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Chapter 18 : Chronic Fatigue and Postinfective Fatigue Syndromes

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Abstract:

Chronic fatigue syndrome (CFS) is the label most commonly applied to a symptom complex characterized by unexplained, persistent, and disabling fatigue, when no clear implication of an infective or other cause for the prolonged illness can be inferred (1). Constitutional symptoms, including myalgia, arthralgia, sore throat, headache, and tender lymph nodes, are also common. In addition, complaints of unrefreshing sleep, irritability, and neurocognitive abnormalities, like short-term memory impairment and concentration difficulty, are typical (1). CFS is also commonly termed myalgic encephalomyelitis, particularly in the United Kingdom, based on a premise of inflammation within the central nervous system—although this remains unproven (2). The US Institute of Medicine recently proposed that the condition be renamed “systemic exertion intolerance disease” to reflect a phenomenon characteristic of the illness, which is an exacerbation of fatigue and other symptoms after exercise or activity, termed “postexertional malaise” (3). However, only the name CFS has been accepted in common use internationally.

Citation: Lloyd A. 2017. Chronic Fatigue and Postinfective Fatigue Syndromes, p 371-384. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch18
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FIGURE 1

Time to resolution of symptoms in 50 patients monitored prospectively from the time of diagnosis of serologically documented acute EBV infection. The vertical axis indicates the percentage of the group reporting the symptom. (Used with permission by A.R. Lloyd, unpublished.)

Citation: Lloyd A. 2017. Chronic Fatigue and Postinfective Fatigue Syndromes, p 371-384. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch18
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Image of FIGURE 2
FIGURE 2

Approach to the clinical and laboratory assessment of patients with chronic fatigue. Adapted from reference ( )

Citation: Lloyd A. 2017. Chronic Fatigue and Postinfective Fatigue Syndromes, p 371-384. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch18
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References

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