321:485491[CrossRef].[PubMed]
79. Chuhjo T, Nakao S, Matsuda T. 1999. Successful treatment of persistent erythroid aplasia caused by parvovirus B19 infection in a patient with common variable immunodeficiency with low-dose immunoglobulin. Am J Hematol 60:222224[CrossRef].[PubMed]
80. Crabol Y, Terrier B, Rozenberg F, Pestre V, Legendre C, Hermine O, Montagnier-Petrissans C, Guillevin L, Mouthon L Groupe d'experts de l'Assistance Publique-Hôpitaux de Paris. 2013. Intravenous immunoglobulin therapy for pure red cell aplasia related to human parvovirus b19 infection: a retrospective study of 10 patients and review of the literature. Clin Infect Dis 56:968977[CrossRef].[PubMed]
81. Frickhofen N , et al. 1990. Persistent B19 parvovirus infection in patients infected with human immunodeficiency virus type 1 (HIV-1): a treatable cause of anemia in AIDS. Ann Intern Med 113:926933[CrossRef].[PubMed]
82. Koduri PR, Kumapley R, Valladares J, Teter C. 1999. Chronic pure red cell aplasia caused by parvovirus B19 in AIDS: use of intravenous immunoglobulin—a report of eight patients. Am J Hematol 61:1620[CrossRef].[PubMed]
83. Kurtzman G, Frickhofen N, Kimball J, Jenkins DW, Nienhuis AW, Young NS. 1989. Pure red-cell aplasia of 10 years’ duration due to persistent parvovirus B19 infection and its cure with immunoglobulin therapy. N Engl J Med 321:519523[CrossRef].[PubMed]
84. Selbing A, Josefsson A, Dahle LO, Lindgren R. 1995. Parvovirus B19 infection during pregnancy treated with high-dose intravenous gammaglobulin. Lancet 345:660661[CrossRef].[PubMed]
85. Matsuda H, Sakaguchi K, Shibasaki T, Takahashi H, Kawakami Y, Furuya K. 2005. Intrauterine therapy for parvovirus B19 infected symptomatic fetus using B19 IgG-rich high titer gammaglobulin. J Perinat Med 33:561563[CrossRef].[PubMed]
86. Ballou WR, Reed JL, Noble W, Young NS, Koenig S. 2003. Safety and immunogenicity of a recombinant parvovirus B19 vaccine formulated with MF59C.1. J Infect Dis 187:675678[CrossRef].[PubMed]
87. Bernstein DI, El Sahly HM, Keitel WA, Wolff M, Simone G, Segawa C, Wong S, Shelly D, Young NS, Dempsey W. 2011. Safety and immunogenicity of a candidate parvovirus B19 vaccine. Vaccine 29:73577363[CrossRef].[PubMed]
88. Christensen A, Nordbø SA, Krokstad S, Rognlien AG, Døllner H. 2008. Human bocavirus commonly involved in multiple viral airway infections. J Clin Virol 41:3437[CrossRef].[PubMed]
89. Martin ET, Fairchok MP, Kuypers J, Magaret A, Zerr DM, Wald A, Englund JA. 2010. Frequent and prolonged shedding of bocavirus in young children attending daycare. J Infect Dis 201:16251632[CrossRef].[PubMed]
90. Wang K, Wang W, Yan H, Ren P, Zhang J, Shen J, Deubel V. 2010. Correlation between bocavirus infection and humoral response, and co-infection with other respiratory viruses in children with acute respiratory infection. J Clin Virol 47:148155[CrossRef].[PubMed]
91. Christensen A, Nordbø SA, Krokstad S, Rognlien AG, Døllner H. 2010. Human bocavirus in children: mono-detection, high viral load and viraemia are associated with respiratory tract infection. J Clin Virol 49:158162[CrossRef].[PubMed]
92. Doyle S. 2011. The detection of parvoviruses. Methods Mol Biol 665:213231[CrossRef].[PubMed]
93. Jordan JA,. 2011. Human Parvoviruses, p. 16361646. In Landry ML, Caliendo AM, Ginoccchio CC, Tang YW, Valsamakis A (eds.), Manual of Clinical Microbiology, 10th ed., vol 2. ASM Press, Washington, DC.
94. Peterlana D, Puccetti A, Corrocher R, Lunardi C. 2006. Serologic and molecular detection of human Parvovirus B19 infection. Clin Chim Acta 372:1423[CrossRef].[PubMed]
95. Young NS, Brown KE. 2004. Parvovirus B19. N Engl J Med 350:586597[CrossRef].[PubMed]
96. Butchko AR, Jordan JA. 2004. Comparison of three commercially available serologic assays used to detect human parvovirus B19-specific immunoglobulin M (IgM) and IgG antibodies in sera of pregnant women. J Clin Microbiol 42:31913195[CrossRef].[PubMed]
97. Doyle S, Kerr S, O'Keeffe G, O'Carroll D, Daly P, Kilty C. 2000. Detection of parvovirus B19 IgM by antibody capture enzyme immunoassay: receiver operating characteristic analysis. J Virol Methods 90:143152[CrossRef].[PubMed]
98. Ferguson M, Heath A. 2004. Report of a collaborative study to calibrate the Second International Standard for parvovirus B19 antibody. Biologicals 32:207212[CrossRef].[PubMed]
99. Bonvicini F, Manaresi E, Gallinella G, Gentilomi GA, Musiani M, Zerbini M. 2009. Diagnosis of fetal parvovirus B19 infection: value of virological assays in fetal specimens. BJOG 116:813817[CrossRef].[PubMed]
100. Lamont RF, Sobel JD, Vaisbuch E, Kusanovic JP, Mazaki-Tovi S, Kim SK, Uldbjerg N, Romero R. 2011. Parvovirus B19 infection in human pregnancy. BJOG 118:175186[CrossRef].[PubMed]
101. Prassouli A, Papadakis V, Tsakris A, Stefanaki K, Garoufi A, Haidas S, Dracou C. 2005. Classic transient erythroblastopenia of childhood with human parvovirus B19 genome detection in the blood and bone marrow. J Pediatr Hematol Oncol 27:333336[CrossRef].[PubMed]
102. Dijkmans BA, van Elsacker-Niele AM, Salimans MM, van Albada-Kuipers GA, de Vries E, Weiland HT. 1988. Human parvovirus B19 DNA in synovial fluid. Arthritis Rheum 31:279281[CrossRef].[PubMed]
103. Nikkari S, Roivainen A, Hannonen P, Möttönen T, Luukkainen R, Yli-Jama T, Toivanen P. 1995. Persistence of parvovirus B19 in synovial fluid and bone marrow. Ann Rheum Dis 54:597600[CrossRef].[PubMed]
104. Dwivedi M, Manocha H, Tiwari S, Tripathi G, Dhole TN. 2009. Coinfection of parvovirus b19 with other hepatitis viruses leading to fulminant hepatitis of unfavorable outcome in children. Pediatr Infect Dis J 28:649650[CrossRef].[PubMed]
105. Molina KM, Garcia X, Denfield SW, Fan Y, Morrow WR, Towbin JA, Frazier EA, Nelson DP. 2013. Parvovirus B19 myocarditis causes significant morbidity and mortality in children. Pediatr Cardiol 34:390397[CrossRef].[PubMed]
106. Cohen BJ, Gandhi J, Clewley JP. 2006. Genetic variants of parvovirus B19 identified in the United Kingdom: implications for diagnostic testing. J Clin Virol 36:152155[CrossRef].[PubMed]
107. Liefeldt L, Plentz A, Klempa B, Kershaw O, Endres AS, Raab U, Neumayer HH, Meisel H, Modrow S. 2005. Recurrent high level parvovirus B19/genotype 2 viremia in a renal transplant recipient analyzed by real-time PCR for simultaneous detection of genotypes 1 to 3. J Med Virol 75:161169[CrossRef].[PubMed]
108. Modrow S, Wenzel JJ, Schimanski S, Schwarzbeck J, Rothe U, Oldenburg J, Jilg W, Eis-Hübinger AM. 2011. Prevalence of nucleic acid sequences specific for human parvoviruses, hepatitis A and hepatitis E viruses in coagulation factor concentrates. Vox Sang 100:351358[CrossRef].[PubMed]
109. Grabarczyk P, Kalińska A, Sulkowska E, Brojer E. 2010. False negative results in high viremia parvovirus B19-samples tested with real-time PCR. Pol J Microbiol 59:129132.[PubMed]
110. Cassinotti P, Burtonboy G, Fopp M, Siegl G. 1997. Evidence for persistence of human parvovirus B19 DNA in bone marrow. J Med Virol 53:229232[CrossRef].[PubMed]
111. Cassinotti P, Siegl G. 2000. Quantitative evidence for persistence of human parvovirus B19 DNA in an immunocompetent individual. Eur J Clin Microbiol Infect Dis 19:886887[CrossRef].[PubMed]
112. Lefrère JJ, Servant-Delmas A, Candotti D, Mariotti M, Thomas I, Brossard Y, Lefrère F, Girot R, Allain JP, Laperche S. 2005. Persistent B19 infection in immunocompetent individuals: implications for transfusion safety. Blood 106:28902895[CrossRef].[PubMed]
113. Baylis SA, Chudy M, Blümel J, Pisani G, Candotti D, José M, Heath AB. 2010. Collaborative study to establish a replacement World Health Organization International Standard for parvovirus B19 DNA nucleic acid amplification technology (NAT)-based assays. Vox Sang 98(3p2):441446[CrossRef].[PubMed]
114. Mylonakis E, Dickinson BP, Mileno MD, Flanigan T, Schiffman FJ, Mega A, Rich JD. 1999. Persistent parvovirus B19 related anemia of seven years’ duration in an HIV-infected patient: complete remission associated with highly active antiretroviral therapy. Am J Hematol 60:164166[CrossRef].[PubMed]
115. Katragadda L, Shahid Z, Restrepo A, Muzaffar J, Alapat D, Anaissie E. 2013. Preemptive intravenous immunoglobulin allows safe and timely administration of antineoplastic therapies in patients with multiple myeloma and parvovirus B19 disease. Transpl Infect Dis 15:354360[CrossRef].[PubMed]
116. Tang JW, Lau JS, Wong SY, Cheung JL, Chan CH, Wong KF, Wong A, Chan PK. 2007. Dose-by-dose virological and hematological responses to intravenous immunoglobulin in an immunocompromised patient with persistent parvovirus B19 infection. J Med Virol 79:14011405[CrossRef].[PubMed]
117. Brown KE, Young NS, Alving BM, Barbosa LH. 2001. Parvovirus B19: implications for transfusion medicine. Summary of a workshop. Transfusion 41:130135[CrossRef].[PubMed]
118. Koppelman MH, Cuijpers HT, Wessberg S, Valkeajärvi A, Pichl L, Schottstedt V, Saldanha J. 2012. Multicenter evaluation of a commercial multiplex polymerase chain reaction test for screening plasma donations for parvovirus B19 DNA and hepatitis A virus RNA. Transfusion 52:14981508[CrossRef].[PubMed]
119. Lindner J, Modrow S. 2008. Human bocavirus–a novel parvovirus to infect humans. Intervirology 51:116122[CrossRef].[PubMed]
120. Vafaie J, Schwartz RA. 2004. Parvovirus B19 infections. Int J Dermatol 43:747749[CrossRef].[PubMed]
121. Valentin MN, Cohen PJ. 2013. Pediatric parvovirus B19: spectrum of clinical manifestations. Cutis 92:179184.[PubMed]
122. Ishikawa A, Yoto Y, Tsugawa T, Tsutsumi H. 2014. Quantitation of human parvovirus B19 DNA in erythema infectiosum and aplastic crisis. J Med Virol 86:21022106.
123. Enders M, Weidner A, Rosenthal T, Baisch C, Hedman L, Söderlund-Venermo M, Hedman K. 2008. Improved diagnosis of gestational parvovirus B19 infection at the time of nonimmune fetal hydrops. J Infect Dis 197:5862[CrossRef].[PubMed]
124. Friedman-Einat M, Grossman Z, Mileguir F, Smetana Z, Ashkenazi M, Barkai G, Varsano N, Glick E, Mendelson E. 1997. Detection of adeno-associated virus type 2 sequences in the human genital tract. J Clin Microbiol 35:7178.[PubMed]
125. Gao G, Vandenberghe LH, Alvira MR, Lu Y, Calcedo R, Zhou X, Wilson JM. 2004. Clades of Adeno-associated viruses are widely disseminated in human tissues. J Virol 78:63816388[CrossRef].[PubMed]
126. Kahn JS, Kesebir D, Cotmore SF, D'Abramo A Jr, Cosby C, Weibel C, Tattersall P. 2008. Seroepidemiology of human bocavirus defined using recombinant virus-like particles. J Infect Dis 198:4150[CrossRef].[PubMed]
127. Kantola K, Hedman L, Allander T, Jartti T, Lehtinen P, Ruuskanen O, Hedman K, Söderlund-Venermo M. 2008. Serodiagnosis of human bocavirus infection. Clin Infect Dis 46:540546[CrossRef].[PubMed]
128. Kantola K, Sadeghi M, Antikainen J, Kirveskari J, Delwart E, Hedman K, Söderlund-Venermo M. 2010. Real-time quantitative PCR detection of four human bocaviruses. J Clin Microbiol 48:40444050[CrossRef].[PubMed]
129. Lindner J, Karalar L, Zehentmeier S, Plentz A, Pfister H, Struff W, Kertai M, Segerer H, Modrow S. 2008. Humoral immune response against human bocavirus VP2 virus-like particles. Viral Immunol 21:443450[CrossRef].[PubMed]
130. Cheng WX, Jin Y, Duan ZJ, Xu ZQ, Qi HM, Zhang Q, Yu JM, Zhu L, Jin M, Liu N, Cui SX, Li HY, Fang ZY. 2008. Human bocavirus in children hospitalized for acute gastroenteritis: a case-control study. Clin Infect Dis 47:161167[CrossRef].[PubMed]
131. Norja P, Hedman L, Kantola K, Kemppainen K, Suvilehto J, Pitkäranta A, Aaltonen LM, Seppänen M, Hedman K, Söderlund-Venermo M. 2012. Occurrence of human bocaviruses and parvovirus 4 in solid tissues. J Med Virol 84:12671273[CrossRef].[PubMed]
132. Santos N, Peret TC, Humphrey CD, Albuquerque MC, Silva RC, Benati FJ, Lu X, Erdman DD. 2010. Human bocavirus species 2 and 3 in Brazil. J Clin Virol 48:127130[CrossRef].[PubMed]
133. Xu ZQ, Cheng WX, Li BW, Li J, Lan B, Duan ZJ. 2011. Development of a real-time PCR assay for detecting and quantifying human bocavirus 2. J Clin Microbiol 49:15371541[CrossRef].[PubMed]
134. Wang Y, Gonzalez R, Zhou H, Li J, Li Y, Paranhos-Baccalà G, Vernet G, Guo L, Wang J. 2011. Detection of human bocavirus 3 in China. Eur J Clin Microbiol Infect Dis 30:799805[CrossRef].[PubMed]
135. Lahtinen A, Kivelä P, Hedman L, Kumar A, Kantele A, Lappalainen M, Liitsola K, Ristola M, Delwart E, Sharp C, Simmonds P, Söderlund-Venermo M, Hedman K. 2011. Serodiagnosis of primary infections with human parvovirus 4, Finland. Emerg Infect Dis 17:7982[CrossRef].[PubMed]
136. Maple PA, Beard S, Parry RP, Brown KE. 2013. Testing UK blood donors for exposure to human parvovirus 4 using a time-resolved fluorescence immunoassay to screen sera and Western blot to confirm reactive samples. Transfusion 53:25752584[CrossRef].[PubMed]
137. Väisänen E, Lahtinen A, Eis-Hübinger AM, Lappalainen M, Hedman K, Söderlund-Venermo M. 2014. A two-step real-time PCR assay for quantitation and genotyping of human parvovirus 4. J Virol Methods 195:106111[CrossRef].[PubMed]
138. Bergallo M, Costa C, Sidoti F, Novelli M, Ponti R, Castagnoli C, Merlino C, Bernengo MG, Cavallo R. 2008. Variants of parvovirus B19: bioinformatical evaluation of nested PCR assays. Intervirology 51:7580[CrossRef].[PubMed]
139. Bergallo M, Merlino C, Daniele R, Costa C, Ponzi AN, Cavallo R. 2006. Quantitative competitive-PCR assay to measure human parvovirus B19-DNA load in serum samples. Mol Biotechnol 32:2329[CrossRef].[PubMed]
140. Bonvicini F, Manaresi E, Bua G, Venturoli S, Gallinella G. 2013. Keeping pace with parvovirus B19 genetic variability: a multiplex genotype-specific quantitative PCR assay. J Clin Microbiol 51:37533759[CrossRef].[PubMed]
141. Corcoran C, Hardie D, Yeats J, Smuts H. 2010. Genetic variants of human parvovirus B19 in South Africa: cocirculation of three genotypes and identification of a novel subtype of genotype 1. J Clin Microbiol 48:137142[CrossRef].[PubMed]
142. Daly P, Corcoran A, Mahon BP, Doyle S. 2002. High-sensitivity PCR detection of parvovirus B19 in plasma. J Clin Microbiol 40:19581962[CrossRef].[PubMed]
143. Koppelman MH, van Swieten P, Cuijpers HT. 2011. Real-time polymerase chain reaction detection of parvovirus B19 DNA in blood donations using a commercial and an in-house assay. Transfusion 51:13461354[CrossRef].[PubMed]
144. Manaresi E, Gallinella G, Zuffi E, Bonvicini F, Zerbini M, Musiani M. 2002. Diagnosis and quantitative evaluation of parvovirus B19 infections by real-time PCR in the clinical laboratory. J Med Virol 67:275281[CrossRef].[PubMed]


Generic image for table

References for molecular detection and/or identification of antibodies for non-B19 human parvoviruses

Citation: Buller R. 2016. Parvoviruses, p 443-455. In Loeffelholz M, Hodinka R, Young S, Pinsky B (ed), Clinical Virology Manual, Fifth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819156.ch32
Generic image for table

Laboratory-developed and commercial molecular assays for the detection of parvovirus B19 DNA

Citation: Buller R. 2016. Parvoviruses, p 443-455. In Loeffelholz M, Hodinka R, Young S, Pinsky B (ed), Clinical Virology Manual, Fifth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819156.ch32

This is a required field
Please enter a valid email address
Please check the format of the address you have entered.
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error