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Antibiotics: Challenges, Mechanisms, Opportunities

Editors: Christopher Walsh1, Timothy Wencewicz2
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Affiliations: 1: ChEM-H Institute, Stanford University; 2: Department of Chemistry, Washington University in St. Louis
Content Type: Textbook
Format: Hardcover
Publication Year: 2016

Category: Bacterial Pathogenesis

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focuses on antibiotics as small organic molecules, from both natural and synthetic sourcFes. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets.

This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics.

Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions:

  • What are antibiotics?
  • Where do antibiotics come from?
  • How do antibiotics work?
  • Why do antibiotics stop working?
  • How should our limited inventory of effective antibiotics be addressed?

is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.

“This book provides all the information needed to understand antibiotic genetics, biochemistry, mechanism of action and resistance. Most importantly, Walsh and Wencewicz are optimistic of the prospects of the discovery of novel therapeutic agents obtained by the manipulation of strains and biosynthetic pathways. This beautifully written book deserves to be read and implemented by everyone, especially the pessimists who believe that the antibiotic era has ended. In Antibiotics: Challenges, Mechanisms, Opportunities, Walsh and Wencewicz provide the definitive, ultimate compendium of everything antibiotic.”

— Julian Davies, Professor of Microbiology and Immunology, Life Sciences Institute, University of British Columbia Vancouver

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